1. State Key Laboratory of Stem Cell and Reproductive Biology, IOZ/ Chinese Academy of Sciences, China, Professor  (2009-present)
2. Laboratory of Cellular and Developmental Biology, NIDDK /National Institute of Health, USA，Visiting/Research Fellow (2003-2009)
3. Department of Cell Physiology, IMCR/Gunma University, Japan，Ph.D. Candidate and Postdoctoral Research Fellow (2002-2003)
4. Animal Physiology & Biochemistry, College of Biology, China Agricultural University, China, Research Associate (1994-1997).

Histology and Embryology

Reproductive Biology

1. CAS“100 Talents”Program Recipient (Institute of Zoology/Chinese Academy of Sciences, China), 2009
2. NIH Fellows Award for Research Excellence (NIH), 2007, 2008          
3. NIDDK Nancy Nossal Fellowship Award (formerly NIDDK Scientific Director’s Fellowship Awards, NIDDK/NIH) - Comparable to National Research Service Award, 2005
4. NIDDK Visiting Fellowship (NIDDK/NIH, USA), 7/2004-2008
5. NIA Visiting Fellowship (NIA/NIH, USA), 10/2003-6/2004     
6. Postdoctoral Fellowship for Foreign Researchers (Japan Society for the Promotion of Science, JSPS), 4/2002-9/2003       
7. Yoneyama Doctor Course Scholarship (Rotary Yoneyama Memorial Foundation, Japan), 4/2001-3/2002 

1. Quan Y, Wang M, Xu C, Wang X, Qin D, Lin Y, Lu X, Lu F, Li L. Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition. Nucleic Acids Research. 2022 May 6;50(8):4414-4435. doi: 10.1093/nar/gkac236.

2. Xiong Z, Xu K, Lin Z, Kong F, Wang Q, Quan Y, Sha Q, Li F, Zou Z, Liu L, Ji S, Chen Y, Zhang H, Fang J, Yu G, Liu B, Wang L, Wang H, Deng H, Yang X, Fan H, Li L, Xie W. Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development. Nature Cell Biology. 2022. doi:10.1038/s41556-022-00928-6.

3. Wang Z, Zhang J, Li L. In vitro investigation of mammalian early embryonic development (in Chinese). Hereditas (Beijing). 2022 Apr 20;44(4):269-274. doi: 10.16288/j.yczz.22-034.

4. Quan Y, Wang X, Li L. In vitro investigation of mammalian peri-implantation embryogenesis. Biology of Reproduction. 2022 Mar 16; ioac055. doi: 10.1093/biolre/ioac055. Online ahead of print.

5. Zhang J, Liu W, Li G, Xu C, Nie X, Qin D, Wang Q, Lu X, Liu J, Li L. BCAS2 is involved in alternative splicing and mouse oocyte development. FASEB Journal. 2022 Feb;36(2):e22128. doi: 10.1096/fj. 202101279R.

6. Wang X, Lu X, Xiang Y, Li L. Ash2l-1 is essential for mouse early hematopoietic development of yolk sac (in Chinese). Progress in Biochemistry and Biophysics. 2021; 48(2): 192~203. Doi: 10.16476/j. pibb.2020.0237.

7. Wang X, Xiang Y, Yu Y, Wang R, Zhang Y, Xu Q, Sun H, Zhao Z, Jiang X, Wang X, Lu X, Qin D, Quan Y, Zhang J, Shyh-Chang N, Wang H, Jing N, Xie W, Li L. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Research 2021 May; 31(5): 526-541.  doi.org/10.1038/s 41422-021 -00477-x. 

8. Shyn-Chang N and Li L. Stabilizing formative pluripotent states with germ cell competency. Cell Stem Cell. 2021 Mar; 28(3): 361-363. doi.org/10.1016/j.stem.2021.02.021.

9. Ma H, Wang H, Zheng P, Li L. Comments on 'In vitro culture of cynomolgus monkey embryos beyond early gastrulation'. Journal of Molecular Cell Biology. 2020 Jun 11; 12(5): 400-402. doi: 10.1093/jmcb/ mjz108.

10.  Xiang Y, Zhang Y, Xu Q, Zhou C, Liu B, Du Z, Zhang K, Zhang B, Wang X, Gayen S, Liu L, Wang Y, Li Y, Wang Q, Kalantry S, Li L, Xie W. Epigenomic analysis of gastrulation reveals a unique chromatin state for primed pluripotency. Nature Genetics. 2020 Jan; 52(1): 95-105. doi: 10.1038/s41588-019-0545-1. Epub 2019 Dec 16.

11.  Ma H, Zhai J, Wan H, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao Z, Zhao B, Zheng P, Li L, Wang H.In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019 Oct 31. pii: eaax7890. doi: 10.1126/science.aax7890. [Epub ahead of print]. (Perspective in Science, This Week in Science, News in focus in Nature).

12.  Qin D, Gao Z, Xiao Y, Zhang X, Ma H, Yu X, Nie X, Fan N, Wang X, OuYang Y, Sun QY, Yi Z, Li L. The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Development. 2019 Oct 18; 146(20). pii: dev183616. doi: 10.1242/dev.183616.

13.  Du J, Fan Y, Guo Z, Wang Y, Zheng X, Huang C, Liang B, Gao L, Cao Y, Chen Y, Zhang X, Li L, Xu L, Wu C, Weitz D, Feng X. Compression generated by a 3D supracellular actomyosin cortex promotes embryonic stem cell colony growth and expression of Nanog and Oct4. Cell Systems. 2019 Aug 28; 9(2): 214-220.e5.

14.  Jiang Z, Guang L, Li L, Shyh-Chang N. Putting stem cells on a low-fat diet switches their pluripotent state. Cell Stem Cell. 2019 Jul; 25(1): 3-5.

15.  Meng T, Lu X, Guo L, Hou G, Ma X, Li Q, Huang L, Fan L, Zhao Z, Ou X, OuYang Y, Schatten H, Li L, Wang Z, Sun QY. Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB Journal. 2019 Jan; 33(1):1179-1187.

16.  Wang X, Qin D, Lu X, Li L. An oocyte-embryo-specific subcortical maternal complex in mammals (in Chinese). Scientia Sinica Vitae.2018 Jun; 48(6), 609-617.

17.  Zhang Y, Zhang X, Shi J, Tuorto F, Li X, Liu Y, Liebers R, Zhang L, Qu Y, Qian J, Pahima M, Liu Y, Yan M, Cao Z, Lei X, Cao Y, Peng H, Liu S, Wang Y, Zheng H, Woolsey R, Quilici D, Zhai Q, Li L, Zhou T, Yan W, Lyko F, Zhang Y, Zhou Q, Duan E, Chen Q. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs. Nature Cell Biology. 2018 May; 20(5): 535–540.

18.  Lu X, Zhao Z, Wang X, Zhang X, Zhai Y, Deng W, Yi Z, Li L. Whole-transcriptome splicing profiling of E7.5 mouse primary germ layers reveals frequent usage of alternative promoter during early embryogenesis. Biology Open. 2018, Mar; 7(3). bio032508.

19.  Gao Z, Zhang X, Yu X, Qin D, Yu Y, Liu W, Xiang Y, Xiao Y, Lu X, Yi Z, Li L. Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles. Journal of Molecular Cell Biology. 2018 Feb; 10(1): 74-88.

20.  Yu Y, Wang X, Zhang X, Zhai Y, Lu X, Ma H, Zhu K, Zhao T, Jiao J, Zhao Z, Li L. ERK inhibition promotes neuroectodermal precursor commitment by blocking self-renewal and primitive streak formation of the epiblast. Stem Cell Research & Therapy. 2018 Jan; 9(1): 2. doi: 10.1186/s13287-017 -0750-8.

21. Zhang Y, Xiang Y, Yin Q, Du Z, Peng X, Wang Q, Fidalgo M, Xia W, Li Y, Zhao Z, Zhang W, Ma J, Xu F, Wang J, Li L, Xie W. Dynamic epigenomic landscapes during early lineage specification. Nature Genetics. 2018 Jan; 50(1): 96-105.

22.  Lu X, Gao Z, Qin D, Li L. A maternal functional module in the mammalian oocyte-to-embryo transition. Trends in Molecular Medicine. 2017 Nov; 23 (11) 1014–1023.

23.  Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S. MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production. Journal of Endocrinology. 2017 Jul; 234(1):1-14.

24.  Nie X, Lu X, Li L. First cell lineage specification in mammalian early development (in Chinese). Chinese Science Bulletin. 2017 May; 62(15), 1569-1577.

25.  Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S, Yi Z, Li L. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nature Communications. 2017 Jan; 8: 14182.

26.  Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, Xiang Y, Liu W, Chen J, Yi Z, Li L. Trp-Asp (WD) repeat domain 1 is essential for mouse peri-implantation development and regulates Cofilin phosphorylation. Journal of Biological Chemistry. 2017 Jan; 292(4): 1438-1448.

27.  Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis. Journal of Molecular Cell Biology. 2016 Aug; 8(4): 366-8.

28.  Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q, Li L. MicroRNA-127 promotes primitive streak formation by targeting left-right determination factor 2. Journal of Biological Chemistry. 2016 Jun; 291 (23): 12126-35.

29.  Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H, Huang J, Yi Z, Gao S, Li L. Maternal BCAS2 protects genomic integrity in mouse early embryonic development.Development. 2015 Nov; 142 (22): 3943-53.

30.  Zhao Z, Yu Y, Ma H, Wang X, Lu X, Zhai Y , Zhang X, Wang H, Li L. The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biology. 2015 Aug; 5(8). pii: 150092.

31.  Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P. Filia is an ESC-specific regulator of DNA damage response and safeguards genomic stability. Cell Stem Cell. 2015 Jun; 16 (6): 684-98.

32.  Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J, Li L. Identification of a human subcortical maternal complex. Molecular Human Reproduction. 2015 Apr; 21(4): 320-9.

33.  Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J, Li L. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nature Communications. 2014 Sep; 5: 4887.

34.  Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang Y, Li B, Chen Q, Duan E, Wang H. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Research. 2014 Aug; 24(8): 925-42.

35.  Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang Y, Li L, Wang F, Gao S, Wang H. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biology of Reproduction. 2014 Mar; 90(3): 52, 1-11.

36.  Li L, Lu X and Dean J. The maternal to zygotic transition in mammals. Molecular Aspects of Medicine.2013 Oct; 34(5): 919-38.

37.  Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO Journal. 2013 Oct; 32(20): 2685-96.

38.  Wang J, Xu M, Zhu K, Li L, Liu X. The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA. PLoS ONE. 2012; 7(1): e30209.

39.  Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY, Shi Q. Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes. PLoS ONE. 2012; 7(1): e29735.

40.  Li L, Zheng P and Dean J. Maternal control of early mouse development. Development. 2010 Mar; 137(6): 859-70.

41.  Li L, Baibakov B and Dean J. A subcortical maternal complex essential for pre-implantation mouse embryogenesis. Developmental Cell. 2008 Sep; 15(3): 416-25.

42.  Ohsugi M, Zheng P, Baibakov B, Li L, Dean J. Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development. 2008 Jan; 135(2): 259-69.

43.  Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I. Promotion of b-cell differentiation by Conophylline in fetal and neonatal rat pancreas. Diabetes. 2004 Oct; 53(10): 2596-2602.

44.  Li L, Yi Z, Seno M, and Kojima I. Activin A and Betacellulin: effect on regeneration of pancreatic b-cells in neonatal streptozotocin-treated rats. Diabetes. 2004 Mar; 53(3): 608-615.

45.  Li L, Seno M, Yamada H, and Kojima I. Betacellulin improved glucose metabolism by promoting conversion of intra-islet precursor cells to b-cells in streptozotocin-treated diabetic mice. American Journal of Physiology - Endocrinology and Metabolism. 2003 Sep; 285(3): E577-83.

46.  Li L, Seno M, Yamada H, and Kojima I. Promotion of b-cell regeneration by Betacellulin in 90% pancreatectomized rats. Endocrinology. 2001 Dec; 142(12): 5379-85.

1) Maternal control of mammalian early embryogenesis.
2) Cell lineage specification of early embryonic development.
3) Molecular mechanism of mammalian gametogenesis.

已指导学生

宇兴江  博士研究生  071008-发育生物学  

徐倩华  博士研究生  071008-发育生物学  

朱恺  博士研究生  071008-发育生物学  

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