基本信息
邓菲  女  博导  中国科学院武汉病毒研究所
电子邮件: df@wh.iov.cn
通信地址: 湖北省武汉市小洪山中区44号
邮政编码: 430071

研究领域

   

招生信息

   
招生专业
071005-微生物学
招生方向
病毒学
生物技术

教育背景

   
学历
   
学位
   

工作经历

   
工作简历
2013-08~现在, 中国科学院武汉病毒研究所, 研究员
2007-09~现在, 中国科学院武汉病毒研究所, 副研究员
2003-07~现在, 中国科学院武汉病毒研究所, 助理研究员
社会兼职
   

教授课程

   

专利与奖励

   
奖励信息
(1) 湖北省自然科学一等奖, 一等奖, 省级, 2011
专利成果
( 1 ) 一种用于检测乙型肝炎病毒的生物用品。 , 2008, 第 3 作者, 专利号: ZL 2006 1 0018346.X
( 2 ) 重组杆状病毒AcBac△cc-GP41及其构建方法 , 2011, 第 4 作者, 专利号: ZL 2007 1 0052629.0
( 3 ) 一种用于检测禽流感病毒H5N1亚型的液相芯片。, 2009, 第 4 作者, 专利号: ZL 2006 1 0018603.X
( 4 ) 高效表达SARS冠状病毒S蛋白的重组杆状病毒及构建。 , 2010, 第 3 作者, 专利号: ZL 2007 1 0052485.9
( 5 ) 用于乙型肝炎病毒共价闭合DNA的检测用品及其应用, 2012, 第 4 作者, 专利号: ZL200810197526.8
( 6 ) 用液相芯片检测呼吸道传染病病原的引物和探针及方法, 2012, 第 3 作者, 专利号: ZL201110067021.1
( 7 ) 用于杆状病毒滴度测定的重组细胞系及其测定办法, 2013, 第 1 作者, 专利号: 201310538492.5
( 8 ) 用液相芯片检测虫媒或接触传播病原的引物和探针及方法, 2013, 第 3 作者, 专利号: ZL201110067025.x
( 9 ) 一种可进行生物安全操作的冷冻干燥装置, 2017, 第 2 作者, 专利号: ZL201721487074.8

出版信息

   
发表论文
(1) Detection and characterization of a novel hepacivirus in long-tailed ground squirrels (Spermophilus undulatus) in China., Arch Virol., 2019, 第 11 作者
(2) Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins, Virol Sin., 2019, 第 3 作者
(3) Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1., Front Immunol., 2019, 第 9 作者
(4) Zika virus circumvents host innate immunity by targeting the adaptor proteins MAVS and MITA, FASEB J., 2019, 第 9 作者
(5) The major hurdle for effective baculovirus transduction into mammalian cells is passing early endosomes., J Virol., 2019, 第 4 作者
(6) Taxonomy of the order Bunyavirales: update 2019., Arch Virol., 2019, 第 12 作者
(7) Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1., J Biol Chem., 2019, 第 2 作者
(8) Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection., J Virol., 2019, 第 7 作者
(9) Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus., NPJ Vaccines., 2019, 第 12 作者
(10) Baculovirus Per Os Infectivity Factor Complex: Components and Assembly., J Virol., 2019, 第 12 作者
(11) Single-Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus., Small., 2019, 第 5 作者
(12) Identification and genomic sequence analysis of a new Spodoptera exigua multiple nucleopolyhedrovirus, SeMNPV-QD, isolated from Qingdao, China., J Invertebr Pathol., 2019, 第 5 作者
(13) N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication., Nucleic Acids Res., 2019, 第 11 作者
(14) The group I alphabaculovirus-specific protein, AC5, is a novel component of the occlusion body but is not associated with ODVs or the PIF complex., J Gen Virol., 2018, 第 5 作者
(15) Isolation, Characterization, and Phylogenetic Analysis of Two New Crimean-Congo Hemorrhagic Fever Virus Strains from the Northern Region of Xinjiang Province, China., Virol Sin., 2018, 第 11 作者
(16) Fine mapping epitope on glycoprotein-Gn from Crimean-Congo hemorrhagic fever virus., Comp Immunol Microbiol Infect Dis., 2018, 第 11 作者
(17) Mapping of B-cell epitopes on the N- terminal and C-terminal segment of nucleocapsid protein from Crimean-Congo hemorrhagic fever virus., PLoS One., 2018, 第 11 作者
(18) Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group I of Alphabaculovirus., Virol Sin., 2018, 第 12 作者
(19) Establishment of Baculovirus-Expressed VLPs Induced Syncytial Formation Assay for Flavivirus Antiviral Screening., Viruses., 2018, 第 11 作者
(20) Zika Virus Baculovirus-Expressed Virus-Like Particles Induce Neutralizing Antibodies in Mice., Virol Sin., 2018, 第 11 作者
(21) Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes., Virol Sin., 2018, 第 5 作者
(22) The functional oligomeric state of tegument protein GP41 is essential for baculovirus BV and ODV assembly., J Virol., 2018, 第 4 作者
(23) HearNPV Pseudotyped with PIF1, 2, and 3 from MabrNPV: Infectivity and Complex Stability., Virol Sin., 2018, 第 7 作者
(24) Prevalence and Phylogenetic Analysis of Crimean-Congo Hemorrhagic Fever Virus in Ticks from Different Ecosystems in Xinjiang, China., Virol Sin., 2018, 第 11 作者
(25) A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen., Emerg Microbes Infect., 2018, 第 11 作者
(26) Tick-Borne Viruses., Virol Sin., 2018, 第 11 作者
(27) Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea., PLoS One., 2018, 第 8 作者
(28) A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus., Antiviral Res., 2017, 第 8 作者
(29) A new strain of Crimean-Congo hemorrhagic fever virus isolated from Xinjiang, China., Virol Sin., 2017, 第 11 作者
(30) Three conserved regions in baculovirus sulfhydryl oxidase, P33, are critical for enzymatic activity and function., J Virol., 2017, 第 5 作者
(31) Detection, isolation, and characterization of chikungunya viruses associated with the Pakistan outbreak of 2016-2017., Virol Sin., 2017, 第 9 作者
(32) Antigenicity of severe fever with thrombocytopenia syndrome virus nucleocapsid protein and its potential application in the virus serodiagnosis., Virol Sin., 2017, 第 11 作者
(33) The roles of ebolavirus glycoproteins in viral pathogenesis., Virol Sin., 2017, 第 2 作者
(34) Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction., J Biol Chem., 2017, 第 4 作者
(35) Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo., Protein Cell., 2017, 第 8 作者
(36) Construction and Rescue of a Functional Synthetic Baculovirus., ACS Synth Biol., 2017, 第 11 作者
(37) Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016., Virol Sin., 2017, 第 11 作者
(38) Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection., J Virol., 2017, 第 7 作者
(39) Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province, China., Virol Sin., 2017, 第 10 作者
(40) Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus., Virol Sin., 2016, 第 6 作者
(41) Pathologic Studies of Fatal Encephalomyelitis in Children Caused by Enterovirus 71, Am J Clin Pathol., 2016, 第 10 作者
(42) Spatial Analysis of Severe Fever with Thrombocytopenia Syndrome Virus in China Using a Geographically Weighted Logistic Regression Model., Int J Environ Res Public Health., 2016, 第 2 作者
(43) Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus., Journal of Structural Biology., 2016, 第 11 作者
(44) Genome Sequencing and Analysis of Catopsilia pomona nucleopolyhedrovirus: A Distinct Species in Group I Alphabaculovirus., PLoS One., 2016, 第 9 作者
(45) The Host Specificities of Baculovirus per os Infectivity Factors., PLoS One., 2016, 第 6 作者
(46) Migration, recombination, and reassortment are involved in the evolution of severe fever with thrombocytopenia syndrome bunyavirus., Infect Genet Evol., 2016, 第 9 作者
(47) Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus., J Gen Virol., 2016, 第 11 作者
(48) Phylogenetic analysis revealed the central roles of two African countries in the evolution and worldwide spread of Zika virus., Virol Sin., 2016, 第 11 作者
(49) A 3-year follow-up study of the seroprevalence of antibodies to avian influenza A H5, H6, H7 and H10 viruses among the general population of Wuhan, China., J Clin Virol., 2016, 第 11 作者
(50) Virus like particle-based vaccines against emerging infectious disease viruses., Virol Sin., 2016, 第 11 作者
(51) P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33., Virol Sin., 2016, 第 5 作者
(52) Characterization of two monoclonal antibodies, 38F10 and 44D11, against the major envelope fusion protein of Helicoverpa armigera nucleopolyhedrovirus., Virol Sin., 2016, 第 3 作者
(53) Glycoprotein E of the Japanese Encephalitis Virus forms virus-like particles and induces Syncytia when expressed by a baculovirus. , J Gen Virol. , 2015, 第 11 作者
(54) The FP25K Acts as a Negative Factor for the Infectivity of AcMNPVBudded Virus., PLoS One., 2015, 第 11 作者
(55) 杆状病毒病毒粒子结构与口服感染和系统感染的关系., Chin Sci Bull., 2015, 第 3 作者
(56) An in vitro recombination-based reverse genetic system for rapid mutagenesis of structural genes of the Japanese encephalitis virus., Virol Sin., 2015, 第 11 作者
(57) Genomic Sequencing and Analysis of Sucra jujuba Nucleopolyhedrovirus., Plos One, 2014, 第 11 作者
(58) The ha72 Core Gene of Baculovirus Is Essential for Budded Virus Production and Occlusion-Derived Virus Embedding, and Amino Acid K22 Plays an Important Role in Its Function., J Virol. , 2014, 第 3 作者
(59) Identification and functional analysis of inter-subunit disulfide bonds of F protein of HearNPV. , J Gen Virol. , 2014, 第 4 作者
(60) Fine epitope mapping of the central immunodominant region of nucleoprotein from Crimean-Congo Hemorrhagic Fever Virus (CCHFV). , Plos One, 2014, 第 4 作者
(61) Unraveling the Entry Mechanism of Baculoviruses and Its Evolutionary Implications.,  J Virol . , 2014, 第 11 作者
(62) Serological study of antibodies to influenza A viruses among general population in Wuhan city China., J Clinic Virol. , 2014, 第 11 作者
(63) Characterization and Genomic Analysis of a Plaque Purified Strain of Cyanophage PP., Virologica Sinica., 2013, 第 11 作者
(64) Freshwater Cyanophages., Virologica Sinica. , 2013, 第 3 作者
(65) The ha72 core gene of baculovirus is essential for budded virus production and Occlusion-Derived Virus embedding, and amino acid K22 plays an important role in its function. , J Virol., 2013, 第 3 作者
(66) Reassortment and migration analysis of Crimean–Congo haemorrhagic fever virus., J Gen Virol. , 2013, 第 2 作者
(67) Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus., J Virol., 2013, 第 3 作者
(68)  Betabaculovirus F Proteins Showed Different Efficiency when Rescuing the , Virology., 2013, 第 4 作者
(69) ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex.2012. , Virology., 2012, 第 3 作者
(70) Functional studies of per os infectivity factor 3 of Helicoverpa armigera nucleopolyhedrovirus., J Gen Virol. , 2012, 第 11 作者
(71)  Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro., J Gen Virol. , 2012, 第 11 作者
(72) Analysis of the structural proteins from the Musca domestica hytrosavirus with an emphasis on the major envelope protein., Journal of Invertebrate Pathology., 2012, 第 2 作者
(73) Helicoverpa armigera nucleopolyhedrovirusocclusion-derived virus-associated protein, HA100,affects oral infectivity in vivo but not virus replicationin vitro, Journal of General Virology, 2011, 第 11 作者
(74) Partial Functional Rescue of HearNPV Infectivity by Substitution of F Protein with GP64 from AcMNPV. , Journal of Virology, 2010, 第 11 作者
(75) Proteomics of the Autographa californica Nucleopolyhedrovirus Budded Virions.,  Journal of Virology, 2010, 第 2 作者
(76) Identification of protein–protein interactions of the occlusion-derived virus-associated proteins of Helicoverpa armigera nucleopolyhedrovirus. , Journal of General Virology, 2010, 第 3 作者
(77) AcMNPV efficiently infects Sf9 cells and transduces mammalian cells via direct fusion with the plasma membrane at low pH., Journal of Virology, 2010, 第 4 作者
(78) The F protein of Helicoverpa armigera single nucleopolyhedrovirus can be substituted functionally with its homologue from Spodoptera exigua multiple nuclopolyhedrovirus. , Journal of General Virology, 2009, 第 4 作者
(79) Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus., Journal of General Virology, 2009, 第 11 作者
发表著作
   

科研活动

   
科研项目
( 1 ) 昆虫病毒感染关键步骤的分子机理研究; , 参与, 国家级, 2009-01--2013-12
( 2 ) Ⅱ型包膜病毒的入侵机制 , 参与, 国家级, 2010-01--2014-12
( 3 ) 棉铃虫病毒的结构蛋白HA44的结构与功能及真核定位机理研究, 主持, 国家级, 2007-11--2010-12
( 4 ) 中国境内重要生物安全Ⅲ-Ⅳ级病原的流行病学调查, 主持, 国家级, 2007-08--2010-12
( 5 ) 杆状病毒-昆虫细胞生物反应器的建设与优化, 主持, 部委级, 2011-01--2013-12
( 6 ) 杆状病毒和昆虫细胞间的相互作用, 参与, 国家级, 2008-01--2012-12
( 7 ) 我国重要自然宿主及媒介昆虫的病毒病原调查, 主持, 国家级, 2013-05--2018-12
( 8 ) 生物遗传资源库, 主持, 部委级, 2018-06--2018-12
( 9 ) 重要烈性病毒防控关键技术及产品研发, 参与, 部委级, 2016-01--2018-12
( 10 ) 病毒遗传资源库保藏能力建设, 主持, 部委级, 2017-01--2018-12
( 11 ) 重要RNA病毒的细胞受体研究, 主持, 市地级, 2017-01--2018-12
( 12 ) 欧洲病毒资源库走向全球, 参与, 国家级, 2016-12--2019-11
( 13 ) 生防微生物环境适应性与持效性机制, 主持, 国家级, 2017-07--2020-12
( 14 ) 湖北省发热伴血小板减少综合症病毒传播途径 和致病机理的研究, 主持, 省级, 2019-01--2020-12
( 15 ) 湖北省发热伴血小板减少综合征病毒SFTSV遗传进化与病症相关性研究, 主持, 市地级, 2018-01--2019-12
参与会议
(1)ncorporation of GP64 into Helicoverpa armigera NPV enhances virus infectivity both in vivo and in vitro.   2012国际无脊椎病理和微生物防治会议暨45届无脊椎病理年会   Shu Shen, Yinyin Gan, Manli Wang, Zhihong Hu, Hualin Wang and Fei Deng.    2012-08-05
(2)HA44 is an Essential Gene for Helicoverpa Armigera Nucleopolyhedrovirus Replication and its Coiled-Coil Domain is Functional Important   第44届无脊椎动物病理学年会   邓菲   2011-08-07
(3)Global View and the phenotype model of the Occlusion-Derived Virus of Helicoverpa armigera Nucleopolyhedrovirus   第43届无脊椎动物病理学年会   邓菲   2010-07-09
(4)Identification of Proteins Associated with Autographa californica Nucleopolyhedrovirus Budded Virions   国际无脊椎病理学会第42届年会   邓菲   2009-08-16

合作情况

   
项目协作单位
   

指导学生