基本信息
张键  女  博导  中国科学院深圳先进技术研究院
电子邮件: jian.zhang@siat.ac.cn
通信地址: 深圳市南山区学苑大道1068号
邮政编码: 518055

研究领域

从事活性多肽的发现及其在代谢、生殖与衰老中的作用研究,主要包括:


1)活性多肽在下丘脑效应器官轴(脂肪组织、骨骼、肌肉等)与卵巢的代谢调控关系中的作用及机制;
2)活性多肽在下丘脑效应器官轴(脂肪组织、骨骼、肌肉等)与母-胎代谢互作及母子两代代谢风险的调控关系中的作用及机制。

招生信息

招生专业
071009-细胞生物学
071010-生物化学与分子生物学
071008-发育生物学
招生方向
代谢、生殖与衰老
生物材料与分子影像的应用
内分泌相关肿瘤

教育背景

1999-07--2003-06   中国科学院动物研究所   博士
学历

博士

学位

博士

工作经历

2010年12月至今,     中国科学院深圳先进技术研究院        研究员

2008-2010,          美国斯坦福大学/ELIXIR/PAIRE         Research Scientist

2003-2008,          美国斯坦福大学/妇产科系             博士后


专利与奖励

专利:

    共申请专利90项,已授权40项。
     其中:美容/防脱发、降脂降糖、维持生育力、延缓衰老类相关专利40项(已授权10项);
     保健/功能食品活性成分、药物类专利23项(已授权16项);
     3D打印类专利15项(已授权3项);
     基因、蛋白检测类专利8项(已授权2项);
     装置类专利2项(已授权2项);
     胚胎发育、干细胞类专利2项。


奖励信息:

    

1.  深圳市科技进步二等奖(第一完成人)(2022

2.  深圳市“国家级领军人才”(2021)

3.  中国科学院****择优支持2011

4.  深圳市杰青(2012

5.  深圳市“孔雀计划”海外高层次人才C(2014)/深圳市“孔雀计划”海外高层次人才B类(2016

6.  中国科学院院长优秀奖(2003年)

7.  中国科学院研究生创新津贴(2002年)

8.  德国Weimar会议最佳poster展示奖(2002年)


  


代表性文章

代表性论文:

1.        TAN L B#, OUYANG Z j#, CHEN Z L, SUN F, GUO H C, WANG F, MULDER M, SUN Y, LU XF, ZHANG JV, DANSER AHJ, VERDONK K, FAN X J*, YANG Q*.Adipokine chemerin overexpression in trophoblasts leads to dyslipidemia in pregnant mice: implications for preeclampsia[J]. Lipids Health Dis, 2023 Jan 25;22(1):12.

2.        YANG C#, ZENG QX#, LIU JC, YEUNG WS, ZHANG JV*(共通讯), DUAN YG*.Role of small RNAs harbored by sperm in embryonic development and offspring phenotype[J]. Andrology, 2022 Nov 23. doi: 10.1111/andr.13347.

3.        HUANG C,BIN C, CAI J X, CHEN J ,WANG B B, LI MX, ZHOU WEI, WANG J G,ZHANG P F,ZHANG J V*(通讯). Chondroitin sulfate Targeting Nanodrug Achieves Near-Infrared Fluorescence-guided Chemotherapy Against Triple Negative Breast Primary and Lung Metastatic Cancer[J]. Int J  Nanomed, 2022, 175547—5563.

4.        YU M#, YANG Y L#, ZHAO H , LI M X, CHEN J, WANG B B,XIAO T X, HUANG C,ZHAO HS ,ZHOU W*, ZHANG J V(通讯)*. Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression[J]. Front Pharmacol, 2022, doi: 10.3389/fphar.2022.985618.

5.        GUAN X N#, YU M#, WU LL, CHEN J, TONG J N, WU X X, YIN A Q, XIAO T X, WANG B B, ZHANG J V*(共通讯), NIU J M*. Elevated trophoblastic Siglec6 contributes to the impairment of vascular endothelial cell functions by downregulating Wnt6/beta-catenin signaling in preeclampsia [J]. Arch Biochem Biophys, 2022, 730: 109396.

6.        YU M#, YANG YL#,HUANG C,GE L,XUE L,XIAO ZL,XIAO TX,ZHAO HS,REN PG,ZHANG JV(通讯). Chemerin: a functional adipokine in reproductive health and diseases[J].Biomedicines,2022, 10(8), 1910.

7.        YIN A Q, GUAN X N, ZHANG JV*(共通讯), NIU J M*.Focusing on the role of secretin/adhesion (Class B) G protein-coupled receptors in placental development and preeclampsia[J]. Front Cell Dev Biol, 2022 Sep 14;10:959239.

8.   SONG Q Y, XIAO B, HUANG H L, MA L Y, ZHANG JV*(共通讯), ZHU Y F*.Influences of gestational diabetes mellitus on the oral microbiota in offspring from birth to 1 month old[J]. BMC Pregnancy Childbirth,2022 Apr 6;22(1):289.

9.   ZHANG QQ #,XIAO Z L#, LEE C K, DUAN Y G, FAN X J, YEUNG W S B, CHIU P C N*, ZHANG J V*(通讯). The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy[J]. Front Cell Dev Biol, 2022 May 17;10:883636.

10. MA CY#, XIONG Y#, HAN P#, ZHANG X Y, CAO Y J, WANG B B ,ZHAO H S,DUAN E K, ZHANG J V*(共通讯), LEI X H*. Simulated microgravity potentiates hematopoietic differention of human pluripotent stem cells and supports formation of 3D hematopoietic cluster[J]. Front Cell Dev Biol, 2022 Jan 10;9:797060.

11. LIU H P, ZHANG J V, WANG DW,ALBRECHT A, STEINHÖFEL K, LAI HM. Extended endocrine therapy in breastcancer:A basket of length-constraint  feature selection metaheuristics to balance Type I againstType II errors[J]. J Biomed Inform. 2022 Jun 6;131:104112.

12. LEE CL*, CHEN ZL, ZHANG Q Q, GUO Y, NG VWY, ZHANG B Z, BAI KF, RUAN DG, KAN ASY, CHEUNG KW, MAK ASL, YEUNG WSB, SU R, YANG Q, CHEN M, DU MR, ZHANG J, FAN XJ*, CHIU PCN*. Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia[J]. Clin Transl Med, 2022 Jun;12(6):e826.

13. TAN L B#, CHEN Z L#, SUN F, ZHOU  Z Q, Zhang B Z, WANG B B, CHEN J, LI M X, XIAO T X, NEUMAN RI, NIU J M, VERDONK K, LU X F, ZHANG J V, DANSER AHJ, YANG Q*, FAN X J*. Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms[J]. Clin Sci (Lond),2022 Feb 25;136(4):257-72.

14. SUN F#, CAI H#, TAN L B, QIN D Z, ZHANG J, HUA J L, FAN X J*, PENG S*. Placenta-Specific miR-125b Overexpression Leads to Increased Rates of Pregnancy Loss in Mice[J]. Int J Mol Sci, 2022 Jan 15;23(2):943.

15. 黄容,张键,车旭. SLC4A10表达水平对肝癌患者预后的影响[J].基础医学与临床. 2022, 42(3):461-6.

16. ZHOU X S#,ZHAO J#,ZHANG J V*(共通讯),WU Y L,WANG L,CHEN X Q,JI D M,ZHOU G G Y*.Enhancing Therapeutic Efficacy of Oncolytic Herpes Simplex Virus with MEK Inhibitor Trametinib in Some BRAF or KRAS-Mutated Colorectal or Lung Carcinoma Models[J]. Viruses, 2021, 13(9), 1758.

17. LI R R, MA C Y, XIONG Y, ZHAO H S, YANG Y L, XUE L,WANG B B,XIAO T X ,CHEN J,LEI X H*, MA B H *,ZHANG J V*(通讯). An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic -Pituitary- Ovarian Axis [J].Biomolecules, 2021,11(6):857.

18. SUN LF#, YANG Y L#, WANG M Y, ZHAO H S, XIAO T X, LI M X, WANG B B, HUANG C, REN P G*, ZHANG JV*(通讯).Inhibition of Col6a5 improve lipid metabolism disorder in Dihydrotestosterone-induced hyperandrogenic mice [J].Front Cell Dev Biol2021 , doi: 10.3389/fcell.2021.669189.

19. WANG H F, HUANG B B, HOU A L, XUE L, WANG B B, CHEN J, LI M X, ZHANG J V(通讯). High NOV/CCN3 expression during high-fat diet pregnancy in mice affects GLUT3 expression and the mTOR pathway[J]. Am J Physiol-Endocrinol Metab,2021, DOI: 10.1152/ajpendo.00230.2020

20. ZHANG J Z#, CHEN Z L#, WANG B B, CHEN J, XIAO TX, ZHANG J V*(共同通讯), CHEN S L*, FAN XJ*. Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis  and metastasis of choriocarcinoma in JEG3 cells[J]. Int J Mol Sci, 2021 2021;18(1):207-215.

21. ZHENG X L, ZHANG J V, BAI Y F, WANG J Q, JIANG M F, ZENG S, WANG L H. Upregulation of OATP1A2 in Human Esophageal Squamous Cell Carcinoma Cells via the HDAC6-GCN5/PCAF-H3K9Ac Axis[J]. Xenobiotica, 2021 Nov 25;1-10.  doi: 10.1080/00498254.2021.2001076

22. TAN L B, CHEN Z L, SUN F, ZHOU Z Q, ZHANG B Z, WANG B B, CHEN J, LI MX, XIAO TX, NEUMAN R I, NIU J M, VERDONK K, LU X F, ZHANG J, JAN DANSER A.H., YANG Q, FAN X J. Placental Trophoblast Specific Overexpression of Chemerin Induces Preeclampsia-like Symptoms[J]. Placenta, 2021,112,Page e56.

23. HONG H, CHEN H C, ZHANG Y X, WU Z M,  ZHANG Y Y, ZHANG Y Y,  HU Z, ZHANG J V, LING K,  HU J H, WEI Q. DYF-4 regulates patched-related/ DAF-6-mediated sensory compartment formation in C. elegans[J].  PLoS Genet.2021 17(6): e1009618.

24. ZHAO Y#*, FENG H W#, ZHANG Y H#, ZHANG J V, WANG X H, LIU D T, WANG T R, LI R H W, NG E H Y, YEUNG W S B, RODRIGUEZ-WALLBERG K A, LIU K. Current Understandings of Core Pathways for the Activation of Mammalian Primordial Follicles [J].Cells, 2021, 10(6): 1491.

25. CHEN Y Q#, UDDUTTULA A#, XIE X L, ZHOU M, SHENG W B, YU F, WENG J, WANG D L, TENG B, MANIVASAGAM G, ZHANG J V, REN P G*, KANG B*, ZENG H*.A novel photocrosslinked phosphate functionalized Chitosan-Sr5(PO4)2SiO4 composite hydrogels and in vitro biomineralization, osteogenesis, angiogenesis for bone regeneration application [J]. Compos Part B-Eng, 2021,109057,ISSN 1359-8368.

26. HUANG C#, DAI X Y#, CAI J X#, CHEN J, WANG B B,ZHU W, WANG E, WEI W*, ZHANG J V*(通讯). A screened GPR1 peptide exerts antitumor effects on triple-negative breast cancer[J]. Mol Ther-oncolytics,2020,18:602-12.

27. HUANG B B#, ZHU W#, ZHAO H S#, ZENG F, WANG E, WANG H F, CHEN J, LI M X, HUANG C,REN L R*, NIU J M*, ZHANG J V*(通讯). Placenta-derived Osteoprotegerin is Required for Glucose Homeostasis in Gestational Diabetes Mellitus[J]. Front Cell Dev Biol, 2020 Sep 1;8:563509.

28. TENG B#, HUANG C#, CHENG C L, UDDUTTULA A, YU X F, LIU C, LI J, YAO Z Y, LONG J, MIAO L F, ZOU C, CHU J, ZHANG J V*(共同通讯), REN P G*. Newly identified peptide hormone inhibits intestinal fat absorption and improves NAFLD through its receptor GPRC6A [J]. J Hepatol, 2020,73(2):383-93.

29. UDDUTTULA A#, TENG B#, CHANDRASHEKAR B N, LI J, YU X F, LIU C, SHI R, CHENG C, ZHANG J V*(共同通讯), REN P G*. Novel Sr5(PO4)2SiO4-graphene nanocomposites for applications in bone regeneration in vitro [J]. Appl Surf Sci, Volume 507, 30 March 2020, 145176.

30. HUANG B B#, ZHAO H S#, HUANG C#, WU L L, XIANG L, CHEN J, WANG B B, XIAO T X, LI M X, REN L R*, NIU J M*, ZHANG J V*(通讯). CMKLR1 deficiency attenuates androgen-induced lipid accumulation in mice [J]. Am J Physiol-Endocrinol Metab, 2020, 318(3): E371-E80.

31. LI N, HE F, GAO H, GE Y, FAN X J, ZHANG J V, QI H, REN L L. Elevated cell-free fetal DNA contributes to placental inflammation and antiangiogenesis via AIM2 and IFI16 during pre-eclampsia [J]. J Cell Physiol, 2020 May 7. doi: 10.1002/jcp.29766.

32. ZHAO K#*, CHENG G G#, ZHANG B Z#, LI D, HAN J Y, CHEN J, WANG B B, LI M X, XIAO T X, LE A W, SUN B N, JIN Z, ZHANG J V, FAN X J. Targeting delivery of partial VAR2CSA peptide guided N-2-Hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles for multiple cancer types [J]. Mater Sci Eng C-Mater Biol Appl, 2020, 106:110171.

33. ZHAO H S#, YAN D W#, XIANG L#, HUANG C, LI J, YU X F, HUANG B B, WANG B B, CHEN J, XIAO T X, REN P G*, ZHANG J V*(通讯). Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice [J]. Cell Mol Life Sci, 2019, 76(2): 355-67.

34. YAO Z Y#, LIU C#, YU X F, MENG J, TENG B, SUN Y T, KEREM O E, ISMAYIL A, FANG P, ZHANG J V *(共同通讯), REN P G*. Microarray Profiling and Coexpression Network Analysis of Long Noncoding RNAs in Adipose Tissue of Obesity-T2DM Mouse [J]. Obesity, 2019, 27(10): 1644-51.

35. UDDUTTULA A#, LI J#, ZHAO P Y, WANG G C, ZHANG J V*(共同通讯), REN P G*. Sol-gel derived nanosized Sr5(PO4)2SiO4 powder with enhanced in vitro osteogenesis and angiogenesis for bone regeneration applications [J]. Ceramics International, 2019, 45(3): 3148-58.

36. SUN L F#, YANG Y L#, XIAO T X, LI M X, ZHANG J V(通讯). Removal of DHT can relieve polycystic ovarian but not metabolic abnormalities in DHT-induced hyperandrogenism in mice [J]. Reprod Fertil Dev, 2019, 31(10): 1597-606.

37. JIN P#*, CHEN X F#, YU G Y, LI Z Y, ZHANG Q Q, ZHANG J V*(共同通讯). The Clinical and Experimental Research on the Treatment of Endometriosis with Thiostrepton [J]. Anti-Cancer Agents Med Chem, 2019, 19(3): 323-9.

38. HUANG B B, LIU X C, QIN X Y, CHEN J, REN P G, DENG W F*, ZHANG J V *(通讯). Effect of High-Fat Diet on Immature Female Mice and Messenger and Noncoding RNA Expression Profiling in Ovary and White Adipose Tissue [J]. Reprod Sci, 2019, 26(10): 1360-72.

39. HUANG B B#, ZHU W#, CHANG J L#, DAI X Y, YU G Y, HUANG C, WANG E, LI Z H, LIN L L, WANG B B, CHEN J, XIAO T X, NIU J M*, ZHANG J V *(通讯). Role of G protein-coupled receptor 1 in choriocarcinoma progression [J]. Am J Physiol-Cell Physiol, 2019, 317(3): C556-C65.

40. HUANG B B#, HUANG C#, ZHAO H S#, ZHU W, WANG B B, WANG H F, CHEN J, XIAO T X, NIU J M*, ZHANG J V *(通讯). Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice [J]. Am J Physiol-Endocrinol Metab, 2019, 316(6): E987-E97.

41. 李荣荣薛丽马保华*, 张键*(共同通讯). Adipsin相关疾病的研究进展 [J]. 公共卫生与预防医学, 2019, 30(02): 74-8.

42. ZHAO K#, LI D, CHENG G G, ZHANG B Z, HAN J Y, CHEN J, WANG B B, LI M X, XIAO T X, ZHANG J V, ZHOU D P, JIN Z, FAN X J#. Targeted Delivery Prodigiosin to Choriocarcinoma by Peptide-Guided Dendrigraft Poly-l-lysines Nanoparticles [J]. Int J Mol Sci, 2019, 20(21):5458.

43. QIU C#, LI J#ZHANG J V, HE Q, WANG L, WENG X, GUAN M. Modulation of the airway smooth muscle phenotype in a murine asthma model and effects of nuclear factor-κB inhibition [J]. Journal of Asthma, 2019, 56(12): 1247-56.

44. ZHANG B Z#, TAN L B#, YU Y#, WANG B B, CHEN Z L, HAN J Y, LI M X, CHEN J, XIAO T X, AMBATI B K, CAI L T, YANG Q, NAYAK N R, ZHANG J V *(共同通讯), FAN X J*. Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice [J]. Theranostics, 2018, 8(10): 2765-81.

45. YANG Y L#, SUN L F#, YU Y, XIAO T X, WANG B B, REN P G, TANG H R*, ZHANG J V*(通讯). Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice [J]. Reprod Biol Endocrinol, 2018, 16(1): 50.

46. HUANG C#, HUANG B B#, NIU J M#, YU Y, QIN X Y, YANG Y L, XIAO T X, CHEN J, REN L R*, ZHANG J V*(通讯). Global mRNA and Long Non-Coding RNA Expression in the Placenta and White Adipose Tissue of Mice Fed a High-Fat Diet During Pregnancy [J]. Cell Physiol Biochem, 2018, 50(6): 2260-71.

47. XUE L, YU Y, ZENG F, TANG H R, XIANG L, CHEN J, XIAO T X, REN PG, ZHANG J V(通讯). Alleviation of Diet-Induced Fat Accumulation by a Small Molecule CMKLR1 Antagonist in Mice [J]. Journal of Steroids & Hormonal Science, 2018, 09(01): 10.4172 / 2157-7536.1000191.

48. 范秀军黄晨陈指龙王鹤霏黄斌斌张键(通讯)妊娠期代谢性疾病与胎盘发育 [J]. 中国实用妇科与产科杂志, 2018, 34(09): 959-63.

49. ZHANG B Z#, CHENG G G#, ZHENG M B, HAN J Y, WANG B B, LI M X, CHEN J, XIAO T X, ZHANG J V, CAI L T, LI S J, FAN X J. Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment [J]. Drug Deliv, 2018, 25(1): 461-71.

50. XIAO Z L, LI S J, YU Y, LI M X, CHEN J, WANG F, ZHANG J V, DENG W F*, YANG Q*, FAN X J*. VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors [J]. Mol Cell Biochem, 2018, 449(1-2): 1-8.

51. 余贵媛代小勇张键李秋霞曹冠姝金平. CMKLR1对子宫内膜癌细胞增殖和迁移特性的影响 [J]. 现代妇产科进展, 2018, 27(07): 512-7.

52. CHEN Z L, ZHANG J V, YANG Q*, FAN X J*. A Secreted Protein in the Wnt Signaling Pathway-R-Spondin3: A Mini-Review [J]. Significances of Bioengineering & Biosciences, 2018, 1(4): 10.31031/SBB.2018.01.000518.

53. LI J#, XIANG L#, JIANG X T#, TENG B, SUN Y T, CHEN G L, CHEN J, ZHANG J V*(共同通讯), REN P G*. Investigation of bioeffects of G protein-coupled receptor 1 on bone turnover in male mice [J]. J Orthop Translat, 2017, 10:42-51.

54. WANG L W#, LI J#ZHANG J V#(共一), HE Q, WENG X W, HUANG Y M, GUAN M J, QIU C. Inhibition of TRPC3 downregulates airway hyperresponsiveness, remodeling of OVA-sensitized mouse [J]. Biochem Biophys Res Commun, 2017, 484(1): 209-17.

55. 孙立峰杨雅莉黄晨薛丽, 张键(通讯)脂肪因子Chemerin与多囊卵巢综合征的研究进展综述 [J]. 集成技术, 2017, 6(06): 59-71.

56. 孙立峰薛丽杨雅莉张键(通讯)鸢尾素(Irisin)与能量代谢相关研究进展 [J]. 生理科学进展, 2017, 48(06): 409-16.

57. 姜晓彤向亮范秀军葛利江*, 张键*(通讯). Chemokine-Like Receptor 1信号通路对双氢睾酮诱导小鼠骨密度增加的影响  [J]. 集成技术,2017, 6(02): 32-40.

58. 黄斌斌秦逍云汤惠茹金平, 张键(通讯)长链非编码RNA及其在代谢疾病中研究进展  [J]. 公共卫生与预防医学, 2017, 28(02): 80-4.

59. YANG Y L#, REN L R#, SUN L F#, HUANG C, XIAO T X, WANG B B, CHEN J, ZABEL B A, REN P G*, ZHANG J V*(通讯). The role of GPR1 signaling in mice corpus luteum [J]. J Endocrinol, 2016, 230(1): 55-65.

60. TANG M#, HUANG C#, WANG Y F, REN P G, CHEN L, XIAO T X, WANG B B, PAN Y F, TSANG B K, ZABEL B A, MA B H*, ZHAO H Y*, ZHANG J V*(通讯). CMKLR1 deficiency maintains ovarian steroid production in mice treated chronically with dihydrotestosterone [J]. Sci Rep, 2016, 6:21328.

61. HUANG C#, WANG M M#, REN L R, XIANG L, CHEN J, LI M X, XIAO T X, REN P G, XIONG L K*, ZHANG J V*(通讯). CMKLR1 deficiency influences glucose tolerance and thermogenesis in mice on high fat diet [J]. Biochem Biophys Res Commun, 2016, 473(2): 435-41.

62. GUO C Z#, LI J#, SHE C, SHAO X Z, TENG B, FENG J, ZHANG J V*(共同通讯), REN P G*. Bioeffects of micron-size magnesium particles on inflammatory cells and bone turnover in vivo and in vitro [J]. J Biomed Mater Res Part B, 2016, 104(5): 923-31.

63. 肖仲琳杨青*, 张键范秀军*. 子痫前期动物模型的研究进展 [J]. 生物化学与生物物理进展, 2016, 43(06): 563-9.

64. LIU H D, XIONG W, LIU Q Y, ZHANG J V, DONG S H. Chemokine-Like Receptor 1 Regulates the Proliferation and Migration of Vascular Smooth Muscle Cells [J]. Med Sci Monitor, 2016, 22:4054-61.

65. LI J, XU Q, TENG B, YU C, LI J, SONG L, LAI Y X, ZHANG J V, ZHENG W, REN P G. Investigation of angiogenesis in bioactive 3-dimensional poly(d,l-lactide-co-glycolide)/ nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect [J]. Acta Biomater, 2016, 42:389-99.

66. LE A W, SHAN L L, DAI X Y, XIAO T H, LI X R, WANG Z H, ZHANG J V*(共同通讯), CHEN X Y*. PI3K, AKT, and P-AKT levels in thin endometrium [J]. Genet Mol Res, 2016, 15(1): doi: 10.4238/gmr.15017184.

67. 熊玮董少红张键李江华廖碧红庞新利罗林杰趋化素促进小鼠血管平滑肌细胞增殖的实验研究 [J]. 临床心血管病杂志, 2016, 32(01): 66-9.

68. 刘华东熊玮刘启云李江华吴美善张键, 董少红沉默人趋化因子受体1基因对小鼠血管平滑肌细胞增殖的作用 [J]. 医学研究杂志, 2016, 45(04): 76-9+84.

69. 刘华东熊玮刘启云李江华吴美善张键董少红人趋化因子受体1促进小鼠血管平滑肌细胞增殖的机制研究  [J]. 中华心血管病杂志, 2016, 44(07): 605-9.

70. 刘华东熊玮董少红吴美善李江华张键趋化素上调丝裂原活化蛋白激酶的表达促进大鼠球囊损伤后颈动脉重塑 [J]. 中国介入心脏病学杂志, 2016, 24(11): 651-4.

71. LI J#, TENG B#, LIN R Q, SHE C, YAO Z Y, ZHANG J V, SONG L, REN P G. Neovasculature in 3D-PLGA/nHAp Scaffolds for Murine Critical Sized Bone Defect Regeneration by Photoacoustic Imaging: A Preliminary Study [J]. Iarjset, 2016, 3(4): 162-70.

72. 田小飞马玮娟方光光肖天霞陈杰张键(通讯)干预GPR1通路对实验性小鼠脂肪累积的影响 [J]. 生物化学与生物物理进展, 2015, 42(05): 457-67.

73. ZHANG Q Q, FAN X J*, ZHANG J V*(通讯). The Role of Adipokine Chemerin in Pregnancy Complications [J]. Prog Biochem Biophys, 2015, 42(10): 962-8.

74. QIU C*, ZHANG J V*(共同通讯), SU M P, FAN X J. Nuclear factor-kappa B mediates the phenotype switching of airway smooth muscle cells in a murine asthma model [J]. International Journal of Clinical and Experimental Pathology, 2015, 8(10): 12115-28.

75. JIA Q Y#, CHENG W X#, YUE Y, HU Y P, ZHANG J V, PAN X H, XU Z W*, ZHANG P*. Cucurbitacin E inhibits TNF-alpha-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-kappa B pathways [J]. Int Immunopharmacol, 2015, 29(2): 884-90.

76. 田小飞马玮娟张键(通讯)脂肪因子Chemerin与非酒精性脂肪肝病的关系 [J]. 公共卫生与预防医学, 2015, 26(02): 75-8.

77. 孙立峰杨雅莉张键(通讯)肥胖引起的氧化应激及其对两性生殖的影响 [J]. 公共卫生与预防医学, 2015, 26(04): 71-3.

78. 熊玮董少红张键李江华吴美善廖碧红庞新利罗林杰慢病毒载体构建小鼠CMKLR1基因缺陷性血管平滑肌细胞系  [J]. 中国组织工程研究, 2015, 19(20): 3195-9.

79. 熊玮董少红张键李江华吴美善廖碧红庞新利罗林杰. Chn1基因缺陷性小鼠血管平滑肌细胞株的构建和鉴定 [J]. 广东医学, 2015, 36(16): 2495-8.

80. 熊玮董少红张键李江华廖碧红庞新利罗林杰趋化素通过上调磷酸化JNK促进小鼠血管平滑肌细胞的增殖[J]. 中国病理生理杂志, 2015, 31(12): 2282-6.

81. LI L#, MA P#, HUANG C, LIU Y J, ZHANG Y, GAO C, XIAO T X, REN P G, ZABEL B A, ZHANG J V (通讯). Expression of chemerin and its receptors in rat testes and its action on testosterone secretion [J]. J Endocrinol, 2014, 220(2): 155-63.

82. LI L#, HUANG C#, ZHANG X, WANG J B, MA P, LIU Y J, XIAO T X, ZABEL B A, ZHANG J V (通讯). Chemerin-Derived Peptide C-20 Suppressed Gonadal Steroidogenesis [J]. Am J Reprod Immunol, 2014, 71(3): 265-77.

83. 黄庆生肖天霞张键*(共同通讯)魏彦杰*. 内皮素-1在均匀流中构象改变的分子动力学模拟 [J]. 集成技术, 2014, 3(02): 17-26.

84. 陈曾徐展望向亮张鹏张键(通讯)脂肪因子chemerin与骨质疏松症的关系展望 [J]. 中国骨质疏松杂志, 2014, 20(12): 1506-10.

85. PANDEY V#, WU Z S#, ZHANG M, LI R, ZHANG J V, ZHU T*, LOBIE P E*. Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma [J]. Breast Cancer Research, 2014, 16(5): 429.

86. GRAHAM K L, ZHANG J V , LEWEN S, BURKE T M, DANG T, ZOUDILOVA M, SOBEL R A, BUTCHER E C, ZABEL B A. A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease [J]. Plos One, 2014, 9(12): e112925.

87. ZHANG J V #*(通讯), LI L#, HUANG Q S#, REN P G*. Obestatin receptor in energy homeostasis and obesity pathogenesis [J]. Prog Mol Biol Transl Sci, 2013, 114: 89-107.

88. LI L#, MA P#, LIU Y J, HUANG C, O W S, TANG F, ZHANG J V (通讯). Intermedin Attenuates LPS-induced Inflammation in the Rat Testis [J]. Plos One, 2013, 8(6): e65278.

89. ZHAO L M, PURANDARE B, ZHANG J V, HANTASH B M. beta 2-Microglobulin-free HLA-G activates natural killer cells by increasing cytotoxicity and proinflammatory cytokine production [J]. Hum Immunol, 2013, 74(4): 417-24.

90. ZHANG J V , JAHR H, LUO C W, KLEIN C, VAN KOLEN K, VER DONCK L, DE A, BAART E, LI J, MOECHARS D, HSUEH A J. Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39 [J]. Mol Endocrinol, 2008, 22(6): 1464-75.

91. SAMSON W K*#ZHANG J V #(共一), AVSIAN-KRETCHMER O, CUI K, YOSTEN G L, KLEIN C, LYU R M, WANG Y X, CHEN X Q, YANG J, PRICE C J, HOYDA T D, FERGUSON A V, YUAN X B, CHANG J K, HSUEH A J*. Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions [J]. J Biol Chem, 2008, 283(46): 31949-59.

92. ZHANG J V , KLEIN C, REN P G, KASS S, DONCK L V, MOECHARS D, HSUEH A J W. Response to Comment on "Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake" [J]. Science, 2007, 315(5813): 766d-d.

93. ZHANG J V , REN P G, AVSIAN-KRETCHMER O, LUO C W, RAUCH R, KLEIN C, HSUEH A J. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake [J]. Science, 2005, 310(5750): 996-9.

94. LI J, ZHANG J V , CAO Y J, ZHOU J X, LIU W M, FAN X J, DUAN E K. Inhibition of the beta-catenin signaling pathway in blastocyst and uterus during the window of implantation in mice [J]. Biol Reprod, 2005, 72(3): 700-6.

95. MAZERBOURG S, BOULEY D M, SUDO S, KLEIN C A, ZHANG J V , KAWAMURA K, GOODRICH L V, RAYBURN H, TESSIER-LAVIGNE M, HSUEH A J. Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality [J]. Mol Endocrinol, 2004, 18(9): 2241-54.

96. 赵田夫#张键#(共一)李晶曹宇静李素敏周家喜李福洋药立波段恩奎血管生长抑素在小鼠胚泡中的调节作用 [J]. 生物化学与生物物理进展, 2003, 05): 778-83.

97. ZHANG J V, CAO Y J, LI F Y, LI J, YAO L B, DUAN E K. Effects of Fibronectin, VEGF and Angiostatin on the Expression of MMPs through Different Signaling Pathways in the JEG‐3 Cells [J]. American Journal of Reproductive Immunology, 2003, 50(4): 273-85.

98. ZHANG J V, ZHAO Y G, CAO Y J, SANG Q X A, DUAN EK. Expression and implications of tissue inhibitor of metalloproteinases-4 in mouse embryo [J]. Molecular human reproduction, 2003, 9(3): 143-49.

99. 赵田夫#张键#(共一) 李晶曹宇静李素敏周家喜段恩奎血管生长抑素抑制小鼠胚胎植入的最低有效量及其作用机理 [J]. 动物学报, 2003, 03: 332-8.

100.     DAI BJ C Y, WANG X C, ZHOU J X, ZHANG J V, CHEN D Y, DUAN EK. Expression of LIF, VEGF, CD57 and CD68 after the transfer of rat embryos to mouse uteri [J]. Chinese Science Bulletin, 2003, 06): 542-8.

101.     CAI L Q, ZHANG J V, DUAN E K. Dynamic distribution of epidermal growth factor during mouse embryo peri-implantation [J]. Cytokine, 2003, 23(6): 170-8.

102.     LI S M#, CAO Y J#ZHANG J V#(共一), TIAN Y Q, ZHENG X, DUAN E K. Effects of vascular endothelial growth factor on MMPs during embryo implantation in mice [J]. Chinese Science Bulletin, 2002, 47(24): 2071-4.

103.     ZHANG J V#, CAO Y J#, ZHAO Y J, SANG Q X A, DUAN EK. Expression of matrix metalloproteinase-26 and tissue inhibitor of metalloproteinase-4 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Mol Hum Reprod, 2002, 8(7): 659-66.

104.     ZHANG J V, CAO Y J, LIU W M, ZHAO B S, ZENG G Q, DUAN E K. Expression of matrix metalloproteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 [J]. Chinese Science Bulletin, 2002, 47(9): 732-6.

105.     张键, 段恩奎子宫珠蛋白的结构与功能 [J]. 生物化学与生物物理进展, 2001, 05: 627-30.

106.     ZHANG J V, TIE G D, CAO Y J, DUAN E K. Effect of fibronectin and leukaemia inhibitory factor on matrix metalloproteinases in mouse blastocyst [J]. Chinese Science Bulletin, 2001, 46(15): 1296-300.

107.     张键, 段恩奎. 空间生殖与发育生物学及组织工程研究展望 [J]. 中华航空航天医学杂志, 2001, 03: 57-9.