General

Cell motilities, including mitosis, migration, intracellular transport, and cilia movement, are not only activities important for life, but hallmarks that feature cells as “living organisms” as well. These activities require accurate coordination among multiple players and involve formation of dynamic microtubule (MT) and filamentous actin (F-actin) networks that are capable of self-assembly and autonomous function. My group is interested in the underlying cellular and molecular mechanisms. In the past five years our major achievements lie in mitosis and ciliogenesis.

 In the past five years, my group published 11 research papers as corresponding or co-corresponding author in PLoS Genet (2016), Cell (2015), J Cell Biol (2015, 2015), Dev Cell (2014), Nat Cell Biol (2012, 2013), J Mol Cell Biol (2013), J Biol Chem (2013), and Cell Res (2012, 2012). My group also published 3 invited reviews or research highlight in F1000Research (2016), Exp Cell Res (2013), and Cell Cycle (2016).

Our current and future directions focus on understanding of regional self-assembly of cytoskeleton networks and roles of the spindle matrix from the angle of protein phase transition. We also keep dissecting mechanisms underlying mammalian cilia-related cell motilities.


部门/实验室:生物化学与细胞生物学研究所

Research Areas

Mitosis and ciliogenesis

Education

  1. ​1980-1985:Dept. of Biology, University of Science and Technology ofChina(USTC), Hefei, Anhui,China B. Sc. (major: cell biology)
  2. 1985-1988:Dept. of Biology, USTC, Hefei, Anhui,China M. Sc. (major: genetic engineering)
  3. 1990-1995:Shanghai Institute of Cell Biology, CAS, 320 Yue Yang Road, Shanghai, China (Dissertation was done in Dr. Wen-Hwa Lee’s lab at Dept. of Pathology, University of California, San Diego and Institute of Biotechnology, University of Texas Health Science Center at San Antonio during 1990-1994)Ph. D. (major: cell biology)


Experience

  1. 07/1987 – 12/1990:Assistant lecteurer, Dept. of Biology, USTC

  2. 01/1995 – 09/1995:Lecteurer, Dept. of Biology, USTC

  3. 10/1995 – 06/1997:Postdoctoral fellow, Shanghai Research Center of Life Sciences (SRCLS), CAS

  4. 07/1997 – 05/1999:Associate professor, SRCLS, CAS

  5. 06/1999 – present:Professor, IBCB, SIBS, CAS 


Work Experience
  1. 07/1987 – 12/1990:Assistant lecteurer, Dept. of Biology, USTC

  2. 01/1995 – 09/1995:Lecteurer, Dept. of Biology, USTC

  3. 10/1995 – 06/1997:Postdoctoral fellow, Shanghai Research Center of Life Sciences (SRCLS), CAS

  4. 07/1997 – 05/1999:Associate professor, SRCLS, CAS

  5. 06/1999 – present:Professor, IBCB, SIBS, CAS 

Teaching Experience
  1. 07/1987 – 12/1990:Assistant lecteurer, Dept. of Biology, USTC

  2. 01/1995 – 09/1995:Lecteurer, Dept. of Biology, USTC

  3. 07/1997 – 05/1999:Associate professor, SRCLS, CAS

  4. 06/1999 – present:Professor, IBCB, SIBS, CAS 


Publications

  1. Yan X, Zhao H, and Zhu X* (2016). Production of Basal Bodies in bulk for dense multicilia formation. F1000Res 5:1533. (Review)
  2. Yan X and Zhu X* (2016). PP2A in meiotic oocytes. Cell Cycle 15(15):1950-1951. (Research highlight)
  3. Zeng L#, Cai C#, Li S, Wang W, Li Y, Chen J, Zhu X*, and Zeng Y* (2016). Essential roles of Cyclin Y-like 1 and Cyclin Y in dividing wnt-responsive mammary stem/progenitor cells. PLoS Genet 12(5): e1006055.
  4. Jiang H, Wang S, Huang Y, He X, Cui Hong, Zhu X*, and Zheng Y*(2015). Phase transitions of spindle-associated protein regulate spindle apparatus assembly Cell 163(1):108-22.
  5. Jiang H, He X, Feng D, Zhu X*, Zheng Y*(2015). RanGTP aids anaphase entry through Ubr5-mediated protein turnover. J. Cell Biol. 211(1):7-18.
  6.  Wan Y, Zheng X, Chen H, Guo Y, Jiang H, He X, Zhu X*, and Zheng Y*(2015). Splicing function of mitotic regulators links R-loopmediated DNA damage to tumor cell killing. J. Cell Biol. 209(2), 235-46.
  7. Xu Y, Cao L, Huang S, Feng D, Zhang W, Zhu X* and Yan X* (2015). Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. PLOS ONE 10(4):e0124378.
  8. Jiang H, He X, Wang S, Jia J, Wan Y, Wang Y, Zeng R, Yates III J, Zhu X*, and Zheng Y*(2014). A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. Dev. Cell 28(3):268-281.
  9. Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X* and Zhu X*(2013). The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat. Cell Biol. 15(12):1434-44.
  10. Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H,and Zhu X*(2013).The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J. Biol. Chem. 288(42):30087-93.
  11. Zhou Y, Li S, Huang Q, Xie L, Zhu X*(2013). Nanog suppresses cell migration by downregulating thymosin beta 4 and Rnd3. J. Mol. Cell Biol.5(4):239-49.
  12. Yan X and Zhu X* (2013).Branched F-actin as a negative regulator of cilia formation. Exp Cell Res. 319(2):147-151
  13. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X* and Zhu X*(2012). miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat. Cell Biol. 14:697-706.
  14. Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, and Zhu X*(2012). Misfolded G beta is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res. 22: 1140-1154 
  15. Wu S, Ma L, Wu Y, Zeng R, and Zhu X*(2012). Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct interactions. Cell Res. 22:1270-1284
  16. Zhao H, Zhu L, Jin Y, Ji H, Yan X* and Zhu X*(2012). miR-375 is highly expressed and possibly transactivated by ASCL1 in small cell lung cancer cells. Acta. Biochim. Biophys. Sin. 44(2):177-82.
  17. Du J, Li Y, Zhu X*(2010). Involvement of CENP-F in histone methylation. Acta. Biochim. Biophys. Sin. 42(3):173-6.
  18. Du J, Zhang Y, Liu Y, Li Y, and Zhu X*(2010). Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA-dependent protein kinase. Acta. Biochim. Biophys. Sin. 42: 839–846.
  19. Yan X Shen YZhu X* (2010). Live Show of Rho GTPases in Cell Migration. J. Mol. Cell Biol. 2: 6869.
  20. Zhu X * (2010).Seeing the Yin and Yang in Cell Biology. Mol. Biol. Cell 21: 3827–3828.
  21. Ding C, Liang X, Ma L, Yuan X and Zhu X*. (2009) Opposing effects of Ndel1 and alpha1 or alpha 2 on cytoplasmic dynein through competitive binding to Lis1. J. Cell Sci. 122, 2820-2827.
  22. Zhang Q, Wang F, Cao J, Shen Y, Huang Q, Bao L and Zhu X*. (2009) Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport. Traffic. 10:1337-1349.
  23. Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, and Zhu X* (2009). Nudel and FAK as antagonizing strength modulators of nascent adhesions through Paxillin. PLoS Biol. 7(5): e1000116.
  24. Ma L, Tsai M-Y, Wang S, Lu B, Chen R, Yates III JR, Zhu X*, and Zheng Y *(2009). Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat. Cell Biol. 11: 247-256.
  25. Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X*. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev. Cell 14, 342-353.
  26. Wang F, Zhang Q, Cao J, Huang Q, Zhu X*. (2008) The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules. Exp. Cell Res314, 213-226.
  27. Li Y, Yu W, Liang Y, Zhu X*. (2007) Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment. Cell Res. 17, 701-712.
  28. Liang Y, Yu W, Li Y, Yu L, Zhang Q, Wang F, Yang Z, Du J, Huang Q, Yao X, and Zhu X*. (2007) Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase. Mol. Biol. Cell. 18, 2656-2666.
  29. Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, and Zhu X*. (2006) Nudel contributes to MT anchoring at the mother centriole and is involved in both dynein-dependent and independent centrosomal protein assembly. Mol. Biol. Cell. 17:680-9.
  30. Yang Z, Guo J, Chen Q, Du J, Ding C, and Zhu X*. (2005) Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25, 4062-74.
  31. Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, and Zhu X*. (2005) Mitosin/CENP-F as a negative regulator of activating transcription factor-4. J. Biol. Chem. 280, 13973-7.
  32. Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, and Zhu X*. (2004) Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J. Cell Biol. 164, 557-566.
  33. Yang Z, Guo J, Li N, Qian M, Wang S, Zhu X*. (2003) Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13, 275-283.
  34. Fan L, Yu W, Zhu X*. (2003) Interaction of Sedlin with chloride intracellular channel proteins. FEBS Lett. 540, 77-80.
  35. Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, and Zhu X*. (2003) Human Nudel and NudE as Regulators of Cytoplasmic Dynein in Poleward Protein Transport along the Mitotic Spindle. Mol. Cell. Biol. 23, 1239-50.
  36. Zhao X, Yang Z, Qian M, and Zhu X*. (2001) Interaction among subunits of human Arp2/3 complex: p20-Arc as the hub. Biochem. Biophy. Res. Commun. 280, 513-517.
  37. Yan X., Zhao X, Qian M, Guo N, Gong X, and Zhu X*. (2000) Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I. Biochem. J. 345, 749-757.
  38. Zhu X*. (1999) Structural requirements and dynamics of mitosin-kinetochore interaction in M phase. Mol. Cell. Biol. 19, 1016-1024.
  39. Zhu X*, Ding L, and Pei G (1997). Carboxyl terminus of mitosin is sufficient to confer spindle pole localization. J. Cell. Biochem. 66:441-449. 


Papers
  1. Yan X, Zhao H, and Zhu X* (2016). Production of Basal Bodies in bulk for dense multicilia formation. F1000Res 5:1533. (Review)
  2. Yan X and Zhu X* (2016). PP2A in meiotic oocytes. Cell Cycle 15(15):1950-1951. (Research highlight)
  3. Zeng L#, Cai C#, Li S, Wang W, Li Y, Chen J, Zhu X*, and Zeng Y* (2016). Essential roles of Cyclin Y-like 1 and Cyclin Y in dividing wnt-responsive mammary stem/progenitor cells. PLoS Genet 12(5): e1006055.
  4. Jiang H, Wang S, Huang Y, He X, Cui Hong, Zhu X*, and Zheng Y*(2015). Phase transitions of spindle-associated protein regulate spindle apparatus assembly Cell 163(1):108-22.
  5. Jiang H, He X, Feng D, Zhu X*, Zheng Y*(2015). RanGTP aids anaphase entry through Ubr5-mediated protein turnover. J. Cell Biol. 211(1):7-18.
  6.  Wan Y, Zheng X, Chen H, Guo Y, Jiang H, He X, Zhu X*, and Zheng Y*(2015). Splicing function of mitotic regulators links R-loopmediated DNA damage to tumor cell killing. J. Cell Biol. 209(2), 235-46.
  7. Xu Y, Cao L, Huang S, Feng D, Zhang W, Zhu X* and Yan X* (2015). Characterization of tetratricopeptide repeat-containing proteins critical for cilia formation and function. PLOS ONE 10(4):e0124378.
  8. Jiang H, He X, Wang S, Jia J, Wan Y, Wang Y, Zeng R, Yates III J, Zhu X*, and Zheng Y*(2014). A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. Dev. Cell 28(3):268-281.
  9. Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X* and Zhu X*(2013). The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Nat. Cell Biol. 15(12):1434-44.
  10. Zeng L, Wan Y, Li D, Wu J, Shao M, Chen J, Hui L, Ji H,and Zhu X*(2013).The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J. Biol. Chem. 288(42):30087-93.
  11. Zhou Y, Li S, Huang Q, Xie L, Zhu X*(2013). Nanog suppresses cell migration by downregulating thymosin beta 4 and Rnd3. J. Mol. Cell Biol.5(4):239-49.
  12. Yan X and Zhu X* (2013).Branched F-actin as a negative regulator of cilia formation. Exp Cell Res. 319(2):147-151
  13. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X* and Zhu X*(2012). miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat. Cell Biol. 14:697-706.
  14. Wan Y, Yang Z, Guo J, Zhang Q, Zeng L, Song W, Xiao Y, and Zhu X*(2012). Misfolded G beta is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res. 22: 1140-1154 
  15. Wu S, Ma L, Wu Y, Zeng R, and Zhu X*(2012). Nudel is crucial for the WAVE complex assembly in vivo by selectively promoting subcomplex stability and formation through direct interactions. Cell Res. 22:1270-1284
  16. Zhao H, Zhu L, Jin Y, Ji H, Yan X* and Zhu X*(2012). miR-375 is highly expressed and possibly transactivated by ASCL1 in small cell lung cancer cells. Acta. Biochim. Biophys. Sin. 44(2):177-82.
  17. Du J, Li Y, Zhu X*(2010). Involvement of CENP-F in histone methylation. Acta. Biochim. Biophys. Sin. 42(3):173-6.
  18. Du J, Zhang Y, Liu Y, Li Y, and Zhu X*(2010). Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA-dependent protein kinase. Acta. Biochim. Biophys. Sin. 42: 839–846.
  19. Yan X Shen YZhu X* (2010). Live Show of Rho GTPases in Cell Migration. J. Mol. Cell Biol. 2: 6869.
  20. Zhu X * (2010).Seeing the Yin and Yang in Cell Biology. Mol. Biol. Cell 21: 3827–3828.
  21. Ding C, Liang X, Ma L, Yuan X and Zhu X*. (2009) Opposing effects of Ndel1 and alpha1 or alpha 2 on cytoplasmic dynein through competitive binding to Lis1. J. Cell Sci. 122, 2820-2827.
  22. Zhang Q, Wang F, Cao J, Shen Y, Huang Q, Bao L and Zhu X*. (2009) Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport. Traffic. 10:1337-1349.
  23. Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, and Zhu X* (2009). Nudel and FAK as antagonizing strength modulators of nascent adhesions through Paxillin. PLoS Biol. 7(5): e1000116.
  24. Ma L, Tsai M-Y, Wang S, Lu B, Chen R, Yates III JR, Zhu X*, and Zheng Y *(2009). Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat. Cell Biol. 11: 247-256.
  25. Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X*. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev. Cell 14, 342-353.
  26. Wang F, Zhang Q, Cao J, Huang Q, Zhu X*. (2008) The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules. Exp. Cell Res. 314, 213-226.
  27. Li Y, Yu W, Liang Y, Zhu X*. (2007) Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment. Cell Res. 17, 701-712.
  28. Liang Y, Yu W, Li Y, Yu L, Zhang Q, Wang F, Yang Z, Du J, Huang Q, Yao X, and Zhu X*. (2007) Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase. Mol. Biol. Cell. 18, 2656-2666.
  29. Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, and Zhu X*. (2006) Nudel contributes to MT anchoring at the mother centriole and is involved in both dynein-dependent and independent centrosomal protein assembly. Mol. Biol. Cell. 17:680-9.
  30. Yang Z, Guo J, Chen Q, Du J, Ding C, and Zhu X*. (2005) Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25, 4062-74.
  31. Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, and Zhu X*. (2005) Mitosin/CENP-F as a negative regulator of activating transcription factor-4. J. Biol. Chem. 280, 13973-7.
  32. Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, and Zhu X*. (2004) Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J. Cell Biol. 164, 557-566.
  33. Yang Z, Guo J, Li N, Qian M, Wang S, Zhu X*. (2003) Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13, 275-283.
  34. Fan L, Yu W, Zhu X*. (2003) Interaction of Sedlin with chloride intracellular channel proteins. FEBS Lett. 540, 77-80.
  35. Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, and Zhu X*. (2003) Human Nudel and NudE as Regulators of Cytoplasmic Dynein in Poleward Protein Transport along the Mitotic Spindle. Mol. Cell. Biol. 23, 1239-50.
  36. Zhao X, Yang Z, Qian M, and Zhu X*. (2001) Interaction among subunits of human Arp2/3 complex: p20-Arc as the hub. Biochem. Biophy. Res. Commun. 280, 513-517.
  37. Yan X., Zhao X, Qian M, Guo N, Gong X, and Zhu X*. (2000) Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I. Biochem. J. 345, 749-757.
  38. Zhu X*. (1999) Structural requirements and dynamics of mitosin-kinetochore interaction in M phase. Mol. Cell. Biol. 19, 1016-1024.
  39. ​Zhu X*, Ding L, and Pei G (1997). Carboxyl terminus of mitosin is sufficient to confer spindle pole localization. J. Cell. Biochem. 66:441-449. 


Patents

Zhu XL, Yan XM, Cao JL. A microRNA regulating ciliary development and its appliance. Patent NO: 201210147664.1; Authorized date:2016.1.27.


Research Interests

    My group is interested in the underlying cellular and molecular mechanisms of cell motilities. These cellular activities, including mitosis, cell migration, intracellular transport, and cilia movement, often exhibit transient, regional distributions of functional proteins and organelles, require accurate coordination among multiple players, and involve formation of supramolecular networks abundant of MTs and F-actin. Recently we have been trying to answer the following outstanding questions in mitosis and cilium fields: (1) Control of ciliogenesis in vivo; (2) Components, organization, and functions of the spindle matrix. 


Conferences

1.        Xueliang Zhu. Centriole amplification during multiciliogenesis of epithelial cells. Nov.17-21, 2014. Cold Spring Harbor Asia conference on Dynamics of Cellular Behavior During Development and Disease. Suzhou, China. Invited speaker.

2.        Xueliang Zhu. Ciliogenesis: a tale of tails. Nov.15-17, 2012. The 3rd International Conference on Cellular Dynamics and Chemical Biology. Hefei,China. Invited speaker.

3.        Xueliang Zhu. Orchestration of cell migration by Nudel through protein interactions. Aug. 2-7, 2009. 21st IUBMB & 12th FAOBMB International Congress of Biochemistry and Molecular Biology. Shanghai,China. Invited speaker.

4.        Xueliang Zhu. The dynein pathway in mitotic control. March 6-10, 2006. The 6th HUGO Pacific meeting & 7th Asian-Pacific conference on human genetics. Taipei,Taiwan,China. Invited speaker. 

5.        Xueliang Zhu. The two faces of mitosin/CENP-F in transcription regulation and mitotic control. Jan. 16-20, 2006. Signaling in cell growth & differentiation, Croucher Advanced Study Institute (ASI).  The Hong Kong University of Science and Technology, Hong Kong,China. Invited speaker. 

6.        Xueliang Zhu. The two faces of mitosin/CENP-F in transcription regulation and mitotic control. Nov. 4-5, 2005. International conference on signal transduction. National Taiwan University, Taipei,Taiwan,China. Invited speaker.

7.        Xueliang Zhu. Regulation of cytoplasmic dynein function by Nudel/NudE and Lis1. Nov. 3-6, 2002. The 4th Asia-Pacific organization of cell biology (APOCB) Congress. Taipei,Taiwan,China. Plenary lecture. 


Collaboration

The vertebrate mitotic spindle has been shown to possess a matrix by Dr. Yixian Zheng’s lab. Her lab and mine have then jointly explored the molecular composition, organization, and functions of the spindle matrix and made serial discoveries since 2012. Based on our previous collaborative work, we identified several novel spindle matrix proteins and demonstrated that one of them, BuGZ, is important for efficient and accurate mitosis by both stabilizing the spindle checkpoint protein Bub3 through direct interaction and promoting the end-on microtubule-kinetochore attachment. RanGTP promotes the turnover of BuGZ and Bub3 in metaphase through the proteasome-mediated degradation, which in turn facilitates the metaphase to anaphase transition. More importantly, BuGZ undergoes phase transition through hydrophobic intermolecular interactions to promote the assembly of both spindle matrix and MTs. In addition, we also showed that BuGZ and Bub3 have a role in pre-mRNA splicing during the interphase of the cell cycle. Perturbation of such a role leads to senescence of normal cells but death of cancer cells. These findings shed light on the nature and roles of the spindle matrix during the cell cycle.


Students

已指导学生

沈义栋  博士研究生  071009-细胞生物学  

王福宾  博士研究生  071009-细胞生物学  

李艳  博士研究生  071009-细胞生物学  

杨振业  博士研究生  071009-细胞生物学  

李宁  博士研究生  071009-细胞生物学  

国静  博士研究生  071009-细胞生物学  

单永立  博士研究生  071009-细胞生物学  

郁伟  博士研究生  071009-细胞生物学  

陈琦  硕士研究生  071009-细胞生物学  

宋微  硕士研究生  071009-细胞生物学  

张强鸽  博士研究生  071009-细胞生物学  

陈琦  博士研究生  071009-细胞生物学  

丁翀  博士研究生  071009-细胞生物学  

余礼厚  博士研究生  071009-细胞生物学  

马丽  博士研究生  071009-细胞生物学  

宋微  博士研究生  071009-细胞生物学  

武爽  博士研究生  071009-细胞生物学  

万奕含  博士研究生  071009-细胞生物学  

曹景利  博士研究生  071009-细胞生物学  

周钇灼  博士研究生  071009-细胞生物学  

姜昊  博士研究生  071009-细胞生物学  

赵惠杰  博士研究生  071009-细胞生物学  

张毅荣  博士研究生  071009-细胞生物学  

曾立勇  博士研究生  071009-细胞生物学  

朱蕾  博士研究生  071009-细胞生物学  

何骁男  博士研究生  071009-细胞生物学  

许亚男  博士研究生  071009-细胞生物学  

李珊珊  硕士研究生  430139-生物工程  

王娟  硕士研究生  085238-生物工程  

李国庆  博士研究生  071009-细胞生物学  

肖悦  博士研究生  071009-细胞生物学  

冯迪  硕士研究生  071009-细胞生物学  

段晓萌  硕士研究生  085238-生物工程  

现指导学生

郑建群  博士研究生  071009-细胞生物学  

段世超  博士研究生  071009-细胞生物学  

黄珊  博士研究生  071009-细胞生物学  

陈雅文  博士研究生  071009-细胞生物学  

李亚萍  博士研究生  071009-细胞生物学  

沈川  硕士研究生  071009-细胞生物学  

李昊  博士研究生  071009-细胞生物学  

陈青霞  博士研究生  071009-细胞生物学  

李凡  博士研究生  071009-细胞生物学  

杨森  博士研究生  071009-细胞生物学  

高琪  硕士研究生  071010-生物化学与分子生物学  

刘浩  博士研究生  071009-细胞生物学  

郝楷  博士研究生  071009-细胞生物学  

Honors & Distinctions

1 Outstanding scientific and technological workers2016
2 Outstanding Supervisor of University of Chinese Academy of Sciences, 2014
3 Outstanding Supervisor of University of Chinese Academy of Sciences, 2013
4 Shanghai Leader, 2013
5 Tan Jiazhen prize for life science, 2013
6 Shanghai prize for Natural Science, first class, 2012
7 Outstanding Supervisor of University of Chinese Academy of Sciences, 2011
8 Chinese Society of Cell Biology-CST outstanding achievement award, 2011
9 Shanghai Natural Science peony Award, 2009
10 Outstanding Supervisor of University of Chinese Academy of Sciences, 2007
11 Outstanding Teacher of University of Chinese Academy of Sciences, 2006
12 Millions of Talent Projects National candidates, 2004