基本信息
臧奕  女  博导  中国科学院上海药物研究所
电子邮件: yzang@simm.ac.cn
通信地址: 上海市张江高科技园区郭守敬路189号 国家新药筛选中心
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
分子药理学

教育背景

2003-09--2008-07   中国科学院上海药物研究所   理学博士
1996-09--2001-07   复旦大学(原上海医科大学)   医学学士

工作经历

   
工作简历
2017-12~现在, 中国科学院上海药物研究所, 博士生导师
2014-10~现在, 中国科学院上海药物研究所, 研究员
2011-10~2014-10,中国科学院上海药物研究所, 副研究员
2010-12~现在, 中国科学院上海药物研究所, 硕士生导师
2008-11~2010-07,美国M.D.Anderson Cancer Center, 博士后
2005-07~2010-10,中国科学院上海药物研究所, 助理研究员
2003-09~2008-07,中国科学院上海药物研究所, 理学博士
2001-07~2005-07,中国科学院上海药物研究所, 研究实习员
1996-09~2001-07,复旦大学(原上海医科大学), 医学学士

专利与奖励

   
专利成果
( 1 ) 糖基蒽醌类化合物及其石墨烯传感器构建, 2016, 第 5 作者, 专利号: CN 102875623 B
( 2 ) 罗丹明糖类化合物及其用途公开号, 2015, 第 5 作者, 专利号: CN 103145777 B
( 3 ) 胆酸衍生物及其制备方法和用途, 2017, 第 4 作者, 专利号: 201710464411X
( 4 ) 一类含氟异噁唑类化合物及其制备方法、药物组合物和用途, 2018, 第 4 作者, 专利号: 201810431514.0
( 5 ) 一种噻吩[3,2-d]并嘧啶-4-酮类化合物的药物新用途, 2018, 第 4 作者, 专利号: 201810194967.6

出版信息

   
发表论文
(1) An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance., Chem. Sci,, 2017, 通讯作者
(2) AMPK regulates anaphase central spindle length by phosphorylation of KIF4A., J Mol Cell Biol., 2017, 通讯作者
(3) Activation and Endocytosis Induced by a 2D Material Agonist., ACS Appl Mater Interfaces., 2017, 通讯作者
(4) Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking., Chem Commun (Camb)., 2017, 通讯作者
(5) Remote light-controlled intracellular target recognition by photochromic fluorescent glycoprobes., Nat Commun., 2017, 第 4 作者
(6) Supramolecular Polymer Dot Ensemble for Ratiometric Detection of Lectins and Targeted Delivery of Imaging Agents., ACS Appl Mater Interfaces., 2017, 第 4 作者
(7) Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: Synthesis, characterization and cytotoxicity., J Organomet Chem., 2016, 通讯作者
(8) Development of a novel H2S and GSH detection cocktail for fluorescence imaging., RSC Advances, 2016, 通讯作者
(9) Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites., Chemical Science, 2016, 第 2 作者
(10) Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet., Adv Mater., 2016, 第 3 作者
(11) Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules., Chem. Sci,, 2016, 第 3 作者
(12) Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite., J. Mater. Chem. B., 2015, 通讯作者
(13) Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe., Chem Commun (Camb)., 2015, 第 1 作者
(14) Probing disease-related proteins with fluorogenic composite materials, Chem Soc Rev, 2015, 第 2 作者
(15) Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated grapheme electrodes., Chem. Sci.,, 2015, 第 3 作者
(16) Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases., Sci Rep., 2015, 通讯作者
(17) Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage., Carbohydr Res., 2015, 通讯作者
(18) Protein kinase A rescues Microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating Serine 409., J Biol Chem., 2015, 通讯作者
(19) One-step 'click engineering' considerably ameliorates the practicality of an unqualified rhodamine probe., ACS Appl Mater Interfaces, 2014, 第 3 作者
(20) .Hepatoma-selective imaging of heavy metal ions using a 'clicked' galactosyl rhodamine probe., Chem Commun (Camb)., 2014, 通讯作者
(21) Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells., Carbohydr Res, 2014, 通讯作者
(22) Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation., Biochem Biophys Res Commun., 2014, 第 4 作者
(23) Target-Specific Imaging of Transmembrane Receptors Using Quinonyl Glycosides Functionalized Quantum Dots., Anal Chem., 2014, 第 4 作者
(24) Fluorogenic resveratrol-confined graphene oxide for economic and rapid detection of Alzheimer's disease., ACS Appl Mater Interfaces. 2014,, 2014, 通讯作者
(25) Substitution pattern reverses the fluorescence response of coumarin glycoligands upon coordination with silver (I)., Sci Rep., 2014, 第 4 作者
(26) Revisit of a dipropargyl rhodamine probe reveals it alternative ion sensitivity in both a solution and live cells., Analyst, 2013, 通讯作者
(27) Capturing intercellular sugar-mediated ligand-receptor recognitions via a simple yet highly biospecific interfacial system., Sci Rep, 2013, 第 3 作者
(28) Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite., Adv Mater., 2013, 第 3 作者
(29) Quantitative proteomic analysis of membrane proteins in volved in astroglial differentiation of neural stem cells by SILAC labeling coupled with LC-MS/MS., J Proteome Res., 2012, 第 4 作者
(30) 34. Structural insights into the homology and differences between mouse protein tyrosine phsophatase-sigma and human protein tyrosine phosphatase-sigma., Acta Biochim Biophys Sin (Shanghai)., 2011, 通讯作者
(31) 35. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice., J Clin Invest., 2011, 第 4 作者
(32) 36. miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1., Mol Cancer Res., 2011, 第 1 作者
(33) 33. 5'-AMP-activated protein kinase (AMPK) regulates progesterone receptor transcriptional activity in breast cancer cells., Biochem Biophys Res Commun., 2011, 通讯作者
(34) 38. AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D- ribofuranoside and glucose deprivation by down-regulating phospho- retinoblastoma protein and cyclin D., J Biol Chem, 2009, 第 1 作者
(35) 40. AICAR induces astroglial differentiation of neural stem cells via activating the JAK/STAT3 pathway independently of AMP-activated protein kinase., J Biol Chem, 2008, 第 1 作者

科研活动

   
科研项目
( 1 ) 靶向LSD1的抗血液肿瘤个性化先导化合物发现研究, 主持, 部委级, 2016-01--2017-12
( 2 ) 表观遗传靶标验证:基于PRMT5候选化合物的发现及靶点再确认, 参与, 国家级, 2014-01--2016-12
( 3 ) AMPK在肝纤维化过程中的作用及基于AMPK靶点的化合物作用研究, 主持, 国家级, 2017-01--2020-12
( 4 ) 金纳米颗粒复合载药体系靶向诊疗肝纤维化研究, 主持, 省级, 2016-07--2019-06