基本信息
谢华  女  博导  中国科学院上海药物研究所
电子邮件: hxie@simm.ac.cn
通信地址: 上海张江祖冲之路555号
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
肿瘤药理学
分子与细胞生物学

教育背景

2001-09--2004-07   郑州大学   博士

工作经历

   
工作简历
2011-01~2012-06,美国Hormel研究所, 博士后
2004-08~现在, 上海药物研究所, 研究员
2001-09~2004-07,郑州大学, 博士
1994-08~2004-08,郑州大学, 助教,讲师

教授课程

肿瘤药理学概论
肿瘤药理学
肿瘤药理

专利与奖励

   
专利成果
( 1 ) 5-(硫醚基)嘧啶类化合物及其药用组合物和应用, 2015, 第 5 作者, 专利号: 201510688060.1
( 2 ) 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途, 2016, 第 3 作者, 专利号: 201611045301.1
( 3 ) 萘酰胺类化合物、其制备方法和用途, 2015, 第 4 作者, 专利号: PCT/CN2015/073121
( 4 ) 2-氨基嘧啶类化合物及其药物组合物和应用, 2015, 第 5 作者, 专利号: PCT/CN2015/094954

出版信息

   
发表论文
(1) DW10075, a novel highly selective inhibitor of vascular endothelial growth factor receptor, exhibits antitumor activities both in vitro and in vivo., Acta Pharmacol Sin, 2016, 第 11 作者
(2) Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis and Biological Evaluation., Chem Biol Drug Des., 2016, 第 11 作者
(3) Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)., Chinese Chemical Letters, 2016, 第 11 作者
(4) A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties., Eur J Med Chem, 2016, 第 11 作者
(5) Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors., Bioorg Med Chem, 2016, 第 11 作者
(6) Discovery and structural optimization of N5- substituted 6,7-Dioxo- 6,7- dihydropteridines as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation., J Med Chem, 2016, 第 11 作者
(7) Discovery of Anilinopyrimidine-Based Naphthamide Derivatives as Potent VEGFR-2 Inhibitors., MedChemComm, 2015, 第 11 作者
(8) Design, synthesis and biological evaluation of O-linked indoles as VEGFR-2 kinase inhibitors (I), Chinese Chemical Letters, 2015, 第 11 作者
(9) C-5 Substituted Pyrido[2,3-d] pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinica resistance-related EGFRT790M mutant, MedChemComm, 2015, 第 11 作者
(10) 2, 4- Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR L858R/T790M., Bioorganic & Medicinal Chemistry Letters, 2015, 第 11 作者
(11) Discovery of Anilinopyrimidine-Based Naphthamide Derivatives as Potent VEGFR-2 Inhibitors., MedChemComm, 2015, 第 11 作者
(12) Discovery of Anilinopyrimidine-Based Naphthamide Derivatives as Potent VEGFR-2 Inhibitors., MedChemComm, 2015, 第 11 作者
(13) Design, synthesis and biological evaluation of Novel 6-Alkenylamides Substituted of 4-Anilinothieno[2,3-d]pyrimidines as Irreversible Epidermal Growth Factor Receptor Inhibitors., Bioorg Med Chem, 2014, 第 11 作者
(14) Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors., ACS Med Chem Lett, 2014, 第 11 作者
(15) Topoisomerase II inhibitors from the roots of Stellera chamaejasme L, Bioorg Med Chem, 2014, 第 11 作者
(16) Novel metal complexes of naphthalimide-cyclam conjugates as potential multi-target Receptor Tyrosine Kinase (RTK) inhibitors: synthesis and biological evaluation, European Journal of Medicinal Chemistry, 2014, 第 11 作者
(17) Identification of DW532 as a novel anti-tumor agent targeting both kinase and tubulin, Acta Pharmacologica Sinica, 2014, 第 11 作者
(18) Naphthalimides Exhibit in vitro Antiproliferative and Antiangiogenic Activities by Inhibiting both Topoisomerase II (Topo II) and Receptor Tyrosine Kinases (RTKs), European Journal of Medicinal Chemistry, 2013, 第 11 作者
(19) Design, Synthesis and Biological Evaluation of novel 4-Anilinoquinazolines with C-6 Urea-linked side chains as the Epidermal Growth Factor Receptor (EGFR) Inhibitors, Bioorg Med Chem, 2013, 第 11 作者
(20) Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo, Molecular Cancer Therapeutics, 2013, 第 1 作者
(21) Identification of an Aurora kinase inhibitor specific for the Aurora B isoform., Cancer Research, 2013, 第 1 作者
(22) Discovery of Novel Selective Inhibitors for EGFR-T790M/L858R., Bioorg. Med. Chem. Lett., 2012, 第 11 作者
(23) Identification of mammalian target of rapamycin (mTOR) as a direct target of fenretinib both in vitro and in vivo., Carcinogenesis, 2012, 第 1 作者
(24) Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evaluation of novel inhibitors., Acta Pharmacol Sin., 2011, 第 1 作者
(25) Novel Acenaphtho[1,2-b]pyrrole Derivatives as Potent and Selective Fibroblast Growth Factor Receptors 1 Inhibitors: Design, Synthesis and Biological Evaluation., Journal of Medicinal Chemistry, 2011, 第 11 作者
(26) AST1306, an irreversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, exhibits its anticancer activities both in vitro and in vivo. , PLoS ONE, 2011, 第 1 作者
(27) Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF1R) inhibitors via hierarchical virtual screening.,  Journal of Medicinal Chemistry, 2010, 第 11 作者

科研活动

   
科研项目
( 1 ) 新型VEGFR抑制剂抗肿瘤作用及生物标志物研究, 主持, 部委级, 2015-09--2016-09
( 2 ) EGFR T790M耐药突变选择性抑制剂120067生物标志物研究, 主持, 部委级, 2016-05--2018-12
参与会议
(1)Identification of novel inhibitors against EGFR T790M resistance mutation   2016-12-07