基本信息
赵允  男  博导  中国科学院分子细胞科学卓越创新中心
电子邮件: yunzhao@sibcb.ac.cn
通信地址: 上海岳阳路320号
邮政编码: 200031

招生信息

   
招生专业
071008-发育生物学
071009-细胞生物学
招生方向
细胞内信号传导通路的异常与疾病发生的分子基础
干细胞自我更新及维持的调控机理

教育背景

2004-03--2008-09   美国西南医学中心   博士后
2001-08--2004-02   哈佛大学医学院   博士后
1996-09--2001-07   北京大学   博士

工作经历

   
工作简历
2008-10~现在, 中科院上海生化细胞所, 研究员
2004-03~2008-09,美国西南医学中心, 博士后
2001-08~2004-02,哈佛大学医学院, 博士后
1996-09~2001-07,北京大学, 博士
社会兼职
2016-01-01-2021-12-31,第三届发育生物学专业委员会委员,
2015-01-01-2020-12-31,中国细胞生物学学会第十一届理事会理事,

专利与奖励

   
奖励信息
(1) 细胞凋亡与NF-kappaB激活的信号传导研究, 一等奖, 部委级, 2006
(2) 全国优秀博士学位论文, 一等奖, 部委级, 2003
(3) 非细胞体系核重建(装配)的系统研究, 一等奖, 部委级, 2001
专利成果
( 1 ) VGLL4基因治疗肿瘤的用途及其相关药物, 2013, 第 4 作者, 专利号: 201310493193.4

出版信息

   
发表论文
(1) Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis, Scientific Reports, 2017, 通讯作者
(2) Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-β2 nuclear import system, PLoS Biology, 2017, 通讯作者
(3) UbcD1 regulates the Hedgehog signaling by directly controlling Ci ubiquitination and processing, EMBO Reports, 2017, 通讯作者
(4) SUMO regulates somatic cyst stem cells maintenance and directly targets Hedgehog pathway in adult Drosophila testis, Development, 2016, 通讯作者
(5) A positive role for polycomb in transcriptional regulation via H4K20me1, Cell Research, 2016, 通讯作者
(6) Set7 mediated Gli3 methylation plays a positive role in the activation of Sonic Hedgehog pathway, eLIFE, 2016, 通讯作者
(7) Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription, Scientific Reports., 2016, 通讯作者
(8) Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling, Developmental Cell., 2015, 通讯作者
(9) Decoding Ci: From partial degradation to inhibition, Development, Growth & Differentiation, 2015, 通讯作者
(10) Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila, Cell Discovery, 2015, 通讯作者
(11) Investigation of protein-protein interactions and conformational changes in Hedgehog signaling pathway by FRET, Methods in Molecular Biology, Hedgehog Signaling Protocols (Second Edition, Springer Science), Chapter 6., 2015, 通讯作者
(12) Sqh is involved in the regulation of Ci stability in Hh signaling pathway., Journal of Molecular Cell Biology, 2015, 通讯作者
(13) Haiquan Chen# and Hongbin Ji#. Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, Cancer Letters., 2014, 通讯作者
(14) Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling, Developmental Biology., 2014, 通讯作者
(15) The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway., Journal of Biological Chemistry., 2014, 通讯作者
(16) Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism, Structure., 2013, 通讯作者
(17) Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis., Cell Research, 2013, 通讯作者
(18) Hedgehog in the Drosophila testis niche: what does it do there?, Protein and Cell, 2013, 通讯作者
(19) Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction, Journal of Biological Chemistry., 2013, 通讯作者
(20) Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association., PLoS Biology, 2013, 通讯作者
(21) A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity., Cell Research, 2013, 通讯作者
(22) Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling., Journal of Cell Science, 2013, 通讯作者
(23) Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling, eLIFE., 2013, 通讯作者
(24) Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci., Nature Communications., 2013, 通讯作者
(25) ctivation of Smurf E3 ligase promoted by Smoothened regulates Hedgehog signaling through targeting Patched turnover., PLoS Biology, 2013, 通讯作者
(26) Ter94 ATPase Complex Targets K11-linked Ubiquitinated Ci to Proteasomes for Partial Degradation. ., Developmental Cell, 2013, 通讯作者
(27) Atrophin/Rpd3 complex represses Hedgehog signaling by acting as a co-repressor of CiR, Journal of Cell Biology, 2013, 通讯作者
(28) aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC, Acta Biochimica et Biophysica Sinica., 2013, 通讯作者
(29) aPKC ι/λ: a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC, Acta Biochimica et Biophysica Sinica., 2013, 通讯作者
(30) Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control, Journal of Biological Chemistry., 2012, 通讯作者
(31) Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus (Ci), Cell Research, 2011, 通讯作者
(32) G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila., Gene and Development, 2010, 第 4 作者
(33) Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss., PLoS Genet, 2010, 第 3 作者
(34) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade., PNAS, 2009, 通讯作者
(35) Transducing the Hedgehog Signal Across the plasma Membrane., Fly, 2007, 第 1 作者
(36) Hedgehog regulates Smoothened activity by inducing a conformational switch, Nature, 2007, 第 1 作者
(37) Failure of Elastic Fiber Homeostasis Leads to Pelvic Floor Disorders, Am J Pathol., 2006, 第 2 作者
(38) Hedgehog-regulated Costal2/kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus, Developmental Cell, 2005, 第 2 作者
(39) Elastic fiber homeostasis requires lysyl oxidase-like 1 protein., Nature Genetics, 2004, 第 2 作者
(40) The retinitis pigmentosa GTPase Regulator (RPGR)-interacting protein: Subserving RPGR function and participating in disk morphogenesis, PNAS, 2003, 第 1 作者
(41) Effect of phosphocreatine on apoptosis induced in Xenopus cell-free system, JBC, 2001, 第 1 作者
(42) Analysis of nuclear apoptotic process in a cell-free system, Cellular and Molecular Life Science, 2001, 第 1 作者
(43) In vitro nuclear reconstitution could be induced in a plant cell-free system, FEBS letters, 2000, 第 1 作者
(44) Apoptosis of mouse liver nuclei induced in the cytosol of carrot cells, FEBS letters, 1999, 第 1 作者

科研活动

   
科研项目
( 1 ) Hh 信号通路中Ci SUMO 化修饰的作用机制及功能研究, 主持, 国家级, 2014-01--2017-12
( 2 ) 发育中PRC1调控H h信号通路Ci/Gli转录的分子机制及功能研究, 主持, 国家级, 2017-01--2021-12
( 3 ) 着丝粒蛋白质机器调控细胞命运抉择的效应机制, 参与, 国家级, 2017-07--2022-06
参与会议
(1)Mechanism of the graded Hh signal transduction   厦门举办的第三届“模式生物与人类健康”发育遗传学全国学术研讨会。   2014-07-18
(2)Mechanism of the graded Hh signal transduction。   台北举办的2014 国际癌症新知研讨会/第十一届前瞻生物医学科学新知研讨会暨第十三届海峡两岸生物医学研讨会   2014-06-28
(3)Decoding Ci: from partial degradation to inhibition   第47 届亚太地区发育生物学年会   2014-05-30
(4)Ter94 is involved the selective degradation of Ci   新加坡参加会议   2013-10-08