基本信息
孔庆鹏  男  博导  中国科学院昆明动物研究所
电子邮件: kongqp@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区茨坝青松路21号
邮政编码: 650223

招生信息

   
招生专业
071007-遗传学
招生方向
人类进化遗传学
疾病基因组学

教育背景

1999-09--2005-06   中国科学院研究生院   理学博士
1995-09--1999-06   兰州大学   理学学士

工作经历

   
工作简历
2008-09~现在, 中国科学院昆明动物研究所, 研究员
2005-12~2008-08,中国科学院昆明动物研究所, 副研究员
2005-06~2005-11,中国科学院昆明动物研究所, 助理研究员
1999-09~2005-06,中国科学院研究生院, 理学博士
1995-09~1999-06,兰州大学, 理学学士
社会兼职
2015-05-01-今,SCI期刊《Scientific Reports》编委, 编委
2013-01-01-2018-12-31,中国遗传学会青年委员会, 副主任
2009-01-30-2010-12-31,SCI期刊《Human Biology》编委, 编委

专利与奖励

   
奖励信息
(1) 万人计划, 国家级, 2016
(2) 云南省科学技术奖, 特等奖, 省级, 2014
(3) 国家自然科学奖, 二等奖, 国家级, 2014
(4) 吴旻人类与医学遗传创新奖, 专项, 2013
(5) 云南省中青年学术和技术带头人, 省级, 2012
(6) 中国科学院西部学者突出贡献奖, , 部委级, 2011
(7) 中国科学院卢嘉锡青年人才奖, , 部委级, 2008
(8) 全国百篇优秀博士学位论文奖, , 国家级, 2007
(9) 国家自然科学奖二等奖, 二等奖, 国家级, 2006
(10) 云南省科学技术奖一等奖, 一等奖, 省级, 2005
(11) 第四届云南省青年科技奖, , 省级, 2005
(12) 中国科学院院长奖学金特别奖, , 部委级, 2005
专利成果
( 1 ) 一种大样本高通量生物数据关联分析方法, 2019, 第 2 作者, 专利号: ZL201510353906.6

出版信息

   
发表论文
(1) Neolithic millet farmers contributed to the permanent settlement of the Tibetan Plateau by adopting barley agriculture, Natil Sci Rev, 2019, 通讯作者
(2) Dynamic DNA Methylation During Aging: A “Prophet” of Age-Related Outcomes, Front Genet, 2019, 通讯作者
(3) Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA, PeerJ, 2019, 通讯作者
(4) TICRR Contributes to Tumorigenesis Through Accelerating DNA Replication in Cancers, Front Oncol, 2019, 通讯作者
(5) River valleys shaped the maternal genetic landscape of Han Chinese, Mol Biol Evol, 2019, 通讯作者
(6) Cultural diffusion of IndoAryan languages into Bangladesh: A perspective from mitochondrial DNA, Mitochondrion, 2018, 通讯作者
(7) Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans, Clinical Epigenetics, 2018, 通讯作者
(8) Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians, Genome Research, 2018, 通讯作者
(9) Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA, PeerJ, 2018, 通讯作者
(10) A Normalization-free and nonparametric method sharpens large-scale transcriptome analysis and reveals common gene alteration patterns in cancers, Theranostics, 2017, 通讯作者
(11) Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway, Oncotarget, 2017, 通讯作者
(12) ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers, Oncotarget, 2017, 通讯作者
(13) Mitochondrial DNA plays an equal role in influencing female and male longevity in Chinese centenarians, Experimental Gerontology, 2016, 通讯作者
(14) Exploring the maternal history of the Tai people, Journal of Human Genetics, 2016, 通讯作者
(15) Progress on the role of DNA methylation in aging and longevity, Progress on the role of DNA methylation in aging and longevity, 2016, 第 2 作者
(16) Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway, Oncotarget, 2016, 通讯作者
(17) Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance, Epigenetics & Chromatin, 2016, 通讯作者
(18) ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers, Oncotarget, 2016, 通讯作者
(19) Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring, Neurobiology of Aging, 2016, 通讯作者
(20) Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families, Scientific Reports, 2016, 通讯作者
(21) Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China, Scientific Reports, 2015, 通讯作者
(22) The whole mitochondrial genome of the Cynomolgus macaque (Macaca fascicularis), Mitochondrial DNA, 2015, 通讯作者
(23) A dual origin of the Tibetans: evidence from mitochondrial genomes, Journal of Human Genetics, 2015, 通讯作者
(24) Decline in blood hemoglobin concentrations is associated with familial longevity, Archives of Biological Sciences, 2015, 通讯作者
(25) Absence of mutation in miR-34a gene in a Chinese longevity population, Zoological Research, 2015, 通讯作者
(26) Discovery of the Fuyan teeth: challenging or complementing the out-of-Africa scenario?, Zoological Research, 2015, 通讯作者
(27) Ancient inland human dispersals from Myanmar into interior East Asia since the Late Pleistocene, Scientific Report, 2015, 通讯作者
(28) Agenetic contribution from the Far East into Ashkenazi Jews via the ancient Silk Road, Scientific Report, 2015, 通讯作者
(29) A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes , PLOS ONE, 2015, 通讯作者
(30) Decreased thyroid function changes with age and may contribute to longevity in Chinese centenarians’ families, Journal of the American Geriatrics Society, 2015, 通讯作者
(31) Mitochondrial DNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians, Neurobiology of Aging, 2014, 通讯作者
(32) The MNS16A polymorphism of TERT gene in peri-centenarians from Han Chinese Population, SCIENCE CHINA Life Sciences, 2014, 通讯作者
(33) The reduction of vascular disease risk mutations contributes to longevity in Chinese, Meta Gene, 2014, 通讯作者
(34) Reappraising the relationship between mitochondrial DNA variant m.16189T-C and type 2 diabetes mellitus in East Asian populations, Current Molecular Medicine, 2014, 通讯作者
(35) Absence of A673T variant in APP gene indicates an alternative protectivemechanism contributing to longevity in Chinese individuals , Neurobiology of Aging, 2014, 通讯作者
(36)  Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism rs11977526 with longevity in Chinese nonagenarians and centenarians, Aging-US, 2014, 通讯作者
(37) Decreased thyroid function changes with age and may contribute to longevity in Chinese centenarians’ families, Journal of the American Geriatrics Society , 2014, 通讯作者
(38) A decrease of mitochondrial DNA copy number contributes to high-altitude adaptation in Tibetans, Mitochondrial DNA, 2014, 通讯作者
(39) Evaluating the susceptibility of mitochondrial DNA germline mutations in Chinese cancer patients, Current Molecular Medicine, 2014, 通讯作者
(40) Assessment of the health status of centenarians in the South of China: a cross-sectional study, Journal of the American Geriatrics Society , 2014, 通讯作者
(41) Deciphering the signature of selective constraints on cancerous mitochondrial genome, Molecular Biology and Evolution, 2012, 通讯作者
(42) Revisiting the role of the Himalayas in peopling Nepal: new insights from mitochondrial DNA genomes, Journal of Human Genetics, 2012, 通讯作者
(43) Uncovering the profile of somatic mtDNA mutations in colorectal cancer patients, PLoS ONE, 2011, 通讯作者
(44) Large-scale mtDNA screening reveals a surprising matrilineal complexity in East Asia and its implications to the peopling of the Region, Molecular Biology and Evolution, 2011, 通讯作者
(45) Inland post-Glacial dispersals in East Asia revealed by mitochondrial haplogroup M9a’b, BMC Biology, 2011, 通讯作者
(46) Tracing the Austronesian footprint in mainland Southeast Asia: a perspective from mitochondrial DNA, Molecular Biology and Evolution, 2010, 通讯作者
(47) Mitochondrial genome evidence reveals successful Late Paleolithic settlement on the Tibetan Plateau, PNAS, 2009, 通讯作者
(48) Distilling artificial recombinants from large sets of complete mtDNA genomes, PLoS ONE, 2008, 第 1 作者
(49) Somatic mutations of mitochondrial genome in early stage breast cancer, International Journal of Cancer , 2007, 通讯作者
(50) Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations, Human Molecular Genetics, 2006, 通讯作者
(51) The dazzling array of basal branches in the mtDNA macrohaplogroup M from India as inferred from complete genomes, Molecular Biology and Evolution, 2006, 第 1 作者
(52) Different matrilineal contributions to genetic structure of ethnic groups in the Silk Road region in China, Molecular Biology and Evolution , 2004, 第 1 作者
(53) Phylogeny of East Asian mitochondrial DNA lineages inferred from complete sequences, American Journal of Human Genetics, 2003, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于线粒体基因组和Y染色体遗传信息追溯美洲印第安人的源流历史, 主持, 国家级, 2017-01--2021-12
( 2 ) 健康长寿人群基因组表观修饰模式及功能作用研究, 主持, 部委级, 2016-08--2020-12
( 3 ) 中国健康长寿人群基因组DNA甲基化修饰模式及其功能作用 研究, 主持, 国家级, 2018-01--2020-12
( 4 ) 中国科学院昆明动物研究所健康衰老分子机理研究与应用省创新团队, 主持, 省级, 2017-08--2020-08
( 5 ) 昆明市健康衰老分子机理研究及应用重点实验室, 主持, 研究所(学校), 2018-01--2020-12
( 6 ) 人类早期活动及其对高寒环境的适应策略, 主持, 部委级, 2018-01--2022-12
( 7 ) 中国健康长寿大人群多队列的系统研究, 主持, 国家级, 2018-12--2022-12
( 8 ) 长寿人群健康老龄关键因子鉴定, 主持, 部委级, 2020-01--2021-12
( 9 ) 适应高原人群的遗传学机制, 主持, 国家级, 2019-11--2022-10
( 10 ) 云南省健康衰老与疾病防治重点实验室, 主持, 省级, 2018-10--2020-10
参与会议
(1)科研论文的撰写技巧   广西医学会检验医学分会青年委员会学术论坛   2019-12-09
(2)Transcriptomic insights into the protective factors in Chinese centenarians   亚洲衰老研究研讨会   2018-03-18
(3)健康长寿人群老年性疾病低发的遗传学基础研究   中国心脏大会   2016-08-11
(4)Deciphering the signature of selective constraints on cancerous mitochondrial genome   全球华人遗传学大会   孔庆鹏   2012-07-06
(5)mtDNA phylogenomics in East Asia   第三届国际线粒体生物医学学术会议   孔庆鹏   2009-08-10