基本信息
何建华  男  博导  中国科学院上海应用物理研究所
电子邮件: hejh@sinap.ac.cn
通信地址: 上海市浦东新区张衡路239号
邮政编码: 201204

招生信息

   
招生专业
082703-核技术及应用
071011-生物物理学
招生方向
同步辐射技术
蛋白质晶体学

工作经历

   
社会兼职
2013-10-28-今,中国生物物理学会, 理事
2012-08-24-今,中国晶体学会, 理事
2008-01-30-今,省(自治区、直辖市)政协常委,

专利与奖励

   
奖励信息
(1) 上海光源国家重大科学工程, 特等奖, 部委级, 2012
(2) 上海光源团队, , 院级, 2011

出版信息

   
发表论文
(1) Crystal structure of the Vibrio cholerae VqmA–ligand–DNA complex provides insight into ligand-binding mechanisms relevant for drug design, Journal of Biological Chemistry, 2019, 通讯作者
(2) Upgrade of macromolecular crystallography beamline BL17U1 at SSRF, Nuclear Science and Techniques, 2018, 通讯作者
(3) The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45, Nucleic Acids Research, 2017, 通讯作者
(4) Structural consistency analysis of recombinant and wild-type human, Journal of Molecular Structure, 2016, 通讯作者
(5) Crystal structure and enantioselectivity of terpene, Biochemical Journal, 2016, 通讯作者
(6) Automatic crystal centring procedure at the SSRF, J. Synchrotron Rad., 2016, 通讯作者
(7) Status of the crystallography beamlines at SSRF, Eur. Phys. J. Plus, 2015, 第 1 作者
(8) A quality comparison of protein crystals grown under containerless conditions generated by diamagnetic levitation, silicone oil and agarose ge, Acta Cryst. D, 2013, 通讯作者
(9) Structural Insights into the Mechanism for Recognizing Substrate of the Cytochrome P450 Enzyme TxtE, PloS ONE, 2013, 通讯作者
(10) Fragment-Based Drug Discovery of 2?Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain,  J. Med. Chem., 2013, 通讯作者
(11) Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90, Acta Biochimica et Biophysica Sinica, 2012, 通讯作者
(12) 利用晶体多重衍射进行同步辐射光子能量标定, Calibration of synchrotron radiation photon energy using crysatl multiple diffraction, 光学精密工程, 2011, 通讯作者
(13) The sandwich method for protein crystallization and its effect on crystal growth, Acta Biochimica et Biophysica Sinica, 2010, 通讯作者
(14) Epitaxial growth of trichosanthin protein crystals on mica surface, Crystal Growth and Design, 2010, 通讯作者
(15) Crystal structure and function of C-terminal Sau3AI domain, Biochimica et Biophysica Acta (Proteins and Proteomics), 2009, 通讯作者
(16) Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry, Acta Cryst. D, 2009, 通讯作者
(17) Peptide Nanofilaments Used for Replica Molding: A Combination of ‘Bottom-up’and ‘Top-down, Surface Review and Letters, 2007, 通讯作者
(18) Crystal structure of human u-crystallin complexed with NADPH,  Protein Science, 2007, 通讯作者
(19) Epitaxial Growth of Peptide Nanofilaments on Inorganic Surfaces: Effects of Interfacial Hydrophobicity/Hydrophilicity, Angew. Chem. Int. Ed., 2006, 通讯作者
(20) Effects of the silanized mica surface on protein crystallization, Acta Cryst. D, 2005, 通讯作者

科研活动

   
科研项目
( 1 ) FBLD技术平台在抗菌新药研究中的应用, 参与, 国家级, 2016-07--2019-06
( 2 ) 上海光源线站工程, 参与, 国家级, 2016-11--2022-10
( 3 ) 微小晶体高效结构测定技术研究, 主持, 国家级, 2017-07--2022-01