基本信息
林鑫华  男    中国科学院动物研究所
电子邮件: xinhua.lin@ioz.ac.cn
通信地址: 北京市朝阳区北辰西路1号院5号 中国科学院动物研究所生物膜与膜生物工程国家重点实验室细胞信号转导和发育机理研究组
邮政编码: 100101

招生信息

   
招生专业
071009-细胞生物学
071008-发育生物学
招生方向
细胞信号转导在干细胞以及相关疾病中的作用机制
发育过程中形态发生素浓度梯度的形成机制

教育背景

1990-07--1995-05   美国华盛顿大学   分子遗传学 博士
1984-09--1987-07   中国科学院上海细胞生物学研究所   细胞生物学 硕士
1980-09--1984-07   浙江大学(原杭州大学)   生物学 学士

工作经历

   
工作简历
2009-07~现在, 中国科学院动物研究所, 研究员
2000-04~2008-11,美国辛辛那提儿童医院医学中心, 助理教授、副教授、教授
1995-05~2000-04,美国哈佛大学医学院, 博士后
1990-07~1995-05,美国华盛顿大学, 分子遗传学 博士
1984-09~1987-07,中国科学院上海细胞生物学研究所, 细胞生物学 硕士
1980-09~1984-07,浙江大学(原杭州大学), 生物学 学士
社会兼职
2011-01-01-今,中国细胞生物学会发育生物学分会会长, 会长
2011-01-01-今,中国细胞生物学会常务理事, 常务理事
2009-01-01-今,中国动物学会常务理事,
2009-01-01-今,北京细胞生物学会副理事长,
2009-01-01-今,中国遗传学会发育遗传专业委员会副主任,

教授课程

干细胞研究进展系列讲座
遗传学与发育生物学进展
中科院夏季学期前沿系列讲座

专利与奖励

   
奖励信息
(1) 美国癌症协会学者奖, , 研究所(学校), 2007
(2) 海外杰出青年科学家奖, , 国家级, 2007
(3) 美国畸形儿基金会学者奖, , 研究所(学校), 2005

出版信息

   
发表论文
(1) Genome-Wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila, Cell Reports, 2015, 通讯作者
(2) Debra-mediated Ci degradation controls tissue homeostasis in Drosophila adult midgut, Stem cell reports, 2014, 通讯作者
(3) Drosophila Perlecan Regulates Intestinal Stem Cell Activity via Cell-Matrix Attachment, Stem cell reports, 2014, 通讯作者
(4) Drosophila heparin sulfate 3-O sulfotransferase B null mutant is viable and exhibits no defects in Notch signaling, Journal of Genetics and Genomics, 2014, 通讯作者
(5) dBrms1 acts as a positive regulator of Notch signaling in Drosophila wing, Journal of Genetics and Genomics, 2014, 通讯作者
(6) Hs3st-A and Hs3st-B Regulate Intestinal Homeostasis in Drosophila Adult Midgut, Cellular Signalling, 2014, 通讯作者
(7) Ubr3 E3 ligase regulates apoptosis by controlling the activity of DIAP1 in Drosophila, Cell Death Differentiation, 2014, 通讯作者
(8)  The Drosophila tankyrase regulates Wg signaling depending on the concentration of Daxin, Cellular Signalling, 2014, 通讯作者
(9) The sterile 20-like kinase tao controls tissue homeostasis by regulating the hippo pathway in Drosophila adult midgut, Journal of Genetics and Genomics, 2014, 通讯作者
(10) Retromer promotes immune quiescence by suppressing Sp?tzle-Toll pathway in Drosophila,  Journal of Cellular Physiology, 2014, 通讯作者
(11) Hyperplastic Discs Differentially Regulates the Transcriptional Outputs of Hedgehog Signaling, Mechanisms of Development, 2014, 通讯作者
(12) 器官来源的DPP信号维持果蝇中肠稳态, Trachea-Derived Dpp Controls Adult Midgut Homeostasis in Drosophila, Development Cell, 2013, 通讯作者
(13) Drosophila miR-932 modulates hedgehog signaling by targeting its co-receptor Brother of ihog, Developmental Biology, 2013, 通讯作者
(14) Drosophila miR-960 negatively regulates Hedgehog signaling by suppressing Smoothened, Costal-2 and Fused, Cellular Signalling, 2013, 通讯作者
(15) Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development, Developmental Biology, 2013, 通讯作者
(16) The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine, Development, 2013, 第 2 作者
(17) Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space, Neuron, 2012, 通讯作者
(18) Drosophila miR-5 suppresses Hedgehog signaling by directly targeting Smoothened, FEBS letters, 2012, 通讯作者
(19) Roles of N-glycosylation and lipidation in Wg secretion and signaling, Developmental Biology, 2012, 通讯作者
(20) Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless, Cell Research, 2011, 通讯作者
(21) Hedgehog signaling uses lipid metabolism to tune smoothened activation, Developmental cell, 2010, 通讯作者
(22)  Two cell-surface proteins Dally-like and Ihog play distinctive roles in Hh signalling and distribution development, Development, 2010, 通讯作者
(23) Shaping Morphogen Gradients by Proteoglycans, Cold Spring Harbor Perspectives in Biology, 2009, 通讯作者
(24) The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling, Developmental cell, 2009, 通讯作者
(25) An essential glycobiology resource for developmental biologists., Development, 2009, 通讯作者
(26) Glypican shows its versatility in Hh signaling, Nature Cell Biology, 2008, 通讯作者
(27) The retromer complex is involved in Wnt secretion by recycling Wntless from endosomes to trans Golgi network. ,  Developmental Cell, 2008, 通讯作者
(28) Pygopus 2 has a critical, Wnt pathway-independent function in lens induction., Development, 2007, 通讯作者

科研活动

   
科研项目
( 1 ) 发育过程中形态发生素梯度形成和信号转导的调控机制, 负责人, 国家任务, 2011-01--2015-08
( 2 ) 果蝇肠干细胞的维持和定向分化的分子机理, 负责人, 国家任务, 2011-01--2014-12
( 3 ) Wnt蛋白分泌调控的分子机制, 参与, 国家任务, 2011-01--2013-12
( 4 ) 干细胞与再生医学研究专项, 参与, 中国科学院计划, 2011-01--2015-12
( 5 ) 囊泡复合体Retromer在发育中的作用, 负责人, 中国科学院计划, 2009-10--2011-12
( 6 ) H. pylori (Hp) 感染通过调控成体胃干细胞影响胃癌发生的研究, 负责人, 国家任务, 2014-01--2016-12
参与会议
(1)Mechanisms of gut stem cell activity and tissue homeostasis   2014北京西山发育与再生生物学研讨会   林鑫华   2014-08-19
(2)Mechanisms of gut stem cell activity and tissue homeostasis   第五届细胞结构与功能的信号基础研讨会   林鑫华   2014-08-09
(3)Mechanisms of gut stem cell activity and tissue homeostasis   林鑫华   2014-07-17
(4)Roles of BMP and Hh morphogens in gut homeostasis and stem cell regulation   林鑫华   2014-05-27
(5)Debra-mediated Ci degradation controls stem cell aging and tissue homeostasis in Drosophila adult midgut   林鑫华   2013-08-21
(6)Trachea-derived BMP controls adult midgut homeostasis in Drosophila   北京生命科学论坛第二十三次会议—干细胞生物学研讨会   林鑫华   2013-06-25
(7)Trachea-derived BMP controls adult midgut homeostasis in Drosophila   林鑫华   2013-06-16
(8)Roles of morphogen signaling in patterning and homeostasis     第二届中国果蝇大会   林鑫华   2013-04-28
(9)Roles of BMP signaling in regulation of gut hemostasis    中国细胞生物学学会2013年全国学术大会   林鑫华   2013-04-19
(10)Molecular mechanisms of Wnt secretion and signaling   林鑫华   2012-10-05
(11)Hedgehog信号在果蝇生长发育中的调节作用   Hedgehog信号在发育进化和疾病中的作用   林鑫华   2012-03-17
(12)Roles of Chondroitin sulfate in cell growth duirng development   林鑫华   2011-10-15
(13)Regulation of Wnt Morphogen Gradient by Retromer complex and Snx1   林鑫华   2011-10-11
(14)Regulation of Wnt Morphogen Gradient by Proteoglycans and Vesicle Trafficking   2011年中国细胞生物学大会   林鑫华   2011-07-15
(15)Control of Wnt secretion by Vesicle trafficking and Retromer complex   2010年全国发育生物学研讨会   林鑫华   2010-09-17
(16)在果蝇Intestinal干细胞发育过程中具有重要作用的基因的鉴定   第三届北京干细胞论坛   林鑫华   2010-09-12
(17)Two cell-surface proteins Dally-like and Ihog differentially regulate Hh signalling strength and range during development   林鑫华   2010-07-11
(18)Two cell-surface proteins Dally-like and Ihog differentially regulate Hh signalling strength and range during development   林鑫华   2010-06-20
(19)Two cell-surface proteins Dally-like and Ihog differentially regulate Hh signalling strength and range during development   林鑫华   2010-05-27
(20)Shaping Wnt Morphogen Gradient by Proteoglycans   林鑫华   2010-05-12
(21)Regulation of Wnt signaling and distribution during development   中国遗传学会模式生物与人类健康研讨会   林鑫华   2010-04-12
(22)Biphasic Roles of Proteoglycan Dally-like in Wnt Signaling and Distribution   中国发育生物学年会   林鑫华   2009-09-26