基本信息
季红斌  男  博导  中国科学院分子细胞科学卓越创新中心
email: Hbji@sibcb.ac.cn
address: 上海市岳阳路320号
postalCode:
部门/实验室:生物化学与细胞生物学研究所

招生信息

   
招生专业
071009-细胞生物学
招生方向
肺癌发病的分子机理

教育背景

1995-09--2000-07   中科院上海生命科学院   博士学位

工作经历

   
工作简历
2007-05~现在, 中国科学院上海生命科学研究院生物化学与细胞生物学研究所, 研究员
2000-08~2007-04,美国哈佛大学医学院, 博士后、讲师
1995-09~2000-07,中科院上海生命科学院, 博士学位

教授课程

细胞生物学
Cancer Cell

专利与奖励

   
奖励信息
(1) 第七届上海青年科技英才, 省级, 2014
(2) 肺腺癌的分子分型及临床应用, 二等奖, 省级, 2013
专利成果
( 1 ) 一种检测RET基因融合的方法及其应用, 2015, 第 1 作者, 专利号: ZL 2012 1 0069592.3

出版信息

   
发表论文
(1) In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis, Proc Natl Acad Sci U S A, 2018, 通讯作者
(2) A novel BMX variant promotes tumor cell growth and migration in lung adenocarcinoma, Oncotarget, 2017, 通讯作者
(3) YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63–GPX2 Axis and ROS Accumulation, Cancer Res., 2017, 通讯作者
(4) Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis., Sci Rep. , 2017, 通讯作者
(5) Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma., Am J Pathol, 2017, 通讯作者
(6) Evolution from genetics to phenotype:reinterpretation of NSCLC plasticity,heterogeneity, and drug resistance, Protein Cell., 2017, 通讯作者
(7) Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma., Cell Res, 2016, 通讯作者
(8) Cetuximab-modified mesoporous silica nano-medicine specifically targets EGFR-mutant lung cancer and overcomes drug resistance., Sci Rep. , 2016, 通讯作者
(9) Squamous Transition of Lung Adenocarcinoma and Drug Resistance, Trends Cancer, 2016, 通讯作者
(10) LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response., Cancer Cell, 2015, 通讯作者
(11) YAP Promotes Malignant Progression of Lkb1-Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin., Cancer Res., 2015, 通讯作者
(12) VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex., Cell Res, 2014, 通讯作者
(13) Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma, Nat Commun, 2014, 通讯作者
(14) A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer, Cancer Cell, 2014, 通讯作者
(15) Integrative Genomic Analysis Reveals a High Frequency of LKB1 Genetic Alteration in Chinese Lung Adenocarcinomas., J Thorac Oncol, 2014, 通讯作者
(16) Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, Cancer Lett, 2014, 通讯作者
(17) Synthesis and evaluation of 2-anilinopyrimidines bearing 3-aminopropamides as potential epidermal growth factor receptor inhibitors, Eur J Med Chem, 2014, 通讯作者
(18) Regulation of EGFR nanocluster formation by ionic protein-lipid interaction., Cell Res, 2014, 通讯作者
(19) YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression, Nat Commun, 2014, 通讯作者
(20) NEDD9 promotes lung cancer metastasis through Epithelial-Mesenchymal Transition, Int J Cancer, 2014, 通讯作者
(21) Novel Hybrids of (Phenylsulfonyl)furoxan and Anilinopyrimidine as Potent and Selective Epidermal Growth Factor Receptor Inhibitors for Intervention of Non-Small-Cell Lung Cancer., J Med Chem., 2013, 通讯作者
(22) Nitric oxide donating anilinopyrimidines: Synthesis and biological evaluation as EGFR inhibitors., Eur J Med Chem., 2013, 通讯作者
(23) ANCCA Protein Expression is a Novel Independent Poor Prognostic Marker in Surgically Resected Lung Adenocarcinoma., Ann Surg Oncol., 2013, 通讯作者

科研活动

   
科研项目
( 1 ) 炎症相关肿瘤中癌基因和抑癌基因的异常调控网络研究, 主持, 国家级, 2012-01--2016-08
( 2 ) 呼吸系统肿瘤, 主持, 国家级, 2014-01--2017-12
( 3 ) EGFR质膜动态定位的功能和机制研究, 主持, 国家级, 2014-01--2017-12
( 4 ) 肿瘤细胞与胞外基质的相互作用调控肺腺癌向鳞癌转分化的作用及其分子机制, 主持, 国家级, 2015-01--2019-12
( 5 ) 肺腺鳞癌转分化的分子机制研究, 主持, 省级, 2015-05--2018-04
( 6 ) 肺组织生理病理动态转化的小鼠模型和类器官模型的构建及研究, 主持, 国家级, 2017-01--2021-12
( 7 ) 肿瘤恶性进展及耐药复发中的可塑性变化及机理, 主持, 部委级, 2016-07--2021-06
( 8 ) 癌细胞在肺腺鳞癌转分化过程中的变异与适应性规律研究, 主持, 国家级, 2018-01--2019-12
参与会议
(1)恶性肿瘤的细胞异质性、可塑性与精准医学   2015-10-11
(2)LKB1调控肺癌转移及腺鳞癌转分化   2015-09-24
(3)Evidence and mechanism for transdifferentiation of lung adenocarcinoma to squamous cell carcinoma   2015-06-05
(4)Transdifferentiation of lung adenocarcinoma to squamous cell carcinoma   2014-10-25
(5)Transdifferentiation of lung adenocarcinoma to squamous cell carcinoma   2014-06-26
(6)Molecular mechanisms in lung tumorigenesis   2014-05-27
(7)LKB1 in lung adenocarcinoma to squamous cell carcinoma transdifferentiation   中国细胞生物学学会2013年全国学术大会   2013-04-19