General
Ling CHEN 陈凌
Principal Investigator, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science;
Standing Deputy Director General, State Key Laboratory of Respiratory Disease;
Email: chen_ling@gibh.ac.cn
Telephone: 020-32015289
Address: 190#, Kaiyuan Avenue, Science park, Huangpu District, Guangzhou, Guangdong, China
Postcode: 501530
Principal Investigator, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science;
Standing Deputy Director General, State Key Laboratory of Respiratory Disease;
Email: chen_ling@gibh.ac.cn
Telephone: 020-32015289
Address: 190#, Kaiyuan Avenue, Science park, Huangpu District, Guangzhou, Guangdong, China
Postcode: 501530
Research Areas
Research areas include
HIV Vaccine;
Influenza research;
New technologies for antibody discovery and vaccine delivery.
Education
1992-01--1994-06 Postdoc at Harvard Medical School & DFCI
1985-09--1991-12 Ph.D. School of Medicine, Indiana University, USA
1979-09--1985-06 Shanghai First Medical College (Fudan university)
1985-09--1991-12 Ph.D. School of Medicine, Indiana University, USA
1979-09--1985-06 Shanghai First Medical College (Fudan university)
Experience
Work Experience
2004.03-so far Principal Investigator, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science
2012.08-so far Standing Deputy Director General of State Key Laboratory of Respiratory Disease
2012.01-2012.07 Sanofi Pasteur, VP of R&D
2008.08-2011.12 GlaxoSmithKline, VP of R&D
2006 National Science Fund for Outstanding Young Scholars
2004.01-2008. 07 Founding Director General of GIBH
2001.03-2003.12 Lexicon Genetics Inc, Director of Biophama department
1997.01-2001.04 Merck Research Laboratories,Senior Research Fellow
1994.01-1996.12 Harvard Medical School, Instructor
2012.08-so far Standing Deputy Director General of State Key Laboratory of Respiratory Disease
2012.01-2012.07 Sanofi Pasteur, VP of R&D
2008.08-2011.12 GlaxoSmithKline, VP of R&D
2006 National Science Fund for Outstanding Young Scholars
2004.01-2008. 07 Founding Director General of GIBH
2001.03-2003.12 Lexicon Genetics Inc, Director of Biophama department
1997.01-2001.04 Merck Research Laboratories,Senior Research Fellow
1994.01-1996.12 Harvard Medical School, Instructor
Publications
Papers
1. Zhi, H., L. Qu, F. Wu, L. Chen and J. Tao. "Group Iie Secretory Phospholipase A2 Regulates Lipolysis in Adipocytes." Obesity (Silver Spring) 23, no. 4 (2015): 760-8.
2. Zhang, Y., L. Feng, L. Li, D. Wang, C. Li, C. Sun, P. Li, X. Zheng, Y. Liu, W. Yang, X. Niu, N. Zhong and L. Chen. "Effects of the Fusion Design and Immunization Route on the Immunogenicity of Ag85a-Mtb32 in Adenoviral Vectored Tuberculosis Vaccine." Hum Vaccin Immunother 11, no. 7 (2015): 1803-13.
3. Jin, Y., C. Sun, L. Feng, P. Li, L. Xiao, Y. Ren, D. Wang, C. Li and L. Chen. "Regulation of Siv Antigen-Specific Cd4+ T Cellular Immunity Via Autophagosome-Mediated Mhc Ii Molecule-Targeting Antigen Presentation in Mice." PLoS One 9, no. 3 (2014): e93143.
4. Pan, W., L. Han, Z. Dong, X. Niu, Z. Li, L. Bao, C. Li, Q. Luo, Z. Yang, X. Li, J. Huang, L. Feng, C. Qin, N. Zhong and L. Chen. "Induction of Neutralizing Antibodies to Influenza a Virus H7n9 by Inactivated Whole Virus in Mice and Nonhuman Primates." Antiviral Res 107, (2014): 1-5.
5. Xiao, L. J., D. M. Wang, P. C. Li, Y. Jin, L. Q. Feng, C. J. Sun and L. Chen. "Enhancement of Siv-Specific Cell Mediated Immune Responses by Co-Administration of Soluble Pd-1 and Tim-3 as Molecular Adjuvants in Mice." Human Vaccines & Immunotherapeutics 10, no. 3 (2014): 724-733.
6. Meng, W., W. Pan, A. J. Zhang, Z. Li, G. Wei, L. Feng, Z. Dong, C. Li, X. Hu, C. Sun, Q. Luo, K. Y. Yuen, N. Zhong and L. Chen. "Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases." PLoS One 8, no. 6 (2013): e66276.
7. Pan, W., Z. Dong, F. Li, W. Meng, L. Feng, X. Niu, C. Li, Q. Luo, Z. Li, C. Sun and L. Chen. "Visualizing Influenza Virus Infection in Living Mice." Nat Commun 4, (2013): 2369.
8. Sun, C., Z. Chen, X. Tang, Y. Zhang, L. Feng, Y. Du, L. Xiao, L. Liu, W. Zhu, L. Chen and L. Zhang. "Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys." J Virol 87, no. 10 (2013): 5669-77.
9. Zhang, Y., C. Sun, L. Feng, L. Xiao and L. Chen. "Enhancement of Gag-Specific but Reduction of Env- and Pol-Specific Cd8+ T Cell Responses by Simian Immunodeficiency Virus Nonstructural Proteins in Mice." AIDS Res Hum Retroviruses 28, no. 4 (2012): 374-83.
10. Sun, C., Y. Zhang, L. Feng, W. Pan, M. Zhang, Z. Hong, X. Ma, X. Chen and L. Chen. "Epidemiology of Adenovirus Type 5 Neutralizing Antibodies in Healthy People and Aids Patients in Guangzhou, Southern China." Vaccine 29, no. 22 (2011): 3837-41.
11. Guan, M., L. Qu, W. Tan, L. Chen and C. W. Wong. "Hepatocyte Nuclear Factor-4 Alpha Regulates Liver Triglyceride Metabolism in Part through Secreted Phospholipase a(2) Gxiib." Hepatology 53, no. 2 (2011): 458-66.
12. Sun, C., Y. Zhang, Y. Liu, M. Zhang and L. Chen. "Short Communication: Enhancement of Immunogenicity of Replication-Defective Adenovirus-Based Human Immunodeficiency Virus Vaccines in Rhesus Monkeys." AIDS Res Hum Retroviruses 27, no. 6 (2011): 681-6.
13. Hu, X., W. Meng, Z. Dong, W. Pan, C. Sun and L. Chen. "Comparative Immunogenicity of Recombinant Adenovirus-Vectored Vaccines Expressing Different Forms of Hemagglutinin (Ha) Proteins from the H5 Serotype of Influenza a Viruses in Mice." Virus Res 155, no. 1 (2011): 156-62.
14. Jiang, B., L. Qin, Y. Du, N. Peng, L. Chen, Z. Chen and X. Chen. "Transgenic Plasmodium That Expresses Hiv-1 Gag Elicits Immunity and Protects Mice against Vaccinia Virus-Gag and Malarial Parasites." Vaccine 28, no. 50 (2010): 7915-22.
15. Hu, W., S. Zeng, C. Li, Y. Jie, Z. Li and L. Chen. "Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library." J Med Chem 53, no. 9 (2010): 3831-4.
16. Zhong, M., X. Ma, C. Sun and L. Chen. "Micrornas Reduce Tumor Growth and Contribute to Enhance Cytotoxicity Induced by Gefitinib in Non-Small Cell Lung Cancer." Chem Biol Interact 184, no. 3 (2010): 431-8.
17. Xu, W., L. Yi, Y. Feng, L. Chen and J. Liu. "Structural Insight into the Activation Mechanism of Human Pancreatic Prophospholipase A2." J Biol Chem 284, no. 24 (2009): 16659-66.
18. Li, F., L. Feng, Y. Liu, X. Zhen and L. Chen. "An Integrated Cell Culture and Quantitative Polymerase Chain Reaction Technique for Determining Titers of Functional and Infectious Adenoviruses." Anal Biochem 391, no. 2 (2009): 157-9.
19. Ma, X., L. H. Tang, L. B. Qu, J. Ma and L. Chen. "Identification of 17 Novel Major Histocompatibility Complex-a Alleles in a Population of Chinese-Origin Rhesus Macaques." Tissue Antigens 73, no. 2 (2009): 184-7.
20. Feng, L., F. Li, Y. Liu, X. Zheng, B. Zhang and L. Chen. "A Convenient Plasmid-Based System Containing Three Reporter Genes for Real-Time and Quantitative Analysis of Messenger Rna Silencing." Anal Biochem 394, no. 2 (2009): 284-6.
21. Feng, L., F. Li, X. Zheng, W. Pan, K. Zhou, Y. Liu, H. He and L. Chen. "The Mouse Pol I Terminator Is More Efficient Than the Hepatitis Delta Virus Ribozyme in Generating Influenza-Virus-Like Rnas with Precise 3' Ends in a Plasmid-Only-Based Virus Rescue System." Arch Virol 154, no. 7 (2009): 1151-6.
2. Zhang, Y., L. Feng, L. Li, D. Wang, C. Li, C. Sun, P. Li, X. Zheng, Y. Liu, W. Yang, X. Niu, N. Zhong and L. Chen. "Effects of the Fusion Design and Immunization Route on the Immunogenicity of Ag85a-Mtb32 in Adenoviral Vectored Tuberculosis Vaccine." Hum Vaccin Immunother 11, no. 7 (2015): 1803-13.
3. Jin, Y., C. Sun, L. Feng, P. Li, L. Xiao, Y. Ren, D. Wang, C. Li and L. Chen. "Regulation of Siv Antigen-Specific Cd4+ T Cellular Immunity Via Autophagosome-Mediated Mhc Ii Molecule-Targeting Antigen Presentation in Mice." PLoS One 9, no. 3 (2014): e93143.
4. Pan, W., L. Han, Z. Dong, X. Niu, Z. Li, L. Bao, C. Li, Q. Luo, Z. Yang, X. Li, J. Huang, L. Feng, C. Qin, N. Zhong and L. Chen. "Induction of Neutralizing Antibodies to Influenza a Virus H7n9 by Inactivated Whole Virus in Mice and Nonhuman Primates." Antiviral Res 107, (2014): 1-5.
5. Xiao, L. J., D. M. Wang, P. C. Li, Y. Jin, L. Q. Feng, C. J. Sun and L. Chen. "Enhancement of Siv-Specific Cell Mediated Immune Responses by Co-Administration of Soluble Pd-1 and Tim-3 as Molecular Adjuvants in Mice." Human Vaccines & Immunotherapeutics 10, no. 3 (2014): 724-733.
6. Meng, W., W. Pan, A. J. Zhang, Z. Li, G. Wei, L. Feng, Z. Dong, C. Li, X. Hu, C. Sun, Q. Luo, K. Y. Yuen, N. Zhong and L. Chen. "Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases." PLoS One 8, no. 6 (2013): e66276.
7. Pan, W., Z. Dong, F. Li, W. Meng, L. Feng, X. Niu, C. Li, Q. Luo, Z. Li, C. Sun and L. Chen. "Visualizing Influenza Virus Infection in Living Mice." Nat Commun 4, (2013): 2369.
8. Sun, C., Z. Chen, X. Tang, Y. Zhang, L. Feng, Y. Du, L. Xiao, L. Liu, W. Zhu, L. Chen and L. Zhang. "Mucosal Priming with a Replicating-Vaccinia Virus-Based Vaccine Elicits Protective Immunity to Simian Immunodeficiency Virus Challenge in Rhesus Monkeys." J Virol 87, no. 10 (2013): 5669-77.
9. Zhang, Y., C. Sun, L. Feng, L. Xiao and L. Chen. "Enhancement of Gag-Specific but Reduction of Env- and Pol-Specific Cd8+ T Cell Responses by Simian Immunodeficiency Virus Nonstructural Proteins in Mice." AIDS Res Hum Retroviruses 28, no. 4 (2012): 374-83.
10. Sun, C., Y. Zhang, L. Feng, W. Pan, M. Zhang, Z. Hong, X. Ma, X. Chen and L. Chen. "Epidemiology of Adenovirus Type 5 Neutralizing Antibodies in Healthy People and Aids Patients in Guangzhou, Southern China." Vaccine 29, no. 22 (2011): 3837-41.
11. Guan, M., L. Qu, W. Tan, L. Chen and C. W. Wong. "Hepatocyte Nuclear Factor-4 Alpha Regulates Liver Triglyceride Metabolism in Part through Secreted Phospholipase a(2) Gxiib." Hepatology 53, no. 2 (2011): 458-66.
12. Sun, C., Y. Zhang, Y. Liu, M. Zhang and L. Chen. "Short Communication: Enhancement of Immunogenicity of Replication-Defective Adenovirus-Based Human Immunodeficiency Virus Vaccines in Rhesus Monkeys." AIDS Res Hum Retroviruses 27, no. 6 (2011): 681-6.
13. Hu, X., W. Meng, Z. Dong, W. Pan, C. Sun and L. Chen. "Comparative Immunogenicity of Recombinant Adenovirus-Vectored Vaccines Expressing Different Forms of Hemagglutinin (Ha) Proteins from the H5 Serotype of Influenza a Viruses in Mice." Virus Res 155, no. 1 (2011): 156-62.
14. Jiang, B., L. Qin, Y. Du, N. Peng, L. Chen, Z. Chen and X. Chen. "Transgenic Plasmodium That Expresses Hiv-1 Gag Elicits Immunity and Protects Mice against Vaccinia Virus-Gag and Malarial Parasites." Vaccine 28, no. 50 (2010): 7915-22.
15. Hu, W., S. Zeng, C. Li, Y. Jie, Z. Li and L. Chen. "Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library." J Med Chem 53, no. 9 (2010): 3831-4.
16. Zhong, M., X. Ma, C. Sun and L. Chen. "Micrornas Reduce Tumor Growth and Contribute to Enhance Cytotoxicity Induced by Gefitinib in Non-Small Cell Lung Cancer." Chem Biol Interact 184, no. 3 (2010): 431-8.
17. Xu, W., L. Yi, Y. Feng, L. Chen and J. Liu. "Structural Insight into the Activation Mechanism of Human Pancreatic Prophospholipase A2." J Biol Chem 284, no. 24 (2009): 16659-66.
18. Li, F., L. Feng, Y. Liu, X. Zhen and L. Chen. "An Integrated Cell Culture and Quantitative Polymerase Chain Reaction Technique for Determining Titers of Functional and Infectious Adenoviruses." Anal Biochem 391, no. 2 (2009): 157-9.
19. Ma, X., L. H. Tang, L. B. Qu, J. Ma and L. Chen. "Identification of 17 Novel Major Histocompatibility Complex-a Alleles in a Population of Chinese-Origin Rhesus Macaques." Tissue Antigens 73, no. 2 (2009): 184-7.
20. Feng, L., F. Li, Y. Liu, X. Zheng, B. Zhang and L. Chen. "A Convenient Plasmid-Based System Containing Three Reporter Genes for Real-Time and Quantitative Analysis of Messenger Rna Silencing." Anal Biochem 394, no. 2 (2009): 284-6.
21. Feng, L., F. Li, X. Zheng, W. Pan, K. Zhou, Y. Liu, H. He and L. Chen. "The Mouse Pol I Terminator Is More Efficient Than the Hepatitis Delta Virus Ribozyme in Generating Influenza-Virus-Like Rnas with Precise 3' Ends in a Plasmid-Only-Based Virus Rescue System." Arch Virol 154, no. 7 (2009): 1151-6.
Patents
1. 陈凌，陈志伟，张林琦，孙彩军. 联合使用痘病毒载体HIV疫苗与腺病毒载体HIV疫苗的方法及其应用PCT/CN2010/076905
2. 陈凌，陈志伟，张林琦，孙彩军. 联合使用痘病毒载体HIV疫苗与腺病毒载体HIV疫苗的方法及其应用. 200910192351.6/ CN 101670102 A
3. 陈凌、冯立强、孙彩军、秦成峰. 复制型重组人55型腺病毒载体及其制备方法和应用. 201410293359.2
4. 孙彩军，陈凌，靳怡. 一种引发强效CD4+T细胞免疫反应的新型HIV疫苗. 200910036668
5. 孙彩军，陈凌. 克服预存免疫反应对腺病毒载体产品不利影响的方法及其应用. 200910036668
6. 陈凌，李楚芳，徐伟，肖益平，杨令芝. 用于流感病毒M2离子通道阻断剂筛选的荧光细胞模型及其应用方法. 200910036424.2
7. 李峰，冯立强，陈凌. 一种NA片段携带外源基因的重组流感病毒载体及其制备方法和应用 . 200910038838.9
8. 陈凌，李峰，潘蔚绮，杨化强. 一种流感病毒疫苗种子株的制备方法. 200810029130.2
9. 陈凌，李峰. 互补型高容量腺病毒载体系统及其构建的疫苗和基因治疗产品. 200710026571.2/ CN 101363028 A
10. 陈凌，马鑫. 携带HIV基因的腺病毒载体疫苗. ZL 2007 1 0026295.X
2. 陈凌，陈志伟，张林琦，孙彩军. 联合使用痘病毒载体HIV疫苗与腺病毒载体HIV疫苗的方法及其应用. 200910192351.6/ CN 101670102 A
3. 陈凌、冯立强、孙彩军、秦成峰. 复制型重组人55型腺病毒载体及其制备方法和应用. 201410293359.2
4. 孙彩军，陈凌，靳怡. 一种引发强效CD4+T细胞免疫反应的新型HIV疫苗. 200910036668
5. 孙彩军，陈凌. 克服预存免疫反应对腺病毒载体产品不利影响的方法及其应用. 200910036668
6. 陈凌，李楚芳，徐伟，肖益平，杨令芝. 用于流感病毒M2离子通道阻断剂筛选的荧光细胞模型及其应用方法. 200910036424.2
7. 李峰，冯立强，陈凌. 一种NA片段携带外源基因的重组流感病毒载体及其制备方法和应用 . 200910038838.9
8. 陈凌，李峰，潘蔚绮，杨化强. 一种流感病毒疫苗种子株的制备方法. 200810029130.2
9. 陈凌，李峰. 互补型高容量腺病毒载体系统及其构建的疫苗和基因治疗产品. 200710026571.2/ CN 101363028 A
10. 陈凌，马鑫. 携带HIV基因的腺病毒载体疫苗. ZL 2007 1 0026295.X
Research Interests
Our lab main focused on HIV and respiratory diseases, such as influenza virus, adenovirus, Ebola and so on.