基本信息
谢华  女  博导  中国科学院上海药物研究所
电子邮件: hxie@simm.ac.cn
通信地址: 上海张江祖冲之路555号
邮政编码:

招生信息

   
招生专业
100706-药理学
招生方向
肿瘤药理学
分子与细胞生物学

教育背景

2001-09--2004-07   郑州大学   博士

工作经历

   
工作简历
2011-01~2012-06,美国Hormel研究所, 博士后
2004-08~现在, 上海药物研究所, 研究员
2001-09~2004-07,郑州大学, 博士
1994-08~2004-08,郑州大学, 助教,讲师

教授课程

肿瘤药理学概论
肿瘤药理学
肿瘤药理

专利与奖励

   
专利成果
( 1 ) 5-(硫醚基)嘧啶类化合物及其药用组合物和应用, 2015, 第 5 作者, 专利号: 201510688060.1
( 2 ) 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途, 2016, 第 3 作者, 专利号: 201611045301.1
( 3 ) 萘酰胺类化合物、其制备方法和用途, 2015, 第 4 作者, 专利号: PCT/CN2015/073121
( 4 ) 2-氨基嘧啶类化合物及其药物组合物和应用, 2015, 第 5 作者, 专利号: PCT/CN2015/094954

出版信息

   
发表论文
(1) DW10075, a novel highly selective inhibitor of vascular endothelial growth factor receptor, exhibits antitumor activities both in vitro and in vivo., Acta Pharmacol Sin, 2016, 通讯作者
(2) Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis and Biological Evaluation., Chem Biol Drug Des., 2016, 通讯作者
(3) Design, synthesis and biological evaluation of biphenylurea derivatives as VEGFR-2 kinase inhibitors (II)., Chinese Chemical Letters, 2016, 通讯作者
(4) A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties., Eur J Med Chem, 2016, 通讯作者
(5) Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors., Bioorg Med Chem, 2016, 通讯作者
(6) Discovery and structural optimization of N5- substituted 6,7-Dioxo- 6,7- dihydropteridines as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation., J Med Chem, 2016, 通讯作者
(7) Discovery of Anilinopyrimidine-Based Naphthamide Derivatives as Potent VEGFR-2 Inhibitors., MedChemComm, 2015, 通讯作者
(8) Design, synthesis and biological evaluation of O-linked indoles as VEGFR-2 kinase inhibitors (I), Chinese Chemical Letters, 2015, 通讯作者
(9) C-5 Substituted Pyrido[2,3-d] pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinica resistance-related EGFRT790M mutant, MedChemComm, 2015, 通讯作者
(10) 2, 4- Diarylamino-pyrimidines as kinase inhibitors co-targeting IGF1R and EGFR L858R/T790M., Bioorganic & Medicinal Chemistry Letters, 2015, 通讯作者
(11) Discovery of Anilinopyrimidine-Based Naphthamide Derivatives as Potent VEGFR-2 Inhibitors., MedChemComm, 2015, 通讯作者
(12) Discovery of Anilinopyrimidine-Based Naphthamide Derivatives as Potent VEGFR-2 Inhibitors., MedChemComm, 2015, 通讯作者
(13) Design, synthesis and biological evaluation of Novel 6-Alkenylamides Substituted of 4-Anilinothieno[2,3-d]pyrimidines as Irreversible Epidermal Growth Factor Receptor Inhibitors., Bioorg Med Chem, 2014, 通讯作者
(14) Discovery of a New Series of Naphthamides as Potent VEGFR-2 Kinase Inhibitors., ACS Med Chem Lett, 2014, 通讯作者
(15) Topoisomerase II inhibitors from the roots of Stellera chamaejasme L, Bioorg Med Chem, 2014, 通讯作者
(16) Novel metal complexes of naphthalimide-cyclam conjugates as potential multi-target Receptor Tyrosine Kinase (RTK) inhibitors: synthesis and biological evaluation, European Journal of Medicinal Chemistry, 2014, 通讯作者
(17) Identification of DW532 as a novel anti-tumor agent targeting both kinase and tubulin, Acta Pharmacologica Sinica, 2014, 通讯作者
(18) Naphthalimides Exhibit in vitro Antiproliferative and Antiangiogenic Activities by Inhibiting both Topoisomerase II (Topo II) and Receptor Tyrosine Kinases (RTKs), European Journal of Medicinal Chemistry, 2013, 通讯作者
(19) Design, Synthesis and Biological Evaluation of novel 4-Anilinoquinazolines with C-6 Urea-linked side chains as the Epidermal Growth Factor Receptor (EGFR) Inhibitors, Bioorg Med Chem, 2013, 通讯作者
(20) Discovery of the novel mTOR inhibitor and its antitumor activities in vitro and in vivo, Molecular Cancer Therapeutics, 2013, 第 1 作者
(21) Identification of an Aurora kinase inhibitor specific for the Aurora B isoform., Cancer Research, 2013, 第 1 作者
(22) Discovery of Novel Selective Inhibitors for EGFR-T790M/L858R., Bioorg. Med. Chem. Lett., 2012, 通讯作者
(23) Identification of mammalian target of rapamycin (mTOR) as a direct target of fenretinib both in vitro and in vivo., Carcinogenesis, 2012, 第 1 作者
(24) Establishment of platform for screening insulin-like growth factor-1 receptor inhibitors and evaluation of novel inhibitors., Acta Pharmacol Sin., 2011, 第 1 作者
(25) Novel Acenaphtho[1,2-b]pyrrole Derivatives as Potent and Selective Fibroblast Growth Factor Receptors 1 Inhibitors: Design, Synthesis and Biological Evaluation., Journal of Medicinal Chemistry, 2011, 通讯作者
(26) AST1306, an irreversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, exhibits its anticancer activities both in vitro and in vivo. , PLoS ONE, 2011, 第 1 作者
(27) Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF1R) inhibitors via hierarchical virtual screening.,  Journal of Medicinal Chemistry, 2010, 通讯作者

科研活动

   
科研项目
( 1 ) 新型VEGFR抑制剂抗肿瘤作用及生物标志物研究, 主持, 部委级, 2015-09--2016-09
( 2 ) EGFR T790M耐药突变选择性抑制剂120067生物标志物研究, 主持, 部委级, 2016-05--2018-12
参与会议
(1)Identification of novel inhibitors against EGFR T790M resistance mutation   2016-12-07