长期从事细菌的代谢工程改造和系统生物学研究。目前主要研究方向为：在系统生物学分析和关键基因功能解析的基础上，通过代谢工程改造工业微生物的核心代谢途径及关键酶，生产大宗化学品和高附加值精细化学品。

   

071005-微生物学

工业微生物功能基因分析及代谢工程改造

2001-10--2006-06   德国不伦瑞克工业大学/德国国家生物工程中心   博士
1993-09--1996-06   山东大学   硕士
1989-09--1993-06   山东大学   学士

   

2014-04~现在, 中科院天津工业生物技术研究所, 研究员
2008-07~2014-04,中科院天津工业生物技术研究所, 副研究员
2007-09~2008-06,德国赫尔姆霍茨传染病研究中心, 博士后
2000-10~2001-09,德国国家工程中心, 研究助理
1996-09~2000-07,山东轻工业学院, 讲师

工业生物技术前沿
系统生物学

   

（1） 赖氨酸工业菌种创新, , 部委级, 2014

[1] 孙际宾, 陈久洲, 蒲伟, 郑平, 周文娟, 石拓, 蔡柠匀. 高产5-氨基乙酰丙酸的工程菌株及5-氨基乙酰丙酸高产菌株的构建方法. CN115747125A, 2023-03-07.
[2] 郑平. 丙酸诱导型启动子的突变体及其应用. 202211478530.8, 2022-11-23.
[3] 孙际宾, 陈久洲, 李广玉, 郑平, 蔡柠匀, 周文娟, 李德衡, 刘娇, 刘世周, 赵兰坤. 谷氨酸脱氢酶启动子突变体及其应用. 202211146300.1, 2022-09-20.
[4] 郑平, 周文娟, 李广玉, 孙际宾, 蔡柠匀, 陈久洲, 王小平, 刘世周, 赵兰坤. 柠檬酸合酶启动子突变体及其应用. 202211145762.1, 2022-09-20.
[5] 郑平, 陈久洲, 蔡柠匀, 孙际宾, 周文娟, 钟沙沙. 突变型柠檬酸合酶及其应用. 202211146281.2, 2022-09-20.
[6] 郑平, 刘娇, 孙际宾, 周文娟, 刘建行, 孙冠男, 乔倩倩. 一种谷氨酰激酶的表达调控序列及其应用. 202211027795.6, 2022-08-25.
[7] 郑平, 刘娇, 孙际宾, 赵晓佳, 周文娟, 刘欣洋, 孙冠男. 一种人工表达调控元件及其应用. 202210923995.3, 2022-08-02.
[8] 郑平, 王钰, 孙际宾, 张知慧, 周文娟, 凡立稳. 一种提高微生物对甲醛耐受性的方法. 202210923993.4, 2022-08-02.
[9] 郑平, 王钰, 蔡柠匀, 孙际宾, 车斌, 高宁, 周文娟, 陈久洲, 倪晓蒙, 凡立稳. 甲醇耐受性蛋白及提高微生物的甲醇耐受性或利用率的方法. 202210833003.8, 2022-07-14.
[10] 孙际宾, 张伟, 郑平, 刘娇, 周文娟. 一种ramB突变体及其构建赖氨酸生产菌株的方法. CN202210400927.9, 2022-04-18.
[11] 孙际宾, 刘娇, 郑平, 赵晓佳, 王钰, 周文娟. 一种提高微生物对渗透压的耐受性的方法. 202210349424.3, 2022-04-01.
[12] 郑平, 蒲伟, 陈久洲, 孙际宾, 刘娇, 周文娟, 王钰. 一种氨基酸生物传感器及其应用. CN202210195613.X, 2022-03-01.
[13] 郑平, 刘娇, 孙际宾, 刘莫识, 周文娟, 孙冠男, 王钰, 石拓, 郭轩, 马延和. 高产L-脯氨酸的谷氨酸棒杆菌以及高产L-脯氨酸的方法. CN: CN114107141A, 2022-03-01.
[14] 孙际宾, 刘娇, 王兴初, 周文娟, 郑平, 马延和. 反式-4-羟基-L-脯氨酸的生产菌株及其构建方法和应用. CN: CN111349640B, 2022-03-01.
[15] 孙际宾, 陈久洲, 郑平, 蔡柠匀, 周文娟, 王钰. 一种DNA聚合酶IIIα亚基突变体及其应用. CN202210141981.6, 2022-02-16.
[16] 郑平, 赵晶, 谭子瑊, 陈久洲, 饶德明, 孙际宾, 马延和. 5-氨基乙酰丙酸合成酶突变体及其宿主细胞和应用. CN: CN114032224A, 2022-02-11.
[17] 孙际宾, 陈久洲, 郑平, 朱成超, 郭轩, 周文娟, 马延和. 5-氨基乙酰丙酸合成酶突变体及其宿主细胞和应用. CN: CN114032225A, 2022-02-11.
[18] 孙际宾, 刘娇, 郑平, 刘莫识, 王钰, 周文娟, 孙冠男. 具有 L-脯氨酸外排功能的蛋白及其应用. 202110045175.4, 2022-01-13.
[19] 孙际宾, 赵晶, 刘超, 周文娟, 郑平, 郭轩, 刘娇, 马延和. 一种新型的脯氨酸3-羟化酶及其应用. CN: CN110804596B, 2021-12-28.
[20] 郑平, 石拓, 陈久洲, 孙际宾, 周文娟, 蔡柠匀, 刘娇. 氨基酸生产菌株的构建方法及其应用. CN202111600320.7, 2021-12-24.
[21] 孙际宾, 刘娇, 郑平, 石拓, 周文娟, 陈久洲, 郭轩, 马延和. 丙酮酸羧化酶基因启动子的突变体及其应用. CN: CN113755492A, 2021-12-07.
[22] 郑平, 郑小梅, 孙际宾, 陈美玲, 周文娟, 卢玉丹, 马延和. 一种生产柠檬酸的工程菌及其构建方法和应用. CN202111407487.1, 2021-11-24.
[23] 郑平, 郑小梅, 孙际宾, 卢玉丹, 周文娟, 张立辉, 马延和. 一种柠檬酸的生产方法及其应用. CN202111306184.0, 2021-11-05.
[24] 孙际宾, 刘娇, 郑平, 孙冠男, 周文娟, 倪晓蒙, 陈久洲. 基于赖氨酸外排蛋白构建的重组微生物及生产赖氨酸的方法. CN202111283285.0, 2021-11-02.
[25] 孙际宾, 郑小梅, 郑平, 张立辉, 周文娟, 卢玉丹, 马延和. 生产柠檬酸的微生物及其构建方法和应用. CN202111235410.0, 2021-10-22.
[26] 郑平, 张伟, 周文娟, 孙际宾, 刘娇, 郭轩, 马延和. 生产氨基酸的谷氨酸棒杆菌以及利用该谷氨酸棒杆菌生产氨基酸的方法. CN113462583A, 2021-10-01.
[27] 郑平, 陈久洲, 孙际宾, 蒲伟, 蔡柠匀, 周文娟, 刘娇, 马延和. 磷酸烯醇式丙酮酸羧化酶突变体及其应用. CN202111082664.3, 2021-09-15.
[28] 郑平, 蒲伟, 陈久洲, 孙际宾, 蔡柠匀, 王钰, 周文娟, 马延和. 一种转录调控因子 LysG 的突变体及其应用. CN202111028178.3, 2021-09-02.
[29] 郑平, 陈久洲, 孙际宾, 蒲伟, 蔡柠匀, 周文娟, 王钰, 马延和. 一种转录调控因子 LysG 的突变体及其应用. CN202111026806.4, 2021-09-02.
[30] 郑平, 陈久洲, 黄婧文, 孙际宾, 周文娟, 石拓, 马延和. 一种突变的高渗诱导型启动子PproP及其应用. CN113278620A, 2021-08-20.
[31] 郑平, 刘娇, 孙际宾, 刘莫识, 周文娟, 孙冠男, 王钰, 石拓, 郭轩, 马延和. 高产L-脯氨酸的谷氨酸棒杆菌以及高产L-脯氨酸的方法. CN202110952846.5, 2021-08-19.
[32] 孙际宾, 郑小梅, 张立辉, 周文娟, 郑平, 马延和. 有机酸产量提高的菌株及其构建方法和应用. CN: CN113265417A, 2021-08-17.
[33] 郑平, 陈久洲, 孙际宾, 蔡柠匀, 郭轩, 周文娟, 刘坯, 刘娇, 马延和. 丙酮酸脱氢酶的突变体及其用于生产L-氨基酸的方法. CN113249347A, 2021-08-13.
[34] 孙际宾, 刘娇, 郑平, 刘莫识, 孙冠男, 周文娟, 马延和. 具有启动子活性的多核苷酸及其在生产目标化合物中的用途. CN: CN113201539A, 2021-08-03.
[35] 郑平, 刘娇, 王钰, 周文娟, 孙际宾, 陈久洲, 马延和. 具有天冬氨酸激酶活性的多肽及其在生产氨基酸中的应用. CN: CN113201514A, 2021-08-03.
[36] 郑平, 刘娇, 孙际宾, 周文娟, 石拓, 郭轩, 马延和. 具有启动子活性的多核苷酸及其在生产氨基酸中的应用. CN: CN113201536A, 2021-08-03.
[37] 孙际宾, 刘娇, 郑平, 周文娟, 马延和. 谷氨酸脱氢酶基因启动子的突变体及其应用. CN: CN113201535A, 2021-08-03.
[38] 郑平, 刘娇, 孙际宾, 周文娟, 孙冠男, 赵晓佳, 刘欣洋, 王钰, 倪晓蒙, 马延和. 启动子突变体文库的构建方法及启动子突变体文库. CN202110859066.6, 2021-07-28.
[39] 孙际宾, 刘娇, 郑平, 周文娟, 孙冠男, 陈久洲. 基于 dapB 基因的具有启动子活性的多核苷酸及其用途. CN202110638508.4, 2021-06-08.
[40] 郑平, 刘娇, 孙际宾, 孙冠男, 周文娟, 郭轩. 基于 mdh 基因的具有启动子活性的多核苷酸及其用途. CN202110638496.5, 2021-06-08.
[41] 孙际宾, 陈久洲, 郑平, 周文娟, 郭轩, 马延和. 生产赖氨酸的微生物以及赖氨酸的生产方法. CN: CN112877269A, 2021-06-01.
[42] 孙际宾, 陈久洲, 郑平, 朱成超, 郭轩, 周文娟, 马延和. 5-氨基乙酰丙酸合成酶突变体及其宿主细胞和应用. CN: CN112831483A, 2021-05-25.
[43] 孙际宾, 陈久洲, 黄婧文, 郑平, 周文娟, 刘娇, 马延和. 具有启动子活性的多核苷酸及其在生产目标化合物中的用途. CN202110505665.8, 2021-05-10.
[44] 郑平, 陈久洲, 黄婧文, 孙际宾, 周文娟, 王钰, 马延和. 具有启动子活性的多核苷酸及其用途和生产目标化合物的方法. CN202110504946.1, 2021-05-10.
[45] 孙际宾, 刘娇, 郑平, 石拓, 周文娟, 马延和. 一种天冬氨酸激酶基因表达调控序列及其应用. CN: CN112695036A, 2021-04-23.
[46] 孙际宾, 王钰, 郑平, 凡立稳, 周文娟, 马延和. 一种提高微生物对甲醇的耐受性和利用率的方法. CN: CN112680389A, 2021-04-20.
[47] 孙际宾, 王钰, 郑平, 凡立稳, 周文娟, 马延和. 一种提高菌株的甲醇生物耐受性和生物转化效率的方法. CN: CN112680468A, 2021-04-20.
[48] 徐庆阳, 孙际宾, 张玉富, 郑平, 李燕军, 张成林, 陈宁. 一种高密度发酵生产L-赖氨酸的培养基及其方法. CN: CN112662713A, 2021-04-16.
[49] 徐庆阳, 孙际宾, 张玉富, 郑平, 李燕军, 张成林, 陈宁. 一种赖氨酸循环发酵方法和应用. CN: CN112646844A, 2021-04-13.
[50] 徐庆阳, 孙际宾, 刘云鹏, 郑平, 李燕军, 周文娟, 张成林. 一种L-赖氨酸的发酵方法. CN: CN112626143A, 2021-04-09.
[51] 郑平, 郑小梅, 孙际宾, 卢玉丹, 周文娟, 张立辉, 马延和. 真菌来源的强启动子及其应用. CN202110268572.8, 2021-03-12.
[52] 郑平, 刘娇, 王钰, 孙际宾, 刘莫识, 周文娟, 郭轩, 马延和. γ-谷氨酰激酶突变体及其应用. CN: CN112111469B, 2021-02-26.
[53] 郑平, 刘娇, 孙际宾, 刘莫识, 周文娟, 马延和. 生产L-脯氨酸的菌株及其构建方法和应用. CN202110161475.9, 2021-02-05.
[54] 郑平, 郑小梅, 孙际宾, 周文娟, 张立辉, 马延和. 葡萄糖转运蛋白及其在提高有机酸生产中的应用. CN: CN112250740A, 2021-01-22.
[55] 孙际宾, 李庆刚, 郑平, 王晓玮, 周文娟, 陈久洲, 王钰, 马延和. 一种赖氨酸生产菌株的构建方法和应用. CN: CN112251391A, 2021-01-22.
[56] 郑平, 陈久洲, 黄婧文, 孙际宾, 周文娟, 马延和. 具有启动子活性的多核苷酸及其在生产目标化合物中的用途. CN202110036121.1, 2021-01-12.
[57] 郑平, 郭轩, 陈久洲, 周文娟, 孙际宾, 马延和. 一种从发酵液中制备5-氨基乙酰丙酸的方法及其应用. CN: CN111838421A, 2020-10-30.
[58] 孙际宾, 李庆刚, 周文娟, 郑平, 马延和. L-赖氨酸高产菌株及其构建方法和应用. CN: CN111635879A, 2020-09-08.
[59] 郑平, 郭轩, 陈久洲, 周文娟, 孙际宾. 一种从发酵液中制备5-氨基乙酰丙酸盐酸盐的生产工艺及其应用. CN: CN111517973A, 2020-08-11.
[60] 孙际宾, 刘娇, 王兴初, 郭轩, 周文娟, 郑平, 马延和. 反式-L-羟脯氨酸的生产菌株及其构建方法和应用. CN: CN111484997A, 2020-08-04.
[61] 郑平, 陈久洲, 周文娟, 孙际宾, 马延和. 5-氨基乙酰丙酸生产菌株及其构建方法和应用. CN: CN110862952B, 2020-06-09.
[62] 孙际宾, 陈久洲, 郑平, 饶德明, 王钰, 周文娟, 郭轩, 马延和. 5-氨基乙酰丙酸生产菌株及其构建方法和应用. CN: CN110862952B, 2020-06-09.
[63] 孙际宾, 赵晶, 刘超, 周文娟, 郑平, 马延和. 新型脯氨酸4-羟化酶及其应用. CN: CN110804595A, 2020-02-18.
[64] 郑平, 王钰, 孙际宾, 凡立稳, T·菲利伯特, 马延和. 甲醇生物转化菌株的构建方法以及构建的菌株和应用. CN: CN110760536A, 2020-02-07.
[65] 孙际宾, 李庆刚, 周文娟, 德莱奥西班乔·泰沃, 郑平, 马延和. MviN蛋白突变体、含有该突变体的表达载体和宿主细胞及其应用. CN: CN110283796A, 2019-09-27.
[66] 孙际宾, 李庆刚, 郑平, 周文娟, 张晓立, 德莱奥西班乔·泰沃, 马延和. 活性提高的磷酸转酮酶及在生产代谢物中的应用. CN: CN110218710A, 2019-09-10.
[67] 孙际宾, 李庆刚, 郑平, 王晓玮, 周文娟, 陈久洲, 王钰, 马延和. 赖氨酸生产菌株的构建方法和应用. CN: CN110129247A, 2019-08-16.
[68] 孙际宾, 李庆刚, 杨静, 周文娟, 赵晶, 郑平, 马延和. 高丝氨酸乙酰基转移酶突变体及其宿主细胞和应用. CN: CN110129294A, 2019-08-16.
[69] 郑平, 陈久洲, 孙际宾, 饶德明, 朱成超, 潘丹丹, 周文娟, 马延和. 一种5-氨基乙酰丙酸高产菌株及其制备方法与应用. CN: CN109722459A, 2019-05-07.
[70] 李德衡, 赵兰坤, 徐庆阳, 马延和, 孙际宾, 刘元涛, 许传高, 户红通, 郑平, 高翠娟, 赵凤良, 孙钦波, 范婷婷, 贾召鹏. 谷氨酸的绿色清洁发酵工艺. CN: CN109652478A, 2019-04-19.
[71] 郑平, 陈久洲, 孙际宾, 周文娟, 孙村民, 郭轩, 马延和. 5-氨基乙酰丙酸高产菌株及其制备方法和应用. CN: CN108517327A, 2018-09-11.
[72] 岳国君, 孙际宾, 郑平, 刘娇, 李庆刚, 夏令和, 周永生, 罗虎, 周勇, 满云, 卢宗梅, 马延和. 天冬氨酸激酶III突变体及其宿主细胞和应用. CN: CN108486082A, 2018-09-04.
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[49] DeleOsibanjo, Taiwo, Li, Qinggang, Zhang, Xiaoli, Guo, Xuan, Feng, Jinhui, Liu, Jiao, Sun, Xue, Wang, Xiaowei, Zhou, Wenjuan, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Growth-coupled evolution of phosphoketolase to improve l-glutamate production by Corynebacterium glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(20): 8413-8425, https://www.webofscience.com/wos/woscc/full-record/WOS:000491439700013.
[50] Fan, Liwen, Wang, Yu, Tuyishime, Philibert, Gao, Ning, Li, Qinggang, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Engineering Artificial Fusion Proteins for Enhanced Methanol Bioconversion. CHEMBIOCHEM[J]. 2018, 19(23): 2465-2471, https://www.webofscience.com/wos/woscc/full-record/WOS:000452035700008.
[51] Xu, Deyu, Zhao, Jing, Cao, Guoqiang, Wang, Jinyu, Li, Qinggang, Zheng, Ping, Zhao, Shuxin, Sun, Jibin. Removal of Feedback Inhibition of Corynebacterium glutamicum Phosphoenolpyruvate Carboxylase by Addition of a Short Terminal Peptide. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING[J]. 2018, 23(1): 72-78, https://www.webofscience.com/wos/woscc/full-record/WOS:000427741600010.
[52] Wang, Yu, Cao, Guoqiang, Xu, Deyu, Fan, Liwen, Wu, Xinyang, Ni, Xiaomeng, Zhao, Shuxin, Zheng, Ping, Sun, Jibin, Ma, Yanhe. A Novel Corynebacterium glutamicum L-Glutamate Exporter. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 84(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000426389400027.
[53] Jibin Sun. Mutations on Peptidoglycan Synthesis Gene ponA Improve Electro-transformation Efficiency of Corynebacterium glutamicum ATCC 13869. Applied and Environmental Microbiology. 2018, [54] Jibin Sun. Comprehensive Optimization of the Metabolomics Methodology for Metabolite Profiling of Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 2018, [55] 曲戈, 赵晶, 郑平, 孙际宾, 孙周通. 定向进化技术的最新进展. 生物工程学报[J]. 2018, 34(1): 1-11, http://lib.cqvip.com/Qikan/Article/Detail?id=674348257.
[56] Kou, Fengyu, Zhao, Jing, Liu, Jiao, Sun, Cunmin, Guo, Yanmei, Tan, Zijian, Cheng, Feng, Li, Zhimin, Zheng, Ping, Sun, Jibin. Enhancement of the thermal and alkaline pH stability of Escherichia coli lysine decarboxylase for efficient cadaverine production. BIOTECHNOLOGY LETTERS[J]. 2018, 40(4): 719-727, https://www.webofscience.com/wos/woscc/full-record/WOS:000428052600013.
[57] Jibin Sun. Heterologous and endogenous U6 snRNA promoters enabled CRISPR/Cas9 mediated genome editing in Aspergillus niger. Fungal Biology and Biotechnology. 2018, [58] Liu, Jiao, Wang, Yu, Zheng, Ping, Sun, Jibin. CRISPR/Cas9-mediated ssDNA Recombineering in Corynebacterium glutamicum. BIO-PROTOCOL[J]. 2018, 8(19): http://dx.doi.org/10.21769/BioProtoc.3038.
[59] Wang, Yu, Liu, Ye, Liu, Jiao, Guo, Yanmei, Fan, Liwen, Ni, Xiaomeng, Zheng, Xiaomei, Wang, Meng, Zheng, Ping, Sun, Jibin, Ma, Yanhe. MACBETH: Multiplex automated Corynebacterium glutamicum base editing method. METABOLIC ENGINEERING[J]. 2018, 47: 200-210, http://dx.doi.org/10.1016/j.ymben.2018.02.016.
[60] Liu, Jiao, Wang, Yu, Lu, Yujiao, Ni, Xiaomeng, Guo, Xuan, Zhao, Jing, Chen, Jiuzhou, DeleOsibanjo, Taiwo, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Mutations in Peptidoglycan Synthesis Gene ponA Improve Electrotransformation Efficiency of Corynebacterium glutamicum ATCC 13869. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 84(24): https://www.webofscience.com/wos/woscc/full-record/WOS:000451988000019.
[61] Tuyishime, Philibert, Wang, Yu, Fan, Liwen, Zhang, Qiongqiong, Li, Qinggang, Zheng, Ping, Sun, Jibin, Ma, Yanhe. Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production. METABOLIC ENGINEERING[J]. 2018, 49: 220-231, http://dx.doi.org/10.1016/j.ymben.2018.07.011.
[62] Zhang, Qiongqiong, Zheng, Xiaomei, Wang, Yu, Yu, Jiandong, Zhang, Zhidan, DeleOsibanjo, Taiwo, Zheng, Ping, Sun, Jibin, Jia, Shiru, Ma, Yanhe. Comprehensive optimization of the metabolomic methodology for metabolite profiling of Corynebacterium glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(16): 7113-7121, https://www.webofscience.com/wos/woscc/full-record/WOS:000440109200029.
[63] Wang, XingChu, Liu, Jiao, Zhao, Jing, Ni, XiaoMeng, Zheng, Ping, Guo, Xuan, Sun, CunMin, Sun, JiBin, Ma, YanHe. Efficient production of trans-4-hydroxy-L-proline from glucose using a new trans-proline 4-hydroxylase in Escherichia coli. JOURNAL OF BIOSCIENCE AND BIOENGINEERING[J]. 2018, 126(4): 470-477, http://dx.doi.org/10.1016/j.jbiosc.2018.04.012.
[64] 王迎春, 刘娇, 倪晓蒙, 雷宇, 郑平, 刁爱坡. 基于时间序列转录组筛选谷氨酸棒杆菌内源高效组成型启动子. 生物工程学报[J]. 2018, 34(11): 1760-1771, http://lib.cqvip.com/Qikan/Article/Detail?id=676852119.
[65] Xiaolu Wang, Yu Wang, Jiao Liu, Qinggang Li, Zhidan Zhang, Ping Zheng, Fuping Lu, Jibin Sun. Biological conversion of methanol by evolved Escherichia coli carrying a linear methanol assimilation pathway. BIORESOURCES AND BIOPROCESSING[J]. 2017, 4(1): 1-6, http://dx.doi.org/10.1186/s40643-017-0172-6.
[66] 饶德明, 张良程, 陈久洲, 孙德虎, 孙村民, 郑小梅, 郑平, 刁爱坡. 谷氨酸棒状杆菌合成5-氨基乙酰丙酸的途径构建与发酵优化. 生物技术通报[J]. 2017, 33(1): 148-156, http://lib.cqvip.com/Qikan/Article/Detail?id=671270638.
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[68] 王晓璐, 王钰, 刘娇, 郑平, 路福平. 利用定向进化提高基因工程大肠杆菌的甲醇利用能力. 生物技术通报[J]. 2017, 33(9): 101-109, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6073830&detailType=1.
[69] 徐德雨, 郑小梅, 赵晶, 郑平, 赵树欣. 谷氨酸棒杆菌天冬氨酸激酶G359D突变解除赖氨酸与苏氨酸协同抑制的研究. 生物技术通报[J]. 2017, 33(11): 143-152, http://lib.cqvip.com/Qikan/Article/Detail?id=673984471.
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[72] Wang, Yan, Li, Qinggang, Zheng, Ping, Guo, Yanmei, Wang, Lixian, Zhang, Tongcun, Sun, Jibin, Ma, Yanhe. Evolving the L-lysine high-producing strain of Escherichia coli using a newly developed high-throughput screening method. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2016, 43(9): 1227-1235, http://www.irgrid.ac.cn/handle/1471x/1180936.
[73] Meng, Qunglong, Zhang, Yanfei, Ju, Xiaozhi, Ma, Chunling, Ma, Hongwu, Chen, Jiuzhou, Zheng, Ping, Sun, Jibin, Zhu, Jun, Ma, Yanhe, Zhao, Xueming, Chen, Tao. Production of 5-aminolevulinic acid by cell free multi-enzyme catalysis. JOURNAL OF BIOTECHNOLOGY[J]. 2016, 226: 8-13, http://dx.doi.org/10.1016/j.jbiotec.2016.03.024.
[74] Fengyu Kou, Jing Zhao, Jiao Liu, Jie Shen, Qin Ye, Ping Zheng, Zhimin Li, Jibin Sun, Yanhe Ma. Characterization of a new lysine decarboxylase from Aliivibrio salmonicida for cadaverine production at alkaline pH. JOURNAL OF MOLECULAR CATALYSIS. B, ENZYMATIC. 2016, 133: S88-S94, http://dx.doi.org/10.1016/j.molcatb.2016.11.023.
[75] Liu, Yanan, Li, Qinggang, Zheng, Ping, Zhang, Zhidan, Liu, Yongfei, Sun, Cunmin, Cao, Guoqiang, Zhou, Wenjuan, Wang, Xiaowei, Zhang, Dawei, Zhang, Tongcun, Sun, Jibin, Ma, Yanhe. Developing a high-throughput screening method for threonine overproduction based on an artificial promoter. MICROBIAL CELL FACTORIES[J]. 2015, 14(1): http://www.irgrid.ac.cn/handle/1471x/1111645.
[76] 郑小梅, 张晓立, 于建东, 郑平, 孙际宾. CRISPR-Cas9介导的基因组编辑技术的研究进展. 生物技术进展[J]. 2015, 5(1): 1-9, http://lib.cqvip.com/Qikan/Article/Detail?id=663551668.
[77] Wu, Yong, Li, Pengpeng, Zheng, Ping, Zhou, Wenjuan, Chen, Ning, Sun, Jibin. Complete genome sequence of Corynebacterium glutamicum B253, a Chinese lysine-producing strain. JOURNAL OF BIOTECHNOLOGY[J]. 2015, 207: 10-11, http://dx.doi.org/10.1016/j.jbiotec.2015.04.018.
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[79] Xu ZiXiang, Zheng Ping, Sun JiBin. Reconstruction of Whole Cell Network and Design of Cell Factory. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 41(2): 105-114, http://124.16.173.210/handle/834782/1379.
[80] Zheng, Ping, Sun, Jibin. Protein engineering for strain engineering. NEW BIOTECHNOLOGY[J]. 2014, 31: S163-S163, http://dx.doi.org/10.1016/j.nbt.2014.05.2024.
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[82] 孙际宾. 全细胞网络重建与细胞工厂设计. 生物化学与 生物物理进展. 2014, [83] He, Feng Q, Wang, Wei, Zheng, Ping, Sudhakar, Padhmanand, Sun, Jibin, Zeng, AnPing. Essential O-2-responsive genes of Pseudomonas aeruginosa and their network revealed by integrating dynamic data from inverted conditions. INTEGRATIVE BIOLOGY[J]. 2014, 6(2): 215-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000330795500010.
[84] Zixiang Xu, Ping Zheng, Jibin Sun, Yanhe Ma. ReacKnock: Identifying Reaction Deletion Strategies for Microbial Strain Optimization Based on Genome-Scale Metabolic Network. PLOS ONE[J]. 2013, 8(12): http://www.irgrid.ac.cn/handle/1471x/1111630.
[85] Geng, Feng, Chen, Zhen, Zheng, Ping, Sun, Jibin, Zeng, AnPing. Exploring the allosteric mechanism of dihydrodipicolinate synthase by reverse engineering of the allosteric inhibitor binding sites and its application for lysine production. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(5): 1963-1971, http://www.irgrid.ac.cn/handle/1471x/483729.
[86] 蒲伟, 陈久洲, 孙村民, 陈宁, 孙际宾, 郑平, 马延和. 琥珀酸脱氢酶或琥珀酰辅酶A合成酶缺失促进大肠杆菌积累5-氨基乙酰丙酸. 生物工程学报[J]. 2013, 29(10): 1494-1503, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4958966&detailType=1.
[87] Jibin Sun. Cloning of two 5-Aminolevulinic Acid Synthase Isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characters for 5-aminolevulinic acid production. Biotechnology Letters. 2013, [88] Chen, Lin, Chen, Zhen, Zheng, Ping, Sun, Jibin, Zeng, AnPing. Study and reengineering of the binding sites and allosteric regulation of biosynthetic threonine deaminase by isoleucine and valine in Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2013, 97(7): 2939-2949, http://www.irgrid.ac.cn/handle/1471x/483730.
[89] 马延和, 郑平, 陈久洲, 蒲伟, 孙际宾. 5-氨基乙酰丙酸高产菌株及其制备方法和应用. 2013, http://124.16.173.210/handle/312001/336.
[90] Zhang, Lilu, Chen, Jiuzhou, Chen, Ning, Sun, Jibin, Zheng, Ping, Ma, Yanhe. Cloning of two 5-aminolevulinic acid synthase isozymes HemA and HemO from Rhodopseudomonas palustris with favorable characteristics for 5-aminolevulinic acid production. BIOTECHNOLOGY LETTERS[J]. 2013, 35(5): 763-768, http://124.16.173.210/handle/834782/1295.
[91] 吴新阳, 裴广胜, 郑小梅, 曹国强, 刘娇, 郑平, 王敏, 孙际宾. 不同抑制剂对谷氨酸棒状杆菌磷酸烯醇式丙酮酸羧化酶酶活的影响. 生物技术通报[J]. 2013, 172-178, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4895212&detailType=1.
[92] 姜安娜, 曹名锋, 李庆刚, 郑平, 杨洪江, 孙际宾. 一种改进的赖氨酸浓度测定方法. 生物技术通报[J]. 2013, 190-194, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4780390&detailType=1.
[93] 姜金国, 宋理富, 郑平, 孙际宾, 孙际宾. 谷氨酸棒状杆菌集成细胞网络的构建与结构分析. 生物工程学报[J]. 2012, 28(5): 577-591, http://lib.cqvip.com/Qikan/Article/Detail?id=41939456.
[94] 郭小飞, 陈久洲, 张莉露, 贾士儒, 郑平. 利用5-氨基乙酰丙酸脱水酶缺失的重组大肠杆菌合成5-氨基乙酰丙酸. 天津科技大学学报[J]. 2012, 27(4): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=42984875.
[95] 尚柯, 郭小飞, 王艳萍, 郑平. 5一氨基乙酰丙酸脱水酶缺失对大肠杆菌生长的影响. 现代食品科技[J]. 2011, 27(7): http://124.16.173.210/handle/311007/603.
[96] 尚柯, 郭小飞, 王艳萍, 郑平. 5-氨基乙酰丙酸脱水酶缺失对大肠杆菌生长的影响. 现代食品科技[J]. 2011, 27(7): 742-746, http://lib.cqvip.com/Qikan/Article/Detail?id=38640657.
[97] 马建刚, 刘娇, 曾祥峰, 郑平, 贾士儒, 孙际宾. 大肠杆菌9种有机酸代谢产物的高效液相检测条件优化. 现代食品科技[J]. 2011, 27(5): 591-594, http://lib.cqvip.com/Qikan/Article/Detail?id=37823681.
[98] 孙际宾, 刘娇, 郑平. 苹果酸酶突变体及其应用. 2011, http://124.16.173.210/handle/0/185.
[99] 杨晓涛, 郭艳梅, 曾祥峰, 满云, 郑平, 王昌禄, 孙际宾. 黑曲霉产柠檬酸的发酵过程表征及乙醛酸的形成. 现代食品科技[J]. 2011, 27(10): 1183-1186, http://lib.cqvip.com/Qikan/Article/Detail?id=39651067.
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（ 1 ） 能源微藻采收、油脂提取及生物柴油制备原理与方法, 主持, 国家级, 2011-01--2012-12
（ 2 ） 天津工业生物技术研究所优秀青年科技专项, 主持, 部委级, 2011-01--2013-12
（ 3 ） 大肠杆菌5-氨基乙酰丙酸穿膜运输的分子基础, 主持, 国家级, 2011-01--2013-12
（ 4 ） 生物制造5-氨基乙酰丙酸的关键技术, 主持, 省级, 2010-04--2013-03
（ 5 ） 留学人员科技活动项目, 主持, 国家级, 2010-08--2012-07
（ 6 ） 黑曲霉整合型细胞网络的构建和在柠檬酸代谢工程方面的应用, 参与, 国家级, 2009-01--2011-12
（ 7 ） 琥珀酸发酵生产的系统生物技术改造及中等规模实验, 参与, 省级, 2009-04--2011-09
（ 8 ） 异戊醇生物制造的途径构建及系统优化, 参与, 部委级, 2009-01--2011-12
（ 9 ） 油藻高值产品开发和整合系统的数学模型, 主持, 国家级, 2011-01--2012-12
（ 10 ） 工业微生物基因组测序及分析, 参与, 部委级, 2011-01--2013-12
（ 11 ） 大肠杆菌基因组理性设计, 主持, 省级, 2011-10--2014-09
（ 12 ） 基因组理性设计与氨基酸生产菌种的构建, 主持, 国家级, 2012-11--2015-12
（ 13 ） 赖氨酸高产菌种改造, 参与, 研究所（学校）, 2011-09--2014-09
（ 14 ） 柠檬酸高产菌株的改造, 参与, 研究所（学校）, 2010-10--2012-12
（ 15 ） 谷氨酸脱氨与脱羧衍生转化关键技术 , 参与, 国家级, 2014-01--2016-12
（ 16 ） 人工细胞工厂创新团队, 参与, 部委级, 2014-01--2016-12
（ 17 ） 微生物细胞工厂设计创新团队, 参与, 省级, 2016-01--2017-12
（ 18 ） 生物法生产1，5-戊二胺中试放大, 主持, 院级, 2017-10--2018-10
（ 19 ） 甲醇制氨基酸, 主持, 部委级, 2016-01--2018-12
（ 20 ） 柠檬酸生产菌株高产分析, 主持, 院级, 2017-08--2018-01

已指导学生

杨宝银  硕士研究生  430139-生物工程  

潘丹丹  硕士研究生  085238-生物工程  

于建东  硕士研究生  085238-生物工程