General

         Jian Zhang,Ph.D,Professor/Doctoral Supervisor,Director of Center for Reproduction and Health Development.

“Hundred Talents Program” of CAS,2011,

Distinguished Younge Scholars of Shenzhen ,2012,

Shenzhen overseas high-level talents category C (Peacock plan),2014,

Shenzhen overseas high-level talents category B (Peacock plan),2016,

Member of American Diabetes Association, American Society for Endocrinology,

Member of reproductive biology branch of Chinese society of zoology


Research Achievements

1.   Prof. Zhang has discovered and successfully isolated and purified two peptide hormones: Obestatin and Neuronostatin; Applied for 34 international patents, 54 Chinese patents, of which 9 have been authorized.

2.    More than 75 papers have been published in domestic and foreign academic journals, including 59 SCI papers, including Science, J Hepatology,JBC, Molecular Endocrinology,Scientific Reports,Plos One and Molecular Human Reproduction, etc., with 1378 citations, and reviewers of many journals.

3.    Prof. Zhang now is the member of American Diabetes Association, American society for endocrinology, director of reproductive biology, branch of China zoological society.

4.    Fellowships: Graduate Innovation Grant of CAS, 2002; Excellence Award of CAS, 2003; the Best Posters of Weimar Germany, 2002.










Research Areas

1)Research in the role and transformation of peptides and its receptors in metabolic diseases and reproductive diseases:

Metabolic diseases: Obesity, Nonalcoholic fatty liver disease(NAFLD), Diabetes and osteoporosis.

Reproductive diseases: infertility(Premature Ovarian Failure(POF), Polycystic ovary syndrome (PCOS)), Metabolic diseases of pregnancy(GDM、PE、obesity), Endocrine related tumor(Endometrial Carcinoma, Ovarian Cancer and Breast Cancer).

  2)Application of biomaterials and molecular imaging techniques in metabolic diseases and reproductive diseases related to endocrine metabolism.


Education

1999-2003,Ph.D. in Physiology , Institute of Zoology, Chinese Academy of Sciences (Supervisor: Prof. Duan Enkui)


Experience

   2003-2008,Postdoctoral Research in Stanford University(Supervisor: Prof. Aaron JW Hsueh

   2008-2010,Stanford University Research ScientistDec,2010 till now, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences



Work Experience

2003-2008,Postdoctoral Research in Stanford University(Supervisor: Prof. Aaron JW Hsueh)

      2008-2010,Stanford University Research ScientistDec,2010 till now, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

      2010-up to now,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Researcher

Publications


Papers

(一)Corresponding author SCI papers (27)

1.Teng B.#, Huang C.#, Cheng C.#, Yu X., Liu C., Udduttulal A., Zhao P., Li J., Yao Z., Zou C., Chu J., Miao L.,Zhang J.*, Ren P.*,Metabolitin, a New Peptide Hormone Inhibits Intestinal Fat Absorption and Improves NAFLD through Its Receptor GPRC6A, J Hepatology, 2020(accepted).

2.Huang B.#, Zhao H.#, Huang C#, Wu L., Xiang L., Chen J., Wang B., Xiao T., Li M., Ren L.*, Niu J*,Zhang J.*,CMKLR1 deficiency attenuates androgen-inducedlipid accumulation in mice.,Am J Physiol Endocrinol Metab, 2020 Jan 7. doi: 10.1152/ajpendo.00176.

3.Udduttula A.#, Teng B#,Chandrashekar B., Li J., Yu X., Liu C., Shi R., Cheng C.*,Zhang J.*,Ren P.*,Novel Sr5(PO4)2SiO4-Graphene Nanocomposites for Applications in Bone regeneration In Vitro,Applied Surface Science,2019,https://doi.org/10.1016/j.apsusc.2019.145176.

4.Huang B.#, Zhu W.#, Chang J.#,Dai X., Yu G., Huang C., Wang E., Li Z., Lin L., Wang B., Chen J., Xiao T., Niu J.*,Zhang J.*,The Role of G Protein-coupled Receptor 1 in Choriocarcinoma Progression[J],American journal of physiology, 2019 ,DOI: 10.1152/ajpcell.00059.

5.Yao Z.#, Liu C.#, Yu X., Meng J., Teng B., Sun Y., Kerem G., Ismayi A., Fang P.,Zhang J. V.*, Ren P.*, Microarray Profiling and Coexpression Network Analysis of Long Noncoding RNAs in Adipose Tissue of Obesity-T2DM Mouse[J], Obesity, 2019,27,1644-1651. doi:10.1002 /oby.22590.

6.Sun L.#, Yang Y.#, Xiao T., Li M.,Zhang J. V.,Removal of DHT can relieve polycystic ovary but not metabolic abnormalities in DHT-induced hyperandrogenism mice [J]. Reproduction Fertility and Development, 2019, 31(10) 1597-1606.

7.Huang B., Huang C., Zhao H., Zhu W., Wang B., Wang H., Chen J., Xiao T., Niu J.,Zhang J. V.The Impact of GPR1 Signaling on Maternal High-fat Feeding and Placenta Metabolism in Mice [J]. Am J Physiol Endocrinol Metab, 2019,316: E987-E997.

8.Zhao H., Yan D., Xiang L., Huang C., Li J., Yu X., Huang B., Wang B., Chen J., Xiao T., Ren P. G.*,Zhang J. V.*,Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cell Mol Life Sci, 2019, 76(2): 355-367.

9.Udduttula A., Li J., Zhao P., Wang G.,Zhang J. V*., Ren P*. Sol-gel derived nanosized Sr-5(PO4)(2)SiO4 powder with enhanced in vitro osteogenesis and angiogenesis for bone regeneration applications [J]. Ceramics International, 2019, 45(3): 3148-3158.

10.Huang C., Huang B. B., Niu J. M., Yu Y., Qin X. Y., Yang Y. L., Xiao T. X., Chen J., Ren L. R.,Zhang J. V. Global mRNA and Long Non-Coding RNA Expression in the Placenta and White Adipose Tissue of Mice Fed a High-Fat Diet During Pregnancy [J]. Cellular Physiology and Biochemistry, 2018, 50(6): 2260-2271.

11.Zhang B., Tan L., Yu Y., Wang B., Chen Z., Han J., Li M., Chen J., Xiao T., Ambati B. K., Cai L., Yang Q., Nayak N. R.,Zhang J.*, Fan X*. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice [J]. Theranostics, 2018, 8(10): 2765-2781.

12.Yang Y. L., Sun L. F., Yu Y., Xiao T. X., Wang B. B., Ren P. G., Tang H. R.,Zhang J.V.Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice [J]. Reproductive Biology and Endocrinology, 2018, 16: 1-11.

13.Jin P., Chen F. X., Li Y. Z., Zhang Q. Q.,Zhang J. The clinical and experimental research on the treatment of endometriosis with thiostrepton [J]. Anticancer Agents Med Chem, 2018,doi: 10.2174/ 1871520618666180108100211.

14.Huang B. B., Liu X. C., Qin X. Y., Chen J., Ren P. G., Deng W. F.,Zhang J.Effect of High-Fat Diet on Immature Female Mice and Messenger and Noncoding RNA Expression Profiling in Ovary and White Adipose Tissue [J]. Reprod Sci, 2018: 1933719118765966.

15.Li J., Xiang L., Jiang X., Teng B., Sun Y., Chen G., Chen J.,Zhang J. V.*, Ren P. G. *Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice [J]. J Orthop Translat, 2017, 10: 42-51.

16.Yang Y. L., Ren L. R., Sun L. F., Huang C., Xiao T. X., Wang B. B., Chen J., Zabel B. A., Ren P. G.,Zhang J. V.The role of GPR1 signaling in mice corpus luteum [J]. Journal of Endocrinology, 2016, 230(1): 55-65.

17.Huang C., Wang M. M., Ren L. R., Xiang L., Chen J., Li M. X., Xiao T. X., Ren P. G., Xiong L. K.,Zhang J. V.CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet [J]. Biochemical and Biophysical Research Communications, 2016, 473(2): 435-441.

18.Li J., Xu Q., Teng B., Yu C., Li J., Song L., Lai Y. X.,Zhang J., Zheng W.,Ren P. G. Investigation of angiogenesis in bioactive 3-dimensional poly (d,l-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect [J]. Acta Biomater, 2016, 42: 389-399.

19.Tang M., Huang C., Wang Y. F., Ren P. G., Chen L., Xiao T. X., Wang B. B., Pan Y. F., Tsang B. K., Zabel B. A., Ma B. H., Zhao H. Y.,Zhang J. V.CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone [J]. Scientific Reports, 2016 Feb 19;6:21328.

20.Guo C. Z., Li J., She C., Shao X. Z., Teng B., Feng J.,Zhang J. V.*, Ren P. G. *Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro [J]. Journal of Biomedical Materials Research Part B-Applied Biomaterials, 2016, 104(5): 923-931.

21.Qiu C.*,Zhang J.*, Su M. P.,Fan X. J. Nuclear factor-kappa B mediates the phenotype switching of airway smooth muscle cells in a murine asthma model [J]. International Journal of Clinical and Experimental Pathology, 2015, 8(10): 12115-12128.

22.Zhang Q. Q., Fan X. J.,Zhang J.The Role of Adipokine Chemerin in Pregnancy Complications [J]. Progress in Biochemistry and Biophysics, 2015, 42(10): 962-968.

23.Tian X. F., Ma W. J., Fang G.G., Xiao T. X., Chen J.,Zhang J.. The Effects of Experimental Mice Adipose Accumulation by Targeting GPR1 Pathway. Progress in Biochemistry and Biophysics, 2015,42(5):457-467.

24.Li L., Huang C., Zhang X., Wang J. B., Ma P., Liu Y. J., Xiao T. X., Zabel B. A.,Zhang J. V.Chemerin-Derived Peptide C-20 Suppressed Gonadal Steroidogenesis [J]. American Journal of Reproductive Immunology, 2014, 71(3): 265-277.

25.Li L., Ma P., Huang C., Liu Y. J., Zhang Y., Gao C., Xiao T. X., Ren P. G., Zabel B. A.,Zhang J. V.Expression of chemerin and its receptors in rat testes and its action on testosterone secretion [J]. Journal of Endocrinology, 2014, 220(2): 155-163.

26.Li L., Ma P., Liu Y. J., Huang C., O W. S., Tang F.,Zhang J. V.Intermedin Attenuates LPS-induced Inflammation in the Rat Testis [J]. Plos One, 2013, 8(6).

27.Zhang J. V., Li L., Huang Q. S.,Ren P. G. Obestatin Receptor in Energy Homeostasis and Obesity Pathogenesis [J]. Prog Nucleic Acid Res Mol Biol, 2013, 114: 89-107.


(二)First or co-author SCI papers (14)

1. Zhang J. V., Jahr H., Luo C. W., Klein C., Van Kolen K., Donck L. V., De A., Baart E., Li J., Moechars D.,Hsueh A. J. W. Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39 [J]. Molecular Endocrinology, 2008, 22(6): 1464-1475.

2.Samson W. K.,Zhang J. V., Avsian-Kretchmer O., Cui K., Yosten G. L. C., Klein C., Lyu R. M., Wang Y. X., Chen X. Q., Yang J., Price C. J., Hoyda T. D., Ferguson A. V., Yuan X. B., Chang J. K.,Hsueh A. J. W. Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions [J]. Journal of Biological Chemistry, 2008, 283(46): 31949-31959.

3.Zhang J. V., Klein C., Ren P. G., Kass S., Donck L. V., Moechars D.,Hsueh A. J. W. Response to comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake" [J]. Science, 2007, 315(5813).

4.Zhang J. V., Ren P. G., Avsian-Kretchmer O., Luo C. W., Rauch R., Klein C.,Hsueh A. J. W. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake [J]. Science, 2005, 310(5750): 996-999.

5.Li J.,Zhang J.V., Cao Y. J., Zhou J. X., Liu W. M., Fan X. J.,Duan E. K. Inhibition of the beta-catenin signaling pathway in blastocyst and uterus during the window of implantation in mice [J]. Biology of Reproduction, 2005, 72(3): 700-706.

6.Zhang J., Cao Y. J., Li F. Y., Li J., Yao L. B.,Duan E. K. Effects of fibronectin, VEGF and angiostatin on the expression of MMPs through different signaling pathways in the JEG-3 cells [J]. American Journal of Reproductive Immunology, 2003, 50(4): 273-285.

7.Zhang J., Zhao Y. G., Cao Y. J., Sang Q. X. A.,Duan E. K. Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo [J]. Molecular Human Reproduction, 2003, 9(3): 143-149.

8.Zhao Tianfu,Zhang Jian, Li Jing, Cao Yujing, Li Sumin, Zhou Jiaxi,Duan Enkui. Minimum effective dose and regulatory mechanism of angiostatin-inhibited embryo implantation in the mouse [J]. Acta zoologica Sinica, 2003, 49(3): 332-338.

9.Zhao Tianfu,Zhang Jian, Li Jing, Cao Yujing, Li Sumin, Zhou Jiaxi, Li Fuyang, Yao Libo,Duan Enkui. Regulation effects of angiostatin on the mouse blastocysts [J]. Progress in Biochemistry and Biophysics, 2003, 30(5): 778-783.

10.Zhang J., Cao Y. J., Zhao Y. G., Sang Q. X. A.,Duan E. K. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Molecular Human Reproduction, 2002, 8(7): 659-666.

11.Li S. M., Cao Y. J.,Zhang J., Tian Y. Q., Zheng X.,Duan E. K. Effects of vascular endothelial growth factor on MMPs during embryo implantation in mice [J]. Chinese Science Bulletin, 2002, 47(24): 2071-2074.

12.Zhang J., Cao Y. J., Liu W. M., Zhao B. S., Zeng G. Q.,Duan E. K. Expression of matrix metalloproteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Chinese Science Bulletin, 2002, 47(9): 732-736.

13.Zhang J., Tie G. D., Cao Y. J.,Duan E. K. Effect of fibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst [J]. Chinese Science Bulletin, 2001, 46(15): 1296-1300.

14.Zhang J.,Duan E. K. Uteroglobin: Structure and function [J]. Progress in Biochemistry and Biophysics, 2001, 28(5): 627-630.


(三)Other SCI papers (not first author or correspondence) (14)

1.Zhao K.#*, Cheng G.#,Li D., Han J., Chen J., Wang B., Li M., Xiao T., Le A., Sun B., Jin Z.,Zhang J., Fan X.*,Targeting delivery of partial VAR2CSA peptide guided N-2-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles for multiple cancer types[J],Materials Science & Engineering C, 2020 Jan;106:110171. doi: 10.1016.

2.Xiao Z. L., Li S. J., Yu Y., Li M. X., Chen J., Wang F.,Zhang J., Deng W. F., Yang Q.,Fan X. J. VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors [J]. Molecular and Cellular Biochemistry, 2018, 449(1-2): 1-8.

3.Zhang B. Z., Cheng G. G., Zheng M. B., Han J. Y., Wang B. B., Li M. X., Chen J., Xiao T. X.,Zhang J., Cai L. T., Li S. J.,Fan X. J. Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment [J]. Drug Delivery, 2018, 25(1): 461-471.

4.Wang L. W., Li J.,Zhang J., He Q., Weng X. W., Huang Y. M., Guan M. J.,Qiu C. Inhibition of TRPC3 downregulates airway hyperresponsiveness, remodeling of OVA-sensitized mouse [J]. Biochemical and Biophysical Research Communications, 2017, 484(1): 209-217.

5.Le A. W., Shan L. L., Dai X. Y., Xiao T. H., Li X. R., Wang Z. H.,Zhang J., Chen X. Y. PI3K, AKT, and P-AKT levels in thin endometrium [J]. Genetics and Molecular Research, 2016, 15(1): gmr7184.

6.Liu H. D., Xiong W., Liu Q. Y.,Zhang J., Dong S. H. Chemokine-Like Receptor 1 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells [J]. Medical Science Monitor, 2016, 22: 4054-4061.

7.Xiao Z. L., Yang Q.,Zhang J., Fan X. J.. Advance of Animal Models for Preeclampsia. Progress in Biochemistry and Biophysics, 2016, 43(6):563-569 .

8.Jia Q. Y., Cheng W. X., Yue Y., Hu Y. P.,Zhang J., Pan X. H., Xu Z. W.,Zhang P. Cucurbitacin E inhibits TNF-alpha-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-kappa B pathways [J]. International Immunopharmacology, 2015, 29(2): 884-890.

9.Pandey V., Wu Z. S., Zhang M., Li R.,Zhang J., Zhu T.,Lobie P. E. Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma [J]. Breast Cancer Research, 2014, 16(5).

10.raham K. L.,Zhang J. V., Lewen S., Burke T. M., Dang T., Zoudilova M., Sobel R. A., Butcher E. C.,Zabel B. A. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease [J]. Plos One, 2014, 9(12):1-26

11.Zhao L., Purandare B.,Zhang J.,Hantash B. M. beta2-Microglobulin-free HLA-G activates natural killer cells by increasing cytotoxicity and proinflammatory cytokine production [J]. Hum Immunol, 2013, 74(4): 417-24.

12.Mazerbourg S., Bouley D. M., Sudo S., Klein C. A.,Zhang J. V., Kawamura K., Goodrich L. V., Rayburn H., Tessier-Lavigne M.,Hsueh A. J. Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality [J]. Molecular Endocrinology, 2004, 18(9): 2241-54.

13.Cai L.,Zhang J.,Duan E. Dynamic distribution of epidermal growth factor during mouse embryo peri-implantation [J]. Cytokine, 2003, 23(6): 170-8.

14.Dai B. J., Cao Y. J., Wang X. C., Zhou J. X.,Zhang J., Chen D. Y.,Duan E. K. Expression of LIF, VEGF, CD57 and CD68 after the transfer of rat embryos to mouse uteri [J]. Chinese Science Bulletin, 2003, 48(6): 542-548.


(四)Chinese core journals and non-sci journals (20)

  1. Li R.R., Li X., Ma B. H.*, Zhang J.*. Advances in adipsin research. Journal of Public Health and Preventive Medicine, 2019,30(2):74-78

  2. Yu G. Y., Dai X. Y., Zhang J., Li Q. X., Cao G. S., Jin P..Impact of CMKLR1 on migration and proliferation properties of endometrial carcinoma. Progress in Obstetrics and Gynecology, 2018,277:512-517

  3. Fan X.J, Huang C., Chen Z. L., Wang H.F., Huang B.B., Zhang J..Metabolic disorders during pregnancy and placenta development.Chinese Journal of Practical Gynecology and Obstetrics, 2018, 34(9):959-963

  4. Chen Z. L., Zhang J., Yang Q.* and Fan X. J.*, A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review, Significances of Bioengineering & Biosciences, 2018 May 22.Volume 1-Issue-4.

  5. Huang B. B., Qin X. Y., Tang H. R., Jin P., Zhang J.. Longnon-coding NAs andits research progressin metabolic diseases. Journal of Public Health and Preventive Medicine, 2017, 28(2):80-84.

  6. Xue L.#, Yu Y.#, Zeng F. #,Tang H. R., Xiang L., Chen J., Xiao T. X., Ren P. G., Zhang J V.,. Alleviation of Diet-Induced Fat Accumulation by a Small Molecule CMKLR1 Antagonist in Mice. Journal of Steroids & Hormonal Science. 2018, Vol 9(1): 191 DOI: 10.4172/2157-7536.1000191.

  7. Sun L. F., Xue L.,Yang Y. L., Zhang J.. The Research Progress on Irisin and Energy Metabolism, Progress in Physiological Sciences,,2017,48(6):409-416.

  8. Sun L.F, Yang Y. L., Zhang J..Review on Progress in Chemerin, anAdipokine, and Polycystic OvarianSyndrome (PCOS). Journal of Integration Technology,2017 , 6 (6) :59-71.

  9. Liu H. D., Xiong W., Liu Q. Y., Li J. H., Wu M. S., Zhang J., Dong S. H.. Role of CMKLRl on mouse vascular smooth muscle cells proliferation and related mechanism. Chinese Journal of Cardiology, 2016, 44(7), 605-609.

  10. Jiang X. T., Xiang L., Fan X. J., Ge L. J., Zhang J.. Effects of Chemokine-Like Receptor 1 Signal Pathway on Mice Inducedby Dihydrotestosterone Increased Bone Mineral Density, Journal of Integration Technology,2017,62:32-40.

  11. Li J.#,Teng B.#, Lin R.Q., She C.,Yao Z. Y., Zhang J.,Song L.,Ren P. G.*. Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study[J]. International Advanced Research Journal in Science, Engineering and Technology,2016,DOI10.17148.

  12. Liu H. D., Xiong W., Liu Q. Y., Li J. H., Wu M. S., Zhang J., Dong S. H.. Role of CMKLR1 Receptor in the Proliferation of Mouse Vascular Smooth Muscle Cells. Journal of Medical Research, 2016 , 45 (4) :76-79.

  13. Xiong W., Dong S. H.,Zhang J., Li J. H., Liao B. H., Pang X. L., Luo L. J.. The research of chemerin promoting proliferation of vascular smooth muscle cells , Journal of Clinical Cardiology,2016,321,66-69.

  14. Xiong W., Dong S. H., Zhang J., Li J. H., Wu M. S., Liao B. H., Pang X. L., Luo L. J. Construction and identification of vascular smooth muscle cell lines from Chn1 gene deficient mice,Guangdong Medical Journal,2015,(16):2495-2498.

  15. Xiong W., Dong S. H., Zhang J., Li J. H., Liao B. H.,Pang X. L., Luo L. J.. Chemerin promotes proliferation of mouse vascular smooth muscle cells by up-regulating p-JNK,Chinese Journal of Pathophysiology, 2015,(12): 2282-2286.

  16. Sun L. F., Yang Y. L., Zhang J.. Oxidative stress induced by obesity and its effect on sexual reproduction. Journal of Public Health and Preventive Medicine,2015,26(4):71-73.

  17. Tian X. F., Ma W. J., Zhang J.. The relationship between chemerin and nonalcoholic fatty liver disease. Journal of Public Health and Preventive Medicine, 2015, 26(2):75-77.

  18. Chen Z., Xu Z. W., Xiang L., Zhang P., Zhang J.. The perspective of the relationship between chemerin and osteoporosis. Chinese Journal of Osteoporosis,2014,(12):1506-1510.

  19. Huang Q. S., Xiao T. X., Zhang J., Wei Y.J. . Molecular Dynamics Simulation of Endothelin-1 Conformational Changes within Uniform Flow, Journal of Integration Technology, 2014,2(02):17-262014,3(2),17-26.

  20. Zhang J., Duan E. K..Prospect of space reproductive, developmental biology and tissue engineering,Chinese Journal of Aerospace Medicine,2001,12(3):184-186.

Patents

(一) Published or authorized patents (9)

  1. Jian Zhang, Orna Avsian-Kretchmer, Aaron Hsueh,Ghrelin associated peptide and      its uses,2006.10.12,PCT,US20060229250 A1 US 11/372,888
  2. Aaron J W      Hsueh, Ching-Wei Luo,Jian Zhang,Mammalian obestatin      receptors,2007.2.22,PCT,US20070042409 A1PCT/US2006/030648
  3. Aaron J.      W. Hsueh,Jian Zhang, Orna Avsian-Kretchmer,Neuronostatin and      its uses,2007.8.14,PCT,WO2009023125 A1 PCT/US2008/009498
  4. Kareem      Graham,Jian Zhang, Eugene C. Butcher, Brian A. Zabel,Small      Molecule CMKLR1 Antagonists in Demyelinating      Disease,2013.7.25,PCT,WO2013109543 A1 PCT/US2013/021588
  5. Pei-gen      RenJian ZhangJie-wen ZhouDan LiXiao-yong GuoJian Li,Animal simulated weightlessness training apparatus,authorization date2016.2.24,Chinese patent,201210575057.5
  6. Jian ZhangPei-gen RenChun-hong YuLei LiShu-hua Mu,Yong-jun Liu,Chemokine derivatives and their      expression genes and applications,authorization date2016.12.21,Chinese patent,201210235624.2
  7. Jian ZhangHua-shan ZhaoYa-li YangLi-XueBao-bei Wang,A wire-drawing 3D printer,authorization date2018.07.31,Chinese patent,201721736347.8
  8. Jian ZhangHua-shan ZhaoYa-li YangLi-XueBao-bei Wang,A rotary 3D printer,authorization date2018.10.12,Chinese patent,201721735486.9
  9. Jian ZhangHua-shan ZhaoYa-li YangLi-XueLifeng-SunMeng-xia LiXiao-yong DaiAminiature intragembrane excision deviceauthorization date2019.5.28Chinese patent201820616303.X

(二)Patents under application (30 PCT + 49 Chinese patents)

  1. Ren Peigen,Zhang Jian,Teng      Bin,Li Jian,Yao Zhenyu.Polypeptides regulating energy metabolism      and their applications2019.09.13,特願2019-550656
  2. Ren Peigen,Zhang Jian,Teng Bin,Li Jian,Yao Zhenyu.Polypeptides regulating energy      metabolism and their applications2019.09.16US16/572584
  3. Ren Peigen,Zhang Jian,Teng Bin,Li Jian,Yao Zhenyu.Polypeptides regulating energy      metabolism and their applications2019.09.30EP17901101.0
  4. Ren Peigen,Zhang Jian,Teng Bin,Li Jian,Yao Zhenyu에너지대사를조절하는폴리펩티드및그용도2019.11.08KR1020197029172
  5. Zhang Jian,Ren      Peigen,Huang Chen,Wang Miaomiao.Related applications of female      reproductive disease target CMKLR1 and its antagonist2015.12.29PCT/CN2015/099464
  6. Fan Xiujun,Zhang Baozhen,Tan Lunbo,Wang Baobei,Cheng Guogang,Xiao      Zhonglin,Han Jinyu,Chen Zhilong,Xiao Tianxia,Li Mengxia,Zheng Mingbin,Cai Lintao,Zhang      Jian.Target placenta-like chondroitin sulfate peptide, targeted      delivery system, preparation method and application2017.10.31PCT/CN2017/108646
  7. Zhang Jian,Yang Yali,Sun      Lifeng,Xiao Tianxia,Wang Baobei.Application of GPR1 target and its antagonist      in infertility-related diseases2017.12.12PCT/CN2017/115741
  8. Zhang Jian,Zhao      huashan,Yang Yali,Xue Li,Wang Baobei.A rotary 3D printing method and a      rotary 3D printer2017.12.13PCT/CN2017/116003
  9. Zhang Jian,Zhao      huashan,Yang Yali,Xue Li,Wang Baobei.A wire-drawing 3D printing method and      a wire-drawing 3D printe2017.12.13PCT/CN2017/116007
  10. Zhang Jian,Huang Chen,Zhao      huashan,Wang Baobei,Chen Zhilong,Xue Li,Yang Yali.A 3d-printed fat tissue2017.12.13PCT/CN2017/116247
  11. Zhang Jian,Yang Yali,Huang      Binbin,Dai Xiaoyong,Chen Jie,Xiao Tianxia.Anti-tumor related application      of GPR1 target and its antagonist2017.12.14PCT/CN2017/116239
  12. Zhang juzuo,Fan Xiujun,Zhang Jian,Chen Zhilong,Wang      Baobei,Huang Chen,Chen Jie,Li Mengxia.An immune composition of placental      like chondroitin sulfate A and its application2017.12.15PCT/CN2017/116629
  13. Zhang      juzuo,Fan Xiujun,Zhang Jian,Cheng Guogang,Chen Zhilong,Zhang      Baozhen,Xiao Zhonglin,Han Jinyu.A maffinity chromatography method for purification      of placental like chondroitin sulfate A and its derivatives2017.12.15PCT/CN2017/116624
  14. Zhang Jian,Li Mengxia,Chen      Jie,Xiao Tianxia.A detection strip for chemotactic elements and their      derived polypeptides and its preparation method2017.12.15PCT/CN2017/116588
  15. Zhang Jian,Ruan      Changshun,Zhao huashan,Ren Peigen,Yang Yali,Sun Lifeng,Qu Xinyun,Wu      Mingming.Artificial 3d printing endometrium and its preparation and      application2017.12.15PCT/CN2017/116596
  16. Zhang Jian,Xiang Liang,Ren      Peigen.Artificial 3d printing endometrium and its preparation and      application2017.12.15PCT/CN2017/116598
  17. Zhang Jian,Xiang Liang,Li      Jian,Ren Peigen.Application of GPR1 gene in the diagnosis or treatment of      bone growth or bone disorders2017.12.15PCT/CN2017/116609
  18. Zhang Jian,Xiang Liang,Li      Mengxia,Ren Peigen.Preparation of protein extract from shell nacre and its      application in anti-osteoporosis2017.12.15PCT/CN2017/116615
  19. Zhang Jian,Yang Yali,Zhao      huashan.A 3D printed biological scaffold for artificial ovary capable of      activating primordial follicles and its artificial ovary and application2017.12.15PCT/CN2017/116620
  20. Zhang Jian,Xue Li,Zhao      huashan,Huang Chen,Yang Yali,Wang Baobei.An artificial islet tissue and      its preparation and application2017.12.17PCT/CN2017/116250
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  24. Zhang Jian,Dai      Xiaoyong,Chen Jie,Huang Chen,Xiao Tianxia.A CMKLR1 antagonistic      polypeptide and its derivatives and application2017.12.20PCT/CN2017/117504
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  33. Zhang Jian,Sun      Qince.Application of CMKLR1 small molecule antagonist in prevention and      treatment of obesity and obesity metabolic syndrome.2013.9.17Chinese Patent201310424443.9
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  37. Zhang      juzuo,Fan Xiujun,Zhang Jian,Chen Zhilong,Wang Baobei,Huang      Chen,Chen Jie,Li Mengxia.An immune composition of placental like      chondroitin sulfate A and its application2017.10.17Chinese Patent201710965035.2
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  40. Zhang Jian,Zhao      huashan,Yang Yali,Xue Li,Wang Baobei.A rotary 3D printing method and a      rotary 3D printer2017.12.13Chinese Patent201711331688.1
  41. Zhang Jian,Zhao      huashan,Yang Yali,Xue Li,Wang Baobei.A wire-drawing 3D printing method and      a wire-drawing 3D printer2017.12.13Chinese Patent201711332813.0
  42. Zhang Jian,Huang Chen,Zhao      huashan,Wang Baobei,Chen Zhilong,Xue Li,Yang Yali.A 3d-printed fat tissue2017.12.13Chinese Patent201711342859.0
  43. Zhang Jian,Xue Li,Zhao huashan,Huang      Chen,Yang Yali,Wang Baobei.An artificial islet tissue and its preparation      and application2017.12.14Chinese Patent201711341949.8
  44. Zhang Jian,Yang Yali,Huang      Binbin,Dai Xiaoyong,Chen Jie,Xiao Tianxia.Anti-tumor related application      of GPR1 target and its antagonist2017.12.14Chinese Patent201711336735.1
  45. Zhang Jian,Dai      Xiaoyong,Chen Jie,Yu Guiyuan,Cai Jiaxuan,Huang Chen.A GPR1 antagonistic      polypeptide and its derivatives and application2017.12.19Chinese Patent201711378788.X
  46. Zhang Jian,Dai Xiaoyong,Wang      Baobei,Zhang juzuo,Zhao huashan,Wang Hefei.A GPR1 antagonistic polypeptide      and its derivatives and application2017.12.19Chinese Patent201711376676.0
  47. Zhang Jian,Dai      Xiaoyong,Chen Jie,Chen Zhilong,Zhang Baozhen,Han Jinyu.A GPR1 antagonistic      polypeptide and its derivatives and application2017.12.19Chinese Patent201711376678.X
  48. Zhang Jian,Dai      Xiaoyong,Huang Binbin,Zhu Wen,Li Rongrong,Huang Qiusheng.A GPR1      antagonistic polypeptide and its derivatives and application2017.12.19Chinese Patent201711378799.8
  49. Zhang Jian,Dai      Xiaoyong,Sun Lifeng,Xiao Tianxia,Li Mengxia,Yang Yali.A GPR1 antagonistic      polypeptide and its derivatives and application2017.12.19Chinese Patent201711378017.0
  50. Zhang Jian,Dai      Xiaoyong,Zhang juzuo,Wang Hefei,Zhu Wen,Li Rongrong.A GPR1 antagonistic      polypeptide and its derivatives and application2017.12.19Chinese Patent201711378016.6
  51. Zhang Jian,Dai      Xiaoyong,Xiao Zhonglin,Zhang Baozhen,Zhao huashan,Chen Zhilong,Han Jinyu.A      GPR1 antagonistic polypeptide and its derivatives and application2017.12.19Chinese Patent201711378062.6
  52. Zhang Jian,Dai      Xiaoyong,Chen Jie,Xiao Tianxia,Huang Chen,Wang Baobei.A GPR1 antagonistic      polypeptide and its derivatives and application2017.12.19Chinese Patent201711378037.8
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  60. Ren Peigen,Zhang Jian,Yao Zhenyu, Li Jian,Teng Bin,Liu Chang,      Yu XiangfangAn ELISA kit for the detection of      metabolins2017.12.22201711409132.X
  61. Ren Peigen,Zhang Jian,Yao Zhenyu, Li Jian,Teng Bin,Liu Chang,      Yu XiangfangA metabolin polypeptide artificial      antigen as well as antibodies and applications2017.12.22201711409139.1
  62. Ren Peigen,Zhang Jian,Yao Zhenyu, Li Jian,Teng Bin,Liu Chang,      Yu XiangfangAn artificial antigen for a      metabolin polypeptide and its preparation, antibody and application2017.12.22201711405982.2
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  78. Zhang Jian,Zhao huashan,Xue LiA tissue and cell      cryopreservation solution and its cryopreservation method2018.11.14201811353544.0
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Research Interests

1、Physiology

2、Cytobiology

3、Biochemistry & Molecular Biology

Students

已指导学生

黄晨  博士研究生  071010-生物化学与分子生物学  

孙立峰  博士研究生  071010-生物化学与分子生物学  

黄斌斌  博士研究生  071010-生物化学与分子生物学  

现指导学生

朱雯  博士研究生  071010-生物化学与分子生物学  

赵沛一  硕士研究生  085238-生物工程  

杨雅莉  博士研究生  071010-生物化学与分子生物学  

连前进  硕士研究生  085238-生物工程  

柴德智  硕士研究生  086000-生物与医药