基本信息
徐华强  男  博导  中国科学院上海药物研究所
电子邮件: eric.xu@simm.ac.cn
通信地址: 上海市浦东张江海科路501号1715室
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
100701-药物化学
招生方向
结构生物学
药物化学

教育背景

1994-11--1996-12   美国麻省理工学院   博士后
1991-01--1994-10   美国德州大学西南医学中心   博士学位
1985-09--1988-12   清华大学   硕士学位
1980-09--1985-07   清华大学   学士学位

工作经历

   
工作简历
2013-04~现在, 中国科学院受体结构与功能重点实验室, 创办人,主任
2010-07~现在, 中国科学院上海药物所, 药靶结构与功能中心主任
2010-01~2010-07,美国Van Andel研究所结构科学与药物发现中心, 中心主任
2007-03~2009-12,美国Van Andel研究所结构科学部, 杰出PI/教授
2002-08~2007-03,美国Van Andel研究所结构科学部, 资深PI/教授
2001-08~2002-07,美国格兰素威康研究所结构科学部, 高级研究人员
1999-08~2001-07,美国格兰素威康研究所结构化学系, 二级研究员
1996-12~1999-07,美国格兰素威康研究所结构化学系, 一级研究院
1994-11~1996-12,美国麻省理工学院, 研究助理
1994-11~1996-12,美国麻省理工学院, 博士后
1991-01~1994-10,美国德州大学西南医学中心, 博士学位
1985-09~1988-12,清华大学, 硕士学位
1980-09~1985-07,清华大学, 学士学位
社会兼职
2015-01-01-今,《类固醇》(Steroids), 编委
2014-01-01-今,《基因与发育》(CSHL), 编委
2012-01-01-今,《中国药理学报》(APS), 副主编
2008-06-25-今,美国NIH/NCCAM CERC研究部评委,
2008-02-13-今,美国NIH 分子与细胞内分泌学研究部评委,
2007-07-01-2010-07-31,《分子内分泌学》编委, 编委
2006-01-01-今,美国科学促进会(AAAS), 会员
2004-07-01-今,《核受体信号》编委, 编委
2004-07-01-2010-07-01,美国分子内分泌学协会会员,
2004-01-01-今,美国密西根州中心Life Sciences-CAT synchrotron beam at APS结构生物学管理委员会执行委员会, 成员
1996-07-01-2010-07-31,美国化学协会会员,

专利与奖励

   
奖励信息
(1) 2016年国际蛋白质学会Hans Neurath奖, 其他, 2016
(2) 2016药明康德生命化学杰出成就奖, 特等奖, 其他, 2016
(3) “攻克细胞信号传导重大科学”难题入选两院院士评选2015重大十大科技进展新闻, 国家级, 2015
(4) 阐明独脚金内酯调控水稻分蘖和株型的信号途径荣获2014年度中国科学十大进展, 国家级, 2014
(5) GSK最高杰出研究奖, , 其他, 2001
(6) GSK杰出研究奖, , 其他, 1999
专利成果
( 1 ) N-(3-氟-4-氯苄基)吲哚衍生物及其用途, 2014, 第 2 作者, 专利号: 201410025241.1
( 2 ) PPARγ选择性调控剂及其制备方法和用途, 2014, 第 2 作者, 专利号: 201410289010.1
( 3 ) HIGHLY POTENT GLUCOCORTICOIDS, 2014, 第 1 作者, 专利号: WO2015/048316A1

出版信息

   
发表论文
(1) A Highly Sensitive Non-Radioactive Activity Assay for AMP-Activated Protein Kinase (AMPK), Methods and Protocols, 2018, 通讯作者
(2) Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, Cell Discov, 2018, 通讯作者
(3) Amyloid beta: structure, biology and structure-based therapeutic development, Acta Pharmacol Sin, 2017, 通讯作者
(4) Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites, J Biol Chem, 2017, 通讯作者
(5) γ-Secretase Epsilon-cleavage Assay, Bio Protoc, 2017, 通讯作者
(6) Detection of Membrane Protein Interactions by Cell-based Tango Assays, Bio Protoc, 2017, 通讯作者
(7) Streptavidin Bead Pulldown Assay to Determine Protein Homooligomerization, Bio Protoc, 2017, 通讯作者
(8) An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, Cell Discov, 2017, 通讯作者
(9) Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, J Biol Chem, 2017, 通讯作者
(10) Structure of the PRC2 complex and application to drug discovery, Acta Pharmacol Sin, 2017, 通讯作者
(11) Defining the minimum substrate and charge recognition model of gamma-secretase, Acta Pharmacol Sin, 2017, 通讯作者
(12) Molecular assembly of rhodopsin with G protein-coupled receptor kinases, Cell Res, 2017, 通讯作者
(13) Deconvoluting AMP-dependent kinase (AMPK) adenine nucleotide binding and sensing, J Biol Chem, 2017, 通讯作者
(14) A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex, Sci Adv, 2017, 通讯作者
(15) Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors, Cell, 2017, 通讯作者
(16) Generation and characterization of a human nanobody against VEGFR-2, Acta Pharmacol Sin, 2016, 通讯作者
(17) Differential requirement of the extracellular domain in activation of class B G protein-coupled receptors, J Biol Chem, 2016, 通讯作者
(18) The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer, Acta Pharmacol Sin, 2016, 通讯作者
(19) Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio, Cell Discov, 2016, 通讯作者
(20) Structural basis for recognition of diverse transcriptional repressors by the Topless family of corepressors, Science Advances, 2015, 通讯作者
(21) High yield and efficient expression and purification of the human 5-HT3A receptor, Acta Pharmacol Sin, 2015, 通讯作者
(22) Crystallization Scale Purification of the Alpha7 Nicotinic Acetylcholine Receptor from Mammalian Cells using a BacMam Expression System, Acta Pharmacol Sin, 2015, 通讯作者
(23) Structural basis of JAZ-mediated repression of MYC transcription factors in jasmonate signaling, Nature, 2015, 通讯作者
(24) Structural basis for corepressor assembly by the orphan nuclear receptor TLX, Genes Dev, 2015, 通讯作者
(25) Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser, Nature, 2015, 通讯作者
(26) Ion channels gated by acetylcholine and serotonin: structures, biology, and drug discovery, Acta Pharmacol Sin, 2015, 通讯作者
(27) Structural basis of the Norrin-Frizzled 4 interaction, Cell Res, 2015, 通讯作者
(28) Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, Cell Research, 2015, 通讯作者
(29) Structures and mechanism for the design of highly potent glucocorticoids., Cell Research, 2014, 通讯作者
(30) DWARF 53 acts as a repressor of strigolactone signalling in rice., Nature, 2014, 通讯作者
(31) Structural Basis for Molecular Recognition at Serotonin Receptors, Science, 2013, 通讯作者
(32) Structural basis for molecular recognition of folic acid by folate receptors, Nature, 2013, 通讯作者
(33) An ABA- mimicking ligand that reduces water loss and promotes drought resistance in plants, Cell Research, 2013, 通讯作者
(34) The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation, PLoS ONE, 2013, 通讯作者
(35) Crystal structure of small heterodimer partner reveals a new interface bound to E1A-like inhibitor of differentiation, PNAS, 2013, 通讯作者
(36) Structure of a PLS-Class Pentatricopeptide Repeat Protein Provides Insights into Mechanism of RNA Recognition, JBC, 2013, 通讯作者
(37) Structure Modelling Using Genetically-Engineered Crosslinking, Cell, 2013, 通讯作者
(38) Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases , Science, 2012, 通讯作者
(39) Couple Dynamics: PPARγ and Its Ligand Partners, Structure , 2012, 第 2 作者
(40) Identification of a lysosomal pathway that potently modulates glucocorticoid signaling and inflammation response., Science Signaling, 2011, 通讯作者
(41) Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by Class B G-protein coupled receptors., PLOS One, 2011, 通讯作者
(42) The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor. ,  JBC, 2011, 通讯作者
(43) Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases., PNAS, 2011, 通讯作者
(44) Structural basis for hormone recognition by the human CRFR2alpha G protein-coupled receptor., JBC, 2010, 第 3 作者
(45) Thirsty plants and beyond: structural mechanisms of abscisic acid perception and signaling., Current Opinion in Structural Biology , 2010, 通讯作者
(46) Structural basis for agonism and antagonism of hepatocyte growth factor., PNAS, 2010, 通讯作者
(47) Identification and Mechanism of ABA Receptor Antagonism., Nature Structural Molecular Biology , 2010, 通讯作者
(48)  Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation., JBC, 2010, 通讯作者
(49) Identification of SRC3/AIB1 as A Preferred Coactivator for Hormone-Activated Androgen Receptor., JBC, 2010, 通讯作者
(50) Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs., Protein Expr Purif, 2010, 通讯作者
(51) A gate-latch-lock mechanism for hormone signaling by abscisic acid receptors.,  Nature, 2009, 通讯作者
(52) Molecular recognition of parathyroid hormone-related peptide (PTHrP) by the extracellular domain of its G protein-coupled receptor PTH1R., JBC, 2009, 通讯作者
(53) Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver, Cell, 2009, 第 3 作者
(54) Ligand-dependent and –independent regulation of PPARγ and Orphan Nuclear receptors., Science Signaling, 2008, 第 1 作者
(55) Molecular Recognition of corticotropin releasing factor by its G-protein coupled receptor CRFR1., JBC, 2008, 通讯作者
(56) Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid Activated Receptor., PLOS Biology, 2008, 通讯作者
(57) Molecular recognition of nitro-fatty acids by PPARγ. , Nature Structure and Molecular Biology, 2008, 通讯作者
(58) Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol.,  Mol Cell Biol., 2008, 通讯作者
(59)  A Structural Mechanism for Recognition of Parathyroid Hormone by its G Protein Coupled Receptor. , PNAS, 2008, 通讯作者
(60) Mutations of Glucocorticoid Receptor Differentially Affect AF2 Domain Activity in a Steroid-Selective Manner To Alter the Potency and Efficacy of Gene Induction and Repression., Biochemistry, 2008, 第 3 作者
(61)  Structural and Biochemical Basis for the Binding Selectivity of PPARγ to PGC-1α. ,  JBC, 2008, 通讯作者
(62) Structural and Biochemical Basis for the Binding Selectivity of PPARγ to PGC-1α., JBC, 2008, 通讯作者
(63) A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist. , PNAS, 2007, 通讯作者
(64)  Induction of Nuclear Translocation of Constitutive Androstane Receptor by Peroxisome Proliferator-activated Receptor {alpha} Synthetic Ligands in Mouse Liver. , JBC, 2007, 通讯作者
(65) Crystallographic Identification and Functional Characterization of Phospholipids as Ligands for the Orphan Nuclear Receptor Steroidogenic Factor-1. ,  Molecular Cell, 2005, 通讯作者
(66)  Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner. , PNAS, 2005, 通讯作者
(67)  Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor.,  Molecular Cell , 2005, 通讯作者
(68) The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. ,  Molecular Cell, 2004, 通讯作者
(69) Activation of Nuclear Receptors: A Perspective from Structural Genomics. , Structure, 2003, 通讯作者
(70) Structural mechanisms of ligand-mediated signaling by nuclear receptors,  Handbook of Cell Signaling, 2003, 第 1 作者
(71) Structural insights into regulation of nuclear receptors by ligands.,  Nuclear Receptor Signaling, 2003, 第 1 作者
(72) Structural basis of antagonist-mediated recruitment of nuclear corepressors by PPAR alpha.,  Nature, 2002, 第 1 作者
(73) Interactions that determine the assembly of a retinoid X receptor/corepressor complex. , PNAS, 2002, 通讯作者
(74) Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition.,  Cell, 2002, 通讯作者
(75) Cooperative interactions between the GAL80 and the GAL4 proteins define a novel mechanism for differential repression of galactose-regulated genes.,  EMBO J. , 2001, 通讯作者
(76) A selective peroxisome proliferator-activated receptor ? agnoist promotes reverse cholesterol transport.,  PNAS, 2001, 通讯作者
(77) Structural Determinants of Ligand Binding Selectivity between the Peroxisome Proliferator-activated Receptors.,  PNAS, 2001, 第 1 作者
(78) Asymmetry in the PPAR?/RXR? Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors., Molecular Cell, 2000, 通讯作者
(79)  Structural Basis for Auto-Repression of Retinoid X Receptor by Tetramer Formation and the AF-2 Helix.,  Genes Dev., 2000, 通讯作者
(80) Molecular Recognition of Fatty Acids by Peroxisome Proliferator-Activated Receptors., Molecular Cell, 1999, 第 1 作者
(81)  Crytstal Structure of the human PAX6 paired domain-DNA complex reveals specific DNA Recognition by the C-terminal subdomain and the linker. , Genes Dev., 1999, 第 1 作者
(82) One Dimer of GAL4 Is Sufficient To Activate a Maximum Level of Transcription In Vivo., PNAS, 1995, 第 1 作者
(83) Yeast Bleomycin Hydrolase Is a DNA-Binding Cysteine Protease.,  J. Biol. Chem., 1994, 第 1 作者
(84)  ,  How Do Zn2 Cys6 Proteins Distinguish between Similar Upstream Activation Sites , J. Biol. Chem., 1993, 第 2 作者
(85) Gene Transfer and Expression in Protoplastes of Chinese Cabbage and Cucumber by Electroporation., Acta Bot. Sin. , 1991, 第 1 作者
(86) Gene Transfer into Intact Plant Cells by Electroporation, Aeta Bot. Sin., 1990, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于蛋白质结构与功能的药物多靶标作用机制研究, 参与, 部委级, 2011-01--2013-12
( 2 ) ****启动项目, 主持, 国家级, 2010-07--2015-07
( 3 ) 与神经系统疾病相关的离子通道的结构与功能研究, 主持, 国家级, 2012-01--2015-12
( 4 ) 组合化学制备化合物研究, 主持, 部委级, 2012-01--2012-12
( 5 ) 重要GPCR三维结构解析, 参与, 国家级, 2012-01--2016-08
( 6 ) 离子通道和膜转运蛋白的结构与功能研究, 主持, 国家级, 2013-01--2017-08
( 7 ) 基于GPCR结构与功能的药物发现关键技术发展与平台建设, 主持, 国家级, 2012-01--2015-12
( 8 ) 生物膜感受与转导外界信号的过程, 主持, 部委级, 2014-01--2018-12
参与会议
(1)Structures and ligand regulation of orphan nuclear receptor   第八届厦门冬季国际学术会议   2017-12-08
(2)Structure of a GPCR-arrestin complex   H Eric Xu   2016-06-18
(3)Structure of rhodopsin-arrestin complex   H Eric Xu   2016-03-20
(4)X-ray laser Structure of rhodopsin-arrestin complex   H Eric Xu   2015-12-01
(5)Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser   H Eric Xu   2015-09-24
(6)Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser   H Eric Xu   2014-08-05
(7)The Rhodopsin-Arrestin Structure by femtosecond X-ray laser   H Eric Xu   2014-06-06
(8)Arrestin coupling to GPCRs: a new paradigm of cell signaling by a molten globule protein   H Eric Xu   2014-03-13
(9)Crystal structure of rhodopsin bound to arrestin determined by free electron X-ray laser diffraction   H Eric Xu   2013-12-05
(10)Structural mechanism of transcriptional repression by orphan nuclear receptors   苏州冷泉港会议   H Eric Xu   2013-11-05
(11)靶向GPCR的药物研发   东方科技论坛第164期学术研讨会   徐华强   2010-11-09