基本信息
陈国强  男  博导  上海交通大学医学院
email: gqchen@sibs.ac.cn
address: 上海市重庆南路280号西二栋905室
postalCode: 200025

招生信息

   
招生专业
100104-病理学与病理生理学
071010-生物化学与分子生物学
招生方向
白血病及肿瘤的病理生理学与治疗学基础研究
抗肿瘤药物靶标识别和先导化合物研究
蛋白质组学研究

教育背景

1993-09--1996-07   上海第二医科大学(现上海交通大学医学院)   博士
1985-09--1988-07   上海第二医科大学(现上海交通大学医学院)   硕士
1980-09--1985-07   湖南衡阳医学院(现南华大学)   学士

工作经历

   
工作简历
2010-12~现在, 上海交通大学, 副校长
2010-11~现在, 上海交通大学医学院, 院长
2006-07~2010-11,上海交通大学医学院, 副院长
2005-07~现在, 上海交通大学医学院细胞分化与凋亡教育部重点实验室, 主任、教育部长江特聘教授
2002-05~2008-11,上海交通大学医学院病理生理学教研室, 教授、主任
2001-08~现在, 中科院上海生命科学研究院-健康所, “****”课题组长
1999-09~2001-08,美国Mount-Saint医学中心, visiting assistant professor
1997-05~1997-12,法国巴黎Saint Louis医院, 访问学者
1996-07~2002-08,上海第二医科大学附属瑞金医院, 副研究员、研究员
1993-09~1996-07,上海第二医科大学(现上海交通大学医学院), 博士
1988-07~1993-08,湖南衡阳医学院, 助教、讲师
1985-09~1988-07,上海第二医科大学(现上海交通大学医学院), 硕士
1980-09~1985-07,湖南衡阳医学院(现南华大学), 学士
社会兼职
2015-08-01-今,中国病理生理学会, 副理事长
2015-07-31-今,中国生物化学与分子生物学会, 常务理事,医学分会副理事长
2015-07-31-今,中国老年医学学会, 副理事长
2015-01-17-今,上海市病理生理学会, 理事长(法人)
2012-04-30-今,上海市医学会, 副会长

教授课程

病理学与病理生理学总论
基础肿瘤学理论与实践
病理生理学

专利与奖励

   
奖励信息
(1) 何梁何利基金科学与技术进步奖, 其他, 2012
(2) 白血病细胞分化与凋亡的新机制, 二等奖, 国家级, 2010
(3) 白血病细胞分化和凋亡相关的若干问题, 一等奖, 市地级, 2008
(4) 白血病细胞生命活动规律的新发现, 一等奖, 省级, 2008
(5) 白血病细胞分化与凋亡新机制的提出与发展, 一等奖, 其他, 2005
(6) 上海市自然科学牡丹奖, 特等奖, 省级, 2005
(7) 上海市青年科技英才, 特等奖, 省级, 2004
(8) 中国青年科技奖, 特等奖, 国家级, 2004
(9) 三氧化二砷单用或联合全反式维甲酸治疗急性早幼粒细胞白血病作用机制及临床研究, 一等奖, 其他, 2004
(10) 全反式维甲酸和三氧化二砷治疗恶性血液疾病的分子机制研究, 二等奖, 国家级, 2001
(11) 血液系统恶性肿瘤基因产物靶向治疗的机制研究, 特等奖, 其他, 2000
专利成果
( 1 ) 川藏香茶菜甲素在防治急性淋巴细胞白血病及宫颈癌中的应用, 2012, 第 1 作者, 专利号: ZL200910045118.5

出版信息

   
发表论文
(1) Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma, Cell Death Dis, 2015, 通讯作者
(2) ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells, Oncotarget, 2015, 通讯作者
(3) Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma, Cell Death Dis, 2015, 通讯作者
(4) AIF inhibits tumor metastasis by protecting PTEN from oxidation, EMBO reports, 2015, 通讯作者
(5) MiR-630 suppresses breast cancer progression by targeting metadherin, Oncotarget, 2015, 通讯作者
(6) Natural products against hematological malignancies and identification of their targets, SCIENCE CHINA Life Sciences, 2015, 通讯作者
(7) Leukemia propagating cells rebuild an evolving niche in response to therapy, Cancer Cell, 2014, 通讯作者
(8) Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity, Cancer Cell, 2014, 通讯作者
(9) Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells, Cell Death Dis, 2014, 通讯作者
(10) Important role of SUMOylation of Spliceosome factors in prostate cancer cells, J Proteome Res, 2014, 通讯作者
(11) Sumoylation of hypoxia inducible factor-1α and its significance in cancer, SCIENCE CHINA Life Sciences, 2014, 通讯作者
(12) HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation, Cell Death Differ, 2013, 通讯作者
(13) Targeting peroxiredoxins against leukemia, Exp Cell Res, 2013, 通讯作者
(14) Preventive and therapeutic effects of adenanthin on experimental autoimmune encephalomyelitis by inhibiting NF-κB signaling, J Immunol, 2013, 通讯作者
(15) Phosphoproteomics study on the activated PKCδ-induced cell death, J Proteome Res, 2013, 通讯作者
(16) Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer, Carcinogenesis, 2011, 通讯作者
(17) Ikaros is degraded by proteasome-dependent mechanism in the early phase of apoptosis induction, Biochemical and Biophysical Research Communications, 2011, 通讯作者
(18) Pharicin B stabilizes retinoic acid receptor-α and presents synergistic differentiation induction with ATRA in myeloid leukemic cells., Blood, 2010, 通讯作者
(19) Molecular mechanisms of leukemia-associated protein degradation, Front. Med. China, 2010, 通讯作者
(20) Current advences in the application of proteomics in apoptosis research, Scientia Sinica Vitae, 2010, 通讯作者
(21) Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 通讯作者
(22) Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells, Carcinogenesis, 2010, 通讯作者
(23) The downregulation of onzin expression by PKCe-ERK2 signaling and its potential role in AML cell differentiation, Leukemia, 2010, 通讯作者
(24) Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells, Carcinogenesis, 2010, 通讯作者
(25) Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes, Chemico-Biological Interactions, 2010, 通讯作者
(26) Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells, Proteomics, 2009, 通讯作者
(27) Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells., PLoS One., 2009, 通讯作者
(28) Hypoxia-HIF-1alpha-C/EBPalpha/Runx1 signaling in leukemic cell differentiation., Pathophysiology, 2009, 通讯作者
(29) Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis, Apoptosis, 2009, 通讯作者
(30) PU.1, a novel capase-3 substrate, partially contributes to chemotherapeutic agents-induced apoptosis in leukemic cells, Biochemical and Biophysical Research Communications, 2009, 通讯作者
(31) NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis., Proteomics, 2009, 通讯作者
(32) NSC606985 induces apoptosis, exerts synergistic effects with cisplatin, and inhibits hypoxia-stabilized HIF-1alpha protein in human ovarian cancer cells., Cancer Lett. , 2009, 通讯作者
(33) Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction, E X P E R I M E N T A L C E L L R E S E A R C H, 2009, 通讯作者
(34) Accumulation of hypoxia-inducible factor-1a protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid, haematologica, 2008, 通讯作者
(35) Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity, Leukemia, 2008, 通讯作者
(36) Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1a, Oncogene, 2008, 通讯作者
(37) Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic, Oncogene, 2008, 通讯作者
(38) Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cd, Leukemia, 2007, 通讯作者
(39) Subcellular Proteome Analysis of Camptothecin Analogue NSC606985-Treated Acute Myeloid Leukemic Cells, Journal of Proteome Research, 2007, 通讯作者
(40) Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells, Oncogene, 2006, 通讯作者
(41) Inducible expression of AML1-ETO fusion protein endows leukemic cells with susceptibility to extrinsic and intrinsic apoptosis, Leukemia, 2006, 通讯作者
(42) Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia, Blood, 2006, 通讯作者
(43) Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells, haematologica, 2005, 通讯作者
(44) Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cd–dependent mechanisms, BLOOD, 2005, 通讯作者
(45) Protein kinase Cd mediates retinoic acid and phorbol myristate acetate–induced phospholipid scramblase 1 gene expression:its role in leukemic cell differentiation, Blood, 2005, 通讯作者
(46) Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of hypoxia-inducible factor-1a, Leukemia, 2003, 通讯作者
(47) Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells, Leukemia, 2003, 通讯作者
(48) Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia, Leukemia, 2000, 通讯作者

科研活动

   
科研项目
( 1 ) 影响蛋白质修饰的活性小分子化合物的发现和活性机制研究, 负责人, 国家任务, 2009-01--2013-08
( 2 ) 白血病细胞分化与凋亡信息基础的化学生物学研究, 负责人, 国家任务, 2009-01--2012-12
( 3 ) 肿瘤病理生理学创新团队, 负责人, 地方任务, 2009-01--2011-12
( 4 ) Cbx4经SUMO化修饰增强HIF-1a转录活性的分子机制与肝癌发生发展, 负责人, 国家任务, 2015-01--2019-12
( 5 ) 腺花素清除白血病起始细胞的分子机制, 负责人, 国家任务, 2015-01--2015-12
( 6 ) 肿瘤细胞中凋亡诱导因子表达下调导致EMT的机制, 负责人, 国家任务, 2013-01--2017-12
参与会议
(1)Hypoxia-downregulated AIF inhibits tumor metastasis by protecting PTEN from oxidation   中国病理生理学会第十届全国代表大会暨学术会议   2015-11-06
(2)Hypoxia-downregulated AIF inhibits tumor metastasis by protecting PTEN from oxidation   第五届全国跨学科蛋白质研究学术讨论会   2015-10-17