General

Bing Sun, Professor,

Shanghai Institute of Biochemistry and Cell Biology,

Chinese Academy of Sciences.

320 Yueyang Road

                                         Shanghai 200031, P. R. China


Research Areas

Molecular Immunology

Education

Oct 1978-Jul 1983    

MD. School of Medicine, Xinjiang Medical College,   P.R.China

Sep 1983-Jul 1986

MS. School of Medicine, Xinjiang Medical College,   P.R.China,

Major: Pharmacology

Mar 1988-Jan 1991

Ph.D. Department of Basic Immunology, Shanghai Second   Medical  University, P.R. China, Major:   Immunology

Jan 1994-Jan 1999

Postdoctoral training, Section on Immunoregulation,   Lab. Of Immunology, NEI, NIH, USA


Experience

   
Work Experience

Aug 1986-Mar 1988

Teaching Assistant, Department of   Pharmacology, Xinjiang Medical College, P.R.China

Jan 1991-Jan 1994

Lecturer (Jan 1991 - Oct 1993)
  Associate Professor (Oct 1993-Jan 1994)

Department of Pharmacology, School of   Pharmacy, Shanghai Medical University,    P.R.China

Jan 1994-Jan 1999

Visiting Scientist, Section on Immunoregulation, Lab.   of

Immunology, NEI, NIH, USA

May1998-May 2006

Professor, Chief, Lab of Molecular   Immunology, Institute of Biochemistry and Cell Biology, Chinese Academy of   Sciences. Shanghai, P. R. China

April 2006-Dec 2016

Co-director, Professor, Lab of Molecular   Virology, Institute Pasteur of Shanghai, Chinese Academy of Sciences

April 2006-Dec 2016

Guest Professor, Institute of Biochemistry   and Cell Biology, Chinese Academy of Sciences.

Jan 2017-present

Professor, Chief, Lab of Molecular   Immunology, Institute of Biochemistry and Cell Biology, Chinese Academy of   Sciences. Shanghai, P. R. China

Honors & Distinctions

2003

Shanghai Science and Technology System advanced workers

2007

Shanghai outstanding academic leaders

2012

Shanghai Natural Science Award

2013

National Natural Science Award


Publications


Papers

1.      Qiaoshi Lian, Jun Xu, Shanshan Yan, Min Huang*, Honghua Ding, Xiaoyu Sun, Aiwei Bi, Jian Ding*, Bing Sun*, Meiyu Geng*, Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Research (2017) 27:784-800.

2.      Wang WS, Sun XY, Li YB, Su JP, Ling ZY, Zhang TL, Wang F, Zhang H, Chen HL, Ding JP, Sun B*. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature Communications 2016; 7:12.

3.      Pan Su, Sheng Chen, Yu Han ZhengJinfang Zhu, Zhi-Ying Wu and Bing Sun*. Novel function of Extracellular matrix protein 1 in suppressing Th17 cell development in experimental autoimmune encephalomyelitis. J Immunol. 2016 Aug 15;197(4):1054-64

4.      Zhang RH, Wang K, Ping XQ, Yu WJ, Qian ZK, Xiong SD,Sun B*. The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis. Journal of Virology 2015; 89(22):11383-11395.

5.      Yangming Wang, Qiaoshi Lian, Bo Yang and Bing Sun*. TRIM30α is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLOS Pathogens. 2015;11(6):18.

6.      Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, Zhang H, Sun S, Wu X, Meng G, Pei G*Sun B*β-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes J Immunol. 2015 Feb 15;194(4):1867-73.

7.      Sha W, Mitoma H, Hanabuchi S, Bao M, Weng L, Sugimoto N, Liu Y, Zhang Z, Zhong J, Sun B*Liu YJ*Human NLRP3 inflammasome senses multiple types of bacterial RNAsPNAS. 2014 Nov 11;111(45):16059-64.

8.      Zhou H, Wang Y, Lian Q, Yang B, Ma Y, Wu X, Sun S, Liu Y, Sun B*.Differential IL-10 production by DCs determines the distinct adjuvant effects of LPSand PTX in EAE inductionEur J Immunol. 2014 May;44(5):1352-62.

9.      Wang J, Yang B, Hu Y, Zheng Y, Zhou H, Wang Y, Ma Y, Mao K, Yang L, Lin G, Ji Y, Wu X, Sun B*. Negative regulation of Nmi on virus-triggered type I IFN production by targeting . J Immunol. 2013 Sep 15;191(6):3393-9

10.   OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B*Chou JJ*Unusual architecture of the p7 channel from hepatitis C virus. Nature. 2013 Jun 27;498(7455):521-5.

11.   Yang B, Wang J, Wang Y, Zhou H, Wu X, Tian Z, Sun B*. Novel function of Trim44 promotes an antiviral response by stabilizing VISA. J Immunol. 2013 Apr 1;190(7):3613-9.

12.   Mao K, Chen S, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W, Chen C, Meng G, Sun B*Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 2013 Feb;23(2):201-12

13.   Zhenhu Li,Yuan Zhang, Zhiduo Liu, Xiaodong Wu, Yuhan Zheng, Zhiyun Tao Kairui Mao, Jie Wang, Guomei Lin, Lin Tian, Yongyong Ji, Meiling Qin, Shuhui Sun, Xueliang Zhu, and Bing Sun*Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1. Nat Immunol. 2011 Feb;12(2):178-85

14.   Hu Y, Mao K, Zeng Y, Chen S, Tao Z, Yang C, Sun S, Wu X, Meng G, Sun B*. Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production. J Immunol. 2010 Dec 15;185(12):7699-705

15.   Xu K, Klenk C, Liu B, Keiner B, Cheng J, Zheng BJ, Li L, Han Q, Wang C, Li T, Chen Z, Shu Y, Liu J, Klenk HD, Sun B*. SUMO1 modification of the non-structural protein 1 of influenza A virus. Journal of Virology. 2011 Jan;85(2):1086-98

16.   He Y, Xu K, Keiner B, Zhou J, Czudai V, Li T, Chen Z, Liu J, Klenk HD, Shu YL, Sun B*. Influenza A virus replication Induces Cell Cycle Arrest in G0/G1 Phase. Journal of Virology. 2010 Dec; 84(24):12832-40.

17.   Liu Z, Li Z, Mao K, Zou J, Wang Y, Tao Z, Lin G, Tian L, Ji Y, Wu X, Zhu X, Sun S, Chen W, Xiang C, Sun B*. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.  J Immunol. 2009 Nov 15;183(10):6320-9

18.   Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B*Dong C*. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2009 Dec;10(12):1260-6

19.   Weiwen Deng, Mude Shi, Meifang Han, Jin Zhong, Weina Li, Zhenhu Li, Yu Hu, Lingchen Yan, Jie Wang, Ying He, Hong Tang, Vincent Deubel, Xiaoping Luo, Qin Ning, Bing Sun*. Negative regulation of virus-triggered IFN-b signaling pathway by alternative splicing of TBK1. J Biol Chem. 2008 Dec 19;283(51):35590-7.

20.   Mude Shi, Weiwen Deng, Enguang Bi, Kairui Mao, Yongyong Ji, Guomei Lin, Xiaodong Wu, Zhiyun Tao, Zhenhu Li, Xinfen Cai, Shuhui Sun, Charlie Xiang, Bing Sun*. TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation. Nature Immunology 2008, 9:369-377

21.   Wei Lu, Bojian Zheng, Ke Xu, Wolfgang Schwarz, Jiadong Cheng, Shuming Duan, Vincent Deubel, Bing Sun*.  SARS-CoV 3a protein forms an ion channel and modulates virus release. PNAS 2006 August 15, 103(33);12540-12545

22.   Xiaodong Wu, Wanqiu Hou, Shuhui Sun, Enguang Bi, Yuan Wang, Mude Shi, Jingwu Zang, Chen Dong and Bing Sun. Novel function of IFN-g negative regulation on Dendritic Cell migration and T cell priming. Journal of Immunology 2006 Jul 15;177(2):934-43.

23.  Chunjian Huang, Enguang Bi, Yu Hu, Weiwen Deng, Zhigang Tian, Chen Dong,Yuanjie Hu, and Bing Sun*. A novel NF-kB binding site controls human granzyme B gene transcription. Journal of Immunology, 2006 Apr 1;176(7):4173-81.



Research Interests

1.     Dendritic cell maturation and Th1/Th2/Th17 cell differentiation and their function study in autoimmune disease.

2.     New mechanisms for crosstalk between Th2 and ILC2 cells in allergic asthma disease

3.     Broad neutralizing antibody induction in infectious disease and antibody engineering technology development and its application research


Conferences

Time

Place

Conference name

Report title

2012.1

Taipei, TW.

International Symposium on Viral Membrane Proteins

ORF4a protein of HCoV-229E forms an ion channel   functionally analogous to the SARS-CoV 3a protein

2012.3

ESSENGermany

22nd Annual Meeting of the Society for Virology/   Germany-Essen

Identification of novel mechanisms in the pathogenesis   of influenza A virus infection

2012.4

BeijingChina

Invited report in Tsinghua University

ECM1 controls Th2 cell egress from lymph nodes through   re-expression of S1P1

2012.5

USA

Invited report in Yale University

The mechanism study of Th1/Th2 cell differentiation and   migration

2013.4

BeijingChina

Beijing Xiangshan Conference -Recent Advances in   Immunology

Differential IL-10 production by DCs determines the   distinct adjuvant effects of LPS and PTX in EAE induction1 

2013.1

Xi’an China

2013 International Symposium on Infection, Immunity and   Translational Medicine

Residues on PB1 and PB2 contribute to the polymerase   activity of avian influenza viruses which transmit to human.

2013.1

ChongqingChina

2013International conference of infection and   immunology

PB1 473 mutation plays an important role in   cross-transmission from Avian to Human

2014.5

USA

AAI           IMMUNOLOGY 2014TM

Novel function of ECM1 on inhibiting Th17   differentiation and migration in EAE induction

2014.6

lyonFrance

The World Life Sciences Forum

Vaccines & Immunotherapies

2014.9

Wuhan, China

The 2nd International Forum on Liver Disease and   Infection

Innate Immune response in HCV infection

2014.1

GuangzhouChina

Asian Pacific international conference for the Study of   Liver

Th cell differentitation and viral infection

2015.6

Chicago, USA

World Conference on Flu

Both PB1 473V mutation in RNA polymerase activity and   NP sumoylation play an important role in the pathogenesis of influenza virus   infection

2015.6

Singapore

FIMSA 2015

TRIM30α is a Negative-Feedback Regulator of the   Intracellular DNA and DNA Virus-Triggered Response by targeting STING

2015.8

London, England

International Conference on Influenza 2015

Both PB1 473V mutation in RNA polymerase activity and   NP sumoylation play an important role in the pathogenesis of influenza virus infection

2015.1

Chengdu, China

4th Chinese-German Joint Symposium on Immunology

ECM1 controls TH2 cell egress from lymph nodes through   re-expression of S1P1

2016.4

Münster, Germany

26th Annual Meeting of the Society for Virology

TRIM30α is a Negative Regulator in DNA Virus infection   by targeting STING

2016.9

Wuhan, China

Nature Conference Viral Infection and Immune Response

TRIM30α is a negative regulator in DNA virus infection   by targeting STING


Students

已指导学生

施木德  01  19182  

黄妤  01  19182  

毕恩广  01  19182  

吴亚娣  01  19182  

侯万秋  01  19182  

刘智多  01  19182  

姚刚  01  19182  

胡宇  01  19182  

臧磊  01  19182  

王媛  01  19182  

吴晓东  01  19182  

林瑛  01  19182  

黄春健  01  19182  

袁建伟  02  19186  

罗敏  02  19186  

靖采英  02  19183  

张秀琴  02  19186  

邓位文  01  19182  

吕伟  01  19186  

颜凌晨  01  19186  

徐可  01  19186  

毛开睿  01  19182  

李振虎  01  19182  

王洁  01  19182  

边超  01  19186  

曹刘丽  02  19186  

潘荣  02  19186  

查业  02  19186  

凌志洋  02  19186  

马钊  02  19186  

徐莹  02  19186  

许晨  01  19178  

臧磊  02  19182  

张渊  01  19182  

何源  01  19178  

郑钰涵  01  19182  

汪凯  01  19178  

陈爱中  02  19186  

孙轶卓  02  19186  

崔骏  02  19186  

吴洪强  02  19186  

杨蕾蕾  02  19178  

黄潇  02  19186  

陈淑珍  01  19182  

胡伟斌  01  19178  

马利艳  02  19186  

王凌凌  02  19186  

伊春艳  02  19186  

杨晨  01  19182  

苏攀  01  19182  

谢适其  01  19178  

周海燕  01  19182  

韩青霖  01  19178  

侯建  02  63228  

尹东升  02  19186  

张瑾  02  19186  

王江君  02  63228  

张宏  01  19178  

王岩  01  19178  

何岚  01  19182  

沙文文  01  19178  

王强  01  19178  

苏金鹏  02  63228  

李楠  02  19178  

高秀  02  19178  

赵磊  02  63228  

现指导学生

廉桥石  01  19182  

赵新昊  01  19178  

范卫国  01  19178  

张亚光  01  19182  

孙晓玉  01  19178  

林旋  01  19178  

闫成花  01  19182  

李学真  01  19182  

伊春艳  01  19178  

夏静  01  19178  

温靖  02  19178  

王智硕   02  19181  

陈雯  01  19178