基本信息
潘光锦  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: pan_guangjin@gibh.ac.cn
通信地址: 广州市黄埔区开源大道190号
邮政编码: 510530

招生信息

   
招生专业
071009-细胞生物学
招生方向
多能干细胞的维持与分化调控

教育背景

2005-10--2010-01   美国威斯康星大学   博士后
2002-09--2005-07   清华大学   博士

工作经历

   
工作简历
2010-07~现在, 中国科学院广州生物医药与健康研究院, 研究员
2005-10~2010-01,美国威斯康星大学, 博士后
2002-09~2005-07,清华大学, 博士

专利与奖励

   
奖励信息
(1) EMT-MET的细胞命运调控, 二等奖, 国家级, 2018
(2) 干细胞多能性与重编程机理研究集体, 省级, 2018
(3) 病人特异性功能干细胞获取及致病基因精准修复, 一等奖, 省级, 2018
(4) 干细胞多能性与重编程机理研究, 二等奖, 国家级, 2013
(5) 诱导多能干细胞机理与技术研究, 一等奖, 省级, 2010
专利成果
( 1 ) 用于制备神经干细胞的培养基及其用途, 2014, 第 1 作者, 专利号: ZL 2012 1 0051095.0
( 2 ) 地贫诱导多能干细胞及其制备方法和用途, 2015, 第 1 作者, 专利号: ZL 2012 1 0090003.X
( 3 ) CD61作为生血内皮细胞标志物的用途, 2016, 第 1 作者, 专利号: 201610631439.3
( 4 ) 重组细胞及其制备方法和用途, 2016, 第 1 作者, 专利号: 201610631440.6
( 5 ) 维生素C在制备培养基中的用途, 2017, 第 1 作者, 专利号: 201710576758.3

出版信息

   
发表论文
(1) JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells, Nature Communications, 2020, 通讯作者
(2) Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition, Journal of Biological Chemistry, 2019, 通讯作者
(3) Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition., Journal of Biological Chemistry, 2018, 通讯作者
(4) BMI1 enables interspecies chimerism with human pluripotent stem cells., Nature Communications, 2018, 通讯作者
(5) PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naïve ESCs., Nature Communications, 2017, 通讯作者
(6) Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern., Scientific Reports, 2017, 通讯作者
(7) Suppressing P16Ink4a and P14ARF pathways overcomes apoptosis in individualized human embryonic stem cells, The FASEB Journal, 2017, 通讯作者
(8) Generation and analysis of GATA2w/eGFP 2 human ESCs reveal ITGB3/CD61 as a reliable marker for defining hemogenic endothelial cells during hematopoiesis, Stem Cell Reports, 2016, 通讯作者
(9) Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder, Stem Cell Reports, 2016, 通讯作者
(10) TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells, Scientific Reports, 2016, 通讯作者
(11) 5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons, Scientific Reports, 2016, 通讯作者
(12) Simple and versatile synthetic polydopamine-based surface supports reprogramming of human somatic cells and long-term self-renewal of human pluripotent stem cells under defined conditions, Biomaterials, 2016, 通讯作者
(13) Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in β-Thalassemia Induced Pluripotent Stem Cells (iPSCs), Journal of Biological Chemistry, 2015, 通讯作者
(14) Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response, SCIENCE CHINA-Life Sciences, 2014, 通讯作者
(15) Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells, Life Sciences, 2014, 通讯作者
(16) A reciprocal antagonism between miR-376c and TGF-beta signaling regulates neural differentiation of human pluripotent stem cells, FASEB Journal, 2014, 通讯作者
(17) Transcription Activator-like Effector Nuclease (TALEN)-mediated Gene Correction in Integration-free beta-Thalassemia Induced Pluripotent Stem Cells, Journal of Biological Chemistry, 2013, 通讯作者
(18) Generation of integration-free neural progenitor cells from cells in human urine, Nature Methods, 2013, 通讯作者
(19) Generating a Non-Integrating Human Induced Pluripotent Stem Cell Bank from Urine-Derived Cells, PLoS ONE, 2013, 通讯作者
(20) Low Immunogenicity of Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Derived from Less Immunogenic Somatic Cells, PLoS ONE, 2013, 通讯作者
(21) Ribosomal RNA Gene Transcription Mediated by the Master Genome Regulator Protein CCCTC-binding Factor (CTCF) Is Negatively Regulated by the Condensin Complex, Journal of Biological Chemistry, 2013, 通讯作者
(22) Somatic cell reprogramming for regenerative medicine: SCNT vs. iPS cells, BIOESSAYS, 2012, 第 1 作者
(23) Order from Chaos: Single Cell Reprogramming in Two Phases, Cell Stem Cell, 2012, 第 1 作者
(24)  FGF2 Sustains NANOG and Switches the Outcome of BMP4 Induced Human Embryonic Stem Cell Differentiation, Cell Stem Cell, 2011, 第 2 作者
(25) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells, Cell, 2009, 第 2 作者
(26) Nanog and transcriptional networks in embryonic stem cell pluripotency, Cell Res., 2007, 第 1 作者
(27) Whole genome analysis of Histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells, Cell Stem Cell, 2007, 第 1 作者
(28) PUF proteins control MAP kinase expression in C elegans and human embryonic stem cells, PLOS Genetics, 2007, 第 3 作者
(29) A negative feedback loop of transcription factors that controls stem cell pluripotency and self renewal,  FASEB J., 2006, 第 1 作者
(30) Regulation of the pluripotency marker Rex-1 by Nanog and Sox2, J Biol Chem, 2006, 第 3 作者
(31) The sem cell pluripotency factor nanog activates transcription with two unusually potent subdomains at its C-terminus, J Biol Chem, 2005, 第 1 作者
(32) Identification of a nuclear localization signal in OCT4 and generation of a dominant negative mutant by its ablation, J Biol Chem, 2004, 第 1 作者
(33) Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals, Exp Cell Res, 2004, 第 4 作者
(34) Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog, Cell Res., 2003, 第 1 作者
(35) Stem cell pluripotency and transcription factor Oct4, Cell Res, 2002, 第 1 作者

科研活动

   
科研项目
( 1 ) 血液分化调控研究及其在地中海贫血治疗中的应用, 主持, 省级, 2015-01--2020-01
( 2 ) 治疗性神经干细胞制备的关键技术及其治疗有效性研究, 主持, 省级, 2015-07--2018-06
( 3 ) 神经干细胞移植治疗亨廷顿病的转化医学研究, 参与, 省级, 2016-01--2020-12
( 4 ) 人多能干细胞分化过程中谱系命运决定的调控及异质性机制研究, 主持, 国家级, 2017-07--2021-12
( 5 ) 人多能干细胞异种嵌合障碍机制及策略研究, 主持, 部委级, 2017-12--2021-12
( 6 ) 人尿液细胞重编程为神经干细胞的命运决定分子机制及相关功能研究, 主持, 国家级, 2014-01--2017-12
( 7 ) 非整合病人特异性iPS库的建立及其功能性细胞分化的研究, 主持, 部委级, 2011-01--2015-12
( 8 ) 利用人多能干细胞异种嵌合技术获得功能性人源造血干细胞的可行性研究, 主持, 省级, 2019-04--2021-03
( 9 ) 人多能干细胞与异种动物胚胎嵌合体形成过程中的相互调控研究, 主持, 国家级, 2020-01--2023-12
( 10 ) 人多能干细胞命运决定的机制及功能细胞分化新技术的建立, 主持, 省级, 2018-12--2021-12