基本信息
张云  男  博导  中国科学院昆明动物研究所
email: zhangy@mail.kiz.ac.cn
address: 云南省昆明市教场东路32号
postalCode: 650223

招生信息

   
招生专业
071002-动物学
071010-生物化学与分子生物学
100706-药理学
招生方向
生物化学与分子生物学
动物学
毒理学

教育背景

1994-01--1995-08   法国巴斯德研究所   博士后
1991-01--1992-06   法国巴斯德研究所   合作培养博士
1987-09--1992-09   中国科学院昆明动物研究所   博士
1980-09--1984-07   华东理工大学   学士

工作经历

   
工作简历
1998-10~1999-01,香港科技大学, 访问学者
1997-12~1998-02,美国新墨西哥大学, 访问学者
1994-01~1995-08,法国巴斯德研究所, 博士后
1991-01~1992-06,法国巴斯德研究所, 合作培养博士
1987-09~1992-09,中国科学院昆明动物研究所, 博士
1984-08~现在, 中国科学院昆明动物研究所, 研究实习员,助理研究员,副研究员,研究员,博士生导师,所学术委员会副主任
1980-09~1984-07,华东理工大学, 学士
社会兼职
2013-12-18-今,云南省生物化学与分子生物学学会理事长, 理事长
2013-10-18-今,中国毒理学会生物毒素专业委员会主任,
2013-10-18-今,中国毒理学会, 常务理事
2010-09-02-今,“动物学研究”副主编,
2010-08-05-今,中国生物化学与分子生物学学会理事, 天然毒素专业委员会副主任
2006-04-08-今,SCI杂志Toxicon 编委,
2005-11-04-今,国际生物毒素学会亚太地区理事,

教授课程

生物毒素与疾病
动物模型与人类疾病机理

专利与奖励

   
奖励信息
(1) 云南有毒动物新型肽类毒素的解析和功能, 二等奖, 省级, 2018
(2) 中国科学院昆明分院,优秀共产党员, , 市地级, 2013
(3) 基于生物生存策略的有毒动物中药功能成分定向挖掘技术体系, 二等奖, 国家级, 2013
(4) 人前列腺液抗肿瘤及微生物多肽的分离纯化及活性研究, 三等奖, 省级, 2012
(5) 优秀党务工作者, , 市地级, 2011
(6) 云南省科学技术奖, 一等奖, 省级, 2008
(7) 中国科学院西部之光优秀学者, , 院级, 2006
(8) 中共云南省委员会优秀共产党员, , 省级, 2006
(9) 云南省科学技术奖, 二等奖, 省级, 2004
(10) 云南省科学技术奖, 一等奖, 省级, 2002
(11) 国家知识产权局中国专利优秀奖, , 部委级, 2001
(12) 国务院政府特殊津贴, , 国家级, 2000
(13) 国家“863”计划十五周年纪念, 三等奖, 国家级, 2000
(14) 中国科学院优秀青年, , 院级, 1998
(15) 云南省科技进步奖, 一等奖, 部委级, 1997
(16) 中国科学院昆明分院优秀青年, , 市地级, 1996
(17) 中国科学院院长奖学金, 特等奖, 部委级, 1992
(18) 中国科学院科技进步奖, 三等奖, 部委级, 1991
(19) 中国科学院院长奖学金, , 部委级, 1989
专利成果
( 1 ) 爬行类cathelicidin抗菌肽及衍生物及其应用, 2011, 第 2 作者, 专利号: ZL200810058260.9

( 2 ) 一种抑制血小板活化的方法及该方法的应用,中国, 2010, 第 1 作者, 专利号: 201010183347.6

( 3 ) 非天然D-型蛇毒Cathelicidin抗菌肽及其衍生物、制备方法及应用, 2010, 第 2 作者, 专利号: 201010222328.X

( 4 ) 蛋白酶受体激动剂的制备方法及其应用, 2010, 第 1 作者, 专利号: 201010183337.2

( 5 ) 眼镜王蛇毒蛋白酶抑制剂及其衍生物的应用, 2010, 第 2 作者, 专利号: ZL200710066320.7

( 6 ) 大蹼铃蟾蛋白酶抑制剂及其制备方法和在制药中的应用, 专利号: ZL00122416.6

( 7 ) 大蹼铃蟾多肽在制备抗肿瘤和艾滋病药物中的应用, 专利号: ZL00122417.4

( 8 ) 大蹼铃蟾皮肤肽及其制备方法和在制药中的应用, 专利号: ZL00122415.8

( 9 ) 大蹼铃蟾抗精子多肽及其制备方法和在制药中的应用, 专利号: ZL00130617.0

( 10 ) 抗肿瘤蛋白及其制备方法和其基因, 专利号: ZL01107253.9

( 11 ) 抗微生物肽及其制备方法和其基因, 专利号: ZL01107255.5

( 12 ) 血管扩张因子其制备方法和其基因 , 专利号: ZL01107254.7

( 13 ) 饱食因子及其制备方法, 专利号: ZL021135169

( 14 ) 酸性抗菌肽及其基因和在制药中的应用, 专利号: ZL021135150

( 15 ) 血管收缩因子及其制备方法和在制药中的应用, 专利号: ZL021135177

( 16 ) 大蹼铃蟾非晶状体βγ-晶状体蛋白与三叶因子蛋白复合物和基因及制法及用途, 专利号: ZL200810058028.5

( 17 ) 爬行类cathelicidin抗菌肽及衍生物及其应用, 专利号: ZL200810058260.9

出版信息

   
发表论文
(1) A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions, Journal of Biological Chemistry, 2020, 通讯作者
(2) Comparative analysis of the diverse toxins from a new pharmaceutical centipede, Scolopendra mojiangica, Zoological Research, 2020, 通讯作者
(3) Geraniol targets KV1.3 ion channel and exhibits anti-inflammatory activity i n v i t r o and i n v i v o, Fitoterapia, 2019, 通讯作者
(4) Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation, Communications Biology, 2019, 通讯作者
(5) Pore-forming toxin-like protein complex expressed by frog promotes tissue repairing, FASEB Journal, 2019, 通讯作者
(6) Proteotranscriptomic Analysis and Discovery of the Profile and Diversity of Toxin-like Proteins in Centipede, Mol Cell Proteomics, 2018, 通讯作者
(7) Carboxymethyl chitosan nanoparticles loaded with bioactive peptide OH-CATH30 benefit nonscar wound healing, Int J Nanomedicine, 2018, 其他(合作组作者)
(8) A high concentration of DMSO activates caspase-1 by increasing the cell membrane permeability of potassium, Cytotechnology, 2017, 通讯作者
(9) Host pore-forming protein complex neutralizes the acidification of endocytic organelles to counteract intracellular pathogens, J Infec Dis, 2017, 通讯作者
(10) Characterization of an insulinotropic peptide from skin secretions of Odorrana andersonii, Journal of Peptide Science, 2017, 通讯作者
(11) Novel peptides from skins of amphibians showed broad-spectrum antimicrobial activities, Chem Biol Drug Des, 2016, 通讯作者
(12) Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians, Sci Rep, 2016, 通讯作者
(13) Increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer, PLoS One, 2015, 通讯作者
(14) A distinct three-helix centipede toxin SSD609 inhibits Iks channels by interacting with the KCNE1 auxiliary subunit, Scientific Reports, 2015, 通讯作者
(15) Novel peptides from skins of amphibians showed broad-spectrum antimicrobial activities, Chem Biol Drug Des, 2015, 通讯作者
(16) Rich diversity and potency of skin antioxidant peptides revealed a novel molecular basis for high-altitude adaptation of amphibians, Scientific Reports, 2015, 通讯作者
(17) Why do we study animal toxins, Zoological Research, 2015, 通讯作者
(18) Promoter hypermethylation and down-regulation of trefoil factor 2 in human gastric cancer, Oncology Lettter, 2014, 通讯作者
(19) Comprehensive Transcriptome profiling and functional analysis of the frog (Bombina maxima) immune system, DNA Res, 2014, 通讯作者
(20) The antimicrobial peptide OH-CATH30 as a potential therapy for antibiotic-resistant Pseudomonas aeruginosa keratitis, Antimicrob Agents Chemother, 2014, 通讯作者
(21) Host-derived pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection, Proceedings of the National Academy of the Sciences,USA, 2014, 通讯作者
(22) Prohibitin is involved in the activated internalization and degradation of protease-activated receptor 1, BBA Molecular Cell Research, 2014, 通讯作者
(23) Genome of the Chinese tree shrew, Nature Commun, 2013, 通讯作者
(24) Adenosine-5-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome, PLoS ONE, 2013, 通讯作者
(25) Aberrant Expression of Trefoil Factor 3 Is Associated With Colorectal Carcinoma Metastasis, Journal of Cancer Research and Therapeutics , 2013, 通讯作者
(26) Trefoil factor 1 gene alternations and expression in colorectal carcinomas, Tumori , 2013, 通讯作者
(27) Down-regulation of protease-activated receptor 4 in lung adenocarcinoma is associated with a more aggressive phenotype, Asian Pacific Journal of Cancer Prevention, 2013, 通讯作者
(28) Differential expression and subcellular localization of prohibitin 1 are related to tumorigenesis and progression of non-small cell lung cancer, International Journal of Clinical and Experimental Pathology, 2013, 通讯作者
(29) Antimicrobial peptides from the venom gland of the social wasp Vespa tropica, Toxicon , 2013, 通讯作者
(30) Circulating serum trefoil factor 3 (TFF3) is dramatically increased in chronic kidney disease, PLoS One, 2013, 通讯作者
(31) Naturally occurring antimicrobial peptide OH-CATH30 protects against sepsis by regulating host innate immune responses, J Med Chem, 2013, 通讯作者
(32) Prohibitins are involved in protease-activated receptor 1-mediated platelet aggregation, J Thromb. Haemosta, 2012, 通讯作者
(33) Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs, J Proteome Res, 2012, 通讯作者
(34) The frog trefoil factor Bm-TFF2 activates human platelets via Gq and G12/13 signaling pathway, Toxicon, 2012, 通讯作者
(35) Establishment, characterization and immortalization of a fibroblast cell line from the Chinese red belly toad Bombina maxima skin, Cytotechnology, 2012, 通讯作者
(36) Two novel antimicrobial peptides with multiple activities from skin secretion of Chinese torrent frog Amolops jingdongensis, Biochimie, 2012, 通讯作者
(37) Efficacy of OH-CATH30 and its analogs against drug-resistant bacteria in vitro and in mouse models, Antimicrobial Agents and Chemotherapy, 2012, 通讯作者
(38) Molecular cloning and characterization of a complement-depleting factor from king cobra, Ophiophagus hannah, Toxicon, 2012, 通讯作者
(39) Venomics and Transcriptomic Analysis of Centipede Scolopendra subspinipes dehaani, J Proteome Res, 2012, 通讯作者
(40) Jerdonuxin, a novel snaclec (snake C-type lectin) with platelet aggregation activity from Trimeresurus jerdonii venom, Toxicon, 2011, 通讯作者
(41) A novel platelet glycoprotein Ib-binding protein with human platelet aggregation-inhibiting activity from Trimeresurus jerdonii venom, Toxicon, 2011, 通讯作者
(42) βγ-CAT, a non-lens betagamma-crystallin and trefoil factor complex, induces calcium-dependent platelet apoptosis, Thromb Haemost , 2011, 通讯作者
(43) Cloning and sequence analysis of an Ophiophagus hannah cDNA encoding a precursor of two natriuretic pepide domains, Toxicon, 2011, 通讯作者
(44) Activation of protease-activated receptor 1 by a frog trefoil factor and PAR4 by human trefoil factor 2, Cell. Mol. Life Sci. , 2011, 通讯作者
(45) βγ-CAT, a non-lens betagamma-crystallin and trefoil factor complex, induces calcium-dependent platelet apoptosis., Thrombosis and Haemostasis, 2011, 通讯作者
(46) Venoms of two Elapid snakes (Bungarus multicinctus and Naja atra) and their evolution patterns., BMC Genomics , 2011, 通讯作者
(47) Characterization of the βγ-crystallin domains of βγ-CAT, a non-lens βγ-crystallin and trefoil factor complex, from the skin of the toad Bombina maxima, Biochimie, 2011, 通讯作者
(48) Decreased expression of protease-activated receptor 4 in human gastric cancer, Int J Biochem Cell Biol , 2011, 通讯作者
(49) Decreased expression of protease-activated receptor 4 in human gastric cancer, Int J Biochem Cell Biol , 2011, 通讯作者
(50) Blood cells as targets of snake toxins, Blood Cells, Molecules, and Diseases, 2006, 
(51) Apoptotic activity of frog Bombina maxima skin albumin, Comparative Biochemistry and Physiology, 2006, 
(52) Purification of a lysozyme from skin secretions of Bufo andrewsi, Comparative Biochemistry and Physiology, 2006, 
(53) Bm-TFF2, a trefoil factor protein with platelet activation activity from frog Bombina maxima skin secretions, Biochemical and Biophysical Research Communications, 2005, 
(54) Molecular characterization of Trimeresurus stejnegeri venom L-amino acid oxidase with potential anti-HIV activity, Biochemical and Biophysical Research Communications, 2003, 
(55) An anionic antimicrobial peptide from toad Bombina maxima, Biochemical and Biophysical Research Communications, 2002, 
(56) Identification and cloning of a trypsin inhibitor from skin secretions of Chinese red-belly toad Bombina maxima, Comparative Biochemistry and Physiology, 2002, 
(57) A Novel Bradykinin-Related Peptide from Skin Secretions of Toad Bombina maxima and Its Precursor Containing Six Identical Copies of the Final Product, Biochemical and Biophysical Research Communications, 2001, 
(58) Trimeresurus stejnegeri Snake Venom Plasminogen Activator, SITE-DIRECTED MUTAGENESIS AND MOLECULAR MODELING, THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 第 1 作者
(59) A Novel Plasminogen Activator from Snake Venom. Purification, characterization, and molecular cloning., THE JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 第 1 作者
发表著作
( 1 ) 中国动物多肽毒素, 科技出版社, 2016-09, 第 2 作者

科研活动

   
科研项目
( 1 ) 动物毒素作用新靶点和信号通路, 负责人, 国家任务, 2010-01--2014-12
( 2 ) 眼镜蛇科蛇毒Cathelicidin抗菌肽作为抗耐药病原菌感染候选药物的研究, 负责人, 国家任务, 2009-04--2011-12
( 3 ) 树鼩品系创制, 参与, 中国科学院计划, 2011-01--2013-12
( 4 ) 非晶状体-betagamma-晶状体蛋白与三叶因子复合物在大蹼铃蟾皮肤中的生物学功能和作用机制, 负责人, 国家任务, 2009-01--2011-12
( 5 ) 两栖类肽类毒素多样性, 负责人, 国家任务, 2007-01--2010-12
( 6 ) 云南有毒两栖动物肽类活性物质结构与功能及作用机制, 负责人, 国家任务, 2012-01--2015-12
( 7 ) 离子通道药物研发体系, 负责人, 中国科学院计划, 2013-11--2016-11
( 8 ) 抑 素 蛋 白(prohibitin)1 调控蛋白酶激活受体(protease-activated , 负责人, 国家任务, 2013-01--2016-12
( 9 ) 云南省“云岭学者”人才培养工程, 负责人, 地方任务, 2016-01--2020-12
( 10 ) 云南省高技术产业化项目, 负责人, 地方任务, 2015-01--2017-12
( 11 ) 两栖动物新型孔道形成毒素类似蛋白ALPs的生物学功能研究, 负责人, 国家任务, 2016-01--2019-12
( 12 ) 新型孔道形成蛋白与三叶因子复合物天然免疫功能和机制, 负责人, 国家任务, 2017-01--2020-12
( 13 ) 孔道形成蛋白调控细胞外囊泡分泌的功能和机制, 负责人, 国家任务, 2019-01--2022-12