Bing Sun, Professor,
Shanghai Institute of Biochemistry and Cell Biology,
Chinese Academy of Sciences.
320 Yueyang Road
Shanghai 200031, P. R. China
Research Areas
Molecular Immunology
Education
Oct 1978-Jul 1983 | MD. School of Medicine, Xinjiang Medical College, P.R.China |
Sep 1983-Jul 1986 | MS. School of Medicine, Xinjiang Medical College, P.R.China, Major: Pharmacology |
Mar 1988-Jan 1991 | Ph.D. Department of Basic Immunology, Shanghai Second Medical University, P.R. China, Major: Immunology |
Jan 1994-Jan 1999 | Postdoctoral training, Section on Immunoregulation, Lab. Of Immunology, NEI, NIH, USA |
Experience
Work Experience
Aug 1986-Mar 1988 | Teaching Assistant, Department of Pharmacology, Xinjiang Medical College, P.R.China |
Jan 1991-Jan 1994 | Lecturer (Jan 1991 - Oct 1993) Department of Pharmacology, School of Pharmacy, Shanghai Medical University, P.R.China |
Jan 1994-Jan 1999 | Visiting Scientist, Section on Immunoregulation, Lab. of Immunology, NEI, NIH, USA |
May1998-May 2006 | Professor, Chief, Lab of Molecular Immunology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. Shanghai, P. R. China |
April 2006-Dec 2016 | Co-director, Professor, Lab of Molecular Virology, Institute Pasteur of Shanghai, Chinese Academy of Sciences |
April 2006-Dec 2016 | Guest Professor, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. |
Jan 2017-present | Professor, Chief, Lab of Molecular Immunology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. Shanghai, P. R. China |
Honors & Distinctions
2003 | Shanghai Science and Technology System advanced workers |
2007 | Shanghai outstanding academic leaders |
2012 | Shanghai Natural Science Award |
2013 | National Natural Science Award |
Publications
Papers
1. Qiaoshi Lian, Jun Xu, Shanshan Yan, Min Huang*, Honghua Ding, Xiaoyu Sun, Aiwei Bi, Jian Ding*, Bing Sun*, Meiyu Geng*, Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Research (2017) 27:784-800.
2. Wang WS, Sun XY, Li YB, Su JP, Ling ZY, Zhang TL, Wang F, Zhang H, Chen HL, Ding JP, Sun B*. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature Communications 2016; 7:12.
3. Pan Su, Sheng Chen, Yu Han Zheng,Jinfang Zhu, Zhi-Ying Wu and Bing Sun*. Novel function of Extracellular matrix protein 1 in suppressing Th17 cell development in experimental autoimmune encephalomyelitis. J Immunol. 2016 Aug 15;197(4):1054-64
4. Zhang RH, Wang K, Ping XQ, Yu WJ, Qian ZK, Xiong SD,Sun B*. The ns12.9 Accessory Protein of Human Coronavirus OC43 Is a Viroporin Involved in Virion Morphogenesis and Pathogenesis. Journal of Virology 2015; 89(22):11383-11395.
5. Yangming Wang, Qiaoshi Lian, Bo Yang and Bing Sun*. TRIM30α is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLOS Pathogens. 2015;11(6):18.
6. Mao K, Chen S, Wang Y, Zeng Y, Ma Y, Hu Y, Zhang H, Sun S, Wu X, Meng G, Pei G*, Sun B*. β-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes。 J Immunol. 2015 Feb 15;194(4):1867-73.
7. Sha W, Mitoma H, Hanabuchi S, Bao M, Weng L, Sugimoto N, Liu Y, Zhang Z, Zhong J, Sun B*, Liu YJ*. Human NLRP3 inflammasome senses multiple types of bacterial RNAs. PNAS. 2014 Nov 11;111(45):16059-64.
8. Zhou H, Wang Y, Lian Q, Yang B, Ma Y, Wu X, Sun S, Liu Y, Sun B*.Differential IL-10 production by DCs determines the distinct adjuvant effects of LPSand PTX in EAE induction。Eur J Immunol. 2014 May;44(5):1352-62.
9. Wang J, Yang B, Hu Y, Zheng Y, Zhou H, Wang Y, Ma Y, Mao K, Yang L, Lin G, Ji Y, Wu X, Sun B*. Negative regulation of Nmi on virus-triggered type I IFN production by targeting . J Immunol. 2013 Sep 15;191(6):3393-9
10. OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B*, Chou JJ*,Unusual architecture of the p7 channel from hepatitis C virus. Nature. 2013 Jun 27;498(7455):521-5.
11. Yang B, Wang J, Wang Y, Zhou H, Wu X, Tian Z, Sun B*. Novel function of Trim44 promotes an antiviral response by stabilizing VISA. J Immunol. 2013 Apr 1;190(7):3613-9.
12. Mao K, Chen S, Chen M, Ma Y, Wang Y, Huang B, He Z, Zeng Y, Hu Y, Sun S, Li J, Wu X, Wang X, Strober W, Chen C, Meng G, Sun B*. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Res. 2013 Feb;23(2):201-12
13. Zhenhu Li,Yuan Zhang, Zhiduo Liu, Xiaodong Wu, Yuhan Zheng, Zhiyun Tao, Kairui Mao, Jie Wang, Guomei Lin, Lin Tian, Yongyong Ji, Meiling Qin, Shuhui Sun, Xueliang Zhu, and Bing Sun*. Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1. Nat Immunol. 2011 Feb;12(2):178-85
14. Hu Y, Mao K, Zeng Y, Chen S, Tao Z, Yang C, Sun S, Wu X, Meng G, Sun B*. Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production. J Immunol. 2010 Dec 15;185(12):7699-705
15. Xu K, Klenk C, Liu B, Keiner B, Cheng J, Zheng BJ, Li L, Han Q, Wang C, Li T, Chen Z, Shu Y, Liu J, Klenk HD, Sun B*. SUMO1 modification of the non-structural protein 1 of influenza A virus. Journal of Virology. 2011 Jan;85(2):1086-98
16. He Y, Xu K, Keiner B, Zhou J, Czudai V, Li T, Chen Z, Liu J, Klenk HD, Shu YL, Sun B*. Influenza A virus replication Induces Cell Cycle Arrest in G0/G1 Phase. Journal of Virology. 2010 Dec; 84(24):12832-40.
17. Liu Z, Li Z, Mao K, Zou J, Wang Y, Tao Z, Lin G, Tian L, Ji Y, Wu X, Zhu X, Sun S, Chen W, Xiang C, Sun B*. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. J Immunol. 2009 Nov 15;183(10):6320-9
18. Yang XO, Angkasekwinai P, Zhu J, Peng J, Liu Z, Nurieva R, Liu X, Chung Y, Chang SH, Sun B*, Dong C*. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nat Immunol. 2009 Dec;10(12):1260-6
19. Weiwen Deng, Mude Shi, Meifang Han, Jin Zhong, Weina Li, Zhenhu Li, Yu Hu, Lingchen Yan, Jie Wang, Ying He, Hong Tang, Vincent Deubel, Xiaoping Luo, Qin Ning, Bing Sun*. Negative regulation of virus-triggered IFN-b signaling pathway by alternative splicing of TBK1. J Biol Chem. 2008 Dec 19;283(51):35590-7.
20. Mude Shi, Weiwen Deng, Enguang Bi, Kairui Mao, Yongyong Ji, Guomei Lin, Xiaodong Wu, Zhiyun Tao, Zhenhu Li, Xinfen Cai, Shuhui Sun, Charlie Xiang, Bing Sun*. TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation. Nature Immunology 2008, 9:369-377
21. Wei Lu, Bojian Zheng, Ke Xu, Wolfgang Schwarz, Jiadong Cheng, Shuming Duan, Vincent Deubel, Bing Sun*. SARS-CoV 3a protein forms an ion channel and modulates virus release. PNAS 2006 August 15, 103(33);12540-12545
22. Xiaodong Wu, Wanqiu Hou, Shuhui Sun, Enguang Bi, Yuan Wang, Mude Shi, Jingwu Zang, Chen Dong and Bing Sun* . Novel function of IFN-g negative regulation on Dendritic Cell migration and T cell priming. Journal of Immunology 2006 Jul 15;177(2):934-43.
23. Chunjian Huang, Enguang Bi, Yu Hu, Weiwen Deng, Zhigang Tian, Chen Dong,Yuanjie Hu, and Bing Sun*. A novel NF-kB binding site controls human granzyme B gene transcription. Journal of Immunology, 2006 Apr 1;176(7):4173-81.
Research Interests
1. Dendritic cell maturation and Th1/Th2/Th17 cell differentiation and their function study in autoimmune disease.
2. New mechanisms for crosstalk between Th2 and ILC2 cells in allergic asthma disease
3. Broad neutralizing antibody induction in infectious disease and antibody engineering technology development and its application research
Conferences
Time | Place | Conference name | Report title |
2012.1 | Taipei, TW. | International Symposium on Viral Membrane Proteins | ORF4a protein of HCoV-229E forms an ion channel functionally analogous to the SARS-CoV 3a protein |
2012.3 | ESSEN,Germany | 22nd Annual Meeting of the Society for Virology/ Germany-Essen | Identification of novel mechanisms in the pathogenesis of influenza A virus infection |
2012.4 | Beijing,China | Invited report in Tsinghua University | ECM1 controls Th2 cell egress from lymph nodes through re-expression of S1P1 |
2012.5 | USA | Invited report in Yale University | The mechanism study of Th1/Th2 cell differentiation and migration |
2013.4 | Beijing,China | Beijing Xiangshan Conference -Recent Advances in Immunology | Differential IL-10 production by DCs determines the distinct adjuvant effects of LPS and PTX in EAE induction1 |
2013.1 | Xi’an, China | 2013 International Symposium on Infection, Immunity and Translational Medicine | Residues on PB1 and PB2 contribute to the polymerase activity of avian influenza viruses which transmit to human. |
2013.1 | Chongqing,China | 2013International conference of infection and immunology | PB1 473 mutation plays an important role in cross-transmission from Avian to Human |
2014.5 | USA | AAI IMMUNOLOGY 2014TM | Novel function of ECM1 on inhibiting Th17 differentiation and migration in EAE induction |
2014.6 | lyon,France | The World Life Sciences Forum | Vaccines & Immunotherapies |
2014.9 | Wuhan, China | The 2nd International Forum on Liver Disease and Infection | Innate Immune response in HCV infection |
2014.1 | Guangzhou,China | Asian Pacific international conference for the Study of Liver | Th cell differentitation and viral infection |
2015.6 | Chicago, USA | World Conference on Flu | Both PB1 473V mutation in RNA polymerase activity and NP sumoylation play an important role in the pathogenesis of influenza virus infection |
2015.6 | Singapore | FIMSA 2015 | TRIM30α is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by targeting STING |
2015.8 | London, England | International Conference on Influenza 2015 | Both PB1 473V mutation in RNA polymerase activity and NP sumoylation play an important role in the pathogenesis of influenza virus infection |
2015.1 | Chengdu, China | 4th Chinese-German Joint Symposium on Immunology | ECM1 controls TH2 cell egress from lymph nodes through re-expression of S1P1 |
2016.4 | Münster, Germany | 26th Annual Meeting of the Society for Virology | TRIM30α is a Negative Regulator in DNA Virus infection by targeting STING |
2016.9 | Wuhan, China | Nature Conference Viral Infection and Immune Response | TRIM30α is a negative regulator in DNA virus infection by targeting STING |
Students
已指导学生
施木德 01 19182
黄妤 01 19182
毕恩广 01 19182
吴亚娣 01 19182
侯万秋 01 19182
刘智多 01 19182
姚刚 01 19182
胡宇 01 19182
臧磊 01 19182
王媛 01 19182
吴晓东 01 19182
林瑛 01 19182
黄春健 01 19182
袁建伟 02 19186
罗敏 02 19186
靖采英 02 19183
张秀琴 02 19186
邓位文 01 19182
吕伟 01 19186
颜凌晨 01 19186
徐可 01 19186
毛开睿 01 19182
李振虎 01 19182
王洁 01 19182
边超 01 19186
曹刘丽 02 19186
潘荣 02 19186
查业 02 19186
凌志洋 02 19186
马钊 02 19186
徐莹 02 19186
许晨 01 19178
臧磊 02 19182
张渊 01 19182
何源 01 19178
郑钰涵 01 19182
汪凯 01 19178
陈爱中 02 19186
孙轶卓 02 19186
崔骏 02 19186
吴洪强 02 19186
杨蕾蕾 02 19178
黄潇 02 19186
陈淑珍 01 19182
胡伟斌 01 19178
马利艳 02 19186
王凌凌 02 19186
伊春艳 02 19186
杨晨 01 19182
苏攀 01 19182
谢适其 01 19178
周海燕 01 19182
韩青霖 01 19178
侯建 02 63228
尹东升 02 19186
张瑾 02 19186
王江君 02 63228
张宏 01 19178
王岩 01 19178
何岚 01 19182
沙文文 01 19178
王强 01 19178
苏金鹏 02 63228
李楠 02 19178
高秀 02 19178
赵磊 02 63228
现指导学生
廉桥石 01 19182
赵新昊 01 19178
范卫国 01 19178
张亚光 01 19182
孙晓玉 01 19178
林旋 01 19178
闫成花 01 19182
李学真 01 19182
伊春艳 01 19178
夏静 01 19178
温靖 02 19178
王智硕 02 19181
陈雯 01 19178