General

Principal investigator;

Email: guocx@big.ac.cn

Mailing address:

Beijing Institute of Genomics,

No.1 Beichen West Rd, Chaoyang District, Beijing

Postcode: 100101

Research Areas

DNA damage response, genome instability and human diseases.

Education

Ph.D. in Physiology                                       1996-1999

The State Key Lab of Reproductive Biology

Institute of Zoology

Chinese Academy of Sciences                                                             

 

M.S. in Biotechnology                                     1991-1994                                             

Wuhan University, China

 

B.S. in Cell Biology                                            1987-1991        

Wuhan University, China


Experience

Principal Investigator                                       2009-present                              

Beijing Institute of Genomics

 

Research Assistant Professor of Dep. Pathology                  2008-2009                  

UT Southwestern Medical Center at Dallas

 

Instructor of Dep. Pathology                                 2004-2008                                    

UT Southwestern Medical Center at Dallas

 

Postdoctoral Research Fellowship                                    2001-2004

UT Southwestern Medical Center at Dallas

Advisor:  Professor Errol C. Friedberg                                                    

 

Postdoctoral Research Fellowship                                    1999-2001

University of Kentucky

Advisor:  Associate Professor Ok-Kyong Park-Sarge



Publications

1       Liu H, Li X, Ning G, Zhu S, Ma X, Liu X, Liu C, Huang M, Schmitt I, Wüllner U, Niu Y, Guo C*, Wang Q*, Tang TS*. The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53. PLOS Biol. (2016). 14(11):e2000733. doi: 10.1371/journal.pbio.2000733.

2       Zhang H, Zhang C, Yan J, Sun Z, Song S, Sun Y, Guo C*. Transcriptome analysis of the responses to methyl methanesulfonate treatment in mouse pachytene spermatocytes and round spermatids. Gene. (2016). pii: S0378-1119(16)30800-9.

3       Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A, Tang TS. TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. (2016). 165(6):1454-66.

4       Wang K, Ma X, Zhang X, Wu D, Sun C, Sun Y, Lu X, Wu CI, Guo C*, Ruan J*. Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis. Sci Rep. (2016). 6:25310.

5       Sun Y, Yang Y, Shen H, Huang M, Wang Z, Liu Y, Zhang H, Tang TS, Guo C*. iTRAQ-based chromatin proteomic screen reveals CHD4-dependent recruitment of MBD2 to sites of DNA damage. Biochem Biophys Res Commun. (2016). 471(1):142-8.

6       Wang Z, Huang M, Ma X, Li H, Tang T, Guo C*. REV1 promotes PCNA monoubiquitination through interacting with ubiquitinated RAD18. J Cell Sci. (2016). 129:1223-1233.

7        Yan J, Zhang H, Liu Y, Zhao F, Zhu S, Xie C, Tang TS, Guo C*. Germline Deletion of Huntingtin Causes Male Infertility and Arrested Spermiogenesis in Mice. J Cell Sci. (2016). 129: 492-501.

8       Dai K, Qin F, Zhang H, Liu X, Guo C, Zhang M, Gu F, Fu L, Ma Y. Low expression of BMPRIB indicates poor prognosis of breast cancer and is insensitive to taxane-anthracycline chemotherapy. Oncotarget. (2016). 7(4):4770-84.

9       Liu Y, Ma X, Guo C*. Effects of the N terminus of mouse DNA polymerase κ on the bypass of a guanine-benzo[a]pyrenyl adduct. J Biochem. (2016).159(4):471-9.

10    Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y,  Lv L, Lin Y, Huang M, Zhang T, Pei H, Chen B, Jansen JG, Wind N, Fischhaber P, Friedberg EC, Tang TS and Guo C*. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. 43, 8325-8339 (2015).

11    Qin Y, Guo T, Li G, Tang TS, Zhao S, Jiao X, Gong J, Gao F, Guo C, Simpson JL, Chen ZJ. CSB-PGBD3 Mutations Cause Premature Ovarian Failure. PLoS Genet. 11(7):e1005419. doi: 10.1371/journal.pgen.1005419 ( 2015).

12    Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J. The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection. Curr Biol. 24(18):2097-110. (2014).

13    Wang F, Fischhaber PL, Guo C, Tang TS. Epigenetic modifications as novel therapeutic targets for Huntington's disease. Epigenomics. 6(3):287-97. (2014).

14    Li X, Qu F, Xie W, Wang F, Liu H, Song S, Chen T, Zhang Y, Zhu S, Wang Y, Guo C, Tang TS*. Transcriptomic analyses of neurotoxic effects in mouse brain after intermittent neonatal administration of thimerosal. Toxicol Sci. 139(2):452-65 (2014)

15     Gao M, Wei W, Li MM, Wu YS, Ba Z, Jin KX, Li MM, Liao YQ, Adhikari S, Chong Z, Zhang T, Guo C, Tang TS, Zhu BT, Xu XZ, Mailand N, Yang YG, Qi Y, Rendtlew Danielsen JM. Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination. Cell Res. 24(5):532-41. (2014).

16     Liu Y, Yang Y, Tang TS, Zhang H, Wang Z, Friedberg EC, Yang W, Guo C*. Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[a]pyrene dG adduct. Proc Natl Acad Sci USA. 111(5): 1789-1794. (2014).

17     Lv L, Wang F, Ma X, Yang Y, Wang Z, Liu H, Li X, Liu Z, Zhang T, Huang M, Friedberg E, Tang TS, Guo C*. Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. Nucleic Acid Res. 41(22):10312-10322. (2013).

18      Bétous R, Pillaire MJ, Pierini L, van der Laan S, Recolin B, Ohl-Séguy E, Guo C, Niimi N, Grúz P, Nohmi T, Friedberg E, Cazaux C, Maiorano D, Hoffmann JS. DNA polymerase κ- dependent DNA synthesis at stalled replication forks is important for CHK1 activation. EMBO J. 32(15):2172-2185. (2013).

19     Wang F, Yang Y, Lin X, Wang JQ, Wu YS, Xie W, Wang D, Zhu S, Liao YQ, Sun Q, Yang YG, Luo HR, Guo C*, Han C*, Tang TS*. Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease. Human Mol Genet 22(18):3641-3653. (2013).

20      Wang J, Chen Q, Wang X, Wang Q, Wang Y, Cheng H, Guo C, Sun Q, Chen Q, Tang TS. Dysregulation of Mitochondrial Calcium Signaling and Superoxide Flashes Cause Mitochondrial Genomic DNA Damage in Huntington’s Disease.  J. Biol. Chem. 288(5): 3070-3084. (2013).

21     Zhang X, Lv L, Chen Q, Yuan F, Zhang T, Yang Y, Zhang H, Wang Y, Jia Y, Qian L, Chen B, Zhang Y, Friedberg C, Tang T and Guo C*. Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks. DNA Repair. 12(5):377-88. (2013).

22      Wang Z,Wang F, Tang T, Guo C*.  The role of PARP1 in the DNA damage response and its application in tumor therapy. Front Med. 6(2):156-164 (2012).


Research Interests

My main research interests are focusing on DNA damage response, genome instability and related human diseases (including cancer, birth defect, and ageing) by using experimental approaches including biochemistry, molecular/cellular biology, genomics, proteomics and animal models. These studies will allow us to gain further insight into the molecular mechanisms how gene-environment interaction affects cell proliferation, cell differentiation and death, as well as to develop novel therapeutic strategies for these disorders.


Students

已指导学生

张文靖  02  52764  

赵飞龙  02  19183  

贾艳  02  19183  

吕翎娜  01  19183  

谢成梅  02  19183  

王志峰  01  19183  

孙亚舟  01  19183  

张雪  02  19183  

李慧明  02  19183  

杨业然  01  19183  

现指导学生

马晓璐  01  19183  

孙中帅  01  19183  

黄敏  01  19183  

邢玲玉  02  19183  

孙趁义  02  19183  

姬巧  02  19183  

吴畏  02  19183  

杨飞  02  19183  

张传超  01  19183  

Honors & Distinctions