人类神经精神疾病的遗传解析

树鼩基础生物学

   

071007-遗传学
071009-细胞生物学

神经和免疫系统疾病
线粒体疾病
树鼩生物学

1997-09--2002-12   中国科学院昆明动物研究所   博士
1993-09--1997-07   安徽师范大学   理学学士

1993.09 - 1997.07 安徽师范大学生物系，获学士学位
1997.09 - 2003.02 中国科学院昆明动物研究所/中国科学院研究生院，获博士学位 

2001.05 - 2001.08 德国汉堡大学从事合作研究
2003.02 - 2004.09 约翰斯.霍普金斯大学医学院 (Johns Hopkins University School of Medicine) 从事博士后研究工作
2004.10 - 2008.01 美国国家卫生研究院心脏、肺和血液研究所(National Heart, Lung and Blood Institute, National Institutes of Health), Visiting Fellow

-- 博士

   

2007-12~现在, 中国科学院昆明动物研究所, 学科组负责人
2004-10~2008-01,NHLBI, NIH, Visiting Fellow
2003-02~2004-09,Johns Hopkins University School of Medicine, 博士后

2018-01-01-今,Associate editor of Journal of Alzheimer’s Disease,
2016-07-31-今,Editorial board member of Scientific Reports,
2015-07-30-2017-08-31,Associate editor of Science Bulletin,
2012-08-01-今,Receiving editor of Infection, Genetics and Evolution,
2012-01-01-今,Academic Editor of PLoS ONE,
2011-01-01-今,Associate editor of the Journal of Human Genetics ,
2010-12-01-今,《动物学研究》主编,
2010-10-01-今,Editorial board member of the Journal of Genetics and Genomics,

2010年 云南省有突出贡献优秀专业技术人才奖 二等奖
2009年 入选“新世纪百千万人才工程国家级人选”
2009年 云南青年五四奖章
2006年 国家自然科学奖二等奖; 项目名称: 线粒体基因组多样性与东亚人群历史的研究; 第二获奖人.
2005年 云南省科学技术奖一等奖(自然科学类); 项目名称: 线粒体基因组多样性与东亚人群历史的研究; 第二获奖人
2005年 全国百篇优秀博士论文
2004年 云南省科学技术奖三等奖(科学技术进步类); 项目名称: ß2肾上腺素受体遗传多态性与哮喘关系研究; 第四获奖人
2003年 云南省科学技术奖三等奖(科学技术进步类); 项目名称: 云南汉族系统性红斑狼疮与补体C4、C2基因相关性研究; 第四获奖人
2002年 中国科学院院长奖特别奖
2001年 德意志学术交流中心短期奖学金
2000年 中国科学院地奥奖学金和院长奖学金优秀奖

   

（1） Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., American Journal of Human Genetics, 102: 794 - 805, 2018, 通讯作者
（2） Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer’s disease research?, Journal of Alzheimer’s Disease, 61: 1015 - 1028, 2018, 通讯作者
（3） A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China., British Journal of Dermatology, 178: 931 - 939., 2018, 通讯作者
（4） A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease., Alzheimer's & Dementia, 14: 215 - 229., 2018, 通讯作者
（5） The Arc gene confers genetic susceptibility to Alzheimer’s disease in Han Chinese., Molecular Neurobiology, 55: 1217 - 1226., 2018, 通讯作者
（6） SZDB: A database for schizophrenia genetic research., Schizophrenia Bulletin,43: 459 - 471., 2017, 通讯作者
（7） The OPA1 gene mutations are frequent in Han Chinese patients with suspected optic neuropathy., Molecular Neurobiology, 54: 1622 - 1630., 2017, 通讯作者
（8） Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia., Journal of Genetics and Genomics, 44: 295-306., 2017, 通讯作者
（9） Atg5- and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine, Autophagy, 13: 1496 - 1511, 2017, 通讯作者
（10） The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China, Journal of Dermatological Science, 88: 349 - 356., 2017, 通讯作者
（11） Leber hereditary optic neuropathy: a mitochondrial disease unique in many ways., Handbook of Experimental Pharmacology, 309 - 336., 2017, 通讯作者
（12） mtDNA heteroplasmy in monozygotic twins discordant for schizophrenia., Molecular Neurobiology, 54: 4343 - 4352., 2017, 通讯作者
（13） Female-specific effect of the BDNF gene on Alzheimer's disease., Neurobiology of Aging, 53: 192.e11 - 192.e19., 2017, 通讯作者
（14） Creating animal models, why not use the Chinese tree shrew (Tupaia belangeri chinensis)?, Zoological Research, 38: 118 - 126., 2017, 通讯作者
（15） Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring., Cell Research, 27: 241 - 252., 2017, 通讯作者
（16） Rare genetic variants of the transthyretin gene are associated with Alzheimer’s disease in Han Chinese., Molecular Neurobiology, 54: 5192 - 5200, 2017, 通讯作者
（17） Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew., Proceedings of the National Academy of Sciences of the United States of America, 113: 10950 - 10955, 2016, 通讯作者
（18） PLD3 in Alzheimer's disease: a modest effect as revealed by updated association and expression analyses., Molecular Neurobiology, 53: 4034–4045, 2016, 通讯作者
（19） Mitochondrial DNA haplogroup A decreases the risk of drug addiction but conversely increases the risk of HIV-1 infection in Chinese addicts., Molecular Neurobiology, 53: 3873-3881, 2016, 通讯作者
（20） CFH variants affect structural and functional brain changes and genetic risk of Alzheimer's disease., Neuropsychopharmacology, 41: 1034-1045, 2016, 通讯作者
（21） Integrative analyses of leprosy susceptibility genes indicate a common autoimmune profile., Journal of Dermatological Science, 82: 18-27, 2016, 通讯作者
（22） Mitochondrial genome variations and functional characterization in Han Chinese families with schizophrenia., Schizophrenia Research, 171: 200-206, 2016, 通讯作者
（23） Complement factor H and susceptibility to major depressive disorder in Han Chinese., British Journal of Psychiatry, 208(5): 446-452, 2016, 通讯作者
（24） Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis)., Developmental and Comparative Immunology, 60: 127-138, 2016, 通讯作者
（25） Validating GWAS-identified risk loci for Alzheimer’s disease in Han Chinese populations., Molecular Neurobiology,53(1): 379-390, 2016, 通讯作者
（26） Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China., Scientific Reports, 6: 37086, 2016, 通讯作者
（27） Was ADH1B under selection in European populations?, The American Journal of Human Genetics, 99: 1217 - 1219, 2016, 第 3 作者
（28） Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China., Infection, Genetics and Evolution, 45: 105 - 110, 2016, 通讯作者
（29） Fine mapping of the GWAS loci identifies SLC35D1 and IL23R as potential risk genes for leprosy., Journal of Dermatological Science, 84: 322-329, 2016, 通讯作者
（30） Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication., Cell Research, 26: 556-573, 2016, 第 10 作者
（31） Neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese., Molecular Neurobiology, 53: 4883-4892, 2016, 通讯作者
（32） Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China., Genes & Immunity 16(2): 112-119, 2015, 通讯作者
（33） Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations?, Scientific Reports, 5: 11076, 2015, 通讯作者
（34） Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation, Autophagy, 11: 1745-1759, 2015, 通讯作者
（35） Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China, Journal of Dermatological Science, 80: 133-141, 2015, 通讯作者
（36） Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis)., Developmental and Comparative Immunology, 52(1): 58-68, 2015, 通讯作者
（37） Common variants of IRF3 conferring risk of schizophrenia, Journal of Psychiatric Research, 64: 64-73, 2015, 通讯作者
（38） Mitochondrial DNA haplogroup B5 confers genetic susceptibility to Alzheimers disease in Han Chinese., Neurobiology of Aging, 36: 1604.e7-1604.e16, 2015, 通讯作者
（39） Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina., Gene, 571: 279-285, 2015, 通讯作者
（40） Mitochondrial DNA mutations in single human blood cells., Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 779: 68 - 77, 2015, 第 1 作者
（41） Common variants in the MKL1 gene confer risk of schizophrenia., Schizophrenia Bulletin, 41: 715-727, 2015, 第 7 作者
（42） Caveats about interpretation of ancient chicken mtDNAs from northern China., Proceedings of the National Academy of Sciences of the United States of America, 112: E1970- E1971, 2015, 第 3 作者
（43） Identification of PSEN1 mutations p.M233L and p.R352C in Han Chinese families with early-onset familial Alzheimer's disease., Neurobiology of Aging, 36: 1602.e3-1602.e6, 2015, 通讯作者
（44） Common variants of the PINK1 and PARL genes do not confer genetic susceptibility to schizophrenia in Han Chinese., Molecular Genetics and Genomics, 290: 585-592, 2015, 通讯作者
（45） Tree shrew database (TreeshrewDB): a knowledge base for Chinese tree shrew genome biology, Scientific Reports, 4: 7145, 2014, 通讯作者
（46） No association between genetic variants of the LRRK2 gene and schizophrenia in Han Chinese., Neuroscience Letters, 566: 210-215, 2014, 通讯作者
（47） No association of the LRRK2 genetic variants with Alzheimers disease in Han Chinese individuals., Neurobiology of Aging, 35: 444.e5-444.e9, 2014, 通讯作者
（48） Diverse interleukin-7 mRNA transcripts in Chinese tree shrew (Tupaia belangeri chinensis)., PLoS One, 9(6): e99859, 2014, 通讯作者
（49） Promoter variant rs2301228 on the neural cell adhesion molecule 1 gene conferring risk of schizophrenia in Han Chinese., Schizophrenia Research, 160: 88-96, 2014, 通讯作者
（50） Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia., Journal of Psychiatric Research, 57: 84-89, 2014, 通讯作者
（51） A matrilineal genetic legacy from the last glacial maximum confers susceptibility to schizophrenia in Han Chinese., Journal of Genetics and Genomics, 41: 397-407, 2014, 通讯作者
（52） Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese., Genes and Immunity, 15: 506-510, 2014, 通讯作者
（53） Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer., Gene, 546: 263-270, 2014, 通讯作者
（54） Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens., Gene, 545: 226-232, 2014, 通讯作者
（55） The positively selected genes of the locomotion system in Chinese tree shrew (Tupaia belangeri chinensis)., Zoological Research, 35: 240-248, 2014, 通讯作者
（56） Evaluating risk loci for schizophrenia distilled from genome-wide association studies in Han Chinese from central China., Molecular Psychiatry 18(6):638-9., 2013, 通讯作者
（57） No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese., Psychiatric Genetics, 23(1): 29-32, 2013, 通讯作者
（58） Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background., Stem Cell Research, 10: 361-370, 2013, 通讯作者
（59） Genome of the Chinese tree shrew., Nature Communications, 4: 1426, 2013, 通讯作者
（60） Genetic variants of complement genes Ficolin-2, Mannose-binding lectin and Complement factor H are associated with leprosy in Han Chinese from Southwest China., Human Genetics, 132: 629-640, 2013, 通讯作者
（61） Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-druplex ligands., FEBS Lett. 587(11):1656-62, 2013, 通讯作者
（62） An update to MitoTool: Using a new scoring system for faster mtDNA haplogroup determination., Mitochondrion, 13: 360-363, 2013, 通讯作者
（63） Apparent mtDNA sequence heterogeneity in single human blood CD34+ cells is markedly affected by storage and transport., Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 751-752: 36-41, 2013, 通讯作者
（64） Mutation p.G83R in the transthyretin gene is associated with hereditary vitreous amyloidosis in Han Chinese families., Molecular Vision, 19: 1631-1638, 2013, 通讯作者
（65） Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from Southwest China., PLoS One, 8(7): e67577, 2013, 通讯作者
（66） Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin., Autophagy, 9: 1395-1406, 2013, 通讯作者
（67） Evaluating the phylogenetic position of Chinese tree shrew (Tupaia belangeri chinensis) based on complete mitochondrial genome: implication for using tree shrew as an alternative experimental animal to primates in biomedical research., Journal of Genetics and Genomics, 39: 131-137, 2012, 通讯作者
（68） Mitochondrial DNA mutation m.10680G/A is associated with Leber hereditary optic neuropathy in Chinese patients., Journal of Translational Medicine, 10: 43, 2012, 通讯作者
（69） Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China., Human Genetics, 131: 1251-1260, 2012, 通讯作者
（70） Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China., PLoS ONE, 7(6): e38848, 2012, 通讯作者
（71） Presence of mutation m.14484T/C in a Chinese family with maternally inherited essential hypertension but no expression of LHON., Biochimica et Biophysica Acta-Molecular Basis of Disease, 1822: 1535-1543, 2012, 通讯作者
（72）  Complete mitochondrial DNA genome sequence variation of Chinese families with mutation m.3635G/A and Leber hereditary optic neuropathy., Molecular Vision, 18: 3087-3094, 2012, 通讯作者
（73） Rapid identification of mtDNA somatic mutations in gastric cancer tissues based on the mtDNA phylogeny., Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 709-710:15-20, 2011, 通讯作者
（74） Mitochondrial DNA haplogroup background affects LHON, but not suspected LHON, in Chinese patients., PLoS ONE, 6(11): e27750, 2011, 通讯作者
（75） MitoTool: A web server for the analysis and retrieval of human mitochondrial DNA sequence variations. , Mitochondrion, 11: 351-356, 2011, 通讯作者
（76） Is mitochondrial tRNA-phe variant m.593T/C a synergistically pathogenic mutation in Chinese LHON families with m.11778G/A, PLoS ONE, 6: e26511, 2011, 通讯作者
（77） Identification of mutation c.632G/A (p.G211D) in the ATP2A2 gene and genotype-phenotype correlation in a large Chinese family with Darier disease.,  International Journal of Dermatology, 50: 1366-1370, 2011, 通讯作者
（78） Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkins lymphoma in Chinese patients., Annals of Hematology, 90: 1137-1144, 2011, 通讯作者
（79） Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese. , Behavioral and Brain Functions 6: 75 (doi:10.1186/1744-9081-6-75), 2010, 通讯作者
（80） Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C., PLoS ONE, 5(10): e13426, 2010, 通讯作者
（81） The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells., Human Mutation, 31: 538-543, 2010, 通讯作者
（82） No association between the SNPs (rs3749446 and rs1402000) in the PARL gene and LHON in Chinese patients with m.11778G-A., Human Genetics, 128: 465-468, 2010, 通讯作者
（83） mtDNA data-mining in GenBank needs surveying., American Journal of Human Genetics, 85: 929-933, 2009, 第 1 作者
（84） The exaggerated status of "novel" and "pathogenic" mtDNA sequence variants due to inadequate database searches., Human Mutation, 30: 191-196, 2009, 通讯作者
（85） Mitochondrial DNA haplogroups M7b1'2 and M8a affect clinical expression of Leber Hereditary Optic Neuropathy in Chinese families with the m.11778G→A mutation., American Journal of Human Genetics, 83: 760-768, 2008, 通讯作者
（86） Pseudo-mitochondrial genome haunts disease studies., Journal of Medical Genetics, 45: 769-772, 2008, 通讯作者
（87） A homogenous nature of Chinese native duck matrilineal pool., BMC Evolutionary Biology, 8: 298, 2008, 通讯作者
（88） Population phylogenomic analysis of mitochondrial DNA in wild boars and domestic pigs revealed multiple domestication events in East Asia., Genome Biology, 8:R245, 2007, 第 2 作者
（89） Mitochondrial DNA sequence heterogeneity of single CD34+ cells after nonmyeloablative allogeneic stem cell transplantation., Stem Cells, 25:2670-2676, 2007, 第 1 作者
（90） Mitochondrial DNA sequence variation in single cells from leukemia patients., Blood, 109: 756-762, 2007, 通讯作者
（91） Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background., Human Molecular Genetics, 16: 286-294, 2007, 第 1 作者
（92） Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations., Human Molecular Genetics, 15: 2076-2086, 2006, 第 4 作者
（93） A reappraisal of complete mtDNA variation in East Asian families with hearing impairment., Human Genetics, 119: 505-515, 2006, 通讯作者
（94） Upregulation of placental growth factor by vascular endothelial growth factor via a post-transcriptional mechanism., FEBS Letters, 579: 1227-1234, 2005, 第 1 作者
（95） Different matrilineal contributions to genetic structure of ethnic populations in Silk-Road region in China., Molecular Biology and Evolution, 21: 2265-2280, 2004, 第 1 作者
（96） To trust or not to trust an idiosyncratic mitochondrial data set., American Journal of Human Genetics, 72: 1341-1346, 2003, 通讯作者
（97） Reconstructing the evolutionary history of China: a caveat about inferences drawn from ancient DNA., Molecular Biology and Evolution, 20: 214-219, 2003, 第 1 作者
（98） Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences., American Journal of Human Genetics, 73: 671-676, 2003, 第 2 作者
（99） Phylogeographic differentiation of mitochondrial DNA in Han Chinese., American Journal of Human Genetics, 70: 635-651, 2002, 第 1 作者
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已指导学生

邹阳  博士研究生  071002-动物学  

张阿梅  博士研究生  071009-细胞生物学  

张文  博士研究生  071007-遗传学  

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樊隆  硕士研究生  071009-细胞生物学  

王东  博士研究生  071007-遗传学  

冯月梅  博士研究生  071007-遗传学  

马亮  博士研究生  071007-遗传学  

胡秋香  硕士研究生  071007-遗传学  

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毕蕊  博士研究生  071007-遗传学  

吕莉  硕士研究生  071007-遗传学  

张登峰  博士研究生  071007-遗传学  

李晓  硕士研究生  085238-生物工程  

范宇  博士研究生  071007-遗传学  

彭莉  硕士研究生  085238-生物工程  

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李余  硕士研究生  071007-遗传学  

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张金燕  硕士研究生  071009-细胞生物学  

阳静  硕士研究生  071009-细胞生物学  

刘前进  博士研究生  071007-遗传学  

姚玉林  博士研究生  071007-遗传学