071007-遗传学

人类进化遗传学
疾病基因组学

1999-09--2005-06   中国科学院研究生院   理学博士
1995-09--1999-06   兰州大学   理学学士

   

2008-09~现在, 中国科学院昆明动物研究所, 研究员
2005-12~2008-08,中国科学院昆明动物研究所, 副研究员
2005-06~2005-11,中国科学院昆明动物研究所, 助理研究员
1999-09~2005-06,中国科学院研究生院, 理学博士
1995-09~1999-06,兰州大学, 理学学士

2015-05-01-今,SCI期刊《Scientific Reports》编委, 编委
2013-01-01-2018-12-31,中国遗传学会青年委员会, 副主任
2009-01-30-2010-12-31,SCI期刊《Human Biology》编委, 编委

   

（1） 云岭学者专项, 省级, 2020
（2） 春城科技领军人才专项, 市地级, 2020
（3） 万人计划, 国家级, 2016
（4） 云南省科学技术奖, 特等奖, 省级, 2014
（5） 国家自然科学奖, 二等奖, 国家级, 2014
（6） 吴旻人类与医学遗传创新奖, 专项, 2013
（7） 云南省中青年学术和技术带头人, 省级, 2012
（8） 中国科学院西部学者突出贡献奖, , 部委级, 2011
（9） 中国科学院卢嘉锡青年人才奖, , 部委级, 2008
（10） 全国百篇优秀博士学位论文奖, , 国家级, 2007
（11） 国家自然科学奖二等奖, 二等奖, 国家级, 2006
（12） 云南省科学技术奖一等奖, 一等奖, 省级, 2005
（13） 第四届云南省青年科技奖, , 省级, 2005
（14） 中国科学院院长奖学金特别奖, , 部委级, 2005

（ 1 ） 指征健康衰老关键通路的血清蛋白质标志物及应用, 2020, 第 1 作者, 专利号: 202010242240.8

（ 2 ） 健康衰老血清蛋白标志物及应用, 2020, 第 1 作者, 专利号: 202010242240.8

（ 3 ） 指征健康老龄关键通路的内源性代谢小分子标志物及应用, 2020, 第 1 作者, 专利号: 202010242240.8

（ 4 ） 健康老龄诊断标志物及应用, 2020, 第 1 作者, 专利号: 202010242240.8

（ 5 ） 指示健康衰老关键通路的circRNA小分子标志物及应用, 2020, 第 1 作者, 专利号: 202010242240.8

（ 6 ） 健康衰老诊断circRNA标志物及应用, 2020, 第 1 作者, 专利号: 202010242240.8

（ 7 ） 基于特异性外周血DNA甲基化位点的人类健康长寿标志物及应用, 2020, 第 1 作者, 专利号: 202010242240.8

（ 8 ） 与健康老龄相关的关键通路及其外周血DNA甲基化位点标志物和应用, 2020, 第 1 作者, 专利号: 202010235853.9

（ 9 ） 神经退行性疾病内源性小分子早期预测标志物及应用, 2020, 第 3 作者, 专利号: 202010242240.8

（ 10 ） 帕金森病特异血清内源小分子标志物及应用, 2020, 第 3 作者, 专利号: 202010242240.8

（ 11 ） 阿兹海默病标志物及应用, 2020, 第 3 作者, 专利号: 202010242240.8

（ 12 ） 一种大样本高通量生物数据关联分析方法, 2019, 第 2 作者, 专利号: ZL201510353906.6

   

（1） Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging, NATIONAL SCIENCE REVIEW, 2023, 通讯作者
（2） Mitogenome evidence shows two radiation events and dispersals of matrilineal ancestry from Northern Coastal China to the Americas and Japan, CELL REPORTS, 2023, 通讯作者
（3） Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation, AGING AND DISEASE, 2022, 通讯作者
（4） Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity, GENES, 2022, 通讯作者
（5） System-level metabolic modeling facilitates unveiling metabolic signature in exceptional longevity, AGING CELL, 2022, 通讯作者
（6） Multiple time-series expression trajectories imply dynamic functional changes during cellular senescence, COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022, 通讯作者
（7） ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity, SCIENCE ADVANCES, 2022, 通讯作者
（8） Decoding the role of long noncoding RNAs in the healthy aging of centenarians, BRIEFINGS IN BIOINFORMATICS, 2021, 通讯作者
（9） Complete mitogenomes document substantial genetic contribution from the Eurasian Steppe into northern Pakistani Indo-Iranian speakers, EUROPEAN JOURNAL OF HUMAN GENETICS, 2021, 通讯作者
（10） Senolytic targets and new strategies for clearing senescent cells, MECHANISMS OF AGEING AND DEVELOPMENT, 2021, 通讯作者
（11） Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance, RNA BIOLOGY, 2020, 通讯作者
（12） Identification of DNA N 6 -methyladenine sites by integration of sequence features, EPIGENETICS & CHROMATIN, 2020, 通讯作者
（13） rs11046147 mutation in the promoter region of lactate dehydrogenase-B as a potential predictor of prognosis in triple-negative breast cancer, rs11046147 mutation in the promoter region of lactate dehydrogenase‐B as a potential predictor of prognosis in triple‐negative breast cancer, CANCER COMMUNICATIONS, 2020, 通讯作者
（14） Exploring European ancestry among the Kalash population: a mitogenomic perspective, Exploring European ancestry among the Kalash population: a mitogenomic perspective, ZOOLOGICAL RESEARCH, 2020, 通讯作者
（15） River Valleys Shaped the Maternal Genetic Landscape of Han Chinese, MOLECULAR BIOLOGY AND EVOLUTION, 2019, 通讯作者
（16） Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA, PEERJ, 2019, 通讯作者
（17） TICRR Contributes to Tumorigenesis Through Accelerating DNA Replication in Cancers, FRONTIERS IN ONCOLOGY, 2019, 通讯作者
（18） Neolithic millet farmers contributed to the permanent settlement of the Tibetan Plateau by adopting barley agriculture, Neolithic millet farmers contributed to the permanent settlement of the Tibetan Plateau by adopting barley agriculture, 国家科学评论:英文版, 2019, 第 10 作者
（19） Dynamic DNA Methylation During Aging: A "Prophet" of Age-Related Outcomes, FRONTIERSINGENETICS, 2019, 通讯作者
（20） 遗传学视角下东亚人群的起源和演化, The origin and evolution history of East Asian populations from genetic perspectives, 遗传, 2018, 第 3 作者
（21） Bioactivities of EF24, a novel curcumin analog: A review. Frontiers in Oncology, FRONTIERS IN ONCOLOGY, 2018, 通讯作者
（22） Bioactivities of EF24, a Novel Curcumin Analog: A Review, FRONTIERS IN ONCOLOGY, 2018, 第 5 作者
（23） Cultural diffusion of Indo-Aryan languages into Bangladesh: A perspective from mitochondrial DNA, MITOCHONDRION, 2018, 通讯作者
（24） Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death, CELL RESEARCH, 2018, 第 13 作者
（25） Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans, CLINICAL EPIGENETICS, 2018, 通讯作者
（26） Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians, GENOME RESEARCH, 2018, 通讯作者
（27） Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway, ONCOTARGET, 2017, 通讯作者
（28） A Normalization-Free and Nonparametric Method Sharpens Large-Scale Transcriptome Analysis and Reveals Common Gene Alteration Patterns in Cancers, THERANOSTICS, 2017, 通讯作者
（29） ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers, ONCOTARGET, 2017, 通讯作者
（30） DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY, ARCHIVES OF BIOLOGICAL SCIENCES, 2016, 通讯作者
（31） Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring, NEUROBIOLOGY OF AGING, 2016, 通讯作者
（32） Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance, EPIGENETICS & CHROMATIN, 2016, 通讯作者
（33） Mitochondrial DNA plays an equal role in influencing female and male longevity in Chinese centenarians, EXPERIMENTALGERONTOLOGY, 2016, 通讯作者
（34） Progress on the role of DNA methylation in aging and longevity, BRIEFINGS IN FUNCTIONAL GENOMICS, 2016, 第 2 作者
（35） Exploring the maternal history of the Tai people, JOURNAL OF HUMAN GENETICS, 2016, 通讯作者
（36） Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians, EXPERIMENTAL GERONTOLOGY, 2016, 通讯作者
（37） Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families, SCIENTIFIC REPORTS, 2016, 通讯作者
（38） Decline in blood hemoglobin concentrations is associated with familial longevity, ARCHIVES OF BIOLOGICAL SCIENCES, 2016, 第 13 作者
（39） Mitochondrial DNA contributes equally to female and male longevity in Chinese centenarians, EXPERIMENTAL GERONTOLOGY, 2016, 通讯作者
（40） Lower mitochondrial DNA content relates to high-altitude adaptation in Tibetans, MITOCHONDRIAL DNA PART A, 2016, 通讯作者
（41） A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes, PLOS ONE, 2015, 第 6 作者
（42） Discovery of the Fuyan teeth: challenging or complementing the out-of-Africa scenario?, ZOOLOGICAL RESEARCH, 2015, 第 3 作者
（43） Thyroid Function Decreases with Age and May Contribute to Longevity in Chinese Centenarians' Families, JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2015, 第 9 作者
（44） A dual origin of Tibetans: evidence from mitochondrial genomes, JOURNAL OF HUMAN GENETICS, 2015, 第 3 作者
（45） Decreased thyroid function changes with age and may contribute to longevity in Chinese centenarians’ families, Journal of the American Geriatrics Society, 2015, 通讯作者
（46） A genetic contribution from the Far East into Ashkenazi Jews via the ancient Silk Road, SCIENTIFIC REPORTS, 2015, 通讯作者
（47） Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China, SCIENTIFIC REPORTS, 2015, 通讯作者
（48） Ancient inland human dispersals from Myanmar into interior East Asia since the Late Pleistocene, SCIENTIFIC REPORTS, 2015, 通讯作者
（49） **基因组视角下的人类起源演化, 科学通报, 2015, 第 3 作者
（50） Absence of mutation in miR-34a gene in a Chinese longevity population, ZOOLOGICAL RESEARCH, 2015, 第 4 作者
（51） The whole mitochondrial genome of the Cynomolgus macaque (Macaca fascicularis), MITOCHONDRIAL DNA, 2015, 通讯作者
（52） Reappraising the Relationship Between Mitochondrial DNA Variant m.16189T > C and Type 2 Diabetes Mellitus in East Asian Populations, CURRENT MOLECULAR MEDICINE, 2014, 
（53） Assessment of the health status of centenarians in the South of china: a cross-sectional study, JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2014, 第 7 作者
（54） Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism rs11977526 with longevity in Chinese nonagenarians and centenarians, 2014, 通讯作者
（55） Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians, AGING-US, 2014, 通讯作者
（56） The MNS16A polymorphism in the TERT gene in peri-centenarians from the Han Chinese population, SCIENCE CHINA-LIFE SCIENCES, 2014, 通讯作者
（57） The reduction of vascular disease risk mutations contributes to longevity in the Chinese population, META GENE, 2014, 
（58） A decrease of mitochondrial DNA copy number contributes to high-altitude adaptation in Tibetans, Mitochondrial DNA, 2014, 通讯作者
（59） Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals, NEUROBIOLOGY OF AGING, 2014, 第 7 作者
（60） Evaluating the Susceptibility of Mitochondrial DNA Germline Mutations in Chinese Cancer Patients, CURRENT MOLECULAR MEDICINE, 2014, 
（61） 中国汉族人群长寿老人TERT基因MNS16A长度多态研究, 中国科学:生命科学 ,, 2014, 第 8 作者
（62） Mitochondrial DNA content contributes to healthy aging in Chinese:a study from nonagenarians and centenarians, NEUROBIOLOGY OF AGING, 2014, 通讯作者
（63） Mitochondrial DNA Content Contributes to Climate Adaptation Using Chinese Populations as a Model, PLOS ONE, 2013, 通讯作者
（64） Revisiting the role of the Himalayas in peopling Nepal: new insights from mitochondrial DNA genomes, Journal of Human Genetics, 2012, 通讯作者
（65） 能量代谢途径相关基因变异与肿瘤细胞适应性进化, 动物学研究, 2012, 第 2 作者
（66） Deciphering the Signature of Selective Constraints on Cancerous Mitochondrial Genome, MOLECULAR BIOLOGY AND EVOLUTION, 2012, 通讯作者
（67） Mitochondrial DNA evidence supports northeast Indian origin of the aboriginal Andamanese in the Late Paleolithic, JOURNAL OF GENETICS AND GENOMICS, 2011, 通讯作者
（68） Inland post-Glacial dispersals in East Asia revealed by mitochondrial haplogroup M9a’b, BMC Biology, 2011, 通讯作者
（69） Inland post-glacial dispersal in East Asia revealed by mitochondrial haplogroup M9a'b, BMC BIOLOGY, 2011, 通讯作者
（70） Large-Scale mtDNA Screening Reveals a Surprising Matrilineal Complexity in East Asia and Its Implications to the Peopling of the Region, MOLECULAR BIOLOGY AND EVOLUTION, 2011, 通讯作者
（71） Uncovering the Profile of Somatic mtDNA Mutations in Chinese Colorectal Cancer Patients, PLOS ONE, 2011, 第 7 作者
（72） Reply to van Oven: Suggestions and caveats for naming mtDNA haplogroup, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 通讯作者
（73） Tracing the Austronesian Footprint in Mainland Southeast Asia: A Perspective from Mitochondrial DNA, MOLECULAR BIOLOGY AND EVOLUTION, 2010, 通讯作者
（74） Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 通讯作者
（75） 人类线粒体DNA世系的系统发育关系研究, Phylogeny of human mitochondrial DNA lineages and its applications, 生命科学, 2008, 第 1 作者
（76） Application of the phylosenetic analysis in mitochondrial disease study, Application of the phylosenetic analysis in mitochondrial disease study, 中国科学通报：英文版, 2008, 第 2 作者
（77） Distilling artificial recombinants from large sets of complete mtDNA genomes, PLOSONE, 2008, 通讯作者
（78） Strikingly different penetrance of LHON in two Chinese families with primary mutation G11778A is independent of mtDNA haplogroup background and secondary mutation G13708A, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2008, 第 4 作者
（79） 系统发育分析在线粒体遗传病研究中的应用, 科学通报, 2008, 第 2 作者
（80） Application of the phylogenetic analysis in mitochondrial disease study, CHINESE SCIENCE BULLETIN, 2008, 第 2 作者
（81） Somatic mutations of mitochondrial genome in early stage breast cancer, INTERNATIONALJOURNALOFCANCER, 2007, 通讯作者
（82） Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations, HUMAN MOLECULAR GENETICS, 2006, 通讯作者
（83） The dazzling array of basal branches in the mtDNA macrohaplogroup M from India as inferred from complete genomes, MOLECULAR BIOLOGY AND EVOLUTION, 2006, 
（84） Different matrilineal contributions to genetic structure of ethnic groups in the Silk Road region in China, MOLECULAR BIOLOGY AND EVOLUTION, 2004, 
（85） 人类线粒体D N A 中碱基缺失/ 插人的真伪能否从世系的系统发育关系来推断？, 科学通报, 2003, 第 2 作者
（86） Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences, AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 
（87） 人类线粒体DNA中碱基缺失／插入的真伪能否从世系的系统发育关系来推断？, 科学通报, 2003, 第 2 作者
（88） 基于全序列的东亚人群mtDNA系统发育及汉族人群的遗传分化研究, 中国遗传学会第七次代表大会暨学术讨论会, 2003, 第 1 作者

   

（ 1 ） 基于线粒体基因组和Y染色体遗传信息追溯美洲印第安人的源流历史, 负责人, 国家任务, 2017-01--2021-12
（ 2 ） 健康长寿人群基因组表观修饰模式及功能作用研究, 负责人, 中国科学院计划, 2016-08--2020-12
（ 3 ） 中国健康长寿人群基因组DNA甲基化修饰模式及其功能作用 研究, 负责人, 国家任务, 2018-01--2020-12
（ 4 ） 中国科学院昆明动物研究所健康衰老分子机理研究与应用省创新团队, 负责人, 地方任务, 2017-08--2020-08
（ 5 ） 昆明市健康衰老分子机理研究及应用重点实验室, 负责人, 其他国际合作项目, 2018-01--2020-12
（ 6 ） 人类早期活动及其对高寒环境的适应策略, 负责人, 中国科学院计划, 2018-01--2022-12
（ 7 ） 中国健康长寿大人群多队列的系统研究, 负责人, 国家任务, 2018-12--2022-12
（ 8 ） 长寿人群健康老龄关键因子鉴定, 负责人, 中国科学院计划, 2020-01--2021-12
（ 9 ） 适应高原人群的遗传学机制, 负责人, 国家任务, 2019-11--2022-10
（ 10 ） 云南省健康衰老与疾病防治重点实验室, 负责人, 地方任务, 2018-10--2020-10
（ 11 ） 春城科技领军人才专项, 负责人, 地方任务, 2021-01--2025-12
（ 12 ） 云岭学者专项, 负责人, 地方任务, 2021-01--2025-12
（ 13 ） 衰老的调控与干预, 参与, 中国科学院计划, 2022-07--2027-07

（1）科研论文的撰写技巧   广西医学会检验医学分会青年委员会学术论坛   2019-12-09
（2）Transcriptomic insights into the protective factors in Chinese centenarians   亚洲衰老研究研讨会   2018-03-18
（3）健康长寿人群老年性疾病低发的遗传学基础研究   中国心脏大会   2016-08-11
（4）Deciphering the signature of selective constraints on cancerous mitochondrial genome   全球华人遗传学大会   孔庆鹏   2012-07-06
（5）mtDNA phylogenomics in East Asia   第三届国际线粒体生物医学学术会议   孔庆鹏   2009-08-10