基本信息
臧奕  女  博导  中国科学院上海药物研究所
电子邮件: yzang@simm.ac.cn
通信地址: 上海市张江高科技园区郭守敬路189号 国家新药筛选中心
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
分子药理学

教育背景

2003-09--2008-07   中国科学院上海药物研究所   理学博士
1996-09--2001-07   复旦大学(原上海医科大学)   医学学士

工作经历

   
工作简历
2017-12~现在, 中国科学院上海药物研究所, 博士生导师
2014-10~现在, 中国科学院上海药物研究所, 研究员
2011-10~2014-10,中国科学院上海药物研究所, 副研究员
2010-12~现在, 中国科学院上海药物研究所, 硕士生导师
2008-11~2010-07,美国M.D.Anderson Cancer Center, 博士后
2005-07~2010-10,中国科学院上海药物研究所, 助理研究员
2003-09~2008-07,中国科学院上海药物研究所, 理学博士
2001-07~2005-07,中国科学院上海药物研究所, 研究实习员
1996-09~2001-07,复旦大学(原上海医科大学), 医学学士

专利与奖励

   
专利成果
( 1 ) 糖基蒽醌类化合物及其石墨烯传感器构建, 2016, 第 5 作者, 专利号: CN 102875623 B
( 2 ) 罗丹明糖类化合物及其用途公开号, 2015, 第 5 作者, 专利号: CN 103145777 B
( 3 ) 胆酸衍生物及其制备方法和用途, 2017, 第 4 作者, 专利号: 201710464411X
( 4 ) 一类含氟异噁唑类化合物及其制备方法、药物组合物和用途, 2018, 第 4 作者, 专利号: 201810431514.0
( 5 ) 一种噻吩[3,2-d]并嘧啶-4-酮类化合物的药物新用途, 2018, 第 4 作者, 专利号: 201810194967.6

出版信息

   
发表论文
(1) An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance., Chem. Sci,, 2017, 第 11 作者
(2) AMPK regulates anaphase central spindle length by phosphorylation of KIF4A., J Mol Cell Biol., 2017, 第 11 作者
(3) Activation and Endocytosis Induced by a 2D Material Agonist., ACS Appl Mater Interfaces., 2017, 第 11 作者
(4) Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking., Chem Commun (Camb)., 2017, 第 11 作者
(5) Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes., Nat Commun., 2017, 第 4 作者
(6) Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents., ACS Appl Mater Interfaces., 2017, 第 4 作者
(7) Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: Synthesis, characterization and cytotoxicity., J Organomet Chem., 2016, 第 11 作者
(8) Development of a novel H2S and GSH detection cocktail for fluorescence imaging., RSC Advances, 2016, 第 11 作者
(9) Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites., Chemical Science, 2016, 第 2 作者
(10) Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet., Adv Mater., 2016, 第 3 作者
(11) Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules., Chem. Sci,, 2016, 第 3 作者
(12) Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite., J. Mater. Chem. B., 2015, 第 11 作者
(13) Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe., Chem Commun (Camb)., 2015, 第 1 作者
(14) Probing disease-related proteins with fluorogenic composite materials, Chem Soc Rev, 2015, 第 2 作者
(15) Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated grapheme electrodes., Chem. Sci.,, 2015, 第 3 作者
(16) Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases., Sci Rep., 2015, 第 11 作者
(17) Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage., Carbohydr Res., 2015, 第 11 作者
(18) Protein kinase A rescues Microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating Serine 409., J Biol Chem., 2015, 第 11 作者
(19) One-step 'click engineering' considerably ameliorates the practicality of an unqualified rhodamine probe., ACS Appl Mater Interfaces, 2014, 第 3 作者
(20) .Hepatoma-selective imaging of heavy metal ions using a 'clicked' galactosyl rhodamine probe., Chem Commun (Camb)., 2014, 第 11 作者
(21) Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells., Carbohydr Res, 2014, 第 11 作者
(22) Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation., Biochem Biophys Res Commun., 2014, 第 4 作者
(23) Target-Specific Imaging of Transmembrane Receptors Using Quinonyl Glycosides Functionalized Quantum Dots., Anal Chem., 2014, 第 4 作者
(24) Fluorogenic resveratrol-confined graphene oxide for economic and rapid detection of Alzheimer's disease., ACS Appl Mater Interfaces. 2014,, 2014, 第 11 作者
(25) Substitution pattern reverses the fluorescence response of coumarin glycoligands upon coordination with silver (I)., Sci Rep., 2014, 第 4 作者
(26) Revisit of a dipropargyl rhodamine probe reveals it alternative ion sensitivity in both a solution and live cells., Analyst, 2013, 第 11 作者
(27) Capturing intercellular sugar-mediated ligand-receptor recognitions via a simple yet highly biospecific interfacial system., Sci Rep, 2013, 第 3 作者
(28) Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite., Adv Mater., 2013, 第 3 作者
(29) Quantitative proteomic analysis of membrane proteins in volved in astroglial differentiation of neural stem cells by SILAC labeling coupled with LC-MS/MS., J Proteome Res., 2012, 第 4 作者
(30) 34. Structural insights into the homology and differences between mouse protein tyrosine phsophatase-sigma and human protein tyrosine phosphatase-sigma., Acta Biochim Biophys Sin (Shanghai)., 2011, 第 11 作者
(31) 35. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice., J Clin Invest., 2011, 第 4 作者
(32) 36. miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1., Mol Cancer Res., 2011, 第 1 作者
(33) 33. 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells., Biochem Biophys Res Commun., 2011, 第 11 作者
(34) 38. AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranoside and glucose deprivation by down-regulating phospho- retinoblastoma protein and cyclin D., J Biol Chem, 2009, 第 1 作者
(35) 40. AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase., J Biol Chem, 2008, 第 1 作者

科研活动

   
科研项目
( 1 ) 靶向LSD1的抗血液肿瘤个性化先导化合物发现研究, 主持, 部委级, 2016-01--2017-12
( 2 ) 表观遗传靶标验证:基于PRMT5候选化合物的发现及靶点再确认, 参与, 国家级, 2014-01--2016-12
( 3 ) AMPK在肝纤维化过程中的作用及基于AMPK靶点的化合物作用研究, 主持, 国家级, 2017-01--2020-12
( 4 ) 金纳米颗粒复合载药体系靶向诊疗肝纤维化研究, 主持, 省级, 2016-07--2019-06