Precision medicine in genitourinary cancers

Ph.D.   Institute of Biophysics, Chinese Academy of Sciences.   1999/09-2004/07                   

B.S.      Beijing Normal University                                               1995/09-1999/07

Full Professor                                                             2014/01-present

Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences. Beijing, China. 100101

Associate Professor                                                   2009/08-2014/01

Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences. Beijing, China. 100101

Post-Doctoral Fellow                                                2008/01-2009/08

Division of Hematology/Oncology, Weill Cornell Medical College, 413 E 69th Street, New York, NY 10021

Post-Doctoral Fellow                                                 2004/10-2008/01

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine. 1300 Morris Park Avenue, Bronx, NY 10461

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1. Lu H^#, Liang Y^#, Guan B^#, Shi Y, Gong Y, Li J, Kong W, Liu J, Fang D, Liu L, He Q, Shakeel M, Li X^*, Zhou L^* and Ci W^*.Aristolochic acid mutational signature defines the low-risk subtype in upper tract urothelial carcinoma. Theranostics. 2020,10(10): 4323-4333.

2. Xu Z^#, Ge G^#, Guan B^#, Lei Z^#, Hao X, Zhou Y, Shi Y, Lu H, Wang J, Peng D, Wu K, He H^*, Zhang B^*, Li X^*, Zhou L^* and Ci W^*. Reply to Yejinpeng Wang, Yaoyi Xiong, and Xinghuan Wang's Letter to the Editor re: Zhengzheng Xu, Guangzhe Ge, Bao Guan, et al. Noninvasive Detection and Localization of Genitourinary Cancers Using Urinary Sediment DNA Methylomes and Copy Number Profiles. Eur Urol 2020;77:288-90. European Urology. 2020, 77(4):e91-e92.

3. Xu Z^#, Ge G^#, Guan B^#, Lei Z^#, Hao X, Zhou Y, Shi Y, Lu H, Wang J, Peng D, Wu K, He H^*, Zhang B^*, Li X^*, Zhou L^* and Ci W^*. Non-invasive detection and localization of genitourinary cancers using urinary sediment DNA methylomes and copy number profiles. European Urology. 2020,77(2):288-290.

4. Ge G^#, Peng D^#, Guan B^#, Zhou Y^#, Gong Y^#, Shi Y^#, Hao X, Xu Z, Qi J, Lu H, Zhang X, Zhan Y, Li Y, Wu Y, Ding G, Shen Q, He Q, Li X^*, Zhou L^* and Ci W^*. Detection of urothelial carcinoma based on copy number profiles of urinary cell-free DNA using shallow whole-genome sequencing. Clinical Chemistry. 2020, 66(1):188–198.

5. Ma Q, Xu Z, Lu H, Xu ZY, Zhou Y, Yuan B, Ci W*. Distal regulatory elements identified by methylation and hydroxymethylation haplotype blocks from mouse brain. Epigenetics Chromatin. 2018,11(1):75.

6. Peng D^#, Ge G, Xu Z, Ma Q, Shi Y, Zhou Y, Gong Y, Xiong G, Zhang C, He S, He Z, Li X*, Ci W*, Zhou L*. Diagnostic and prognostic biomarkers of common urological cancers based on aberrant DNA methylation. Epigenomics. 2018,10(9):1189-1199.

7. Peng D^#, Ge G, Gong Y, Zhan Y, He S, Guan B, Li Y, Xu Z, Hao H, He Z, Xiong G, Zhang C, Shi Y, Zhou Y, Ci W*, Li X*, Zhou L*. Vitamin C increases 5-hydroxymethylcytosine level and inhibits the growth of bladder cancer. Clinical Epigenetics. 2018;10(1):94.

8. Ge G^#, Peng D^#, Xu Z^#, G B, Xin Z, He Q, Zhou Y, Li X*, Zhou L*, Ci W*. Restoration of 5-hydroxymethylcytosine by ascorbate blocks kidney tumour growth, EMBO Reports, 2018, 19(8).pii: e45401.

9. Ma Q ^#, Lu H, Xu Z, Zhou Y, and Ci W*. Mouse Olfactory Bulb Methylome and Hydroxymethylome Maps Reveal Noncanonical Active Turnover of DNA Methylation. Epigenetics, 2017, 25:1-7.

10. Valls, E^#, Lobry C^#, Geng H, Wang L, Cardenas M, Rivas M, Cerchietti L, Oh P,  Yang S, Oswald E, Graham C, Jiang Y, Hatzi K, Agirre X, Perkey E, Li Z, Tam W, Bhatt K, Leonard J, Zweidler-McKa P, Maillard P, Elemento O, Ci W*, Aifantis I*, Melnick A*. BCL6 antagonizes NOTCH2 to maintain survival of human follicular lymphoma cells, Cancer Discovery, 2017,7(5):506-521.

11. Chen K^#, Zhang J^#, Guo Z^#, Ma Q, Xu Z, Zhou Y, Xu Z, Li Z, Liu Y, Ye X, Li X, Yuan B, Ke Y, He C, Zhou L*, Liu J*, Ci W*. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer, Cell Research, 2016, 26(1):103-118.

12. Ci W^# and Liu J*.Programming and Inheritance of Parental DNA Methylomes in Vertebrates, Physiology, 2015, 30(1): 63– 68.

13. Li G^#, Ci W^#, Karmakar S^#, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J*, White KP*. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer, Cancer Cell, 2014, 25(4)：455-468.

14. Jiang L^#, Zhang J^#, Wang J^#, Wang L, Zhang L, Li G, Yang X, Ma X, Sun X, Cai J, Zhang J, Huang X, Yu M, Wang X, Liu F, Wu CI, He C, Zhang B, Ci W*, Liu J*.Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos, Cell, 2013, 153(4):773-784.

15. Ci W^#, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN, Ye K, Farinha P, Horsman DE, Gascoyne RD, Elemento O, Melnick A*.The BCL6 transcriptional program features repression of multiple oncogenes in primary B-cells and is deregulated in DLBCL. Blood, 2009, 113(22):5536-5348.

16. POLO JM^#, CI W^#, LICHT J, MELNICK A*, Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B-cells. Blood, 2008, 112(3):644-651.

17. CI W^#, POLO JM^#, Melnick A*. B-cell lymphoma 6 and the molecular pathogenesis of non-Hodgkin’s lymphoma. 2008. Curr Opin Hematol. 15(4):381-390.​

Dr. CI's current research focuses on DNA methylation reprogramming in tissue-specific cell differentiation and tumorigenesis. The ultimate goal of my laboratory is to define the DNA methylation changes that occur in cancers especially renal cell carcinomas, to discover the molecular causes of these changes, and to translate that newly gained knowledge into the clinic in the form of novel, epigenetic-based therapies. A wide spectrum of experimental approaches will be employed, including molecular and cellular biology, biochemistry, genomics and proteomics

已指导学生

许争争  硕士研究生  085238-生物工程  

郝雪玉  硕士研究生  0710Z1-基因组学  

马琴  博士研究生  071007-遗传学  

徐子瑛  博士研究生  0710J3-生物信息学  

葛广哲  博士研究生  0710Z1-基因组学  

许争争  博士研究生  0710Z1-基因组学  

鲁欢  博士研究生  0710Z1-基因组学  

齐杰  博士研究生  0710Z1-基因组学  

樊健  博士研究生  0710J3-生物信息学  

王基陆  博士研究生  0710Z1-基因组学  

田创宇  硕士研究生  0710Z1-基因组学  

孔雯雯  硕士研究生  0710Z1-基因组学  

于子惠  博士研究生  0710Z1-基因组学  

窦延良  硕士研究生  0710Z1-基因组学  

邹道嘉  硕士研究生  1001Z1-精准医学  

韩漾  博士研究生  0710J3-生物信息学  

李娟  博士研究生  0710J3-生物信息学  

包海南  硕士研究生  1001Z1-精准医学  

现指导学生

杨洋  博士研究生  0710Z1-基因组学  

王平  博士研究生  1001Z1-精准医学  

王颖  硕士研究生  0710Z1-基因组学  

张琪  博士研究生  0710Z1-基因组学  

谭耶真  博士研究生  0710Z1-基因组学  

何玉丹  博士研究生  0710Z1-基因组学  

郭彬  博士研究生  0710Z1-基因组学  

李高杰  博士研究生  0710J3-生物信息学  

左一帆  硕士研究生  1001Z1-精准医学  

丑善源  博士研究生  0710Z1-基因组学