College of Life Sciences
Graduate University, Chinese Academy of Sciences
Beijing 100049, China
Overall, we are interested in the structure/function relationship of transmembrane proteins, particularly in retinal-binding proteins. There are three major projects undergoing as below.
1.Structural studies of leptosphaeria rhodopsin, proteorhodopsin, bacteriorhodopsin, and channelrhodopsin by crystallography and electron paramagnetic resonance
2.Ion transport mechanism in retinal-binding proteins by time resolved absorption and photocurrent analysis
3.Functional implications of retinal-binding proteins in biosensor and biomaterial fields
1993 - 1997 B. S., Biochemistry, Department of Biology, Xiamen University
1998 - 2003 Ph.D., Biophysics, Institute of Biophysics, Chinese Academy of Sciences
2008 - 2009, Assistant Specialist, Department of Physiology and Biophysics, University of California, Irvine
2009 - Present, Associate Professor and Lecturer, College of Life Sciences, Graduate University, Chinese Academy of Sciences
Deliang Chen and Janos K. Lanyi*. (2009). Structural changes in the N and N’ states of the bacteriorhodopsin photocycle. Biophysical Journal 96，2779-2788.
Deliang Chen, Jennifer M. Wang and Janos K. Lanyi*. (2007). Electron paramagnetic resonance study of structural changes in the O photointermediate of bacteriorhodopsin. Journal of Molecular Biology 366, 790-805.
Hui Li$, De-Liang Chen$, Sheng Zhong, Bing Xu, Bao-Shan Han, and Kun-Sheng Hu*. (2005). Structural changes of purple membrane and bacteriorhodopsin during its denaturation induced by high pH. Journal of Physical Chemistry B 109, 11273-11278. $ contributed equally to this paper.
De-liang Chen, Ying-jie Lu, Sen-fang Sui, Bing Xu, and Kun-sheng Hu*. (2003). Oriented assembly of purple membrane on solid support, mediated by molecular recognition. Journal of Physical Chemistry B 107, 3598-3605.
Li Hui*, Chen Deliang, Hu Kunsheng, and Han Baoshan. (2003). Imaging surface structure of purple membrane partly dissolved by CHAPS with atomic force microscope. Chinese Science Bulletin 48, 1-4.
Chen De-Liang, Li Hui, Han Bao-Shan, Xu Bing, and Hu Kun-Sheng*. (2003). The direct observation on the surface structure change of purple membrane induced by high pH using atom force microscope. Progress in Biochemistry and Biophysics 30, 711-714.
De-liang Chen, Guang-yu Wang, Bing Xu, and Kun-sheng Hu*. (2002). All-trans to 13-cis retinal isomerization in light-adapted bacteriorhodopsin at acidic pH. Journal of Photochemistry and Photobiology B, 66, 188-194.
Bao-li Yao*, Ying-li Wang, Kun-sheng Hu, De-liang Chen, Yuan Zheng and Ming Lei. (2002) Mechanisms of pulse response and differential response of Bacteriorhodopsin and their relations. Photochemistry and Photobiology, 76(5), 545-548.
Chen De-Liang, Wang Ying-Li, Yao Bao-Li, and Hu Kun-Sheng*. (2002). The primary research on the kinetics of the intermediate M412 in the photocycle of Bacteriorhodopsin. Progress in Biochemistry and Biophysics, 29(3), 487-490.
Bing Xu, De-liang Chen and Kun-sheng Hu*. (2002) The improvement of culture of Halobacterium halobium and purification of PM. Progress in Biochemistry and Biophysics, 29(5), 827.
Yao Bao-Li*, Wang Ying-Li, Hu Kun-Sheng, Chen De-Liang, Zheng Yuan and Lei Ming. (2001). Characteristics and the mechanism of Bacteriorhodopsin photoelectric response. Acta Biochimica et Biophysica Sinica, 33(4), 443-446.
Chen De-liang and Hu Kun-sheng*. (2001). Progress in Bacteriorhodopsin research. Acta Biophysica Sinica, 17(3), 441-448.
Kunsheng Hu*, Ying Sun, Deliang Chen and Yian Zhang. (2000). The effect of lipid environment in purple membrane on bacteriorhodopsin. Journal of Photochemistry and Photobiology B, 58, 163-169.
Chen De-liang, Zhang Yi-nan, Li Mei-fen and Hu Kun-sheng*. (2000). Effect of detergent CHAPS on micro-surroundings in purple membrane bilayer. Acta Biophysica Sinica, 16(4), 801-805.