基本信息
徐华强  男  博导  中国科学院上海药物研究所
电子邮件: eric.xu@simm.ac.cn
通信地址: 上海市浦东张江海科路501号1715室
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
100701-药物化学
招生方向
结构生物学
药物化学

教育背景

1994-11--1996-12   美国麻省理工学院   博士后
1991-01--1994-10   美国德州大学西南医学中心   博士学位
1985-09--1988-12   清华大学   硕士学位
1980-09--1985-07   清华大学   学士学位

工作经历

   
工作简历
2013-04~现在, 中国科学院受体结构与功能重点实验室, 创办人,主任
2010-07~现在, 中国科学院上海药物所, 药靶结构与功能中心主任
2010-01~2010-07,美国Van Andel研究所结构科学与药物发现中心, 中心主任
2007-03~2009-12,美国Van Andel研究所结构科学部, 杰出PI/教授
2002-08~2007-03,美国Van Andel研究所结构科学部, 资深PI/教授
2001-08~2002-07,美国格兰素威康研究所结构科学部, 高级研究人员
1999-08~2001-07,美国格兰素威康研究所结构化学系, 二级研究员
1996-12~1999-07,美国格兰素威康研究所结构化学系, 一级研究院
1994-11~1996-12,美国麻省理工学院, 研究助理
1994-11~1996-12,美国麻省理工学院, 博士后
1991-01~1994-10,美国德州大学西南医学中心, 博士学位
1985-09~1988-12,清华大学, 硕士学位
1980-09~1985-07,清华大学, 学士学位
社会兼职
2015-01-01-今,《类固醇》(Steroids), 编委
2014-01-01-今,《基因与发育》(CSHL), 编委
2012-01-01-今,《中国药理学报》(APS), 副主编
2008-06-25-今,美国NIH/NCCAM CERC研究部评委,
2008-02-13-今,美国NIH 分子与细胞内分泌学研究部评委,
2007-07-01-2010-07-31,《分子内分泌学》编委, 编委
2006-01-01-今,美国科学促进会(AAAS), 会员
2004-07-01-今,《核受体信号》编委, 编委
2004-07-01-2010-07-01,美国分子内分泌学协会会员,
2004-01-01-今,美国密西根州中心Life Sciences-CAT synchrotron beam at APS结构生物学管理委员会执行委员会, 成员
1996-07-01-2010-07-31,美国化学协会会员,

专利与奖励

   
奖励信息
(1) 2016年国际蛋白质学会Hans Neurath奖, 其他, 2016
(2) 2016药明康德生命化学杰出成就奖, 特等奖, 其他, 2016
(3) “攻克细胞信号传导重大科学”难题入选两院院士评选2015重大十大科技进展新闻, 国家级, 2015
(4) 阐明独脚金内酯调控水稻分蘖和株型的信号途径荣获2014年度中国科学十大进展, 国家级, 2014
(5) GSK最高杰出研究奖, , 其他, 2001
(6) GSK杰出研究奖, , 其他, 1999
专利成果
( 1 ) N-(3-氟-4-氯苄基)吲哚衍生物及其用途, 2014, 第 2 作者, 专利号: 201410025241.1
( 2 ) PPARγ选择性调控剂及其制备方法和用途, 2014, 第 2 作者, 专利号: 201410289010.1
( 3 ) HIGHLY POTENT GLUCOCORTICOIDS, 2014, 第 1 作者, 专利号: WO2015/048316A1

出版信息

   
发表论文
(1) A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK), Methods and Protocols, 2018, 第 11 作者
(2) Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, Cell Discov, 2018, 第 11 作者
(3) Amyloid beta: structure, biology and structure-based therapeutic development, Acta Pharmacol Sin, 2017, 第 11 作者
(4) Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites, J Biol Chem, 2017, 第 11 作者
(5) γ-Secretase Epsilon-cleavage Assay, Bio Protoc, 2017, 第 11 作者
(6) Detection of Membrane Protein Interactions by Cell-based Tango Assays, Bio Protoc, 2017, 第 11 作者
(7) Streptavidin Bead Pulldown Assay to Determine Protein Homooligomerization, Bio Protoc, 2017, 第 11 作者
(8) An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, Cell Discov, 2017, 第 11 作者
(9) Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, J Biol Chem, 2017, 第 11 作者
(10) Structure of the PRC2 complex and application to drug discovery, Acta Pharmacol Sin, 2017, 第 11 作者
(11) Defining the minimum substrate and charge recognition model of gamma-secretase, Acta Pharmacol Sin, 2017, 第 11 作者
(12) Molecular assembly of rhodopsin with G protein-coupled receptor kinases, Cell Res, 2017, 第 11 作者
(13) Deconvoluting AMP-dependent kinase (AMPK) adenine nucleotide binding and sensing, J Biol Chem, 2017, 第 11 作者
(14) A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, Sci Adv, 2017, 第 11 作者
(15) Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors, Cell, 2017, 第 11 作者
(16) Generation and characterization of a human nanobody against VEGFR-2, Acta Pharmacol Sin, 2016, 第 11 作者
(17) Differential requirement of the extracellular domain in activation of class B G protein-coupled receptors, J Biol Chem, 2016, 第 11 作者
(18) The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer, Acta Pharmacol Sin, 2016, 第 11 作者
(19) Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio, Cell Discov, 2016, 第 11 作者
(20) Structural basis for recognition of diverse transcriptional repressors by the Topless family of corepressors, Science Advances, 2015, 第 11 作者
(21) High yield and efficient expression and purification of the human 5-HT3A receptor, Acta Pharmacol Sin, 2015, 第 11 作者
(22) Crystallization Scale Purification of the Alpha7 Nicotinic Acetylcholine Receptor from Mammalian Cells using a BacMam Expression System, Acta Pharmacol Sin, 2015, 第 11 作者
(23) Structural basis of JAZ-mediated repression of MYC transcription factors in jasmonate signaling, Nature, 2015, 第 11 作者
(24) Structural basis for corepressor assembly by the orphan nuclear receptor TLX, Genes Dev, 2015, 第 11 作者
(25) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser, Nature, 2015, 第 11 作者
(26) Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery, Acta Pharmacol Sin, 2015, 第 11 作者
(27) Structural basis of the Norrin-Frizzled 4 interaction, Cell Res, 2015, 第 11 作者
(28) Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, Cell Research, 2015, 第 11 作者
(29) Structures and mechanism for the design of highly potent glucocorticoids., Cell Research, 2014, 第 11 作者
(30) DWARF 53 acts as a repressor of strigolactone signalling in rice., Nature, 2014, 第 11 作者
(31) Structural Basis for Molecular Recognition at Serotonin Receptors, Science, 2013, 第 11 作者
(32) Structural basis for molecular recognition of folic acid by folate receptors, Nature, 2013, 第 11 作者
(33) An ABA- mimicking ligand that reduces water loss and promotes drought resistance in plants, Cell Research, 2013, 第 11 作者
(34) The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation, PLoS ONE, 2013, 第 11 作者
(35) Crystal structure of small heterodimer partner reveals a new interface bound to E1A-like inhibitor of differentiation, PNAS, 2013, 第 11 作者
(36) Structure of a PLS-Class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition, JBC, 2013, 第 11 作者
(37) Structure Modelling Using Genetically-Engineered Crosslinking, Cell, 2013, 第 11 作者
(38) Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases , Science, 2012, 第 11 作者
(39) Couple Dynamics: PPARγ and Its Ligand Partners, Structure , 2012, 第 2 作者
(40) Identification of a lysosomal pathway that potently modulates glucocorticoid signaling and inflammation response., Science Signaling, 2011, 第 11 作者
(41) Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by Class B G-protein coupled receptors., PLOS One, 2011, 第 11 作者
(42) The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor. ,  JBC, 2011, 第 11 作者
(43) Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases., PNAS, 2011, 第 11 作者
(44) Structural basis for hormone recognition by the human CRFR2alpha G protein-coupled receptor., JBC, 2010, 第 3 作者
(45) Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling., Current Opinion in Structural Biology , 2010, 第 11 作者
(46) Structural basis for agonism and antagonism of hepatocyte growth factor., PNAS, 2010, 第 11 作者
(47) Identification and Mechanism of ABA Receptor Antagonism., Nature Structural Molecular Biology , 2010, 第 11 作者
(48)  Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation., JBC, 2010, 第 11 作者
(49) Identification of SRC3/AIB1 as A Preferred Coactivator for Hormone-Activated Androgen Receptor., JBC, 2010, 第 11 作者
(50) Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs., Protein Expr Purif, 2010, 第 11 作者
(51) A gate-latch-lock mechanism for hormone signaling by abscisic acid receptors.,  Nature, 2009, 第 11 作者
(52) Molecular recognition of parathyroid hormone-related peptide (PTHrP) by the extracellular domain of its G protein-coupled receptor PTH1R., JBC, 2009, 第 11 作者
(53) Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver, Cell, 2009, 第 3 作者
(54) Ligand-dependent and –independent regulation of PPARγ and Orphan Nuclear receptors., Science Signaling, 2008, 第 1 作者
(55) Molecular Recognition of corticotropin releasing factor by its G-protein coupled receptor CRFR1., JBC, 2008, 第 11 作者
(56) Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid Activated Receptor., PLOS Biology, 2008, 第 11 作者
(57) Molecular recognition of nitro-fatty acids by PPARγ. , Nature Structure and Molecular Biology, 2008, 第 11 作者
(58) Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol.,  Mol Cell Biol., 2008, 第 11 作者
(59)  A Structural Mechanism for Recognition of Parathyroid Hormone by its G Protein Coupled Receptor. , PNAS, 2008, 第 11 作者
(60) Mutations of Glucocorticoid Receptor Differentially Affect AF2 Domain Activity in a Steroid-Selective Manner To Alter the Potency and Efficacy of Gene Induction and Repression., Biochemistry, 2008, 第 3 作者
(61)  Structural and Biochemical Basis for the Binding Selectivity of PPARγ to PGC-1α. ,  JBC, 2008, 第 11 作者
(62) Structural and Biochemical Basis for the Binding Selectivity of PPARγ to PGC-1α., JBC, 2008, 第 11 作者
(63) A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. , PNAS, 2007, 第 11 作者
(64)  Induction of Nuclear Translocation of Constitutive Androstane Receptor by Peroxisome Proliferator-activated Receptor {alpha} Synthetic Ligands in Mouse Liver. , JBC, 2007, 第 11 作者
(65) Crystallographic Identification and Functional Characterization of Phospholipids as Ligands for the Orphan Nuclear Receptor Steroidogenic Factor-1. ,  Molecular Cell, 2005, 第 11 作者
(66)  Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. , PNAS, 2005, 第 11 作者
(67)  Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor.,  Molecular Cell , 2005, 第 11 作者
(68) The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. ,  Molecular Cell, 2004, 第 11 作者
(69) Activation of Nuclear Receptors: A Perspective from Structural Genomics. , Structure, 2003, 第 11 作者
(70) Structural mechanisms of ligand-mediated signaling by nuclear receptors,  Handbook of Cell Signaling, 2003, 第 1 作者
(71) Structural insights into regulation of nuclear receptors by ligands.,  Nuclear Receptor Signaling, 2003, 第 1 作者
(72) Structural basis of antagonist-mediated recruitment of nuclear corepressors by PPAR alpha.,  Nature, 2002, 第 1 作者
(73) Interactions that determine the assembly of a retinoid X receptor/corepressor complex. , PNAS, 2002, 第 11 作者
(74) Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.,  Cell, 2002, 第 11 作者
(75) Cooperative interactions between the GAL80 and the GAL4 proteins define a novel mechanism for differential repression of galactose-regulated genes.,  EMBO J. , 2001, 第 11 作者
(76) A selective peroxisome proliferator-activated receptor ? agnoist promotes reverse cholesterol transport.,  PNAS, 2001, 第 11 作者
(77) Structural Determinants of Ligand Binding Selectivity between the Peroxisome Proliferator-activated Receptors.,  PNAS, 2001, 第 1 作者
(78) Asymmetry in the PPAR?/RXR? Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors., Molecular Cell, 2000, 第 11 作者
(79)  Structural Basis for Auto-Repression of Retinoid X Receptor by Tetramer Formation and the AF-2 Helix.,  Genes Dev., 2000, 第 11 作者
(80) Molecular Recognition of Fatty Acids by Peroxisome Proliferator-Activated Receptors., Molecular Cell, 1999, 第 1 作者
(81)  Crytstal Structure of the human PAX6 paired domain-DNA complex reveals specific DNA Recognition by the C-terminal subdomain and the linker. , Genes Dev., 1999, 第 1 作者
(82) One Dimer of GAL4 Is Sufficient To Activate a Maximum Level of Transcription In Vivo., PNAS, 1995, 第 1 作者
(83) Yeast Bleomycin Hydrolase Is a DNA-Binding Cysteine Protease.,  J. Biol. Chem., 1994, 第 1 作者
(84)  ,  How Do Zn2 Cys6 Proteins Distinguish between Similar Upstream Activation Sites , J. Biol. Chem., 1993, 第 2 作者
(85) Gene Transfer and Expression in Protoplastes of Chinese Cabbage and Cucumber by Electroporation., Acta Bot. Sin. , 1991, 第 1 作者
(86) Gene Transfer into Intact Plant Cells by Electroporation, Aeta Bot. Sin., 1990, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于蛋白质结构与功能的药物多靶标作用机制研究, 参与, 部委级, 2011-01--2013-12
( 2 ) ****启动项目, 主持, 国家级, 2010-07--2015-07
( 3 ) 与神经系统疾病相关的离子通道的结构与功能研究, 主持, 国家级, 2012-01--2015-12
( 4 ) 组合化学制备化合物研究, 主持, 部委级, 2012-01--2012-12
( 5 ) 重要GPCR三维结构解析, 参与, 国家级, 2012-01--2016-08
( 6 ) 离子通道和膜转运蛋白的结构与功能研究, 主持, 国家级, 2013-01--2017-08
( 7 ) 基于GPCR结构与功能的药物发现关键技术发展与平台建设, 主持, 国家级, 2012-01--2015-12
( 8 ) 生物膜感受与转导外界信号的过程, 主持, 部委级, 2014-01--2018-12
参与会议
(1)Structures and ligand regulation of orphan nuclear receptor   第八届厦门冬季国际学术会议   2017-12-08
(2)Structure of a GPCR-arrestin complex   H Eric Xu   2016-06-18
(3)Structure of rhodopsin-arrestin complex   H Eric Xu   2016-03-20
(4)X-ray laser Structure of rhodopsin-arrestin complex   H Eric Xu   2015-12-01
(5)Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser   H Eric Xu   2015-09-24
(6)Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser   H Eric Xu   2014-08-05
(7)The Rhodopsin-Arrestin Structure by femtosecond X-ray laser   H Eric Xu   2014-06-06
(8)Arrestin coupling to GPCRs: a new paradigm of cell signaling by a molten globule protein   H Eric Xu   2014-03-13
(9)Crystal structure of rhodopsin bound to arrestin determined by free electron X-ray laser diffraction   H Eric Xu   2013-12-05
(10)Structural mechanism of transcriptional repression by orphan nuclear receptors   苏州冷泉港会议   H Eric Xu   2013-11-05
(11)靶向GPCR的药物研发   东方科技论坛第164期学术研讨会   徐华强   2010-11-09