General
王晋辉 男 汉族 博导 生物物理研究所
Email: jhw@ibp.ac.cn
Telephone: 1064888472
Address: 北京市朝阳区大屯路15号
Postcode: 100101
部门/实验室:生命科学学院

Research Areas

Neuroscience

Physiology

Education

Ph.D. in Shanghai Institute of Physiology

Experience


Work Experience

Professor in Uinversity of Chinese Academy of Sciences

Professor in Institute of Biophysics Chinese Academy of Sciences

Assistant professor (tennue-track) in Uinversity of Kansas


Teaching Experience
   

Honors & Distinctions

National Award for Young Scientist

Gifted Scientist in Chinese Academy of Sciences

Publications


Papers

Selected peer-reviewed journal papers (The first or corresponding author only)

1)       Jin-Hui Wang and De-Pei Feng (1992). Postsynaptic protein kinase C essential to both induction and maintenance of long-term potentiation in hippocampal CA1 region. Proc. Natl. Acad. Sci. USA, 89, 2576-2580. (IF for 5 years, 10.7).

2)       Jin-Hui Wang and Armin Stelzer (1994). Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation. NeuroReport 5(17), 2377-2380. (IF for 5 years, 1.8).

3)       Jin-Hui Wang and Paul Kelly (1995). Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaM-KII and PKC activity. Neuron DOI:10.1016/0896-6273(95)90048-9 15(2), 443-452. (IF for 5 years, 16.5).

4)       Jin-Hui Wang and Armin Stelzer (1996). Shared calcium signaling pathways in the induction of long-term potentiation and synaptic disinhibition in CA1 pyramidal cell dendrites. Journal of Neurophysiology. 75 (4), 1687-1701. (IF for 5 years, 3.5).

5)       Jin-Hui Wang and Paul Kelly (1996), Regulation of synaptic facilitation by postsynaptic Ca2+ -CaM signaling pathway in rat hippocampal CA1 neurons. Journal of Neurophysiology. 76,276-286. (IF for 5 years, 3.5).

6)       Jin-Hui Wang and Paul Kelly (1996). The balance between postsynaptic Ca2+-dependent protein kinases and phosphates controlling synaptic strength. Learning & Memory 3, 170-181 (special issue on LTP/LTD, IF for 5 years, 5.23).

7)       Jin-Hui Wang and Paul Kelly (1997). Postsynaptic calcineurin activity down-regulates synaptic transmission by weakening intracellular Ca2+ signaling mechanisms in hippocampal CA1 neurons. Journal of Neuroscience. 17, 4600-4611. (IF for 5 years, 7.65).

8)       Jin-Hui Wang and Paul Kelly (1997). Attenuation of paired-pulse facilitation associated with synaptic potentiation mediated by postsynaptic mechanisms. Journal of Neurophysiology. 78, 2707-2716. (IF for 5 years, 3.5).

9)       Jin-Hui Wang, G. Ko and Paul T. Kelly (1997). Cellular and molecular bases of memory: synaptic and neuronal plasticity. Journal of Clinic Neurophysiology. 14 (4), 264-293. (Invited review, IF for 5 years, 1.9).

10)     Jin-Hui Wang* and Paul Kelly (2001). Ca2+/CaM signal pathway up-regulates glutamatergic synaptic function on non-pyramidal fast-spiking neurons in hippocampal CA1. Journal of Physiology (London) 533(2), 407-422. (IF for 5 years, 5.0).

11)     Jin-Hui Wang* (2003). Short-term cerebral ischemia causes the dysfunction of interneurons and more excitation of pyramidal neurons in rats. Brain Research Bulletin 60 (1-2), 53-8. (IF for 5 years, 3.1).

12)     Jin-Hui Wang* and Mei Zhang (2004). Differential modulation of glutamatergic and cholinergic synapses by calcineurin in hippocampal CA1 fast-spiking interneurons. Brain Research 1004(1-2), 125-135. (IF for 5 years, 3.0).

13)     Mei Zhang, Fen-S Hung Yan Zhu, Zuoping Xie and Jin-Hui Wang* (2004). Calcium signal- dependent multigrade-plasticity of neuronal excitability developed postnatally. Journal of Neurobiology 61, 277-287. (IF for 5 years, 3.5).

14)     Jianning Wei, Mei Zhang, Yan Zhu and Jin-Hui Wang* (2004). Ca2+/CaM signal pathway up-regulates GABA synaptic function through cytoskeleton-mediated mechanisms. Neuroscience 127, 637-647. (IF for 5 years, 3.5).

15)     Na Chen, Shuli Chen, Yingliang Wu, Jinhui Wang* (2006). The refractory periods and threshold potentials of sequential spikes measured by whole-cell recording. Biochemical and Biophysical Research Communications 340, 151–157. (IF for 5 years, 2.5).

16)     Sudong Guan, Shanfeng Ma, Yan Zhu, Rongjin Ge, Qiyi Wang and Jin-Hui Wang* (2006). The intrinsic mechanisms underlying the maturation of programming sequential spikes at cerebellar Purkinje cells. Biochemical and Biophysical Research Communications 345, 175-180.

17)     Sudong Guan, Shanfeng Ma, Yan Zhu and Jin-Hui Wang* (2006). The postnatal development of refractory periods and threshold potentials at cerebellar Purkinje neurons. Brain Research, 1097, 59-64. (IF for 5 years, 3.0).

18)     Na Chen, Yan Zhu, Xin Gao, Sudong Guan and Jin-Hui Wang* (2006). Sodium channel- mediated intrinsic mechanisms underlying the differences of spike programming among GABAergic neurons. Biochemical and Biophysical Research Communications 346, 281-287. (IF for 5 years, 2.5).

19)     Na Chen, Xin Chen, Jiandong Yu and Jin-Hui Wang* (2006). After-hyperpolarization improves spike programming through lowering threshold potentials and refractory periods mediated by voltage-gated sodium channels. Biochemical and Biophysical Research Communications 346, 938-945. (IF for 5 years, 2.5).

20)     Shidi Zhao, Na Chen & Jin-Hui Wang* (2008). Ischemia deteriorates the spike encoding of rat cerebellar Purkinje cells by raising intracellular Ca2+. Biochemical and Biophysical Research Communications, 366,401-407. (IF for 5 years, 2.5).

21)     Na Chen, Xin Chen and Jin-Hui Wang* (2008). Homeostasis by coordination of subcellular compartment plasticity improves spike encoding. Journal of Cell Science, 121(17):2961-2971. (IF for 5 years, 6.0).

22)     Jin-Hui Wang*, J. Wei, X. Chen, J. Yu, N. Chen and J. Shi (2008). The gain and fidelity of transmission patterns at cortical excitatory unitary synapses improves spike encoding. Journal of Cell Science, 121(17):2951-2960. (IF for 5 years, 6.0).

23)     Qiyi Wang, Xiuping Liu, Rongjing Ge, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2009). The postnatal development of intrinsic properties and spike encoding at cortical GABAergic neurons. Biochemical and Biophysical Research Communications 378:706-710. (IF for 5 years, 2.5).

24)     Yu Qi, Li Huang, Hong Ni, Xin Zhou, Jing Zhang, Yan Zhu, Ming Ge, Sudong Guan and Jin-Hui Wang* (2009). Intracellular Ca2+ regulates spike encoding at cortical GABAergic neurons and cerebellar Purkinje cells differently. Biochemical and Biophysical Research Communications 381:129-133. (IF for 5 years, 2.5).

25)     Rongjing Ge, Na Chen, Jin-Hui Wang* (2009). Real-time neuronal homeostasis by coordinating VGSC intrinsic properties. Biochemical and Biophysical Research Communications 387:585-589. (IF for 5 years, 2.5).

26)     Li Huang, Na Chen, Ming Ge, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2010). Ca2+ and acidosis initiate the dysfunction of cortical GABAergic neurons synergistically during ischemia. Biochemical and Biophysical Research Communications 394:709-714. (IF for 5 years, 2.5).

27)     Hong Ni, Li Huang, Na Chen, Dongbo Liu, Fengyu Zhang, Ming Ge, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2010). Upregulation of barrel GABAergic neurons is associated with cross-modal plasticity in olfactory deprivation. PLoS One 5(10):e13736. (IF for 5 years, 4.0).

28)     Na Chen, Jiandong Yu, Hao Qian and Jin-Hui Wang* (2010). Axon amplifies somatic incomplete spikes to uniform. PLoS One 5(7):e11868. (IF for 5 years, 4.0).

29)     Li F, Yang Z, Lu Y, Yin D, Wang JH and He R (2010). Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta. PLoS One 5(12) pe15325. (IF for 5 years, 4.0).

30)     Rongjing Ge, Hao Qian and Jin-Hui Wang* (2011). Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons. Molecular Brain 4(19), 1~11. (IF for 5 years, 4.6).

31)     Jiandong Yu, Hao Qian, Na Chen and Jin-Hui Wang* (2011). Quantal glutamate release is essential for reliable neuronal encodings in cerebral networks. PloS One 6(9): e25219. (IF for 5 years, 4.0).

32)     Jun Zhao, Dangui Wang and Jin-Hui Wang* (2012). Barrel cortical neurons and astrocytes coordinately respond to an increased whisker stimulus frequency. Molecular Brain 5,12. (IF for 5 years, 4.6).

33)     Fengyu Zhang, Bei Liu, Zhuofan Lei and Jin-Hui Wang* (2012). mGluR activation improves network asynchrony and GABAergic synapse attenuation in the amygdala: Implication for anxiety-like behavior in DAB/2 mice. Molecular Bain 5(20), 1~12. (IF for 5 years, 4.6).

34)     Bing Ye, Li Huang, Zilong Gao, Ping Chen, Hong Ni, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2012). The functional upregulation of piriform cortex is associated with cross-modal plasticity in loss of whisker tactile inputs. PLoS One 7(8):e41986. (IF for 5 years, 4.0).

35)     Jiandong Yu, Hao Qian and Jin-Hui Wang* (2012). Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes. Molecular Brain 5(26):1~11. (IF for 5 years, 4.6).

36)     Bo Jiang, Wei Wang, Fang Wang, Zhuang-Li Hu, Jun-Li Xiao, Si Yang, Jing Zhang, Xiao-Zhong Peng, Jin-Hui Wang and Jian-Guo Chen (2013). The stability of NR2B in the nucleus accumbens controls behavioral and synaptic adaptations to chronic stress. Biological Psychiatry 74(2):145~155. (IF for 5 years, 10.35).

37)     Guanjun Zhang, Zhilong Gao, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2013). Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs. Molecular Brain 6(2): 1~11. (IF for 5 years, 4.6).

38)     Zhilai Yang and Jin-Hui Wang* (2013). Frequency-dependent reliability of spike propagation is function of axonal voltage-gated sodium channels in cerebellar Purkinje cells. Cerebellum, 12(6):862-869. (IF for 5 years, 2.9).

39)     Longze Sha, Xiaofeng Wu, Yuan Yao, Bo Wen, Jing Feng, Zhiqiang Sha, Xueqing Wang, Xiaoliang Xing, Wanchen Dou, Liri Jin, Wenting Li, Naili Wang, Yan Shen, Jin-Hui Wang and Qi Xu (2014). Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy. Molecular Neurobiology 49(2):633-644. (IF for 5 years, 5.84).

40)     Zhilai Yang and Jin-Hui Wang* (2014). Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells. Molecular Brain 7(1):1-13. (IF for 5 years, 4.6).

41)   Minghui Wang, Na Chen and Jin-Hui Wang* (2014). The coupling features of electrical synapses modulate neuronal synchrony in hypothalamic superachiasmatic nucleus. Brain Research, 1550:9~17. (IF for 5 years, 3.0).

42)   Rongjing Ge, Hao Qian, Na Chen and Jin-Hui Wang* (2014). Input-dependent subcellular localization of spike initiation between soma and axon at cortical pyramidal neurons. Molecular Brain 7(26):1-16. (IF for 5 years, 4.6).

43)   Wei Lu, Bo Wen, Fengyu Zhang and Jin-Hui Wang* (2014). Voltage-independent sodium channels emerge for an expression of activity-induced spontaneous spikes in GABAergic neurons. Molecular Brain 7(38):1-15. (IF for 5 years, 4.6).

44)   Bei Liu, Jing Feng and Jin-Hui Wang* (2014). Protein kinase C is essential for kainate-induced anxiety-like behavior and glutamatergic synapse upregulation in prefrontal cortex. CNS Neuroscience and Therapeutics 20:982-990. (IF for 5 years, 4.1).

45)   Bo Wen, Hao Qian, Jing Feng, Rong-Jing Ge, Xin Xu, Zhi-Qiang Cui, Ru-Yuan Zhu, Long-Sheng Pan, Zhi-Pei Ling and Jin-Hui Wang* (2015). A portion of inhibitory neurons in human TLE are functionally upregulated: an endogenous mechanism for seizure termination. CNS Neuroscience and Therapeutics 21:204-214. (IF for 5 years, 4.1).

46)   Jin-Hui Wang*, Wei Lu and Bo Wen (2015). Neuron-specific mechanisms for epilepsy self-termination. Molecular & Cellular Epilepsy (Invited review). 2: e716.

47)   Dangui Wang, Jun Zhao, Zilong Gao, Na Chen, Bo Wen, Wei Lu, Zhuofan Lei, Changfeng Chen, Yahui Liu, Jing Feng and Jin-Hui Wang* (2015). Neurons in the barrel cortex turn into processing whisker and odor signals: a cellular mechanism for the storage and retrieval of associative signals. Frontier in Cellular Neuroscience. 9:320, 1-17. (IF for 5 years, 4.68).

48)     Li Huang, Shidi Zhao, Wei Lu, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2015). Acidosis-induced dysfunction of cortical GABAergic neurons through astrocyte-related excitotoxicity. PLoS One. 10(10): e0140324. (IF for 5 years, 4.0).

49)     Zhuofan Lei, Bei Liu and Jin-Hui Wang* (2015). Reward memory relieves anxiety-related behavior through synaptic strengthening and protein kinase C in dentate gyrus. Hippocampus, 26:502-516. DOI:10.1002/hipo.22540. Online. (IF for 5 years, 5.48).

50)     Aiping Xu, Shan Cui and Jin-Hui Wang* (2015). Incoordination among subcellular compartments is associated to depression-like behavior induced by chronic mild stress. International Journal of Neuropsychopharmacology. 19(5):1-13. DOI:10.1093/ijnp/pyv122 Online. (IF for 5 years, 5.1).

51)     Jin-Hui Wang* and Shan Cui (2015). Multi-target therapy for subcellular incompatibility in brain disorders. Brain Disorders & Therapy (Invited review). 4:5. DOI:10.4172/2168-975X.1000200.

52)     Ke Ma, Li Guo Aiping Xu, Shan Cui & Jin-Hui Wang* (2016). Molecular mechanism for stress-induced depression assessed by sequencing miRNA and mRNA in medial prefrontal cortex. PLoS One 11(7) e0159093. DOI:10.1371/journal.pone.0159093. (IF for 5 years, 4.0).

53)     Ke Ma, Aiping Xu, Shan Cui, Meng-Ru Sun, Yuan-Chao Xue and Jin-Hui Wang* (2016). Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress. Translational Psychiatry. 6:e910. DOI:10.1038/tp.2016.181 (IF for 5 years, 5.68).

54)     Guan-Yan Wang, Zhao-Ming Zhu, Ke Ma, Shan Cui and Jin-Hui Wang* (2016). Glucocorticoid induces incoordination between glutamatergic and GABAergic neurons in the amygdala. PLoS One 11(11): e0166535. DOI:10.1371/journal.pone.0166535. (IF for 5 years, 4.0).

55)     Fenxia Yan, Zilong Gao, Pin Chen, Li Huang, Dangui Wang, Na Chen, Ruixiang Wu, Jing Feng, Shan Cui, Wei Lu and Jin-Hui Wang* (2016). Coordinated plasticity between barrel cortical glutamatergic and GABAergic neurons during associative memory. Neural Plasticity Online on November 6, 2016:ID5648390, 1~20. DOI:10.1155/2016/5648390. (IF for 5 years, 3.6).

56)   Zilong Gao, Lei Chen, Ruicheng Fan, Wei Lu, Dangui Wang1, Shan Cui1, Li Huang, Shidi Zhao, Sudong Guan, Yan Zhu and Jin-Hui Wang* (2016). Associations of unilateral whisker and olfactory signals induce synapse formation and memory cell recruitment in bilateral barrel cortices: cellular mechanism for unilateral training toward bilateral memory. Frontiers in Cellular Neuroscience 10:285, 1-16. DOI:10.3389/fncel.2016.00285. (IF for 5 years, 4.68).

57)   Wei Lu, Jing Feng, Bo Wen, Kewei Wang and Jin-Hui Wang* (2017). Activity-induced spontaneous spikes in GABAergic neurons suppress seizure discharges: an implication of computational modeling. Oncotarget, 8:32384-32397. DOI:10.18632/oncotarget.15660.15660 (IF for 5 years, 5.42).

58)     Jin-Hui Wang* and Shan Cui (2017). Associative memory cells: Formation, function and perspectives. F1000Research. 6:283. Online3/17/2017. DOI:10.12688/f1000research.11096.1.

59)     Zhaoming Zhu, Guangyan Wang, Ke Ma, Shan Cui and Jin-Hui Wang* (2017). GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression. Oncotarget, 8:35933-35945. DOI:10.18632/oncotarget.16411. (IF for 5 years, 5.42).

60)   Li Huang, Chun Wang, Shidi Zhao, Rongjing Ge, Sudong Guan and Jin-Hui Wang* (2017). PKC and CaMK-II inhibitions coordinately rescue ischemia-induced GABAergic neuron dysfunction. Oncotarget, 8:39309-39322. DOI:10.18632/oncotarget.16947. (IF for 5 years, 5.42).

61)   Rui Guo, Rongjing Ge, Shidi Zhao, Yulong Liu, Xin Zhao, Li Huang, Sudong Guan, Wei Lu, Shan Cui, Shirlene Wang and Jin-Hui Wang* (2017). Associative memory extinction is accompanied by decayed plasticity at motor cortical neurons and persistent plasticity at sensory cortical neurons. Frontiers in Cellular Neuroscience 11:168. DOI:10.3389/fncel.2017.00168. (IF for 5 years, 4.68).

62)     Zhilai Yang, Na Chen, Rongjing Ge, Hao Qian and Jin-Hui Wang* (2017). Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum. Oncotarget, 8(42):72424-72437. DOI:10.18632/oncotarget.19770. (IF for 5 years, 5.42).

63)     Xin Zhao, Li Huang, Rui Guo, Yulong Liu, Shidi Zhao, Sudong Guan, Rongjing Ge, Shan Cui, Shirlene Wang and Jin-Hui Wang* (2017). Coordinated plasticity among glutamatergic and GABAergic neurons and synapses in the barrel cortex is correlated to learning efficiency. Frontiers in Cellular Neuroscience. 11:221. DOI:10.3389/fncel.2017.00221. (IF for 5 years, 4.68).

64)     Yulong Liu, Rongjing Ge, Xin Zhao, Rui Guo, Li Huang, Shidi Zhao, Sudong Guan, Wei Lu, Shan Cui, Shirlene Wang and Jin-Hui Wang* (2017). Activity strengths of cortical glutamatergic and GABAergic neurons are correlated with transgenerational inheritance of learning ability. Oncotarget, 8(68):112401-112416. DOI:10.18632/oncotarget.19918. (IF for 5 years, 5.42).

65)     Yahui Liu, Zilong Gao, Changfeng Chen, Bo Wen, Li Huang, Rongjing Ge, Shidi Zhao, Ruichen Fan, Jing Feng, Wei Lu, Liping Wang and Jin-Hui Wang* (2017). Piriform cortical glutamatergic and GABAergic neurons express coordinated plasticity for whisker-induced odor recall. Oncotarget, 8(56):95719-95740. DOI:10.18632/oncotarget.21207. (IF for 5 years, 5.42).

66)     Zhuofan Lei, Dangui Wang, Na Chen, Ke Ma, Wei Lu, Zhenhua Song, Shan Cui and Jin-Hui Wang* (2017). Synapse innervation and associative memory cell are recruited for integrative storage of whisker and odor signals in the barrel cortex through miRNA-mediated processes. Frontiers in Cellular Neuroscience, 11:316. DOI:10.3389/fncel.2017.00316. (IF for 5 years, 4.68).

67)     Jing Feng, Wei Lu, Dangui Wang, Ke Ma, Zhenhua Song, Na Chen, Yan Sun, Kaixin Du, Mengmeng Shen, Shan Cui and Jin-Hui Wang* (2017). Barrel cortical neuron integrates triple associated signals for their memory through receiving epigenetic-mediated new synapse innervations. Cerebral Cortex, 27(12):5858-5871. DOI:10.1093/cercor/bhx292 (IF for 5 years, 7.32).

68)     Wang Jin-Hui* and Sha Cui (2018). Associative memory cells and their working principles. F1000Research, 7:108. DOI:10.12688/f1000research.13665.1.

69)     Yawei Si, Zhenhua Song, Xiaoyan Sun and Jin-Hui Wang* (2018). microRNA and mRNA profiles in nucleus accumbens underlying depression versus resilience in response to chronic stress. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. In press. (IF for 5 years, 4.32).

70)     Xiaoyan Sun, Zhenhua Song, Yawei Si and Jin-Hui Wang* (2018). microRNA and mRNA profiles in ventral tegmental area relevant to stress-induced depression and resilience. Progress in Neuropsychopharmacology & Biological Psychiatry. 86:150-165. DOI:10.1016/j.pnpbp.2018.05.023. (IF for 5 years, 4.2)


Patents
   

Research Interests

Working principle of associative memory cells

Neural circuits underlying major depression

Neuronal encoding

Conferences

   

Collaboration

   

Students

已指导学生

陈欣  博士研究生  071011-生物物理学  

余建东  博士研究生  071011-生物物理学  

王明辉  博士研究生  071010-生物化学与分子生物学  

葛荣靖  博士研究生  071006-神经生物学  

赵君  博士研究生  071006-神经生物学  

杨志来  博士研究生  071006-神经生物学  

雷卓凡  博士研究生  071006-神经生物学  

温波  博士研究生  071006-神经生物学  

钱浩  博士研究生  071006-神经生物学  

卢炜  博士研究生  071006-神经生物学  

高子龙  博士研究生  071006-神经生物学  

魏忠杰  硕士研究生  071006-神经生物学  

现指导学生

郭莉  博士研究生  071006-神经生物学  

吴瑞祥  博士研究生  071006-神经生物学  

肖华娟  博士研究生  071006-神经生物学  

许杨  博士研究生  071010-生物化学与分子生物学  

崔田亮  硕士研究生  071011-生物物理学  

姜震  硕士研究生  085238-生物工程  

张赟  博士研究生  071009-细胞生物学