基本信息
臧奕  女  博导  中国科学院上海药物研究所
电子邮件: yzang@lglab.ac.cn
通信地址: 上海市张江高科技园区郭守敬路189号 国家新药筛选中心
邮政编码:

招生信息

   
招生专业
100706-药理学
100800-中药学
招生方向
分子药理学
中药药理学

教育背景

2003-09--2008-07   中国科学院上海药物研究所   理学博士
1996-09--2001-07   复旦大学(原上海医科大学)   医学学士

工作经历

   
工作简历
2017-12~现在, 中国科学院上海药物研究所, 博士生导师
2014-10~现在, 中国科学院上海药物研究所, 研究员
2011-10~2014-10,中国科学院上海药物研究所, 副研究员
2010-12~现在, 中国科学院上海药物研究所, 硕士生导师
2008-11~2010-07,美国M.D.Anderson Cancer Center, 博士后
2005-07~2010-10,中国科学院上海药物研究所, 助理研究员
2003-09~2008-07,中国科学院上海药物研究所, 理学博士
2001-07~2005-07,中国科学院上海药物研究所, 研究实习员
1996-09~2001-07,复旦大学(原上海医科大学), 医学学士

专利与奖励

   
专利成果
( 1 ) 苯并噻二唑类化合物在制备抗SARS-COV-2新型冠状病毒药物中的应用, 2022, 第 4 作者, 专利号: CN114159433A

( 2 ) 247种化合物及其组合物在抗新型冠状病毒感染中的应用, 2022, 第 7 作者, 专利号: CN113893345A

( 3 ) 1869种化合物及其组合物在抗新型冠状病毒感染中的应用, 2022, 第 7 作者, 专利号: CN113893347A

( 4 ) 一种momordin Ib的制备方法, 2021, 第 4 作者, 专利号: CN111848716B

( 5 ) 奈非那韦在制备防治非酒精性脂肪性肝炎和/或抗肝纤维化药物中的应用, 2021, 第 3 作者, 专利号: CN113521072A

( 6 ) 含巯基荧光化合物或其硫酯衍生物及制备和应用, 2021, 第 4 作者, 专利号: CN111269160B

( 7 ) 一种基因工程菌及其构建方法和用途, 2021, 第 3 作者, 专利号: CN112795494A

( 8 ) 稠环嘧啶氨基化合物、其制备方法、药物组合物及应用, 2021, 第 5 作者, 专利号: CN112239459A

( 9 ) FXR小分子激动剂及其制备方法和用途, 2020, 第 4 作者, 专利号: CN111825667A

( 10 ) 2-吡啶取代脲结构小分子化合物及其合成和应用, 2020, 第 5 作者, 专利号: CN110818683A

( 11 ) 一类含氟异噁唑类化合物及其制备方法、药物组合物和用途, 2019, 第 4 作者, 专利号: CN110452235A

( 12 ) 胆酸衍生物及其制备方法和用途, 2019, 第 4 作者, 专利号: CN110343140A

( 13 ) 一种噻吩3,2-d并嘧啶-4-酮类化合物的药物新用途, 2019, 第 4 作者, 专利号: CN110240603A

出版信息

   
发表论文
(1) Three new feruloyl glucuronopyranosyl glycerols from Eriocaulon buergerianum with their anti-fibrotic effects on hepatic stellate cells, NATURAL PRODUCT RESEARCH, 2023, 通讯作者
(2) Phosphorylation of PHF2 by AMPK releases the repressive H3K9me2 and inhibits cancer metastasis, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 通讯作者
(3) Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation, GENOMICS, PROTEOMICS & BIOINFORMATICS, 2022, 通讯作者
(4) Synthesis and Biochemical Evaluation of 8H-Indeno1,2-dthiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors, MOLECULES, 2022, 通讯作者
(5) A Tandemly Activated Fluorescence Probe for Detecting Senescent Cells with Improved Selectivity by Targeting a Biomarker Combination, ACS SENSORS, 2022, 通讯作者
(6) High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors, PROTEIN & CELL, 2022, 第 1 作者
(7) Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex, Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex, JOURNAL OF MOLECULAR CELL BIOLOGY, 2022, 通讯作者
(8) Targeting Glutamine Metabolism Ameliorates Autoimmune Hepatitis via Inhibiting T Cell Activation and Differentiation, FRONTIERS IN IMMUNOLOGY, 2022, 通讯作者
(9) Discovery of highly potent SARS-CoV-2 M-pro inhibitors based on benzoisothiazolone scaffold, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 通讯作者
(10) Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis, Discovery of a novel DDRs kinase inhibitor XBLJ-13 for the treatment of idiopathic pulmonary fibrosis, ACTA PHARMACOLOGICA SINICA, 2022, 通讯作者
(11) Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells, CCS CHEMISTRY, 2021, 通讯作者
(12) Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells, Roxithromycin attenuates bleomycin-induced pulmonary fibrosis by targeting senescent cells, ACTA PHARMACOLOGICA SINICA, 2021, 通讯作者
(13) Guaianolide sesquiterpene lactones from Achillea millefolium L, PHYTOCHEMISTRY, 2021, 第 5 作者
(14) Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide+/ Sirtuin-1 pathway in mice, ASIAN JOURNAL OF SURGERY, 2021, 通讯作者
(15) Discovery of a Potential Liver Fibrosis Inhibitor from a Mushroom Endophytic Fungus by Genome Mining of a Silent Biosynthetic Gene Cluster, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 通讯作者
(16) AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ, CELL REPORTS, 2021, 通讯作者
(17) Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection, ANALYTICAL CHEMISTRY, 2020, 通讯作者
(18) Pinkment: a synthetic platform for the development of fluorescent probes for diagnostic and theranostic applications, CHEMICAL SCIENCE, 2020, 第 6 作者
(19) The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells, BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 通讯作者
(20) Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1), EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 5 作者
(21) 内核膜相关的蛋白质降解(INMAD)的研究进展, Research Advances of Inner Nuclear Membrane-Associated Degradation, 中国细胞生物学学报, 2020, 第 2 作者
(22) Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 第 4 作者
(23) Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第11作者
(24) AMPK在肿瘤发生发展中的研究现状, The Role of AMPK in Tumorigenesis and Development, 中国生物化学与分子生物学报, 2020, 第 2 作者
(25) A fluorogenic probe for tracking GSH flux in developing neurons, CHEMICAL COMMUNICATIONS, 2020, 通讯作者
(26) Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system, Selective and sensitive fluorescence imaging reveals microenvironment-dependent behavior of NO modulators in the endothelial system, JOURNAL OF PHARMACEUTICAL ANALYSIS, 2020, 通讯作者
(27) Self-Assembled Thin-Layer Glycomaterials With a Proper Shell Thickness for Targeted and Activatable Cell Imaging, FRONTIERS IN CHEMISTRY, 2019, 通讯作者
(28) AMPK regulates anaphase central spindle length by phosphorylation of KIF4A., J MOL CELL BIOL, 2018, 通讯作者
(29) 肝脏巨噬细胞在组织稳态和肝脏疾病中的功能探讨, The Roles of Hepatic Macrophages in-Tissue Homeostasis and Liver Diseases, 药学进展, 2018, 第 2 作者
(30) Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 4 作者
(31) Activation and Endocytosis Induced by a 2D Material Agonist., ACS Appl Mater Interfaces., 2017, 通讯作者
(32) An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance, CHEMICAL SCIENCE, 2017, 通讯作者
(33) GPCR Activation and Endocytosis Induced by a 2D Material Agonist, ACS APPLIED MATERIALS & INTERFACES, 2017, 通讯作者
(34) Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: synthesis, characterization and cytotoxicity., J Organomet Chem, 2017, 
(35) Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes, NATURE COMMUNICATIONS, 2017, 第 4 作者
(36) Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking, CHEMICAL COMMUNICATIONS, 2017, 通讯作者
(37) 53bp1与dna双链断裂损伤修复, 中国生物化学与分子生物学报, 2016, 第 2 作者
(38) Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules, CHEMICAL SCIENCE, 2016, 第 3 作者
(39) Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet, ADVANCED MATERIALS, 2016, 第 3 作者
(40) Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites, CHEMICAL SCIENCE, 2016, 第 2 作者
(41) Development of a novel H2S and GSH detection cocktail for fluorescence imaging, RSC ADVANCES, 2016, 通讯作者
(42) Protein Kinase A Rescues Microtubule Affinity-regulating Kinase 2-induced Microtubule Instability and Neurite Disruption by Phosphorylating Serine 409, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 通讯作者
(43) Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite, JOURNALOFMATERIALSCHEMISTRYB, 2015, 通讯作者
(44) Probing disease-related proteins with fluorogenic composite materials, CHEMICAL SOCIETY REVIEWS, 2015, 第 2 作者
(45) Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage, CARBOHYDRATE RESEARCH, 2015, 通讯作者
(46) Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe, CHEMICAL COMMUNICATIONS, 2015, 第 2 作者
(47) Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated grapheme electrodes., Chem Sci, 2015, 
(48) Target-Specific Imaging of Transmembrane Receptors Using Quinonyl Glycosides Functionalized Quantum Dots, ANALYTICAL CHEMISTRY, 2014, 
(49) Fluorogenic Resveratrol-Confined Graphene Oxide For Economic and Rapid Detection Of Alzheimer's Disease, ACS APPLIED MATERIALS & INTERFACES, 2014, 
(50) One-Step Click Engineering Considerably Ameliorates the Practicality of an Unqualified Rhodamine Probe, ACS APPLIED MATERIALS & INTERFACES, 2014, 
(51) Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 第 4 作者
(52) Hepatoma-selective imaging of heavy metal ions using a 'clicked' galactosylrhodamine probe, CHEMICAL COMMUNICATIONS, 2014, 
(53) Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells, CARBOHYDRATE RESEARCH, 2014, 通讯作者
(54) Substitution Pattern Reverses the Fluorescence Response of Coumarin Glycoligands upon Coordination with Silver (I), SCIENTIFIC REPORTS, 2014, 第 4 作者
(55) Revisit of a dipropargyl rhodamine probe reveals it alternative ion sensitivity in both a solution and live cells., Analyst, 2013, 通讯作者
(56) Capturing intercellular sugar-mediated ligand-receptor recognitions via a simple yet highly biospecific interfacial system, SCIENTIFIC REPORTS, 2013, 第 3 作者
(57) Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite, ADVANCED MATERIALS, 2013, 第 3 作者
(58) Quantitative Proteomic Analysis of Membrane Proteins Involved in Astroglial Differentiation of Neural Stem Cells by SILAC Labeling Coupled with LC-MS/MS, JOURNAL OF PROTEOME RESEARCH, 2012, 第 4 作者
(59) 应用酵母双杂交系统筛选AMPK相互作用蛋白, Screening of AMPK Interacted Proteins by Yeast Two Hybrid System, 中国生物工程杂志, 2012, 第 6 作者
(60) 大鼠胚胎神经干细胞与永生化神经干细胞系C17.2定向分化为神经元潜能的差异, Variability of directed differentiation potential into between neural stem cells from embryonic rats immortalized neural stem cell line C17. 2 neurons and, 解剖学报, 2012, 第 4 作者
(61) DN-AMPK腺病毒载体的构建及其在小鼠成肌细胞系C2C12肌管分化中的影响, Construction of Recombinant Adenovirus Expression Vector of Dominant Negative AMPK and Its Evaluation in Mouse Myoblast Cell Line C2C12 Differentiation into Myotube, 生物技术通报, 2012, 第 3 作者
(62) 36. miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1., Mol Cancer Res., 2011, 第 1 作者
(63) 33. 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells., Biochem Biophys Res Commun., 2011, 通讯作者
(64) 35. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice., J Clin Invest., 2011, 第 1 作者
(65) 34. Structural insights into the homology and differences between mouse protein tyrosine phsophatase-sigma and human protein tyrosine phosphatase-sigma., Acta Biochim Biophys Sin (Shanghai)., 2011, 通讯作者
(66) 38. AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranoside and glucose deprivation by down-regulating phospho- retinoblastoma protein and cyclin D., J Biol Chem, 2009, 第 1 作者
(67) 40. AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase., J Biol Chem, 2008, 第 1 作者
(68) Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation, GENOMICS, PROTEOMICS & BIOINFORMATICS, 通讯作者

科研活动

   
科研项目
( 1 ) 靶向LSD1的抗血液肿瘤个性化先导化合物发现研究, 负责人, 中国科学院计划, 2016-01--2017-12
( 2 ) 表观遗传靶标验证:基于PRMT5候选化合物的发现及靶点再确认, 参与, 国家任务, 2014-01--2016-12
( 3 ) AMPK在肝纤维化过程中的作用及基于AMPK靶点的化合物作用研究, 负责人, 国家任务, 2017-01--2020-12
( 4 ) 金纳米颗粒复合载药体系靶向诊疗肝纤维化研究, 负责人, 地方任务, 2016-07--2019-06
( 5 ) 靶向新冠病毒3CLpro非拟肽类抑制剂研发, 负责人, 国家任务, 2022-01--2024-12
( 6 ) 基于邻近蛋白组学的胶原受体DDR2相互作用蛋白网络及其信号通路研究, 负责人, 地方任务, 2022-04--2025-03
( 7 ) AMPK参与DNA损伤修复的蛋白调控网络及其分子机制研究, 负责人, 国家任务, 2019-01--2022-12