General

Wenjun Tang

 Research Professor

State Key Laboratory of Bio-Organic & Natural Products Chemistry

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

345 Ling Ling Road, Shanghai 200032

Tel: (+0086)-21-54925515

E-mail: tangwenjun@sioc.ac.cn

Group website:http://wenjuntang.sioc.ac.cn

Research Areas

1) Design and development of novel, efficient, and practical chiral catalytic reactions;

2) Total synthesis of complex and biologically active natural products;

3) Green synthesis of active pharmaceutical drugs or agrochemicals​.

Education

1995  B.Eng., East China University of Sciences and Technology (supervisor: Prof. Guohou Cheng)

1998  M.Sc., Shanghai Institute of Organic Chemistry, CAS (supervisor: Prof. Dawei Ma)

2003  Ph.D., Department of Chemistry, The Pennsylvania State University (supervisor: Prof. Xumu Zhang)

Experience

2003  Postdoctoral fellow, The Scripps Research Institute (supervisor: Prof. KC Nicolaou)

2005  Senior scientist, Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc.

2009  Principal scientist, Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc.

2011  Research professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Work Experience

2003  Postdoctoral fellow, The Scripps Research Institute (supervisor: Prof. KC Nicolaou)

2005  Senior scientist, Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc.

2009  Principal scientist, Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc.

2011  Research professor, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Teaching Experience

Advanced Organic Chemistry

Honors & Distinctions

2012  National “Thousand Talents” Youth program

2012  Thieme Chemistry Journal Award

2015  Asian Core Lectureship Award

2015  National Homogenous Catalysis Youth Award

2017 The National Science Fund for Distinguished Young Scholars

Publications

  1. D. Chen, G. Xu, Q. Zhou, L. -W. Chung, W. Tang* Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons J. Am. Chem. Soc. 2017, 139, 9767-9770.

  2. G. Zhao, G. Xu, Q. Chao, W. Tang* Efficient Enantioselective Syntheses of (+)-Dalesconol A & B J. Am. Chem. Soc., 2017, 139, 3360-3363.

  3. C. Li, Y. Zhang, Q. Sun, T. Gu, H. Peng, W. Tang* Transition-Metal-Free Stereospecific Cross-Coupling with Alkenylboronic Acids as Nucleophiles J. Am. Chem. Soc. 2016, 138, 10774-10777.

  4. N. Hu, K. Li, Z. Wang, W. Tang* Synthesis of Chiral 1,4-Benzodioxanes and Chromans by Enantioselective Palladium-Catalyzed Alkene Aryloxyarylation Angew. Chem., Int. Ed. 2016, 55, 5044-5048

  5. L. Huang, J. Zhu, G. Jiao, Z. Wang, X. Yu, W.-P. Deng,* W. Tang* Highly Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to Simple Ketones: Efficient Synthesis of Escitalopram Angew. Chem., Int. Ed. 2016, 55, 4527-4531.

  6. N. Hu, G. Zhao, Y. Zhang, X. Liu, G. Li, W. Tang* Synthesis of Chiral α-Amino Tertiary Boronic Esters by Enantioselective Hydroboration of α-Arylenamides J. Am. Chem. Soc. 2015, 137, 6746-6749.

  7. C. Li, T. Chen, G. Xiao, B. Li, W. Tang* Efficient Syntheses of Sterically Hindered Acyclic Secondary Alkyl Arenes by Suzuki-Miyaura Cross-Couplings Angew. Chem., Int. Ed. 2015, 54, 3792-3796.

  8. K. Du, P. Guo, Y. Chen, Z. Cao, W. Tang* Enantioselective Palladium-Catalyzed Dearomative Cyclization for Efficient Synthesis of Terpenes and Steroids Angew. Chem., Int. Ed. 2015, 54, 3033-3037.

  9. W. Fu, M. Nie, A. Wang, W. Tang* Highly Enantioselective Nickel-Catalyzed Intramolecular Reductive Cyclization of Alkynone Angew. Chem., Int. Ed. 2015, 54, 2520-2524.

  10. G. Xu, W. Fu, G. Liu, C. H. Senanayake, W. Tang* Efficient Syntheses of Korupensamine A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions J. Am. Chem. Soc. 2014, 136, 570−573.

  11. G. Liu, X. Liu, Z. Cai, G. Jiao, G. Xu, W. Tang* Design of Phosphorus Ligands with Deep Chiral Pockets: Practical Synthesis fo Chiral β-Arylamines by Asymmetric Hydrogenation Angew. Chem., Int. Ed. 2013, 52, 4235-4238

Papers
   
Patents
   

Research Interests

  • Design and development of novel, efficient, and practical chiral catalytic reactions

  • Total synthesis of complex and biologically active natural products

  • Development of efficient, economical, and green chemical processes for pharmaceutically important molecules

Conferences

   

Collaboration

   

Students

Currently we have over 20 group members including postdoctoral fellows, graduate students, and research assistants. For more information, please visit our website at http://wenjuntang.sioc.ac.cn