100701-药物化学
070303-有机化学
100720-药物设计学

有机化学，药物化学
天然药物，糖化学
分子靶向药物

2000-08--2004-02   香港大学   博士后
1997-09--2000-07   四川大学，香港大学   博士

四川大学 19970901--20000701 研究生毕业

四川大学 19970901--20000701 理学博士学位

   

2010-08~2011-08,Washington University in St. Louis, 访问学者
2004-04~现在, 中科院成都生物所, 研究员
2000-08~2004-02,香港大学, 访问学者

新药先导化合物的发现和优化——小分子偶联药物

   

[1] 卢晓霞, 张琪. 一种多拉菌素结构衍生物及其合成方法. CN: CN110818756A, 2020-02-21.
[2] 卢晓霞, 张琪. 一种多拉菌素衍生物的合成及其杀虫应用. CN: CN107501368B, 2020-02-21.
[3] 王飞, 阿彼察·苏萨朗, 张国林. 姜黄素衍生物的用途. CN: CN110327315A, 2019-10-15.
[4] 王飞, 阿彼察·苏萨朗, 张国林",null,"卢晓霞. 姜黄素衍生物的用途. TW: CN110292571A, 2019-10-01.
[5] 张国林, 王飞, 卢晓霞, 闻永举, 周宗元. 一种苄胺酰类衍生物及其在制备抗炎药物中的用途. CN: CN109879772A, 2019-06-14.
[6] 王飞, 卢晓霞, 张国林, 王涛, 彭婷. 一种miRNA生物合成抑制剂. CN: CN109810071A, 2019-05-28.
[7] 卢晓霞, 张琪. 一种新型多拉菌素衍生物的合成及其杀虫应用. CN: CN107501368A, 2017-12-22.

   

[1] Gang Liu, Prasenjit Mondal, Na Sang, Zihua Li, Weihua Ding, Liuyue Yang, Yan Liu, Vishal C Birar, Ashley Gomm, Rudolph E Tanzi, Can Zhang, Shiqian Shen, Changning Wang, Xiaoxia Lu, Ping Bai. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2023, 254: http://dx.doi.org/10.1016/j.ejmech.2023.115327.
[2] 杨建, 石海龙, 刘钢, 卢晓霞. 选择性HDAC6抑制剂4-（（2，4-二氧基-3-苯乙基-3，4-二氢喹唑啉-1（2 H）-基）-甲基）-N-羟基苯甲酰胺的合成. 合成化学[J]. 2022, 30(1): 58-62, http://lib.cqvip.com/Qikan/Article/Detail?id=7106520734.
[3] Yuan Lin, Kanjana Wongkrajang, Xiaofei Shen, Ping Wang, Zongyuan Zhou, hipphawan Chuprajob, Nilubon Sornkaew, Na Yang, Lijuan Yang, Xiaoxia Lu, Ratchanaporn Chokchaisiri, Apichart Suksamrarn, Guolin Zhang, Fei Wang. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorganic & Medicinal Chemistry[J]. 2022, 66: 116811-, [4] Ping Bai, Xiaoxia Lu, Yan Liu, Yu Lan, Hao Wang, Stephanie Fiedler, Robin Striar, Changning Wang. Discovery of a Positron Emission Tomography Radiotracer Selectively Targeting the BD1 Bromodomains of BET Proteins. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2021, 12(2): 282-287, http://dx.doi.org/10.1021/acsmedchemlett.0c00650.
[5] Bai, Ping, Lu, Xiaoxia, Lan, Yu, Chen, Zude, Patnaik, Debasis, Fiedler, Stephanie, Striar, Robin, Haggarty, Stephen J, Wang, Changning. Radiosynthesis and in vivo evaluation of a new positron emission tomography radiotracer targeting bromodomain and extra-terminal domain (BET) family proteins. NUCLEAR MEDICINE AND BIOLOGY[J]. 2020, 84-85: 96-101, http://dx.doi.org/10.1016/j.nucmedbio.2020.04.003.
[6] Bai, Ping, Lan, Yu, Wang, Hao, Chen, Zude, Fiedler, Stephanie, Striar, Robin, Lu, Xiaoxia, Wang, Changning. Development of a Novel Positron Emission Tomography (PET) Radiotracer Targeting Bromodomain and Extra-Terminal Domain (BET) Family Proteins. FRONTIERS IN MOLECULAR BIOSCIENCES[J]. 2020, 7: https://doaj.org/article/a7cb2edc0fcf4e0c8ad1817b14a70e72.
[7] Zhang, Qi, Cheng, Yao, Zheng, Cheng, Bai, Ping, Yang, Jian, Lu, Xiaoxia. Design, Synthesis, and Insecticidal Activity of Novel Doramectin Derivatives Containing Acylurea and Acylthiourea Based on Hydrogen Bonding. JOURNALOFAGRICULTURALANDFOODCHEMISTRY[J]. 2020, 68(21): 5806-5815, http://dx.doi.org/10.1021/acs.jafc.0c00230.
[8] 程瑶, 熊峰, 王涛, 谢昌贤, 云喜报, 张国林, 卢晓霞. 盐霉素原料药中新杂质的检测、分离、鉴定及抗肿瘤活性. 应用与环境生物学报[J]. 2020, 26(6): 1526-1547, http://lib.cqvip.com/Qikan/Article/Detail?id=7103777627.
[9] 卢晓霞. Isolation,identification,andcharacterizationofpotentialimpuritiesofdoramectinandevaluationoftheirinsecticidalactivity. Journal of Pharmaceutical and BiomedicalAnalysis. 2020, [10] Bai, Ping, Bai, Sha, Placzek, Michael S, Lu, Xiaoxia, Fiedler, Stephanie A, Ntaganda, Brenda, Wey, HsiaoYing, Wang, Changning. A New Positron Emission Tomography Probe for Orexin Receptors Neuroimaging. MOLECULES[J]. 2020, 25(5): https://doaj.org/article/172764069a7f46e4aef0af8b1cec3d5d.
[11] Ebokaiwe, Azubuike Peter, Njoya, Emmanuel Mfotie, Sheng, Yuwen, Zhang, Zhonghui, Li, Sheng, Zhou, Zongyuan, Qiang, Zhe, Peng, Ting, Hussein, Ahmed A, Zhang, Guolin, Lu, Xiaoxia, Li, Lin, Wang, Fei. Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2020, 404: http://dx.doi.org/10.1016/j.taap.2020.115203.
[12] Zhang, Qi, Cheng, Yao, Yang, Jian, Zheng, Cheng, Lu, Xiaoxia. Isolation, identification, and characterization of potential impurities of doramectin and evaluation of their insecticidal activity. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2020, 191: http://dx.doi.org/10.1016/j.jpba.2020.113600.
[13] Bai, Ping, Wang, Keren, Zhang, Pengfei, Shi, Jian, Cheng, Xinfeng, Zhang, Qi, Zheng, Cheng, Cheng, Yao, Yang, Jian, Lu, Xiaoxia, Sang, Zhipei. Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 183: http://dx.doi.org/10.1016/j.ejmech.2019.111737.
[14] Zhang, Qi, Bai, Ping, Zheng, Cheng, Cheng, Yao, Wang, Tao, Lu, Xiaoxia. Design, synthesis, insecticidal activity and molecular docking of doramectin derivatives. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2019, 27(12): 2387-2396, http://dx.doi.org/10.1016/j.bmc.2018.12.040.
[15] Wu, Jiasi, Luo, Yu, Jiang, Qing, Li, Sheng, Huang, Wenge, Xiang, Li, Liu, Deming, Hu, Yingfan, Wang, Ping, Lu, Xiaoxia, Zhang, Guolin, Wang, Fei, Meng, Xianli. Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1. PHARMACOLOGICAL RESEARCH[J]. 2019, 147: 104348-, http://dx.doi.org/10.1016/j.phrs.2019.104348.
[16] Bai, Ping, Wey, HsiaoYing, Patnaik, Debasis, Lu, Xiaoxia, Lan, Yu, Rokka, Johanna, Stephanie, Fiedler, Haggarty, Stephen J, Wang, Changning. Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging. CHEMICAL COMMUNICATIONS[J]. 2019, 55(86): 12932-12935, http://dx.doi.org/10.1039/c9cc06734e.
[17] 郑城, 王涛, 谢昌贤, 云喜报, 卢晓霞. 盐霉素类似物的分离及抑制吲哚胺2，3-双加氧酶活性研究. 天然产物研究与开发[J]. 2019, 31(6): 1012-1016, http://lib.cqvip.com/Qikan/Article/Detail?id=7002234383.
[18] Wen, Yongju, Zhou, Zongyuan, Zhang, Guolin, Lu, Xiaoxia. Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethy1-2,3-dehydrosilybin from silybin and their antitumor activities. TETRAHEDRON LETTERS[J]. 2018, 59(17): 1666-1669, https://www.webofscience.com/wos/woscc/full-record/WOS:000430524700013.
[19] Yongju Wen, Zongyuan Zhou, Guolin Zhang, Xiaoxia Lu. Metal coordination protocol for the synthesis of-2,3-dehydrosilybin and 19-O-demethyl-2,3-dehydrosilybin from silybin and their antitumor activities. TETRAHEDRON LETTERS. 2018, 59(17): 1666-1669, http://dx.doi.org/10.1016/j.tetlet.2018.03.052.
[20] Guo-Lin Zhang. Metal Ion Coordination Protocol for the Synthesis 2,3-Dehydrosilybin and 19-O-Demethyl-2,3-dehydrosilybin from Silybin and Their Antitumor Activities. Tetrahedron Letters. 2018, [21] 王涛, 熊峰, 赵澜宁, 卢晓霞. 脂肪酶催化吉法酯的合成研究. 化学研究与应用[J]. 2018, 30(5): 789-794, http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=hxyjyyy201805021.
[22] 万振江, 潘伟, 卢晓霞. 具抗病毒黄精寡糖核心片段的分离纯化与四糖结构. 应用与环境生物学报[J]. 2017, 23(1): 95-99, [23] 张琪, 赵澜宁, 潘伟, 王涛, 卢晓霞. σ1受体配体的合成及其生物活性. 精细化工[J]. 2017, 34(11): 1272-1277, http://lib.cqvip.com/Qikan/Article/Detail?id=673755685.
[24] Zhao, Lanning, Wang, Qilong, Bie, Yi, Lu, Xiaoxia. Isolation, identification and characterization of potential impurities of anidulafungin. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2017, 141(2017): 192-199, http://dx.doi.org/10.1016/j.jpba.2017.04.014.
[25] Lan, Jianyong, Xie, Haisheng, Lu, Xiaoxia, Deng, Yuanfu, Jiang, Huanfeng, Zeng, Wei. Co(II)-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Aryl C-H Bonds with Carboxylic Acids. ORGANIC LETTERS[J]. 2017, 19(16): 4279-4282, https://www.webofscience.com/wos/woscc/full-record/WOS:000408285600032.
[26] Xiao, Xinsheng, Zhang, Wei, Lu, Xiaoxia, Deng, Yuanfu, Jiang, Huangfeng, Zeng, Wei. Copper-Catalyzed Addition of Alkylboranes to Iminoacetates: Access to alpha-Alkyl Branched alpha-Amino Acids. ADVANCED SYNTHESIS & CATALYSIS[J]. 2016, 358(15): 2497-2509, http://www.corc.org.cn/handle/1471x/2195404.
[27] Liu, Jianzhong, Xie, Ying, Zeng, Wei, Lin, Dongen, Deng, Yuanfu, Lu, Xiaoxia. Pd(II)-Catalyzed Pyridine N-Oxides Directed Arylation of Unactivated C-sp(3)-H Bonds. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 80(9): 4618-4626, http://210.75.237.14/handle/351003/27586.
[28] 黄涌澜, 董理进, 王超, 卢晓霞, 孙健. 炔醛参与的直接Mannich反应. 合成化学[J]. 2013, 21(4): 443-446, http://lib.cqvip.com/Qikan/Article/Detail?id=46759044.
[29] Zhu, Shujie, Lu, Xiaoxia, Luo, Yueting, Zhang, Wei, Jiang, Huanfeng, Yan, Ming, Zeng, Wei. Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of alpha-Imino Esters with Dienes. ORGANICLETTERS[J]. 2013, 15(7): 1440-1443, https://www.webofscience.com/wos/woscc/full-record/WOS:000317327900006.
[30] 卢晓霞. Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of r?Imino Esters with Dienes. Org. Lett.. 2013, [31] Xiong, Feng, Qian, Cheng, Lin, Dongen, Zeng, Wei, Lu, Xiaoxia. Palladium-Catalyzed Cascade Oxidation/sp(2) C-H Acylation of Azoarenes with Aryl Methanes. ORGANIC LETTERS[J]. 2013, 15(21): 5444-5447, http://www.irgrid.ac.cn/handle/1471x/900527.
[32] Luo, Yueting, Lu, Xiaoxia, Ye, Yong, Guo, Ya, Jiang, Huanfeng, Zeng, Wei. Pd-Catalyzed Tandem Cyclization of Ethyl Glyoxalate and Amines: Rapid Assembly of Highly Substituted Cyclic Dehydro-alpha-Amino Acid Derivatives. ORGANIC LETTERS[J]. 2012, 14(22): 5640-5643, https://www.webofscience.com/wos/woscc/full-record/WOS:000311324100006.
[33] Chen, Jiayan, Lu, Xiaoxia, Lou, Wenyong, Ye, Yong, Jiang, Huanfeng, Zeng, Wei. Palladium(II)-Catalyzed Enantioselective Arylation of alpha-Imino Esters. JOURNAL OF ORGANIC CHEMISTRY[J]. 2012, 77(19): 8541-8548, https://www.webofscience.com/wos/woscc/full-record/WOS:000313767800017.
[34] 万振江, 卢晓霞. Lipozyme TL IM催化合成Temsirolimus. 合成化学[J]. 2012, 20(2): 248-250, http://lib.cqvip.com/Qikan/Article/Detail?id=41479836.
[35] Tu, Zhude, Wang, Wei, Cui, Jinquan, Zhang, Xiang, Lu, Xiaoxia, Xu, Jinbin, Parsons, Stanley M. Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2012, 20(14): 4422-4429, http://dx.doi.org/10.1016/j.bmc.2012.05.045.
[36] 卢晓霞. Preparation and antiherpetic activities of chemically modi?ed polysaccharides from Polygonatum cyrtonema Hua. Carbohydrate Polymers. 2011, [37] Wu, Xinjun, Li, Yang, Wang, Chao, Zhou, Li, Lu, Xiaoxia, Sun, Jian. Chiral Lewis Base Catalyzed Highly Enantioselective Reduction of N-Alkyl beta-Enamino Esters with Trichlorosilane and Water. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 17(10): 2846-2848, http://www.irgrid.ac.cn/handle/1471x/517894.
[38] 苏鹏, 王晶, 安君霞, 朱启彧, 卢晓霞, 唐亚雄. 毛兰素对人肝癌Huh7细胞的抑制作用. 应用与环境生物学报[J]. 2011, 17(5): 662-665, http://lib.cqvip.com/Qikan/Article/Detail?id=39653275.
[39] Zhang, Zhanbin, Lu, Xiaoxia, Xu, Jinbin, Rothfuss, Justin, Mach, Robert H, Tu, Zhude. Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A. EUROPEANJOURNALOFMEDICINALCHEMISTRY[J]. 2011, 46(9): 3986-3995, http://dx.doi.org/10.1016/j.ejmech.2011.05.072.
[40] 王萌, 王超, 卢晓霞, 孙健. 手性氨基亚磺酰胺的合成及其对N-苯基酮亚胺不对称还原的催化作用. 合成化学[J]. 2011, 19(1): 7-10, http://lib.cqvip.com/Qikan/Article/Detail?id=36734233.
[41] Wei Wang, Jinquan Cui, Xiaoxia Lu, Prashanth K Padakanti, Jinbin Xu, Stanley M Parsons, Robert R Luedtke, Nigam P Rath, Zhude Tu. Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ 1 receptors. JOURNAL OF MEDICINAL CHEMISTRY. 2011, 54(15): 5362-5372, [42] 刘笑笑, 万振江, 邓小波, 石林, 卢晓霞. 雪灵芝不同提取物的生物活性. 应用与环境生物学报[J]. 2010, 16(5): 642-645, http://lib.cqvip.com/Qikan/Article/Detail?id=35638411.
[43] WANG ZhouYu, ZHOU Li, LU XiaoXia, SUN Jian. Chiral N-formyl amino alcohol as Lewis basic organocatalyst for enantioselective hydrosilylation of ketimines. 中国科学通报：英文版[J]. 2010, 1726-1728, http://lib.cqvip.com/Qikan/Article/Detail?id=34286015.
[44] Li, Yinhui, Cheng, Ke, Lu, Xiaoxia, Sun, Jian. A Facile and Efficient Approach to N-Protected-beta-Sulfinylenamines via C-Sulfinylation of Enamides and Enecarbamates. ADVANCED SYNTHESIS & CATALYSIS[J]. 2010, 352(11-12): 1876-1880, [45] 卢晓霞, 石林, 卢晓霞. 姜辣素与姜挥发油的化学成分、提取技术及药理研究进展. 天然产物研究与开发[J]. 2010, 22(B08): 226-231, http://lib.cqvip.com/Qikan/Article/Detail?id=36386668.
[46] 卢晓霞. A Facile and Efficient Approach to N-Protected-b-Sulfinylenamines via C-Sulfinylation of Enamides and Enecarbamates. Adv. Synth.Catal. 2010, [47] 卢晓霞. 雪灵芝不同提取物的生物活性初步研究. 应用与环境微生物学. 2010, [48] Wang ZhouYu, Zhou Li, Lu XiaoXia, Sun Jian. Chiral N-formyl amino alcohol as Lewis basic organocatalyst for enantioselective hydrosilylation of ketimines. CHINESE SCIENCE BULLETIN[J]. 2010, 55(17): 1726-1728, http://lib.cqvip.com/Qikan/Article/Detail?id=34286015.
[49] Lin, Deqing, Cheng, Ke, Lu, Xiaoxia, Sun, Jian. Methyltrichlorosilane-DMSO: A Facile and Highly Efficient Recipe for the Chlorination of Enamides and Enecarbamates. SYNLETT[J]. 2009, 2961-2964, http://www.irgrid.ac.cn/handle/1471x/256560.
[50] Huang, Tai Kun, Shi, Lin, Wang, Rui, Guo, Xing Zhou, Lu, Xiao Xia. Keggin type heteropolyacids-catalyzed synthesis of quinoxaline derivatives in water. CHINESE CHEMICAL LETTERS[J]. 2009, 20(2): 161-164, http://lib.cqvip.com/Qikan/Article/Detail?id=30161681.
[51] 黄泽莲, 林德青, 卢晓霞, 孙健. 手性路易斯碱催化Ⅳ-酰基烯胺不对称还原. 合成化学[J]. 2009, 532-536, http://lib.cqvip.com/Qikan/Article/Detail?id=31700356.
[52] 黄泽莲, 林德青, 卢晓霞, 孙健. 手性路易斯碱催化N-酰基烯胺不对称还原. 合成化学[J]. 2009, 17(5): 532-536, http://210.75.237.14/handle/351003/18337.
[53] 李银慧, 王瑜, 卢晓霞, 孙健. 三氟乙酸对氨基酸催化不对称直接Aldol反应的影响. 合成化学[J]. 2009, 557-559, http://lib.cqvip.com/Qikan/Article/Detail?id=31700362.
[54] 卢晓霞. Methyltrichlorosilane/DMSO: A Facile and Highly Efficient Method for the Chlorination of Enamides/Enecarbamates. Synlett. 2009, [55] Tai Kun Huang Lin Shi Rui Wang Xing Zhou Guo Xiao Xia Lu. Keggin type heteropolyacids-catalyzed synthesis of quinoxaline derivatives in water. 中国化学快报：英文版[J]. 2009, 20(2): 161-164, http://lib.cqvip.com/Qikan/Article/Detail?id=30161681.
[56] Wu, Pengcheng, Lin, Deqin, Lu, Xiaoxia, Zhou, Li, Sun, Jian. Trimethylchlorosilane-promoted aza-Mannich reaction of enecarbamates and aldimines. TETRAHEDRON LETTERS[J]. 2009, 50(52): 7249-7251, http://dx.doi.org/10.1016/j.tetlet.2009.09.097.
[57] 卢晓霞. Synthesis and Biological Activities of Novel Nonpeptide Angiotensin II Receptor Antagonists Based on Benzimidazole Derivatives Bearing a Heterocyclic Ring, Bioorg. Med. Chem.. 2008, [58] Huang, Taikun, Wang, Rui, Shi, Lin, Lu, Xiaoxia. Montmorillonite K-10: An efficient and reusable catalyst for the synthesis of quinoxaline derivatives in water. CATALYSIS COMMUNICATIONS[J]. 2008, 9(6): 1143-1147, http://dx.doi.org/10.1016/j.catcom.2007.10.024.
[59] Guo, XingZhou, Shi, Lin, Wang, Rui, Liu, XiaoXiao, Li, BoGang, Lu, XiaoXia. Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2008, 16(24): 10301-10310, http://dx.doi.org/10.1016/j.bmc.2008.10.040.
[60] 卢晓霞. Short and Efficient Synthesis of Thiol Groups Functionalized Crown Ethers. Synthetic Communications. 2007, [61] Sun, Yong, Lu, Xiaoxia, Wang, Rui, Shi, Lin, Yang, Bin. Short and efficient synthesis of thiol group functionalized crown ethers. SYNTHETIC COMMUNICATIONS[J]. 2007, 37(17): 2995-3002, https://www.webofscience.com/wos/woscc/full-record/WOS:000254130400004.
[62] Wang, Rut, Huang, Taikun, Shi, Lin, Li, Bogang, Lu, Xiaoxia. Heteropoly acids catalyzed direct mannich reactions: Three-component synthesis of N-protected beta-amino ketones. SYNLETT[J]. 2007, 2197-2200, http://www.irgrid.ac.cn/handle/1471x/256404.
[63] Wang, Rui, Lu, Xiaoxia, Yu, Xiaoqi, Shi, Lin, Sun, Yong. Acid-catalyzed solvent-free synthesis of 2-arylbenzimidazoles under microwave irradiation. JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL[J]. 2007, 266(1-2): 198-201, http://dx.doi.org/10.1016/j.molcata.2006.04.071.
[64] Wang, Rui, Li, Bogang, Huang, Taikun, Shi, Lin, Lu, Xiaoxia. NbCl5-catalyzed one-pot Mannich-type reaction: three component synthesis of beta-amino carbonyl compounds. TETRAHEDRON LETTERS[J]. 2007, 48(12): 2071-2073, http://www.irgrid.ac.cn/handle/1471x/256410.
[65] Lu, XX, Cheng, ECC, Zhu, NY, Yam, VWW. Synthesis, luminescence and ion-binding properties of palladium(II) complexes with 1,2-bisdi(benzo-15-crown-5)phosphinoethane (dbcpe). DALTON TRANSACTIONS[J]. 2006, 1803-1808, http://210.75.237.14/handle/351003/26754.
[66] Tang, WS, Lu, XX, Wong, KMC, Yam, VWW. Synthesis, photophysics and binding studies of Pt(II) alkynyl terpyridine complexes with crown ether pendant. Potential luminescent sensors for metal ions. JOURNAL OF MATERIALS CHEMISTRY[J]. 2005, 15(27-28): 2714-2720, https://www.webofscience.com/wos/woscc/full-record/WOS:000230431900011.
[67] Lu, XX, Tang, HS, Ko, CC, Wong, JKY, Zhu, NY, Yam, VWW. Anion-assisted trans-cis isomerization of palladium(II) phosphine complexes containing acetanilide functionalities through hydrogen bonding interactions. CHEMICAL COMMUNICATIONS[J]. 2005, 1572-1574, https://www.webofscience.com/wos/woscc/full-record/WOS:000227653000021.
[68] Wong, KMC, Tang, WS, Lu, XX, Zhu, NY, Yam, VWW. Functionalized platinum(II) terpyridyl alkynyl complexes as colorimetric and luminescence pH sensors. INORGANIC CHEMISTRY[J]. 2005, 44(5): 1492-1498, https://www.webofscience.com/wos/woscc/full-record/WOS:000227346300050.
[69] Li, CK, Lu, XX, Wong, KMC, Chan, CL, Zhu, NY, Yam, VWW. Molecular design of luminescence ion probes for various cations based on weak gold(I)center dot center dot center dot gold(I) interactions in dinuclear gold(I) complexes. INORGANIC CHEMISTRY[J]. 2004, 43(23): 7421-7430, https://www.webofscience.com/wos/woscc/full-record/WOS:000225128900025.
[70] 卢晓霞. Synthesis, Structural Characterization, and Host-Guest Chemistry of Ethynyl Crown Ether Containing Polynuclear Gold(I) Complexes.. Inorg. Chem.. 2004, [71] 卢晓霞. Synthesis, Structure, and Ion-Binding Studies of Cobalt(II) Complexes with Aza-crown Substituted Salicylaldime Schiff Base Ligand.. 2003, [72] 卢晓霞. Two routes for the synthesis of N- (4-Aminophenyl) monoaza crown ethers. Organic Preparations and Procedures Int. 2003, [73] Yam, VWW, Lu, XX, Ko, CC. First observation of alkali metal ion induced trans-cis isomerization of palladium(II) phosphane complexes containing crown ether moieties. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2003, 42(29): 3385-3388, https://www.webofscience.com/wos/woscc/full-record/WOS:000184548700011.
[74] 卢晓霞. Synthesis of Monoaza Crown Ethers with Mono-Schiff Base. Chin. J. Chem.. 2003, [75] Yam, VWW, Tang, RPL, Wong, KMC, Lu, XX, Cheung, KK, Zhu, NY. Syntheses, electronic absorption, emission, and ion-binding studies of platinum(II) C boolean AND N boolean AND C and terpyridyl complexes containing crown ether pendants. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2002, 8(17): 4066-4076, https://www.webofscience.com/wos/woscc/full-record/WOS:000177888300026.
[76] 李仲辉, 李建章, 秦圣英, 卢晓霞. 一系列新的二元西佛碱钴（Ⅱ）配合物的合成. 化学研究与应用[J]. 2000, 12(1): 77-, http://lib.cqvip.com/Qikan/Article/Detail?id=4110255.
[77] Lu, XX, Li, HB, Zeng, W, Yang, H, Qin, SY. Dioxygen affinities and biomimetic catalytic performance of transition-metal complexes with crowned bis-Schiff bases. CHINESE CHEMICAL LETTERS[J]. 2000, 11(12): 1053-1056, http://lib.cqvip.com/Qikan/Article/Detail?id=4000721587.
[78] 卢晓霞. 冠醚膦、冠醚Schiff碱钯、钴配合物的合成、离子识别、光化学及仿生性能研究. 2000, http://www.corc.org.cn/handle/1471x/1904744.
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[80] 李仲辉, 孙斌, 李建章, 卢晓霞, 秦圣英. （苯并—15—冠—5）双Schiff碱的合成. 有机化学[J]. 2000, 20(1): 91-, http://lib.cqvip.com/Qikan/Article/Detail?id=4140891.
[81] 卢晓霞, 秦圣英, 李建章. Schiff碱配合物结构对其催化氧化性能的影响. 化学研究与应用[J]. 1999, 11(3): 305-, http://lib.cqvip.com/Qikan/Article/Detail?id=3721965.
[82] 卢晓霞, 秦圣英. 四Schiff碱（二苯并-18-冠-6）及其钾（I）/钴（II）配合物的合成和性质. 化学学报[J]. 1999, 57(12): 1364-, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=497405&detailType=1.
[83] 卢晓霞, 秦圣英. 冠醚化四Schiff碱双核钴（Ⅱ）配合物的固相合成. 四川大学学报：自然科学版[J]. 1999, 36(4): 792-, http://lib.cqvip.com/Qikan/Article/Detail?id=3639169.
[84] 李建章, 秦圣英, 卢晓霞. 简法合成4′—巯基苯并—15—冠—5. 化学试剂[J]. 1999, 21(6): 332-, http://lib.cqvip.com/Qikan/Article/Detail?id=3894149.
[85] 卢晓霞. 4-硫基苯并-15-冠-5的简便合成. 化学试剂. 1999, [86] Yang, H, Qin, SY, Lu, XX. Dioxygen affinities and catalytic epoxidation performance of transition-metal hydroxamates. CHINESE CHEMICAL LETTERS[J]. 1999, 10(1): 79-82, http://lib.cqvip.com/Qikan/Article/Detail?id=3000840130.
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（ 1 ） （1） 基于Sigma-1受体信号通路的化学小分子的设计合成及其抗癌活性研究, 主持, 国家级, 2013-01--2016-12
（ 2 ） (2) 手性α-氨基酸及其衍生物的绿色不对称合成新技术研究与应用, 主持, 部委级, 2013-01--2015-12
（ 3 ） 微生物发酵产品相关杂质研究, 主持, 院级, 2017-01--2018-12
（ 4 ） 新型微生物源抗逆制剂与杀虫剂的研制及应用, 主持, 部委级, 2016-01--2017-12
（ 5 ） 大环内酯类杂质的相关研究, 主持, 院级, 2018-04--2019-12
（ 6 ） 阿卡波糖类杂质的相关研究, 主持, 院级, 2018-04--2019-12
（ 7 ） 甘类化合物生物活性与生物利用度改进研究, 参与, 部委级, 2019-01--2021-12
（ 8 ） 基于天然产物的老年性疾病候选药物研究, 参与, 国家级, 2019-01--2021-12

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