Marine biology,Microbiology, Molecular biology, Marine ecology 

July,2002-september,1999: Ph.D. , Chinese Academy of Sciences，China.

  Major in marine microbiology. Specialized in fish diseases

July,1999-september,1996:M.S.,National Key Laboratory of Biotechnology for Tropical Agriculture, South China University of Tropical Agriculture.
  Major in biotechnology. Specialized in foreign protein expression in yeast system as well as plant genetic engineering.

July,1996-September,1992:B.A.,Department of Horticulture, South China University of Tropical Agriculture.  

Dec. 2013- Present: Professor and Director of Observe and Reseach Station of South China Sea,SCSIO,CAS
   In charge of ORSSCS, research on the coral diseases and bacteria communities in marine ecosystems.

Feb,2006-Nov,2013: Associate Professor, Key Laboratory of Applied Marine Biology of Guangdong Province. SCSIO. CAS.
   Work  on pathology, epidemiology and molecular biology of marine vibrios.  

April,2004-December ,2005: Post doctor , Department. of Molecular Biology, Umea University. Sweden.
    Work on the molecular mechanism of pathogenicity of Vibrio anguillarum.

June,2002- March,2004: Assistant professor. Department. of Applied Marine Biology, South China Sea Institute of Oceanology,Chinese Academy of Sciences. 

1.Zhuhong Liua, Chang Chen*, Lei Gao, Yuyang Zhang, Jingjing Pei, Chunhua Ren and Chaoqun Hu. 2016.Difference of microbial communities between healthy and bleached Acropora solitaryensis from Xisha Islands, South China Sea. Marine Biology Research. http://dx.doi.org/10.1080/17451000.1236201
2.Zheng Q, Lin W, Liu Y, Chen Chang, Jiao N. 2016. A Comparison of 14 Erythrobacter Genomes Provides Insights into the Genomic Divergence and Scattered Distribution of Phototrophs. Front Microbiol. 7:984. doi: 10.3389/fmicb.2016.00984.
3.Deng Y, Chen Chang*, Zhao Z, Zhao J, Jacq A, Huang X, Yang Y. 2016 .The RNA Chaperone Hfq Is Involved in Colony Morphology, Nutrient Utilization and Oxidative and Envelope Stress Response in Vibrio alginolyticus. PLoS One. Sep 29;11(9):e0163689. doi: 10.1371/journal.pone.0163689.
4.Deng Y, Chen Chang*, Zhao Z, Huang X, Yang Y, Ding X. 2016. Complete Genome Sequence of Vibrio alginolyticus ZJ-T. Genome Announc. 4(5). pii: e00912-16. doi: 10.1128/genomeA.00912-16.
5.Gao L, Deng YQ, Chen Chang*, Ke CW, Li BS, Long YY, Liu ZH, Wei L. 2016. Population Relationship of Vibrio parahaemolyticus Isolates Derived from Aquaculture Ponds, a Seafood Market, Restaurants, and Clinical Samples. Foodborne Pathog Dis. 13(6):333-42. doi: 10.1089/fpd.2015.2098.
6.Chen T, Ren C, Wang Y, Luo P, Jiang X, Huang W, Chen Chang, Hu C. 2016. Molecular cloning, inducible expression and antibacterial analysis of a novel i-type lysozyme (lyz-i2) in Pacific white shrimp, Litopenaeus vannamei. Fish Shellfish Immunol.54:197-203. doi: 10.1016/j.fsi.2016.04.008.
7.Ren C, Hu C, Jiang X, Sun H, Zhao Z, Chen Chang, Luo P. 2013. Distribution and pathogenic relationship of virulence associated genes among Vibrio alginolyticus from the mariculture systems. Mol Cell Probes. 27(3-4):164-8. doi: 10.1016/j.mcp.2013.01.004.
8.Chen Chang*, Wang Qing-bai, Hu Chao-qun et al. 2012. Characterization of role of the toxR gene in the physiology and pathogenicity of Vibrio alginolyticus. ANTON LEEUW INT J G.. 2012. 101(2):281-288.
9.Zuo H, Chen Chang*, Gao Y, Lin J, Jin C, Wang W. 2011. Regulation of shrimp PjCaspase promoter activity by WSSV VP38 and VP41B. Fish Shellfish Immunol. 30(4-5):1188-91. 
10.Zhe Zhao, Lvping Zhang, Chunhua Ren, Jingjing Zhao, Chen Chang*, Xiao Jiang, Peng Luo, Chaoqun Hu. 2011. Autophagy is induced by the type III secretion system of Vibrio alginolyticus in several mammalian cell lines. Arch Microbiol. 193(1):53-61
11.Chen Chang*, Jing-Jing Z, Chun-Hua R, et al. 2010. Deletion of valR, a homolog of Vibrio harveyi luxR generates an intermediate colony phenotype between opaque/rugose and translucent/smooth in Vibrio alginolyticus. Biofouling. 26(5):595-601
12.Jing-Bin Feng, Chao-Qun Hu, Peng Luo, Lv-Ping Zhang and Chen Chang. 2010. Microbiota of yellow grouper (Epinephelus awoora Temminck & Schlegel, 1842) fed two different diets. Aquaculture Research. DOI: 10.1111/j.1365-2109.2010.02481.
13.Liu Z. H., Chen W., Gao L., Zhao JJ, Ren C.H., Hu C. Q. and Chen Chang*. 2012. Analysis of bacteria associated with Acropora solitaryensis by culture-dependent and -independent methods. African Journal of Microbiology Research 6(24): 5205-5209. 
14.Zhe Zhao, Chen Chang, Chao-Qun Hu, Chun-Hua Ren, Jing-Jing Zhao, Lv-Ping Zhang, Xiao Jiang, Peng Luo and Qing-Bai Wang. 2010. The type III secretion system of Vibrio alginolyticus induces rapid apoptosis, cell rounding and osmotic lysis of fish cells. Microbiology. 2010, 156. 2864-2872. 
15.Chen Chang*, Jin X, Chaoqun H. 2009.Phenotypic and genetic differences between opaque and translucent colonies of Vibrio alginolyticus. Biofouling. 25(6):525-31. 
16.Weber B, Hasic M, Chen Chang, Wai SN.et al.. 2009. Type VI secretion modulates quorum sensing and stress response in Vibrio anguillarum. Environmental Microbiology. 11(12):3018–3028.
17.Antony Croxatto, Johan Lauritz,Chen Chang et al.. 2007. Vibrio anguillarum colonization of rainbow trout integument requires a DNA locus involved in exopoly -saccharide transport and biosynthesis. Environmental Microbiology. 2007. 9(2):370-382. 
18.Zhenyu Xie, Chaoqun Hu, Chang Chen,et al.. 2005, Investigation of seven Vibrio virulence genes among Vibrio alginolyticus and Vibrio parahaemolyticus strains from the coastal mariculture systems in Guangdong, China. Letters in Applied Microbiology, 41:202-207. 

现指导学生

刘助红  硕士研究生  070703-海洋生物学  

杨海朋  硕士研究生  070703-海洋生物学