成体组织中存在着能够自我更新、有多种分化潜能的细胞称成体干细胞。成体干细胞对器官的发育、自稳态维持有至关重要的作用，还有可能是癌症发生的细胞靶点。成体干细胞领域的挑战是：1）许多器官成体干细胞的身份属性并不清楚；2）成体干细胞一旦离开了体内的微环境信号，在体外不能维持干细胞的特性（干性），并且干细胞的数量难以在体外扩增，使得相关的分子机制研究难以进行。针对这些挑战和机遇，实验室的近期目标一是发现成体干细胞的身份属性，尤其是干细胞表面的特异标记分子，能够富集并分离得到活体的干细胞；目标二是发现成体干细胞的微环境因子，使得成体干细胞在体外能够长期培养和扩增，并保持干性。

        实验室主要以小鼠乳腺为组织模型，运用原代干细胞培养、基因操纵等体外实验，结合干细胞移植、构建转基因及基因敲除小鼠、损伤修复、谱系示踪等体内实验手段，研究成体干细胞的属性及调控机制。实验室近期的研究方向包括：
1) 发现各器官中成体干细胞的身份属性，包括乳腺、卵巢、血管、胰腺等；
2) 通过对比各成体干细胞，阐明干细胞“干性”的分子组成；
3) 发现成体干细胞新的微环境因子，阐明其调控干细胞的分子机理；
4) 研究干细胞关键调控分子在再生医学、癌症治疗中的调控变化。

         实验室的长远目标是阐明干细胞的分子调控机理，为癌症治疗和再生医学提供新的策略。

2001-01--2005-10   Simon Fraser University   博士

博士研究生

博士学位

细胞生物学
发育生物学

   

（1） 2021年“科学探索”奖, 其他, 2021
（2） 第十三届“谈家桢生命科学创新奖”, 其他, 2020
（3） 2019年度教学科研 “ 领雁银奖（振翅奖）”, , 研究所（学校）, 2019
（4） 中青年科技创新领军人才奖, , 部委级, 2017
（5） 上海市优秀学术带头人, , 省级, 2016
（6） 2015-2016年度上海市三八红旗集体称号, , 省级, 2016
（7） 中国科学院上海分院第五届“杰出青年科技创新人才”, 院级, 2016
（8） 巾帼文明岗, , 省级, 2016
（9） 上海市三八红旗集体称号, , 省级, 2015
（10） 中国细胞生物学学会干细胞分会青年研究员奖, , 其他, 2015
（11） 中国细胞生物学学会青年研究员奖, 其他, 2015
（12） 优秀导师奖, 研究所（学校）, 2015
（13） The Bienz- Waterman Award for best female presenter, 其他, 2014

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[5] 曾艺, 王代松. TNBC划分和治疗的方法和组合物. CN: CN111656194A, 2020-09-11.
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[8] 曾艺, 王代松. 三阴性乳腺癌标记物及其在诊断和治疗中的应用. CN: CN105349618A, 2016-02-24.
[9] 曾艺, 蔡车国. 一种体外扩增乳腺干细胞并维持其干细胞特性的方法及其应用. CN: CN104974981A, 2015-10-14.

   

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[50] Jan, Taha Adnan, Chai, Renjie, Sayyid, Zahra Nabi, van Amerongen, Renee, Xia, Anping, Wang, Tian, Sinkkonen, Saku Tapani, Zeng, Yi Arial, Levin, Jared Ruben, Heller, Stefan, Nusse, Roel, Cheng, Alan GiLun. Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. DEVELOPMENT[J]. 2013, 140(6): 1196-1206, https://www.webofscience.com/wos/woscc/full-record/WOS:000315445800006.
[51] Zeng, Yi Arial. Beyond nutrients and bonding: p63-positive progenitors in breast milk. CELL CYCLE[N]. 2011, 10(4): 576-576, https://www.webofscience.com/wos/woscc/full-record/WOS:000287352500009.
[52] Ceng Yi. Wnt proteins serve as self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell. 2010, [53] Minear, Steven, Leucht, Philipp, Jiang, Jie, Liu, Bo, Zeng, Arial, Fuerer, Christophe, Nusse, Roel, Helms, Jill A. Wnt Proteins Promote Bone Regeneration. SCIENCE TRANSLATIONAL MEDICINE[J]. 2010, 2(29): https://www.webofscience.com/wos/woscc/full-record/WOS:000277304700001.
[54] Nusse, Roel. Wnt signaling and stem cell control. CELL RESEARCHnull. 2008, 18(5): 523-527, http://dx.doi.org/10.1038/cr.2008.47.
[55] Zeng, Yi Arial, Rahnama, Maryam, Wang, Simon, Lee, Wendy, Verheyen, Esther M. Inhibition of Drosophila Wg Signaling Involves Competition between Mad and Armadillo/beta-Catenin for dTcf Binding. PLOS ONE[J]. 2008, 3(12): https://doaj.org/article/fcb42062a597403fbcbf5d0d930cfedb.
[56] Zeng, Yi Arial, Rahnama, Maryam, Wang, Simon, SosuSedzorme, Worlanyo, Verheyen, Esther M. Drosophila Nemo antagonizes BMP signaling by phosphorylation of Mad and inhibition of its nuclear accumulation. DEVELOPMENT[J]. 2007, 134(11): 2061-2071, https://www.webofscience.com/wos/woscc/full-record/WOS:000247719700007.
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（ 1 ） 中科院“****”, 负责人, 中国科学院计划, 2010-08--2013-09
（ 2 ） 蛋白C受体对乳腺干细胞的作用及机制, 负责人, 国家任务, 2016-01--2020-12
（ 3 ） 乳腺干细胞微环境信号及其受激素调控机制的研究, 负责人, 国家任务, 2014-01--2017-12
（ 4 ） 乳腺干细胞自我更新的调控机制, 负责人, 国家任务, 2012-01--2015-12
（ 5 ） 单倍体干细胞的应用研究, 负责人, 国家任务, 2014-01--2018-08
（ 6 ） 建立应用于糖尿病治疗的胰腺成体干细胞体外培养体系, 负责人, 中国科学院计划, 2016-01--2018-12
（ 7 ） 乳腺干细胞的信号调控及其与微环境的相互作用, 负责人, 中国科学院计划, 2011-01--2015-12
（ 8 ） 乳腺干细胞的调控机理, 负责人, 国家任务, 2017-01--2020-12
（ 9 ） EPCR调节特定骨髓微环境对骨髓造血干细胞的归巢与维持, 负责人, 国家任务, 2017-01--2019-12
（ 10 ） 蛋白C受体对乳腺干细胞的作用及机制, 负责人, 地方任务, 2017-05--2020-04
（ 11 ） 细胞可塑性和病变发生的干性因子, 负责人, 中国科学院计划, 2017-01--2021-12
（ 12 ） 三阴性乳腺癌的靶治疗研究, 负责人, 中国科学院计划, 2017-01--2018-12
（ 13 ） 应答激素的新的乳腺干细胞类型的发现及机制研究, 负责人, 国家任务, 2019-01--2023-12
（ 14 ） 研究在孕期乳腺产生的一群新的干细胞, 负责人, 国家任务, 2019-01--2022-12
（ 15 ） 组织器官损伤修复过程中信号转导与代谢的交互调控机制, 参与, 国家任务, 2019-12--2024-11
（ 16 ） 基于成体干细胞的人源胰岛体外重建, 负责人, 中国科学院计划, 2019-08--2022-12
（ 17 ） 蛋白质机器实时动态在体功能研究, 负责人, 国家任务, 2020-11--2025-10
（ 18 ） 激活成体干细胞促进胰岛再生的机制研究, 负责人, 其他任务, 2022-07--2025-06
（ 19 ） 新基石研究员项目, 负责人, 其他任务, 2023-01--2027-12

（1）Identification of mouse pancreatic islet progenitors and its implication in islet regeneration   2023-11-15
（2）Harnessing the science of adult stem cells for pancreatic islet regeneration   2022年“科学探索奖”跨学科交流活动   2023-07-16
（3）Generation of Mouse Pancreatic Islet Organoids Using Resident Procr Progenitors   2022年ISSCR-上海国际论坛   2023-01-13
（4）Procr and Wnt Signaling in Regulating Adult Stem Cells.   2021-08-11
（5）Identifying Novel Resident Progenitors In Pancreatic Islets.   第十八次中国暨国际生物物理大会   2020-11-15
（6）《Identifying novel resident progenitors in pancreatic islets》   第八届细胞结构与功能的信号基础研讨会   2020-10-29
（7）Identify pancreatic islet resident progenitors & expand islet organoids in vitro   中国细胞生物学2020年全国学术大会   2020-08-04
（8）Wnt Signaling and Protein C Receptor in Regulating Mammary Stem Cells and Breast Cancer.   2019-11-04
（9）Protein C Receptor Marks Adult Stem Cells in Multiple Tissue.   2019-09-17
（10）Protein C Receptor In Regulating Mammary Stem Cells And Breast Cancer   2018-11-21
（11）Protein C Receptor In Regulating Mammary Stem Cells And Breast Cancer.   2018-11-01
（12）Protein C receptor in regulating mammary stem cells and breast cancer.   2018-09-12
（13）Protein C receptor in regulating mammary stem cells and breast cancer.   2018-06-20
（14）PROCR in mammary stem cells and beyond.   第五届国际乳腺癌干细胞高峰论坛暨第四届滨海国际医学论坛   2017-10-09
（15）Wnt Signaling in regulating mammary stem cell and breast cancer.   2017年“干细胞微环境研讨会”   2017-09-09
（16）Wnt Signaling in regulating mammary stem cell and breast cancer.   2017年“基因组学、干细胞、组织再生”学术研讨会   2017-08-29
（17）PROCR in Regulating Mammary Stem Cells and Beyond.   2017年GRC“Wnt Signaling”研讨会   2017-08-09
（18）Wnt Signaling in Regulating Mammary Stem Cell and Breast Cancer.   全球华人生物学家大会暨第十六届美洲华人生物科学学会学术研讨会   2017-07-01
（19）Wnt Signaling in Regulating Mammary Stem Cell and Breast Cancer   第21届研究生研讨会   2016-12-01
（20）PROCR in mammary stem cells and beyond   第五届国际乳腺癌干细胞高峰论坛暨第四届滨海国际医学论坛   2016-10-09
（21）Protein C Receptor Marks Mammary Stem Cells and Vascular Endothelial Stem Cells   第六届细胞结构与功能的信号基础研讨会   2016-08-22
（22）Procr Stem Cells in Mammary Development and Cander   2016年高登研究会-“成体内皮干细胞与组织微环境”   2016-08-11
（23）Protein C Receptor as A surface Marker for Mammary Stem Cells & Beyond   华人生物学家协会第十一届双年会   2016-07-30
（24）Protein C receptor as a surface marker stem cells and its implication in breast cancer    第29届国际乳腺癌研究协会大会   2015-10-17
（25）EMT is a shared theme of protein C receptor- positive adult stem cells   美国癌症研究协会大会   2015-10-11
（26）Rspo1 is a novel hormone mediator for mammary stem cell self renewal.   第29届国际乳腺癌研究协会大会    2014-09-15

已指导学生

喻华  博士研究生  071008-发育生物学  

刘纬  博士研究生  071008-发育生物学  

宋文倩  博士研究生  071008-发育生物学  

王代松  博士研究生  071008-发育生物学  

王经强  博士研究生  071008-发育生物学  

吴亭  博士研究生  071008-发育生物学  

耿阿俊  博士研究生  071008-发育生物学  

白蓝月  博士研究生  071008-发育生物学  

刘春业  博士研究生  071008-发育生物学  

现指导学生

陶玉  博士研究生  071008-发育生物学  

杨瑞铠  博士研究生  071008-发育生物学  

陈心怡  博士研究生  071008-发育生物学  

肖天雄  博士研究生  071008-发育生物学  

易周游  硕士研究生  086000-生物与医药  

杨国巍  硕士研究生  086000-生物与医药  

王琳  博士研究生  071008-发育生物学  

苑舒博  博士研究生  071008-发育生物学  

谢之耀  硕士研究生  071008-发育生物学  

徐亦舒  博士研究生  071008-发育生物学  

杨嘉琳  博士研究生  071008-发育生物学  

李浩男  硕士研究生  086000-生物与医药  

丁立佳  硕士研究生  086000-生物与医药