071005-微生物学
086000-生物与医药

链球菌抗氧胁迫及致病的分子机制

2005-03--2005-07   School of Dentistry, University of California, Los angeles   访问学习
2000-08--2003-07   北京大学医学部   博士
1995-08--1998-07   中国医科大学   硕士
1988-08--1993-07   中国医科大学   本科

   

2009-03~2010-03,School of Dentistry, University of Florida, 访问学者
2007-05~现在, 中国科学院微生物研究所, 副研究员
2005-03~2005-07,School of Dentistry, University of California, Los angeles, 访问学习
2003-08~2007-05,中国科学院微生物研究所, 助理研究员
2000-08~2003-07,北京大学医学部, 博士
1995-08~1998-07,中国医科大学, 硕士
1988-08~1993-07,中国医科大学, 本科

微生物学实验技术

   

（1） Pn-AqpC-Mediated Fermentation Pattern Coordination with the Two-Component System 07 Regulates Host N-Glycan Degradation of Streptococcus pneumoniae, MICROBIOLOGY SPECTRUM, 2022, 通讯作者
（2） A Novel Aquaporin Subfamily Imports Oxygen and Contributes to Pneumococcal Virulence by Controlling the Production and Release of Virulence Factors, MBIO, 2021, 通讯作者
（3） RNase Z Oxidative Degradation Impedes tRNA Maturation and is Involved in Streptococcal Translation Regulation in Response to Oxidative Stress, MICROBIOLOGY SPECTRUM, 2021, 通讯作者
（4） Redox-Regulated Adaptation of Streptococcus oligofermentans to Hydrogen Peroxide Stress, MSYSTEMS, 2020, 通讯作者
（5） Redox-Regulated Adaptation of Streptococcus oligofermentans to Hydrogen Peroxide Stress, MSYSTEMS, 2020, 第 1 作者
（6） Prokaryotic Aquaporins, CELLS, 2019, 通讯作者
（7） The carbon catabolite repressor CcpA mediates optimal competence development in Streptococcus oligofermentans through post-transcriptional regulation, MOLECULAR MICROBIOLOGY, 2019, 通讯作者
（8） A Streptococcus aquaporin acts as peroxiporin for efflux of cellular hydrogen peroxide and alleviation of oxidative stress, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 通讯作者
（9） Molecular Insights into Hydrogen Peroxide-sensing Mechanism of the Metalloregulator MntR in Controlling Bacterial Resistance to Oxidative Stresses, JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 通讯作者
（10） Streptococcus oligofermentans Inhibits Streptococcus mutans in Biofilms at Both Neutral pH and Cariogenic Conditions, PLOS ONE, 2015, 第 3 作者
（11） PerR-Regulated Manganese Ion Uptake Contributes to Oxidative Stress Defense in an Oral Streptococcus, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2014, 通讯作者
（12） Complete Genome Sequence of an Oral Commensal, Streptococcus oligofermentans Strain AS 1.3089, GENOME ANNOUNCEMENTS, 2013, 第 1 作者
（13） Function of the Pyruvate Oxidase-Lactate Oxidase Cascade in Interspecies Competition between Streptococcus oligofermentans and Streptococcus mutans, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2012, 通讯作者
（14） Role of Operon aao So -mutT in Antioxidant Defense in Streptococcus oligofermentans, PLOS ONE, 2012, 第 3 作者
（15） Role of Operon aao-mutT in Antioxidant Defense in Streptococcus oligofermentans, PLoS One, 2012, 通讯作者
（16） CcpA-Dependent Carbohydrate Catabolite Repression Regulates Galactose Metabolism in Streptococcus oligofermentans, JOURNAL OF BACTERIOLOGY, 2012, 第 2 作者
（17） The EIIABman PTS permease regulates carbohydrate catabolite repression in Streptococcus gordonii, Appl Environ Microbiol, 2011, 第 1 作者
（18） The EIIAB(Man) Phosphotransferase System Permease Regulates Carbohydrate Catabolite Repression in Streptococcus gordonii, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2011, 第 1 作者
（19） A Preliminary Study of Biological Characteristics of Streptococcus oligofermentans in Oral Microecology, CARIES RESEARCH, 2010, 
（20） Dpr蛋白在寡发酵链球菌抗过氧化氢中的作用, Role of Dpr in hydrogen peroxide tolerance of Streptococcus oligofermentans, 微生物学报, 2009, 第 2 作者
（21） SO-LAAO, a Novel l -Amino Acid Oxidase That Enables Streptococcus oligofermentans To Outcompete Streptococcus mutans by Generating H 2 O 2 from Peptone ▿ †, JOURNAL OF BACTERIOLOGY, 2008, 第 1 作者
（22） SO-LAAO, a novel L-amino acid oxidase that enables Streptococcus oligofermentans to outcompete Streptococcus mutans by generation H2O2 from peptone, J Bacteriol, 2008, 第 1 作者
（23） 寡发酵链球菌分子标识鉴定方法的建立, Development of an identification method for Streptococcus oligofermentans: a new species of oral streptococci with molecular markers, 中华口腔医学杂志, 2007, 第 2 作者
（24） Streptococcus oligofermentans inhibits streptococcus mutans through conversion of lactic acid into inhibitory h2o2: a possible counteroffensive strategy for interspecies competition, MOLECULAR MICROBIOLOGY, 2007, 第 1 作者
（25） 一株口腔链球菌新种-寡发酵链球菌产过氧化氢特性的研究, Characterization of hydrogen peroxide production by a novel oral streptococci,S. oligofermentans isolated from human oral cavity, 微生物学报, 2006, 第 2 作者
（26） Pediococcus ethanolidurans sp nov., isolated from the walls of a distilled-spirit-fermenting cellar, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2006, 第 3 作者
（27） Establishing a genetic system for ecological studies of Streptococcus oligofermentans, FEMS MICROBIOLOGY LETTERS, 2006, 第 1 作者
（28） Molecular Insights into Hydrogen Peroxide-sensing Mechanism of the Metalloregulator MntR in Controlling Bacterial Resistance to Oxidative Stresses *, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 第 5 作者

   

（ 1 ） 寡发酵链球菌抗氧胁迫的分子机制, 负责人, 国家任务, 2014-01--2017-12
（ 2 ） 副乾酪乳桿菌V0151生理、生化特性及动物毒性的影响, 参与, 境内委托项目, 2014-02--2014-08
（ 3 ） 肺炎链球菌水通道蛋白的生理功能及其介导毒力的分子机制, 负责人, 国家任务, 2020-01--2023-12

（1）链球菌抗氧胁迫的分子机制   2019年全国微生物学年会   2019-10-12