071008-发育生物学
071009-细胞生物学

细胞内信号传导通路的异常与疾病发生的分子基础
干细胞自我更新及维持的调控机理

2004-03--2008-09   美国西南医学中心   博士后
2001-08--2004-02   哈佛大学医学院   博士后
1996-09--2001-07   北京大学   博士

   

2008-10~现在, 中科院上海生化细胞所, 研究员
2004-03~2008-09,美国西南医学中心, 博士后
2001-08~2004-02,哈佛大学医学院, 博士后
1996-09~2001-07,北京大学, 博士

2023-01-01-今,上海市第十四届政协委员,
2023-01-01-今,北京大学“细胞增殖与分化”教育部重点实验室学术委员会委员（2023-）,
2022-12-01-今,九三学社第十二次全国代表大会代表,
2022-12-01-今,九三学社第十五届中央委员,
2022-11-01-今,欧美同学会徐汇分会第二届理事会副会长,
2022-07-01-今,九三学社上海市第十八届委员会常委,
2022-01-01-今,九三学社社市委科技委副主任,
2022-01-01-今,北京师范大学教育部细胞增殖及调控生物学重点实验室学术委员会委员,
2022-01-01-今,山东大学山东省动物细胞与发育生物学重点实验室学术委员会委员,
2016-01-01-2021-12-31,第三届发育生物学专业委员会委员,
2015-01-01-2020-12-31,中国细胞生物学学会第十一届理事会理事,

   

（1） 细胞凋亡与NF-kappaB激活的信号传导研究, 一等奖, 部委级, 2006
（2） 全国优秀博士学位论文, 一等奖, 部委级, 2003
（3） 非细胞体系核重建（装配）的系统研究, 一等奖, 部委级, 2001

（ 1 ） KREMEN1和/或ASGR1作为药物靶点在治疗SARS-CoV-2感染中的应用, 2021, 第 3 作者, 专利号: CN113862326A

（ 2 ） 一种分离的多肽及其在制备肿瘤免疫治疗产品中的用途, 2021, 第 1 作者, 专利号: 2021122102553640

（ 3 ） CD300LD抑制剂在制备预防、诊断或治疗肿瘤产品中的用途, 2021, 第 1 作者, 专利号: CN/2021122102553640

（ 4 ） Hilnc或包含其的信号通路作为调控脂质代谢的靶标的应用, 2021, 第 1 作者, 专利号: CN/202111153217.2

（ 5 ） 用于治疗胃癌的环肽及其药物组合物, 2021, 第 6 作者, 专利号: CN113583088A

（ 6 ） Gli1和EpCAM基因共同标记的肝祖细胞群及其应用, 2020, 第 1 作者, 专利号: CN/202011034452.3

（ 7 ） 通佐溴胺在治疗胃癌中的用途, 2020, 第 5 作者, 专利号: CN110833546A

   

（1） Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis., Cell Research, 2023, 
（2） Identification of a rare Gli1(+) progenitor cell population contributing to liver regeneration during chronic injury, CELL DISCOVERY, 2022, 通讯作者
（3） Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2, Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2, CELL RESEARCH, 2022, 通讯作者
（4） Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression, CANCER SCIENCE, 2022, 通讯作者
（5） Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae, STRUCTURE, 2021, 通讯作者
（6） An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis, ADVANCED SCIENCE, 2021, 第11作者
（7） Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediatedMAPK signaling, Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling, CANCER COMMUNICATIONS, 2021, 通讯作者
（8） Loss of Hilnc prevents diet-induced hepatic steatosis through binding of IGF2BP2, NATURE METABOLISM, 2021, 通讯作者
（9） Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release, FRONT MOL BIOSCI, 2021, 通讯作者
（10） The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice, HEPATOLOGY, 2020, 第 14 作者
（11） Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation, CELLREPORTS, 2020, 第 16 作者
（12） Tendon-derived cathepsin K-expressing progenitor cells activate Hedgehog signaling to drive heterotopic ossification, JOURNAL OF CLINICAL INVESTIGATION, 2020, 第 10 作者
（13） Methylation of PLK1 by SET7/9 ensures accurate kinetochore–microtubule dynamics, Methylation of PLK1 by SET7/9 ensures accurate kinetochore-microtubule dynamics, JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 第 16 作者
（14） Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer, CANCER CELL, 2020, 第 15 作者
（15） Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila, CELL DISCOVERY, 2020, 通讯作者
（16） MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway, JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 第 10 作者
（17） PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila, CELL DISCOVERY, 2019, 通讯作者
（18） Architecture, substructures, and dynamic assembly of STRIPAK complexes in Hippo signaling, CELL DISCOVERY, 2019, 第11作者
（19） Dual function of VGLL 4 in muscle regeneration, THE EMBO JOURNAL, 2019, 第 14 作者
（20） Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci), Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci), JOURNAL OF MOLECULAR CELL BIOLOGY, 2018, 通讯作者
（21） Staurosporine targets the Hippo pathway to inhibit cell growth, JOURNAL OF MOLECULAR CELL BIOLOGY, 2018, 第 9 作者
（22） The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 14 作者
（23） Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila, Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila, JOURNAL OF MOLECULAR CELL BIOLOGY, 2018, 通讯作者
（24） UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing, EMBO Reports, 2017, 通讯作者
（25） Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity, DEVELOPMENT, 2017, 第11作者
（26） Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling, MOLECULAR CELL, 2017, 第 14 作者
（27） Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system., PLOS BIOLOGY, 2017, 第 5 作者
（28） Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis, SCIENTIFIC REPORTS, 2017, 通讯作者
（29） A positive role for polycomb in transcriptional regulation via H4K20me1, CELL RESEARCH, 2016, 通讯作者
（30） Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription, SCIENTIFIC REPORTS, 2016, 通讯作者
（31） Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway in mammals., ELIFE, 2016, 通讯作者
（32） SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis, Development, 2016, 通讯作者
（33） Gut–neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila, CELL DISCOVERY, 2015, 通讯作者
（34） Sqh is involved in the regulation of Ci stability in Hh signaling pathway, JOURNAL OF MOLECULAR CELL BIOLOGY, 2015, 通讯作者
（35） Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling, DEVELOPMENTAL CELL, 2015, 第 6 作者
（36） Decoding Ci: From partial degradation to inhibition, DEVELOPMENT GROWTH & DIFFERENTIATION, 2015, 通讯作者
（37） Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET., METHODS IN MOLECULAR BIOLOGY (CLIFTON, N.J.), 2015, 第 4 作者
（38） Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling, DEVELOPMENTAL BIOLOGY, 2014, 通讯作者
（39） Haiquan Chen# and Hongbin Ji#. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, Cancer Letters., 2014, 通讯作者
（40） aPKC tau/lambda: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 通讯作者
（41） Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism, STRUCTURE, 2013, 通讯作者
（42） Hedgehog in the Drosophila testis niche:what does it do there?, Hedgehog in the Drosophila testis niche: what does it do there?, PROTEIN & CELL, 2013, 通讯作者
（43） Atrophin–Rpd3 Complex Represses Hedgehog Signaling by Acting as a Corepressor of CiR, JOURNAL OF CELL BIOLOGY, 2013, 通讯作者
（44） Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci, NATURE COMMUNICATIONS, 2013, 通讯作者
（45） Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction*, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 7 作者
（46） Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling, ELIFE, 2013, 第11作者
（47） Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis, CELL RESEARCH, 2013, 通讯作者
（48） Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation, DEVELOPMENTAL CELL, 2013, 第 9 作者
（49） Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling, JOURNAL OF CELL SCIENCE, 2013, 通讯作者
（50） A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity, CELL RESEARCH, 2013, 第 10 作者
（51） ctivation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover., PLoS Biology, 2013, 通讯作者
（52） Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association, PLOS BIOLOGY, 2013, 第 16 作者
（53） Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus (Ci), Cell Research, 2011, 通讯作者
（54） G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependentand kinase-independent mechanisms in Drosophila, GENES AND DEVELOPMENT, 2010, 第 4 作者
（55） Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss., PLOS GENETICS, 2010, 第 3 作者
（56） Small-Molecule Inhibitors Reveal Multiple Strategies for Hedgehog Pathway Blockade, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 第 4 作者
（57） Hedgehog regulates smoothened activity by inducing a conformational switch, NATURE, 2007, 第 1 作者
（58） Transducing the Hedgehog signal across the plasma membrane, FLY, 2007, 第 1 作者
（59） Failure of elastic fiber homeostasis leads to pelvic floor disorders, AMERICAN JOURNAL OF PATHOLOGY, 2006, 
（60） Hedgehog-Regulated Costal2-Kinase Complexes Control Phosphorylation and Proteolytic Processing of Cubitus Interruptus, DEVELOPMENTAL CELL, 2005, 
（61） Elastic fiber homeostasis requires lysyl oxidase-like 1 protein, NATURE GENETICS, 2004, 
（62） The Retinitis Pigmentosa GTPase Regulator (RPGR)-Interacting Protein: Subserving RPGR Function and Participating in Disk Morphogenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 
（63） Effect of phosphocreatine on apoptosis induced in Xenopus cell-free system, JBC, 2001, 第 1 作者
（64） Analysis of nuclear apoptotic process in a cell-free system, CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 
（65） In vitro nuclear reconstitution could be induced in a plant cell-free system, FEBS LETTERS, 2000, 
（66） Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells, FEBS LETTERS, 1999, 
（67） The Kto-Skd Complex Can Regulate ptc Expression by Interacting with Cubitus interruptus (Ci) in the Hedgehog Signaling Pathway *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 10 作者
（68） Dimerization and Cytoplasmic Localization Regulate Hippo Kinase Signaling Activity in Organ Size Control *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 8 作者

   

（ 1 ） Hh 信号通路中Ci SUMO 化修饰的作用机制及功能研究, 负责人, 国家任务, 2014-01--2017-12
（ 2 ） 发育中PRC1调控H h信号通路Ci/Gli转录的分子机制及功能研究, 负责人, 国家任务, 2017-01--2021-12
（ 3 ） 着丝粒蛋白质机器调控细胞命运抉择的效应机制, 参与, 国家任务, 2017-07--2022-06
（ 4 ） 重要器官细胞增殖与分化过程中关键蛋白质机器的动态调控网络及机制, 负责人, 国家任务, 2020-11--2025-10
（ 5 ） Hilnc调控脂肪代谢的生物学功能及机制研究, 负责人, 国家任务, 2022-01--2026-12
（ 6 ） 肝脏损伤修复过程中蛋白质群体的在体功能机制研究, 负责人, 国家任务, 2023-01--2027-12

（1）Mechanism of the graded Hh signal transduction   厦门举办的第三届“模式生物与人类健康”发育遗传学全国学术研讨会。   2014-07-18
（2）Mechanism of the graded Hh signal transduction。   台北举办的2014 国际癌症新知研讨会/第十一届前瞻生物医学科学新知研讨会暨第十三届海峡两岸生物医学研讨会   2014-06-28
（3）Decoding Ci: from partial degradation to inhibition   第47 届亚太地区发育生物学年会   2014-05-30
（4）Ter94 is involved the selective degradation of Ci   新加坡参加会议   2013-10-08