General

LI, Lei 
Email:  lil@ioz.ac.cn
Telephone: 64807865
Address: The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China 
Postcode: 100101

Research Areas

Development

Education

 
  • Ph.D., Cell Physiology, Department of Cell Physiology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan (1999-2002)       
  • BA., Animal Physiology and Biochemistry,  Department of Animal Physiology and Biochemistry, College of Biological Sciences, China (Beijing) Agricultural University, Beijing, China (1990-1994)

Experience

   
Work Experience
  1. State Key Laboratory of Stem Cell and Reproductive Biology, IOZ/ Chinese Academy of Sciences, China, Professor  (2009-present)
  2. Laboratory of Cellular and Developmental Biology, NIDDK /National Institute of Health, USAVisiting/Research Fellow (2003-2009)
  3. Department of Cell Physiology, IMCR/Gunma University, JapanPh.D. Candidate and Postdoctoral Research Fellow (2002-2003)
  4. Animal Physiology & Biochemistry, College of Biology, China Agricultural University, China, Research Associate (1994-1997).
Teaching Experience

Histology and Embryology

Reproductive Biology

Honors & Distinctions

  1. CAS“100 Talents”Program Recipient (Institute of Zoology/Chinese Academy of Sciences, China), 2009
  2. NIH Fellows Award for Research Excellence (NIH), 2007, 2008          
  3. NIDDK Nancy Nossal Fellowship Award (formerly NIDDK Scientific Director’s Fellowship Awards, NIDDK/NIH) - Comparable to National Research Service Award, 2005
  4. NIDDK Visiting Fellowship (NIDDK/NIH, USA), 7/2004-2008
  5. NIA Visiting Fellowship (NIA/NIH, USA), 10/2003-6/2004     
  6. Postdoctoral Fellowship for Foreign Researchers (Japan Society for the Promotion of Science, JSPS), 4/2002-9/2003       
  7. Yoneyama Doctor Course Scholarship (Rotary Yoneyama Memorial Foundation, Japan), 4/2001-3/2002 

Publications

   
Papers


  1.  Wang X, Qin D, Lu X, Li L*. An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese). Scientia Sinica Vitae. (2018, in press).

  2. Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology. 2018 May; 20(5): 535–540. doi: 10.1038/s41556-018-0087-2.

  3. Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z*, Li L*. Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis. Biology Open. 2018, Mar; 7(3). bio032508.

  4. Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L*. ZBED3 participates in the subcortical maternal complex and regulates the distribution of organelles. Journal of Molecular Cell Biology. 2018 Feb; 10(1): 74-88.

  5. Yu Y, Wang X, Zhang Z, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z*, Li L*. Inhibition of ERK promotes neuroectodermal commitment of EpiSCs by preventing self-renewal and primitive streak formation. Stem Cell Research & Therapy. 2018 Jan; 9(1): 2. doi: 10.1186/s13287-017-0750-8.

  6. Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F. Wang J, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification. Nature Genetics. 2018 Jan; 50(1): 96-105.

  7. Lu X, Gao Z, Qin D, Li L*. A Maternal Functional Module in the Mammalian Oocyte-To-Embryo Transition. Trends in Molecular Medicine.  2017 Nov; 23 (11) 1014–1023.

  8. Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S*. MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. Journal of Endocrinology. 2017 Jul; 234(1):1-14. doi: 10.1530/JOE-16-0488.

  9. Nie X, Lu X, Li L*. First cell lineage specification in mammalian early development (in Chinese). Chinese Science Bulletin. 2017 May; 62(15), 1569-1577.

  10. Liu W Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S*, Yi Z*, Li L*. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nature Communications. 2017 Jan 27; 8:14182.

  11. Xiao Y, Ma H, Wan P, Qin D, Zhang X, Xiang Y, Wang X, Liu W, Chen J*, Yi Z*, and Li L*. Trp-Asp (WD) repeat domain 1 is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. Journal of Biological Chemistry. 2017 Jan 27; 292(4):1438-1448. 2016 Dec 19. pii: jbc.M116.759886. [Epub ahead of print]

  12. Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L*. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis. Journal of Molecular Cell Biology. 2016 Aug; 8(4):366-8.

  13. Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q*,Li L*. MicroRNA-127 promotes primitive streak formation by targeting left-right determination factor 2. Journal of Biological Chemistry. 2016 Jun 3; 291(23):12126-35.

  14. Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H,  Huang J, Yi Z, Gao S*, Li L*. Maternal BCAS2 protects genomic integrity in mouse early embryonic development.Development. 2015 Nov 15; 142 (22):3943-53.

  15. Zhao Z, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y , Zhang X-X, Wang H, Li L*. The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biology. 2015 Aug; 5(8).

  16. Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W,Li L, Zhang R, Zheng P. Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell Stem Cell. 2015 Apr 29.

  17. Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J*,Li L*. Identification of a human subcortical maternal complex. Molecular Human Reproduction. 2015 Apr; 21(4): 320-9.

  18. Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J*, Li L*. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nature Communications. 2014 Sep 11; 5:4887.

  19. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.Cell Research. 2014 Aug; 24(8): 925-42.

  20. Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F*, Gao S*, Wang H*. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biology of Reproduction. 2014 Mar; 90(3): 52, 1-11.

  21. Li L*, Lu X and Dean J*. The maternal to zygotic transition in mammals. Molecular Aspects of Medicine. 2013 Oct; 34(5): 919-38.

  22. Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X*, Fan Z*. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. The EMBO Journal. 2013 Oct; 32(20): 2685-96.

  23. Wang J, Xu M, Zhu K, Li L*, Liu X*. The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA. PLoS ONE. 2012; 7(1): e30209.

  24. Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY, Shi Q*. Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes. PLoS ONE. 2012; 7(1): e29735.

  25. Li L*, Zheng P and Dean J*. Maternal control of early mouse development. Development. 2010Mar; 137(6): 859-70.

  26. Li L*, Baibakov B and Dean J. A subcortical maternal complex essential for pre-implantation mouse embryogenesis. Developmental Cell. 2008 Sep; 15(3): 416-25.

  27. Ohsugi M, Zheng P, Baibakov B, Li L, Dean J*. Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 2008 Jan; 135(2): 259-69.

  28. Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I*. Promotion of b-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas. Diabetes. 2004 Oct; 53(10): 2596-2602.

  29. Li L, Yi Z, Seno M, and Kojima I*. Activin A and Betacellulin: Effect on Regeneration of Pancreatic b-Cells in Neonatal Streptozotocin-treated Rats, Diabetes. 2004 Mar; 53(3): 608-615.

  30. Li L, Seno M, Yamada H, and Kojima I*. Betacellulin Improved Glucose Metabolism by Promoting Conversion of Intra-islet Precursor Cells to-cells in Streptozotocin-treated Diabetic Mice, Am J Physiol Endocrinol Metab. 2003 Sep; 285(3): E577-83. 

  31. Li L, Seno M, Yamada H, and Kojima I*. Promotion of Beta-cell Regeneration by Betacellulin in 90% Pancreatectomized Rats. Endocrinology. 2001 Dec; 142(12): 5379-85.



Patents
   

Research Interests

1) Maternal control of mammalian early embryogenesis.
2) Cell lineage specification of early embryonic development.
3) Molecular mechanism of mammalian gametogenesis.

Conferences

   

Collaboration

   

Students

已指导学生

宇兴江  博士研究生  071008-发育生物学  

徐倩华  博士研究生  071008-发育生物学  

朱恺  博士研究生  071008-发育生物学  

马怀孝  硕士研究生  071008-发育生物学  

余洋  博士研究生  071008-发育生物学  

肖翼  博士研究生  071008-发育生物学  

高征  博士研究生  071008-发育生物学  

卢绪坤  博士研究生  100101-人体解剖与组织胚胎学  

马海霞  博士研究生  071008-发育生物学  

林宇轩  硕士研究生  071008-发育生物学  

马怀孝  博士研究生  100101-人体解剖与组织胚胎学  

何波  博士研究生  100101-人体解剖与组织胚胎学  

现指导学生

秦丹丹  博士研究生  100101-人体解剖与组织胚胎学  

王晓晓  博士研究生  100101-人体解剖与组织胚胎学  

全裕军  博士研究生  100101-人体解剖与组织胚胎学  

任伟倩  硕士研究生  100101-人体解剖与组织胚胎学  

张嘉祺  博士研究生  100101-人体解剖与组织胚胎学  

聂晓庆  博士研究生  100101-人体解剖与组织胚胎学  

王琪智  硕士研究生  100101-人体解剖与组织胚胎学