基本信息
郭瑞庭  男  博导  中国科学院天津工业生物技术研究所
电子邮件: guo_rt@tib.cas.cn
通信地址: 天津空港经济区西七道32号
邮政编码: 300308

研究领域

   

招生信息

   
招生专业
071010-生物化学与分子生物学
071011-生物物理学
071020-生物技术与医药
招生方向
工业酶基因改造
工业酶晶体结构分析
医药酶晶体结构分析

教育背景

2007-11--2009-01 The Scripps Research Institute 博士后
2007-01--2007-10 台湾中央研究院 博士后
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
2007-07--2010-03 台湾基酵生物科技公司 研究总监
社会兼职
   

教授课程

   

专利与奖励

   
奖励信息
(1) 天津市千人计划,省级,2010
专利成果
(1) 具提升酶活性及热稳定性之葡聚醣酶,发明,2011,第1作者,专利号:100107992,注:台湾专利
(2) THERMOSTABLE CELLULASE HAVING INCREASED ENZYME ACTIVITY,发明,2011,第1作者,专利号:13150456,注:美国专利
(3) 耐热性纤维素酶,发明,2011,第1作者,专利号:100105318,注:台湾专利
(4) GLUCANASE HAVING INCREASED ENZYME ACTIVITY AND THERMOSTABILITY,发明,2011,第1作者,专利号:13153618,注:美国专利
(5) 一种纤维素酶及其应用,发明,2011,第1作者,专利号:201110042600.0
(6) 酶活性及热稳定性被提高的葡聚糖酶,发明,2011,第1作者,专利号:201110059681.5

出版信息

   
发表论文
(1) Roles of Amino Acids in the Escherichia coli Octaprenyl Diphosphate Synthase Active Site Probed by Structure-Guided Site-Directed Mutagenesis,Biochemistry,2012,第5作者
(2) Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes ,Angewandte Chemie-Intertional Edition,2012,通讯作者
(3) Rational design to improve thermostability and specific activity of the truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase ,Applied Microbiology and Biotechnology,2012,通讯作者
(4) Diverse substrate recognition mechanism revealed by Thermotoga maritima Cel5A structures in complex with cellotetraose, cellobiose and mannotriose ,Biochimica Et Biophysica Acta-Proteins and Proteomics,2011,通讯作者
(5) Crystal structures of Bacillus alkaline phytase in complex with calcium and inositol hexasulfate,Journal of Molecular Biology,2011,通讯作者
(6) Substrate binding of a GH5 endoglucanase from the ruminal fungus Piromyces rhizinflata ,Acta Crystallographica Section F-Structural Biology and Crystallization Communications ,2011,第3作者
(7) Crystal structure and substrate-binding mechanism of cellulase 12A from Thermotoga maritima,Proteins: Structure, Function, and Bioinformatics.,2011,通讯作者
(8) Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation,JACS,2009,第5作者
(9) Structure of the Alkalohyperthermophilic Archaeoglobus fulgidus Lipase Contains a Unique C-Terminal Domain Essential for Long Chain Substrate Binding,Journal of Molecular Biology,2009,第4作者
(10) Unique mechanism for Ap4A synthesis by human Glycyl-tRNA synthetase,J. Biol. Chem.,2009,第1作者
(11) Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases,Proteins: Structure, Function, and Genetics.,2008,第3作者
(12) Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2,Structure,2008,第3作者
(13) Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates: A Crystallographic and Computational Investigation,Journal of Medicinal Chemistry,2008,第4作者
(14) Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases,J Biomed Biotechnol.,2008,第2作者
(15) Crystal structure of IcaR, a repressor of the TetR family implicated in biofilm formation in Staphylococcus epidermidis,Nucleic Acids Res.,2008,第4作者
(16) Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases,Proc. Natl. Acad. Sci. USA ,2007,第1作者
(17) Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination,J. Biol. Chem.,2006,第2作者
(18) Homodimeric hexaprenyl pyrophosphate synthase from the thermoacidophilic crenarchaeon Sulfolobus solfataricus displays asymmetric subunit structures,J. Bacteriol.,2005,第4作者
(19) Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate and farnesyl thiopyrophosphate: Roles of the metal ion and conserved residues in catalysis,J. Biol. Chem.,2005,第1作者
(20) Structures of Selenomonas ruminantium phytase in complex with persulfated phytate: DSP phytase fold and mechanism for sequential substrate hydrolysis,Structure,2004,第2作者
(21) Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic Thermotoga maritima and mechanism of product chain length determination,J. Biol. Chem.,2004,第1作者
(22) A molecular ruler for chain elongation catalyzed by octaprenyl pyrophosphate synthase and its structure-based engineering to produce unprecedented long-chain trans-prenyl products,Biochemistry,2004,第1作者
(23) Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli,Acta Crystallogr. Sect. D Biol. Crystallogr,2003,第1作者
(24) Expression in Pichia pastoris and Characterization by Circular and NMR of Rhodostomin,Proteins: Structure, Function, and Genetics,2001,第1作者
发表著作
   

科研活动

   
科研项目
(1) 基于 X-光晶体学技术的工业酶分子改造及产业,参与,其他级,2012-01--2012-12
(2) 中科院百人计划,主持,院级级,2011-07--2013-06
(3) 生物制造手性化学品的科学基础之子课题-酶及其底物复合物的结构解析,主持,国家级,2011-01--2015-08
(4) 新型纺织酶的X光结构解析,基因改造及开发,主持,省级,2010-10--2012-09
参与会议
   

合作情况

   
项目协作单位
   

指导学生

现指导学生

姜彤  硕士研究生  071010-生物化学与分子生物学  

任飞飞  博士研究生  071010-生物化学与分子生物学  

肖现沙  硕士研究生  085238-生物工程