基本信息
景乃禾  男  博导  中国科学院分子细胞科学卓越创新中心
email: njing@sibcb.ac.cn
address: 上海冠生园路科苑新村1号1704室
postalCode: 200233

招生信息

   
招生专业
071008-发育生物学
招生方向
干细胞与神经发育

教育背景

1989-01--1991-12   日本理化研究所   博士后
1982-09--1986-09   中科院上海生物化学研究所   博士
1978-09--1982-07   南京大学   学士

工作经历

   
工作简历
2005-01~现在, 中科院上海生物化学与细胞生物学研究所, 课题组长
2003-01~2003-12,日本大阪大学, 访问教授
2000-01~2004-12,中科院上海生物化学与细胞生物学研究所, 所长助理,课题组长
2000-01~2000-12,日本熊本大学, 访问教授
1996-01~1997-12,德国马普生物物理化学研究所, 访问学者
1995-12~2000-12,中科院上海生物化学研究所, 所长助理,课题组长
1995-01~1995-12,法国遗传与分子细胞生物学研究所, 访问学者
1991-01~1995-01,中科院上海生物化学研究所, 课题组长
1989-01~1991-12,日本理化研究所, 博士后
1982-09~1986-09,中科院上海生物化学研究所, 博士
1978-09~1982-07,南京大学, 学士
社会兼职
2013-01-01-2016-12-31,a member of the Editorial Board of Neurogenesis, a member of the Editorial Board
2011-01-01-2013-12-31,a member of the Editorial Board of Mechanisms of Development, a member of the Editorial Board
2011-01-01-2013-12-31,a member of the Editorial Board of Gene Expression Patterns , a member of the Editorial Board
2010-01-01-2012-12-31,a member of the Editorial Board of Developmental Dynamics, a member of the Editorial Board
2009-07-01-2014-09-30,a member of the Editorial Board of the Journal of Biological Chemistry , a member of the Editorial Board
2009-01-01-2011-12-31,a member of the Editorial Board of the IUBMB Life , a member of the Editorial Board
2008-01-01-2011-12-31, Associate Editor of BMC Developmental Biology, Associate Editor

教授课程

发育生物学(总论、小鼠早期胚胎发育)
干细胞研究进展系列讲座

专利与奖励

   
奖励信息
(1) 2014年度上海市自然科学一等奖, 一等奖, 省级, 2014
(2) 上海市科技系统领军人才, , 省级, 2010
专利成果
( 1 ) 从上胚层干细胞建立外胚层干细胞的方法, 2015, 第 1 作者, 专利号: 201510540302.2

( 2 ) 从多潜能干细胞诱导胆碱能神经元的方法, 2015, 第 1 作者, 专利号: ZL201210056400.5

( 3 ) 针对人c-Jun氨基末端激酶的小RNA分子在老年痴呆症中的作用, 2008, 第 1 作者, 专利号: 200810035449.6

出版信息

   
发表论文
(1) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq, Natrue Protocol, 2017, 通讯作者
(2) Opposing Roles of Acetylation and Phosphorylation in LIFR-Dependent Self-Renewal Growth Signaling in Mouse Embryonic Stem Cells., Cell Reports, 2017, 通讯作者
(3) Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-Gastrula Mouse Embryo, Developmental Cell, 2016, 通讯作者
(4) Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Respond to Extrinsic BMP Signaling, J. Biol. Chem., 2016, 通讯作者
(5) ESC-Derived Basal Forebrain Cholinergic Neurons Ameliorate the Cognitive Symptoms Associated with Alzheimer's Disease in Mouse Models, Stem Cell Reports, 2015, 通讯作者
(6) AF9 promotes hESC neural differentiation through recruiting TET2 to neurodevelopmental gene loci for methylcytosine hydroxylation, Cell Discovery, 2015, 通讯作者
(7) Ectodermal progenitors derived from epiblast stem cells by inhibition of Nodal signaling, J Mol Cell Biol, 2015, 通讯作者
(8) Histone deacetylation promotes mouse neural induction by restricting Nodal-dependent mesendoderm fate, Nature Communications, 2015, 通讯作者
(9) Inhibition of TGF-β Signaling can Substitute for Oct4 in Reprogramming and Maintain Pluripotency, J Biol Chem, 2015, 通讯作者
(10) Dual Roles of Histone H3 Lysine 9 Acetylation in Human Embryonic Stem Cell Pluripotency and Neural Differentiation, J Biol Chem, 2015, 通讯作者
(11) The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways, Elife, 2014, 通讯作者
(12) The zinc-finger transcription factor Ovol2 acts downstream of the BMP pathway to regulate the cell fate decision between neuroectoderm and mesendoderm, J Biol Chem, 2013, 通讯作者
(13) AP2 regulates neural and epidermal fates determination as a BMP downstream target, Cell Res, 2012, 通讯作者
(14) Pluripotent stem cell studies elucidate the underlying Mechanisms of early embryonic development, Genes, 2011, 通讯作者
(15) Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/β-catenin pathway., PNAS, 2011, 通讯作者
(16) Expression of the IgSF protein Kirre in the rat central nervous system., Life Sciences , 2011, 通讯作者
(17) Distinct functions of BMP4 during different stages of mouse ES cell neural commitment, Development, 2010, 通讯作者
(18) Dual specificity histone demethylase KIAA1718 regulates neural differentiation through FGF4, Cell Research, 2010, 通讯作者
(19) Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1, PNAS, 2010, 通讯作者
(20) Id Sustains Hes1 Expression to Inhibit Precocious Neurogenesis by Releasing Negative Autoregulation of Hes1. , Dev Cell , 2007, 通讯作者

科研活动

   
科研项目
( 1 ) 细胞谱系的建立与发育调控, 负责人, 国家任务, 2011-01--2015-12
( 2 ) 组蛋白去甲基化酶在胚胎干细胞神经分化过程中的功能与机制研究, 负责人, 国家任务, 2010-01--2012-12
( 3 ) BMP信号在中枢神经系统发育过程中的作用, 负责人, 国家任务, 2009-01--2012-12
( 4 ) 诱导多能干细胞(iPS)的新方法、分子机制及其应用研究, 负责人, 地方任务, 2008-10--2011-09
( 5 ) 原肠运动过程中外胚层的命运决定及表观遗传调控, 负责人, 国家任务, 2015-01--2019-12
( 6 ) 小鼠胚胎发育早期原肠运动中细胞命运决定的分子机制, 负责人, 国家任务, 2016-01--2019-12
( 7 ) 细胞编程和重编程的表观遗传机制, 负责人, 国家任务, 2016-01--2016-12
( 8 ) 小分子介导的功能神经元的重建及在疾病模型中的应用, 参与, 国家任务, 2015-01--2019-12
( 9 ) 单倍体干细胞的应用研究, 参与, 国家任务, 2013-12--2018-12
( 10 ) 内胚层起源及内胚层细胞体内分化的调控机制, 负责人, 国家任务, 2017-01--2021-12
( 11 ) 人胚胎干细胞分化为基底前脑胆碱能神经元和视网膜色素上皮细胞过程中功能性增强子和染色质结构动态变化研究, 负责人, 国家任务, 2017-01--2019-12
( 12 ) 中内胚层细胞分化过程中干细胞命运决定的转录调控, 参与, 国家任务, 2017-06--2021-12