基本信息
潘国宇  男  博导  中国科学院上海药物研究所
电子邮件: gypan@simm.ac.cn
通信地址: 上海张江高科海科路501号1715室
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
招生方向
药代动力学,毒代动力学,药物相互作用,肝肾毒性,

教育背景

2000-09--2003-06   中国药科大学   博士
1997-09--2000-06   中国药科大学   硕士学位
1992-09--1997-06   中国药科大学   学士学位

工作经历

   
工作简历
2011-03~现在, 上海药物研究所, 研究员,课题组长
2008-05~2011-03,美国诺华生物医学研究所, 实验室主管
2007-11~现在, 美国诺华生物医学研究所, 研究员
2004-01~2007-10,美国明尼苏达大学药学院药学系, 博士后
2000-09~2003-06,中国药科大学, 博士
1997-09~2000-06,中国药科大学, 硕士学位
1992-09~1997-06,中国药科大学, 学士学位
社会兼职
2017-11-01-今,中国细胞生物学学会细胞治疗研究与应用分会, 常务委员
2017-09-01-今,中国药理学会药代青委会副主任, 副主任
2015-05-12-今,上海市药物代谢委员会专业委员, 专业委员

教授课程

高等药理学(定量毒理学)

出版信息

   
发表论文
(1) Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor α Activation., Mol Pharmacol, 2018, 通讯作者
(2) Distinct gene expression and epigenetic signatures in hepatocyte-like cells produced by different strategies from the same donor, Stem Cell Reports, 2017, 其他(合作组作者)
(3) Enhanced doxorubicin delivery to hepatocellular carcinoma cells via CD147 antibody-conjugated immunoliposomes, Nanomedicine, 2017, 第 3 作者
(4) The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine, Xenobiotica, 2017, 通讯作者
(5) Preparation, characterization, biotoxicity, and biodistribution of thermo-responsive magnetic complex micelles formed by Mn0.6Zn0.4Fe2O4and a PCL/PEG analogue copolymer for controlled drug delivery, Journal of Materials Chemistry B, 2017, 第 4 作者
(6) Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model, Sci Rep, 2016, 通讯作者
(7) Optimized hepatocyte-like cells with functional drug transporters directly-reprogrammed from mouse fibroblasts and their potential in drug disposition and toxicology, Cell Physiol Biochem, 2016, 通讯作者
(8) Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes., Cell Res, 2016, 通讯作者
(9) Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example., Anal Bioanal Chem, 2016, 通讯作者
(10) Leflunomide-induced hepatotoxicity is attenuated by cytochrome P450-dependent metabolism and increased by inhibition of sodium taurocholate co-transporting polypeptide., Acta Pharmacol Sin., 2016, 通讯作者
(11) Simultaneous determination of gypenoside LVI, gypenoside XLVI, 2α-OH-protopanaxadiol and their two metabolites in rat plasma by LC-MS/MS and its application to pharmacokinetic studies., J Chromatogr B Analyt Technol Biomed Life Sci., 2015, 通讯作者
(12) Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine, Xenobiotica, 2015, 通讯作者
(13) Improving the dissolution and bioavailability of 6-mercaptopurine via co-crystallization with isonicotinamide., Bioorg Med Chem Lett., 2015, 通讯作者
(14) HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters., Oncol Lett., 2015, 通讯作者
(15) The Hepatobiliary disposition of timosaponin B2 is highly dependent on influx/efflux transporters but not metabolism., Drug Metab Dispos, 2014, 通讯作者
(16) Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich cultured rat hepatocytes, Toxicol Lett., 2014, 通讯作者
(17) Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS., Anal Bioanal Chem, 2014, 通讯作者
(18) Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus., Eur J Pharmacol, 2014, 通讯作者
(19) Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters., Acta Pharmacol Sin., 2014, 通讯作者
(20) Evaluation and optimization of high-performance liquid chromatography coupled with high-resolution mass spectrometry for phospholipid quantitation., Rapid Commun Mass Spectrom., 2014, 第 4 作者
(21) Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats., Drug Metab Dispos, 2012, 第 3 作者
(22) Assessment of biliary clearance in early drug discovery using sandwich-cultured hepatocyte model., J Pharm Sci., 2012, 第 1 作者
(23) Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line, Toxicology and Applied Pharmacology, 2011, 通讯作者
(24) Organic Cation Uptake Is Enhanced in bcrp1-Transfected MDCKII Cells, Mol Pharm, 2010, 第 1 作者
(25) Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse, Drug Metab Dispos., 2008, 第 3 作者
(26) Interactions of pluronic block copolymers on P-gp efflux activity: Experience with HIV-1 protease inhibitors., J Pharm Sci., 2008, 第 2 作者
(27) glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution., Drug Metab Dispos., 2007, 第 3 作者
(28) Mitoxantrone Permeability in MDCKII Cells Is Influenced by Active Influx Transport., Mol Pharm, 2007, 第 1 作者
(29) Abcg2/Bcrp1 mediates the polarized transport of anti-retroviral nucleosides Abacavir and Zidovudine (AZT)., Drug Metabolism and Disposition,, 2007, 第 1 作者
(30) Development and validation of a sensitive quantification method for hematoporphyrin monomethyl ether in plasma using high-performance liquid chromatography with fluorescence detection., Biomed Chromatogr, 2006, 第 4 作者
(31)  Simultaneous rapid quantification of ginsenoside Rg1 and its secondary glycoside Rh1 and aglycone protopanaxatriol in rat plasma by liquid chromatography-mass spectrometry after solid-phase extraction.,  J Pharm Biomed Anal. , 2005, 通讯作者
(32) Transport and Bioavailability studies of Astragaloside IV, an active ingredient in Radix Astragali., Pharmacology and Toxicology, 2004, 第 3 作者
(33) The antihyperglycaemic activity of berberine arises from its decreasing of glucose absorption., Planta Medica., 2003, 第 1 作者
(34) The involvement of P-glycoprotein in berberine absorption. , Pharmacology and Toxicology, 2002, 第 1 作者
(35) Cyclosporine A enhanced protection of nimodipine against brain damage induced by hypoxia-ischemia in mice and rats., Acta Pharmacol Sin, 2002, 第 2 作者
(36) Intracarotid infusion of hypertonic mannitol changes permeability of blood-brain barrier to methotrexate in rats., Acta Pharmcol Sin, 2002, 第 1 作者

科研活动

   
科研项目
( 1 ) 项目****, 主持, 部委级, 2011-05--2014-05
( 2 ) 新型体外模型研究糖尿病中肝脏胆酸药物转运体功能变化, 主持, 国家级, 2012-01--2012-12
( 3 ) 肝癌靶向治疗的新型纳米载药系统的构建及其应用研究, 主持, 国家级, 2014-01--2016-10
( 4 ) 有关类风湿关节炎状态下药物相互作用机制, 主持, 国家级, 2016-01--2017-12
( 5 ) ****(A类**), 主持, 部委级, 2014-05--2017-05
( 6 ) 构建新型肝样细胞模型用于药物代谢和安全性评价, 主持, 国家级, 2013-10--2016-10
( 7 ) 生物人工肝的研发, 主持, 部委级, 2013-03--2015-03
( 8 ) 基于人源化动物模型和肝脏生物功能网络的药物肝毒性预测关键新技术, 主持, 国家级, 2012-01--2015-04
( 9 ) 建立符合国际GLP标准要求,以毒性病理学为优势的药物安全评价技术平台, 主持, 国家级, 2012-01--2015-04
( 10 ) 实现转让的临床前研究候选新药ZH-063, 主持, 院级, 2015-03--2020-10
( 11 ) 新型纳米载药与治疗技术研究与应用, 参与, 国家级, 2013-01--2016-12
( 12 ) 人造肝脏类器官的功能和安全性评价, 主持, 部委级, 2017-12--2022-11
( 13 ) 靶向肿瘤的个性化药物的毒性特征和关键技术, 参与, 部委级, 2018-01--2020-09
( 14 ) 治疗2型糖尿病1.5类化学复方候选新药ZH-063的临床前个性化特征研究, 参与, 部委级, 2016-01--2018-12