Luo, Min-hua, Professor, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences (CAS), China.
Telephone: 027-87197600
Address: 44 Xiaohongshan, Wuhan, Hubei

Research Areas

1. Human Cytomegalovirus Infection and neuropathy:
  (1) congenital infection and birth defects;
  (2) persistent/latent infection and glioma.

2. Development of novel neural circuit tracing tool:
  (1) screening and identify novel neural tracing viruses;
  (2) developing novel neural tracing viral s.
  (3) tracing neural circuits with novel tools.


1996/09-1999/06:M.D./Ph.D. in Infectious Diseases, Hunan Medical University, China (Finish the project in Innsbruck University, Austria)

1992/09-1995/06:M.S. in Medical Microbiology, Hunan Medical University, China

1983/09-1988/06:B.S. in Clinic Medicine, Hunan Medical University, China


Work Experience
2009/07-now: Professor, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences (CAS), China

2004/12-2009/06: Research Scientist / Assistant Professor, University of Idaho, USA

2002/08-2004/11: Associate / Full Professor, Hunan Medical University, China. 

1999/07-2002/07: Postdoc, Harvard Medical School, USA.

1988/07-1999/07: Teaching Assistant / Lecturer, Hunan Medical University, China

Honors & Distinctions

2015,First prize, Technology Advancement Award in Hunan Province

2015, Award for Excellent Teacher of Zhuli-Yuehua Prize
2013, Second prize, Award for Excellent Scientific Research (Science and Technology) of Higher School
2008, Outstanding Research Scientist, University of Idaho, USA
2000, First prize, Excellent Thesis Award of Changsha, Hunan


1.   Liu XJ, Yang Y, Huang SN, Wu CC, Li XJ, Cheng S, Jiang X, Hu F, Ming YZ, Nevels M, Britt WJ, Rayner S, Tang Q, Zeng WB*, Zhao Z*, Luo MH*. Human Cytomegalovirus IE1 Downregulates Hes1 in Neural Progenitor Cells as a potential E3 Ubiquitin Ligase. PLoS Pathog. 2017; 13(7):e1006542.
2.  Zeng WB, Jiang HF, Gang YD, Song YG, Shen ZZ, Yang H, Dong X, Tian YL, Ni RJ, Liu Y, Tang N, Li X, Jiang X, Gao D, Androulakis M, He XB, Xia HM, Ming YZ, Lu Y, Zhou JN, Zhang C, Xia XS, Shu Y, Zeng SQ, Xu F*, Zhao F*, Luo MH*. Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129. Mol Neurodegener. 2017; 12:38.
3.   Jiang HF, Wang W, Jiang X, Zeng WB, Shen ZZ, Song YG, Yang H, Liu XJ, Dong X, Zhou J, Sun JY, Yu FL, Guo L, Cheng T, Rayner S, Zhao F, Zhu H*, Luo MH*. ORF7 of Varicella-Zoster Virus Is Required for Viral Cytoplasmic Envelopment in Differentiated Neuronal Cells. J Virol. 2017; 91(12). pii: e00127-17.
4.  Lu Y, Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y, and Zhu LQ.Impairments of spatial memory in Alzheimers's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017 Nov 22;8(1):1676. doi: 10.1038/s41467-017-01943-0.
5.  Cheng S, Jiang X, Yang B, Wen L, Zhao F, Zeng WB, Liu XJ, Dong X, Sun JY, Ming YZ, Zhu H, Rayner S, Tang Q, Fortunato E*, Luo MH*. Infected T98G glioblastoma cells support human cytomegalovirus reactivation from latency. Virology. 2017; 510:205-215.
6.  Zhao F, Jiang HF, Zeng WB, Shu Y, Luo MH*, Duan S. Anterograde Trans-Synaptic Tagging Mediated by Adeno-Associated Virus. Neurosci Bull. 2017; 33:348-350.
7.   Li Y, Xu J, Liu Y, Zhu J, Liu N, Zeng W, Huang N, Rasch MJ, Jiang H, Gu X, Li X, Luo MH, Li C, Teng J, Chen J, Zeng S, Lin L, Zhang X. A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning. Nat Neurosci. 2017; 20:559-570.
8.   Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB. Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Cell Host Microbe. 2017; 21:231-243.
9.  Li XJ, Liu XJ, Yang B, Fu YR, Zhao F, Shen ZZ, Miao LF, Rayner S, Chavanas S, Zhu H, Britt WJ, Tang Q, McVoy MA,Luo MH. 2015. Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells. Journal of virology. 
10. Fu YR, Liu XJ, Li XJ, Shen ZZ, Yang B, Wu CC, Li JF, Miao LF, Ye HQ, Qiao GH, Rayner S, Chavanas S, Davrinche C, Britt WJ, Tang Q, McVoy M, Mocarski E, Luo MH. 2015. MicroRNA miR-21 attenuates human cytomegalovirus replication in neural cells by targeting Cdc25a. Journal of virology 89:1070-1082.
11. Yang CQ, Miao LF, Pan X, Wu CC, Rayner S, Mocarski ES, Ye HQ, Luo MH. 2014. Natural antisense transcripts of UL123 packaged in human cytomegalovirus virions. Archives of virology 159:147-151.
12. Shen ZZ, Pan X, Miao LF, Ye HQ, Chavanas S, Davrinche C, McVoy M, Luo MH. 2014. Comprehensive analysis of human cytomegalovirus microRNA expression during lytic and quiescent infection. PloS one 9:e88531. 
13. Duan YL, Ye HQ, Zavala AG, Yang CQ, Miao LF, Fu BS, Seo KS, Davrinche C, Luo MH, Fortunato EA.     2014. Maintenance of large numbers of virus genomes in human cytomegalovirus-infected T98G glioblastoma cells. Journal of virology 88:3861-3873. 
14. Pan X, Li XJ, Liu XJ, Yuan H, Li JF, Duan YL, Ye HQ, Fu YR, Qiao GH, Wu CC, Yang B, Tian XH, Hu KH, Miao LF, Chen XL, Zheng J, Rayner S, Schwartz PH, Britt WJ, Xu J, Luo MH. 2013. Later passages of     neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection.   Journal of virology 87:10968-10979. 
15. Duan Y, Miao L, Ye H, Yang C, Fu B, Schwartz PH, Rayner S, Fortunato EA, Luo MH. 2012. A faster   immunofluorescence assay for tracking infection progress of human cytomegalovirus. Acta biochimica et   biophysica Sinica 44:597-605. 
16. Luo MH, Hannemann H, Kulkarni AS, Schwartz PH, O’Dowd JM, Fortunato EA. 2010. Human cytomegalovirus infection causes premature and abnormal differentiation of human neural progenitor cells. Journal of virology 84:3528-3541. 
17. Luo MH, Schwartz PH, Fortunato EA. 2008. Neonatal neural progenitor cells and their neuronal and   glial cell derivatives are fully permissive for human cytomegalovirus infection. Journal of virology   82:9994-10007. 
18. Luo MH, Rosenke K, Czornak K, Fortunato EA. 2007. Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. Journal of virology 81:1934-1950. 
19. Luo MH, Fortunato EA. 2007. Long-term infection and shedding of human cytomegalovirus in T98G glioblastoma cells. Journal of virology 81:10424-10436. 
20. Qiang L, Yu W, Andreadis A, Luo MH, Baas PW. 2006. Tau protects microtubules in the axon from severing by katanin. The Journal of neuroscience: the official journal of the Society for Neuroscience 26:3120-3129. 
21. Casavant NC, Luo MH, Rosenke K, Winegardner T, Zurawska A, Fortunato EA. 2006. Potential role for p53 in the permissive life cycle of human cytomegalovirus. Journal of virology 80:8390-8401.
22. Luo MH, Tse SW, Memmott J, Andreadis A. 2004. Novel isoforms of tau that lack the microtubule-   binding domain. Journal of neurochemistry 90:340-351. 

23. Luo MH, Leski ML, Andreadis A. 2004. Tau isoforms which contain the domain encoded by exon 6 and   their role in neurite elongation. Journal of cellular biochemistry 91:880-895.

24. Luo MH, Chen ML, Stoiber H, Dierich MP. 2004. Activation of mitogen activated protein kinases via complement receptor type 2. Chinese medical journal 117:1802-1808.


1. A faster economicimmunofluorescence assay for viral detection on coverslips. Patent No. ZL2013022100040060.
2. The construction method and application of the Human Cytomegalovirus infectious clone. Patent application No. 201510287275.2

3. The construction method and application of HSV1-H129-BAC and its variants. Patent application No. 2015110292388

4. Anterograde multi-synaptic transneuronal tracer, Patent application No. 201610976085.6
5. Anterograde monosynaptic transneuronal tracer system, Patent application No. 201610976316.3
6. Anterograde multi-synaptic transneuronal tracer, Patent application No. PCT/CN2016/104880
7. Anterograde monosynaptic transneuronal tracer system, Patent application No. PCT/CN2016/104882


(1)Human Cytomegalovirus IE1 Downregulates Hes1 in Neural Progenitor Cells as a potential E3 Ubiquitin Ligase .  2017-10-01
(2)Human Cytomegalovirus Infection Alters miRNAs Associated with Perturbation of Neural Progenitor Cell Fate.   2016-07-23
(3)Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells.  2015-07-23





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