X-ray crystallography; protein-protein interaction; structure-function relationship; mechanism; recognition; structure-based drug design; chromatin-remodeling proteins; histone modification.

1985/02 –1987/10    PhD in Chemistry, Fudan University, Shanghai, China

1982/02 –1984/10    MS in Chemistry, Zhongshan University, Guangzhou, China

1978/02 –1982/01     BS in Chemistry, Nanjing University, Nanjing, China

2000/11 – Now        Professor, Institute of Biochemistry and Cell Biology, SIBS, CAS

1998/07 – 2001/06   Associate Research Professor, Department of Chemistry and Chemical Biology, Rutgers University, New Jersey,  USA

1994/01 – 2001/06   Senior Research Scientist, Center for Advanced Biotechnology and Medicine, Rutgers University, New Jersey, USA

1994/01 – 1998/06   Assistant Research Professor, Department of Chemistry and Chemical Biology, Rutgers University, USA

1991/09 – 1993/12   Research Associate, Department of Chemistry and Chemical Biology; Research Scientist, Center for Advanced Biotechnology and Medicine, Rutgers University, USA

1989/07 – 1991/08   Research Fellow of the Alexander von Humboldt Foundation, Institute for Crystallography, Free University of Berlin, Germany

1987/11 – 1989/06   Postdoctoral Associate, Shanghai Institute of Ceramics, CAS

1984/11 – 1985/01   Teaching Associate, Department of Chemistry, Zhongshan University

2000 – 2004    Advanced Biochemistry, SIBCB, SIBS, CAS

2002 – 2004    Advanced Biochemistry, Summer School of Biochemistry, The Second Military Medical University, Shanghai

2004 – 2010    Experimental Biology, SIBS, CAS

2011/9             Biochemistry and Biology, College of Life Sciences, Zhejiang University

2015/4             Structural Biology, College of Life Sciences, ShanghaiTech University

       1989/07 – 1991/08   Research Fellowship, Alexander von Humboldt Foundation, Germany

1994/07    Presidential Award for Distinguish Public Service, Rutgers University

2001         国家人事部留学人员科技活动项目择优资助

2004         国家人事部留学人员科技活动项目择优资助

2004        上海市人事局引进海外高层次人才专项资金二类资助

2004        中国科学院优秀研究生导师奖

2004        日本明治乳业生命科学优秀奖

2006        中国科学院澳大利亚BHP Biliton导师科研奖

2006       国家人事部“新世纪百千万人才工程”国家级人选

2007       入选“上海市优秀学科带头人计划（A类）”

2008       中国科学院朱李月华优秀导师奖

2009      “上海市自然科学奖”二等奖（第三）

2009      “2009药明康德生命化学研究奖”二等奖

2010       2010年度国务院政府特殊津贴

2013       中华全国归国华侨联合会、国务院侨务办公室“全国归侨侨眷先进个人”

2015/9     Arthur Kornberg Memorial Lecture Award, the 18th A-IMBN Conference

2015/12   中共上海市委组织部、上海市人力资源和社会保障局，入选“2015年上海市领军人才培养计划”

1.  Wenshuai Wang$, Xiaoyu Sun$, Yanbing Li$, Jinpeng Su$, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen*,Jianping Ding*, and Bing Sun*“Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses”,Nature Communication,Accepted Oct 17(2016).

2.  Jing Xia$, Rong Wang$, Tianlong Zhang*, andJianping Ding*“Structural insight into the arginine binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling”,Cell Discovery,2:16035, doi: 10.1038/celldisc.2016.35, Accepted Aug 31, Epub Sep 13(2016).

3.  Rong Wang,Zhijing Wang, Tianlong Zhang, andJianping Ding*“Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1”,J. Mol. Cell Biol.,dio:10.1093/jmcb/mjw033, Epub Jul 19(2016).

4.  Fengjuan Lv, Tianlong Zhang, Zhen Zhou, Shuaixin Gao, Catherine CL Wong, Jin-Qiu Zhou, andJianping Ding* “Structural basis for Sfm1 functioning as a protein arginine methyltransferase”,Cell Discovery,1: 15037;doi:10.1038/celldisc.2015.37, Epub Dec 29(2015).

5.  Wenjing Li, Tianlong Zhang, andJianping Ding*“Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi”,Nucleic Acids Res., 43: 10026-10038,doi: 10.1093/nar/gkv979,Epub Oct 1(2015).

6.  Shaoqiong Xu$, Tianlong Zhang$, Shiva N. Kompella$, Mengdi Yan, Aiping Lu, Yanfang Wang, Xiaoxia Shao, Chengwu Chi, David J. Adams*,Jianping Ding*, and Chunguang Wang*“ConotoxinaD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors”,Sci. Rep., 5: 14261, doi: 10.1038/srep14261, Epub Sept 23(2015).($Contributed equally)

7.  Qingyu Tang, Caifeng Liu, Chen Zhong,andJianping Ding*“Crystal structures ofArabidopsis thalianaNudix hydrolase NUDT7 reveal a previously unobserved conformation”,Mol. Plant,8: 1557-1559,doi: 10.1016/j.molp.2015.07.010, Epub Aug 4(2015).

8.  Shanshan Liu, Heng Guo, Tianlong Zhang, Li Han, Pengfei Yao, Yan Zhang, Naiyan Rong, Yi Yu, Wenxian Lan, Chunxi Wang,Jianping Ding, Renxiao Wang, Wen Liu, and Chunyang Cao*“Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis”,Sci. Rep., 5: 12744, doi: 10.1038/srep12744, Epub Aug 5(2015).

9.  Katie Powis$, Tianlong Zhang$, Nicolas Panchaud, Rong Wang, Claudio De Virgilio*, andJianping Ding*“Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling”,Cell Res.,25: 1043-59,doi: 10.1038/cr.2015.86, Epub Jul 24(2015). ($Contributed equally)

10.Fang Yu$, Fangyuan He$, Hongyan Yao, Chengyuan Wang, Jianchuan Wang, Jianxu Li, Xiaofeng Qi, Hong-Wei Xue*,Jianping Ding*, and Peng Zhang* “Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex”,EMBO Rep., 16: 813-823, pii: e201540137, Epub June 12 (2015).($Contributed equally)(F1000Prime Recommended)

11.Lun Zhang, Jianchuan Wang, Li Hou, Pengrong Cao, Li Wu, Qiansen Zhang, Huaiyu Yang, Yi Zhang*,Jianping Ding*and Jia Li* “Functional role of histidine in the conserved His-x-Asp motif in the catalytic core of protein kinases”,Sci. Rep., 5, 10115, doi: 10.1038/srep10115, Epub May 11 (2015).

12.Benshang Li, Hui Li, Yun Bai, Renate Kirschner-Schwabe, Jun J Yang, Yao Chen, Gang Lu, Gannie Tzoneva, Xiaotu Ma, Tongmin Wu, Wenjing Li, Haisong Lu, Lixia Ding, Huanhuan Liang, Xiaohang Huang, Minjun Yang, Lei Jin, Hui Kang, Shuting Chen, Alicia Du, Shuhong Shen,Jianping Ding, Hongzhuan Chen, Jing Chen, Arend von Stackelberg, Longjun Gu, Jinghui Zhang, Adolfo Ferrando, Jingyan Tang, Shengyue Wang & Bin-Bing S Zhou “Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL”,Nature Med., 21: 563-571, doi:10.1038/nm.3840, Epub May 11 (2015).

13.Xiuxiu Lu, Tianlong Zhang, Zeng Xu, Shanshan Liu, Bin Zhao, Wenxian Lan, Chunxi Wang,Jianping Ding, and Chunyang Cao* “Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA”,J. Biol. Chem.,290, 4010-4021,pii: jbc.M114.624262, Epub Dec. 25(2015).

14.Zhe Zhang, Shanshan Wang, Tong Shen, Jiangye Chen, andJianping Ding*“Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2”,Structure, 22, 1408-1420,doi:10.1016/j.str.2014.08.005,EpubSep. 11(2014).(IF=6.794)

15.Zilong Zhang, Jian Wu, Wei Lin, Jin Wang, Han Yan, Wei Zhao, Jun Ma,Jianping Ding*, Peng Zhang*, and Guoping Zhao* “Subdomain II ofa-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition”,J. Biol. Chem.,289, 27966-27978,pii: jbc.M114.559716, Epub Aug. 15(2014).(IF=4.600)

16.Shicheng Zhang, Tianlong Zhang, Minghui Yan,Jianping Ding*, and Jiangye Chen* “Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching ofCandida albicans”,Cell Res.,24, 1108-1120,doi:1038/cr.2014.102,EpubAug. 5(2014).(IF=11.981)

17.Lei Liu, Jian Li, Yan Zhang, Shenghui Zhang, Jianqin Ye, Zhichao Wen, Jianping Ding, Satya P. Kunapuli, Xinping Luo*, and Zhongren Ding* “Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor: evidence from clinic to laboratory”,Thrombosis Res., 134, 866-876, doi:10.1016/j.thromres.2014.07.019, Epub Jul. 17 (2014).(IF=2.427)

18.Zhe Zhang, Tianlong Zhang,Shanshan Wang, Zou Gong, Chun Tang, Jiangye Chen, andJianping Ding*“Molecularmechanismfor Rabex-5GEFactivationby Rabaptin-5”,eLife,doi:10.7554/eLife.02687, 3, e02687,EpubJun. 23(2014).(IF=8.519)

19.Hui Yang, Tianlong Zhang, Ye Tao, Fang Wang, Liang Tong, andJianping Ding* “Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair”,Nucleic Acids Res., 41, 10573-10583,EpubSep.3(2013).(IF=8.278)

20.Shutong Xu, Wenjing Li, Junjun Zhu, Rong Wang, Zheng Li, Guo-Liang Xu, andJianping Ding*“Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed lights on the search for DNA decarboxylase”,Cell Res.,23, 1296-1309, Epub Aug. 6 (2013).(IF=10.526)

21.Jianchuan Wang, Chen Zhong, Fang Wang, Fangfang Qu, andJianping Ding* “Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif”,Biochem. J., 454, 39-47, Epub Jun. 3 (2013).(IF=4.654)

22.Ke Xu, Minhua Zhang, Qin Zhao, Fang Yu, Hui Guo, Chengyuan Wang, Fangyuan He,Jianping Ding, and Peng Zhang* “Crystal structure of a folate ECF transporter from Lactobacillus brevis”,Nature, 497, 268-271, Epub Apr. 14 (2013).(IF=38.597)

23.Xiongjun Wang, Peng Chang,Jianping Ding,and Jiangye Chen* “Distinct and redundant roles of the two MYST histone acetyltransferases Esa1 and Sas2 in cell growth and morphogenesis of Candida albicans”,Eukaryotic Cell, 12, 438-440, Epub Jan. 25 (2013).(IF=3.586)

24.Wei Huang, Zhen Gong, Jian Li, andJianping Ding*“Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism”,J. Struct. Biol., 181, 291-299, Epub Jan. 18 (2013).(IF=3.361)

25.Sisi Li, Jiamu Du, Hui Yang, Juan Yin,Jianping Ding*, and Jiang Zhong* “Functional and structural characterization of DNMT2 from Spodoptera frugiperda”,J. Mol. Cell Biol., 5, 64-66, Epub Oct. 25, 2012 (2013).(IF=7.308)

​

Regulation of gene expression in eukaryotes is much more complex than in prokaryotes, and occurs at multiple levels or steps including transcription, mRNA exportation, translation and post-translation. This complexity drives the processes of cellular differentiation and morphogenesis, leading to the creation of different cell types in multi-cellular organisms where different types of cells may possess different gene expression profiles even though they all share the same genome materials. Transcription is not only dictated by the basal and regulatory transcription factors, but also controlled by the epigenetic regulation including covalent modifications of DNA and histones which can modulate the chromatin structure and subsequently activate or silence the transcription of specific genes. After transcription, the mRNA must be processed, matured, and then exported to cytoplasm before it can be translated. The translation process includes the regulation of the ribosome machinery mostly at the level of initiation by various signaling pathways such as the mTOR signaling pathway and the fidelity control of the protein synthesis by aminoacyl-tRNA synthetases.

All of these processes involve numerous proteins and protein complexes with not well-understood functions and molecular mechanisms. As the biological functions of proteins are largely dictated by their three-dimensional structures, a comprehensive structural and functional knowledge of the proteins will not only enhance the understanding of the structure-function relationship of macromolecules and the relevant biological processes, but also provide molecular basis for the discovery and development of new pharmaceuticals for diagnosis and treatment of human diseases.

Our group is interested in the studies of structures, functions, and molecular mechanisms of proteins and protein complexes involved in the regulation of gene expression in eukaryotes, in particular these of significant biological importance and/or related to human diseases. We utilize primarily structural biology in combination with biochemistry, molecular biology, cell biology, and other biological and biophysical methodologies to determine the three-dimensional structures of these proteins and their complexes with small ligands, substrates, and protein partners, and to elucidate the underlying molecular mechanisms of their biological functions. The primary goal of our research is to understand the basic sciences of biology and in particular the structure-function relationships of proteins and protein complexes. The ultimate goal of our research is to utilize the gained structural and functional knowledge to understand molecular basis of pathogenesis of human diseases and to develop effective drugs for the treatments of human diseases.

已指导学生

查满武  博士研究生  071010-生物化学与分子生物学  

沈宁  博士研究生  071010-生物化学与分子生物学  

卢永城  博士研究生  071010-生物化学与分子生物学  

徐翔  博士研究生  071010-生物化学与分子生物学  

赵景月  博士研究生  071010-生物化学与分子生物学  

俞亚东  博士研究生  071010-生物化学与分子生物学  

侯春晖  博士研究生  071009-细胞生物学  

刘云清  博士研究生  071010-生物化学与分子生物学  

张鹏  博士研究生  071010-生物化学与分子生物学  

李胜  博士研究生  071010-生物化学与分子生物学  

张天龙  博士研究生  071010-生物化学与分子生物学  

武健  博士研究生  071010-生物化学与分子生物学  

杜嘉木  博士研究生  071010-生物化学与分子生物学  

李颖洁  博士研究生  071010-生物化学与分子生物学  

杨贝  博士研究生  071010-生物化学与分子生物学  

董咸池  博士研究生  071010-生物化学与分子生物学  

彭英杰  博士研究生  071010-生物化学与分子生物学  

孙兵法  博士研究生  071010-生物化学与分子生物学  

王冰  博士研究生  071010-生物化学与分子生物学  

常媛媛  博士研究生  071010-生物化学与分子生物学  

王建船  博士研究生  071010-生物化学与分子生物学  

周旻昀  博士研究生  071010-生物化学与分子生物学  

黄炜  博士研究生  071010-生物化学与分子生物学  

徐曙彤  博士研究生  071010-生物化学与分子生物学  

胡宽  硕士研究生  071020-生物技术与医药  

马腾飞  博士研究生  071010-生物化学与分子生物学  

杨荟  博士研究生  071010-生物化学与分子生物学  

唐庆余  博士研究生  071010-生物化学与分子生物学  

吕凤娟  博士研究生  071010-生物化学与分子生物学  

吴丽静  硕士研究生  071020-生物技术与医药  

沈彤  硕士研究生  430139-生物工程  

朱军军  硕士研究生  071010-生物化学与分子生物学  

沈金龙  硕士研究生  085238-生物工程  

陶冶  博士研究生  071010-生物化学与分子生物学  

李文婧  博士研究生  071010-生物化学与分子生物学  

王凯凯  硕士研究生  071010-生物化学与分子生物学  

张世成  博士研究生  071010-生物化学与分子生物学  

王文帅  博士研究生  071010-生物化学与分子生物学  

王闪闪  硕士研究生  085238-生物工程  

张会冰  硕士研究生  085238-生物工程  

陆容  硕士研究生  071010-生物化学与分子生物学  

现指导学生

王嵘  博士研究生  071010-生物化学与分子生物学  

朱涵文  博士研究生  071010-生物化学与分子生物学  

张春笑  博士研究生  071010-生物化学与分子生物学  

王志精  硕士研究生  071009-细胞生物学  

张真  硕士研究生  071010-生物化学与分子生物学  

白图雅  硕士研究生  085238-生物工程  

杨俊  硕士研究生  071010-生物化学与分子生物学  

叶洁  硕士研究生  071010-生物化学与分子生物学  

殷军  博士研究生  071010-生物化学与分子生物学  

孙鹏凯  硕士研究生  085238-生物工程