基本信息
石正丽  女  博导  中国科学院武汉病毒研究所
电子邮件: zlshi@wh.iov.cn
通信地址: 湖北省武汉市武昌小洪山中区44号
邮政编码: 430071

研究领域

动物源新发病毒的病原学、分子流行病学、跨种传播机制、蝙蝠抗病毒机制.

招生信息

   
招生专业
100103-病原生物学
招生方向
病原的分子流行病学

教育背景

1996-10--2000-05   法国蒙彼利埃第二大学   博士学位
1987-09--1990-07   中国科学院武汉病毒研究所   硕士学位
1983-09--1987-07   武汉大学   学士学位

工作经历

   
工作简历
2000-10~现在, 中国科学院武汉病毒研究所, 研究员
1998-07~2000-09,中国科学院武汉病毒研究所, 副研究员
1993-07~1998-06,中国科学院武汉病毒研究所, 助理研究员
1990-07~1993-06,中国科学院武汉病毒研究所, 研究实习员
社会兼职
2018-12-01-今,湖北省微生物学会, 理事长
2017-11-01-今,World Society for Virology管理委员会, 委员
2017-01-01-今,Virologica Sinica, 主编
2015-01-01-2017-12-31,Journal of Medical Virology, 编委
2014-10-01-2016-10-31,《病毒学报》, 编委
2014-01-01-2016-12-30,Scientific Committee of the DIVERSITAS ecoHEALTH Core Project, 成员
2011-10-01-2021-10-31,中国微生物学会病毒专业委员会, 委员

教授课程

分子病毒学
高级微生物学

专利与奖励

   
奖励信息
(1) 中国蝙蝠携带重要病毒研究, 二等奖, 国家级, 2018
(2) 中国蝙蝠携带重要病毒研究, 一等奖, 省级, 2017
(3) 湖北省自然科学优秀学术论文特等奖, 特等奖, 省级, 2014
(4) 湖北省自然科学优秀学术论文, 三等奖, 省级, 2012
(5) 蝙蝠的行为、进化及其与病毒相互关系的研究, 二等奖, 部委级, 2009
(6) 湖北省自然科学优秀学术论文, 一等奖, 省级, 2006

出版信息


发表论文
(1) Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2, Cell, 2020, 通讯作者
(2) A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, 2020, 通讯作者
(3) Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies, Cell Mol Immunol., 2020, 通讯作者
(4) Molecular and serological investigation of 2019-nCoV infected patients: Implication of multiple shedding routes, Emerg Microbes Infect, 2020, 通讯作者
(5) Characterization of a filovirus (Měnglà virus) from Rousettus bats in China., Nature Microbiology, 2019, 通讯作者
(6) Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels., Emerg Microbes Infect., 2019, 通讯作者
(7) Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus bats., Viruses, 2019, 通讯作者
(8) Prevalence of Wēnzhōu virus in small mammals in Yunnan Province, China, PLoS Neglected Tropical Diseases, 2019, 通讯作者
(9) Origin and evolution of pathogenic coronaviruses., Nature Reviews Microbiology, 2019, 通讯作者
(10) Molecular Detection and Genetic Characterization of Novel RNA Viruses in Wild and Synanthropic Rodents and Shrews in Kenya, Frontiers in Microbiology, 2019, 通讯作者
(11) Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China, Virologica Sinica, 2018, 通讯作者
(12) Longitudinal Surveillance of Betacoronaviruses in Fruit Bats in Yunnan Province, China During 2009–2016, Virologica Sinica, 2018, 通讯作者
(13) Dampened STING-Dependent Interferon Activation in Bats, Cell Host & Microbe, 2018, 通讯作者
(14) Fatal Swine Acute Diarrhea Syndrome caused by an HKU2-related Coronavirus of Bat Origin, Nature, 2018, 通讯作者
(15) Discovery of novel bat coronaviruses in south China that use the same receptor as MERS coronavirus, J Virol, 2018, 通讯作者
(16) Molecular detection of viruses in Kenyan bats and discovery of novel astroviruses, caliciviruses and rotaviruses, Virologica Sinica, 2017, 通讯作者
(17) Detection and genome characterization of four novel bat hepadnaviruses and a hepevirus in China, Virology Journal, 2017, 通讯作者
(18) Genetically Diverse Filoviruses in Rousettus and Eonycteris spp. Bats, China, 2009 and 2015, Emerg Infect Dis, 2017, 通讯作者
(19) Novel bat adenoviruses with low G+C content shed new light on the evolution of adenoviruses, J Gen Virol, 2017, 通讯作者
(20) Detection of alpha- and betacoronaviruses in rodents from Yunnan, China, Virology Journal, 2017, 通讯作者
(21) IFNAR2-dependent gene expression profile induced by IFN-α in Pteropus alecto bat cells and impact of IFNAR2 knockout on virus infection, PLoS One, 2017, 通讯作者
(22) Cross-neutralization of SARS coronavirus-specific antibodies against bat SARA-like coronaviruses, Sci China Life Sci, 2017, 通讯作者
(23) Discovery of a rich gene pool of bat SARS-related Coronaviruses provides new insights into the origin of SARS coronavirus, PLoS Pathog, 2017, 通讯作者
(24) Novel bat adenoviruses with an extremely large E3 gene, J Gen Virol, 2016, 通讯作者
(25) Isolation and characterization of adenoviruses infecting endangered golden snub-nosed monkeys (Rhinopithecus roxellana), Virology Journal, 2016, 通讯作者
(26) Isolation and characterization of a novel bat coronavirus closely related to the direct progenitor of SARS coronavirus, J Virol, 2016, 通讯作者
(27) Fugong virus, a novel hantavirus harbored by the small oriental vole (Eothenomys eleusis) in China, Virology journal, 2016, 通讯作者
(28) Bat SARS-like coronavirus WIV1 encodes an extra accessory protein ORFX involved in modulation of host immune response, J Virol, 2016, 通讯作者
(29) A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence, Nat Med, 2015, 通讯作者
(30) Isolation and identification of bat viruses closely related to human, porcine, and mink orthoreoviruses, J Gen Virol, 2015, 通讯作者
(31) Cloning, expression, and antiviral activity of interferon beta from the Chinese microbat, Myotis davidii, Virol Sin, 2015, 通讯作者
(32) Two mutations were critical for bat-to-human transmission of Middle East respiratory syndrome coronavirus, J Virol, 2015, 通讯作者
(33) Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis, J Virol, 2015, 通讯作者
(34) Genetic diversity and temporal dynamics of phytoplankton viruses in East Lake, china, Virol Sin, 2015, 通讯作者
(35) 中国小型哺乳动物星状病毒的检测, Detection of diverse novel astroviruses from small mammals in China, Journal of General Virology, 2014, 通讯作者
(36) Emerging infectious diseases associated with bat viruses, Sci China Life Sci, 2013, 通讯作者
(37) Deep RNA sequencing reveals complex transcriptional landscape of a bat adenovirus, Journ of Virology, 2013, 通讯作者
(38) Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity, Science, 2013, 第 1 作者
(39) Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor, Nature, 2013, 通讯作者
(40) Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in china, J Virol, 2012, 通讯作者
(41) Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities., J Gen Virol, 2012, 通讯作者
(42) A novel totivirus-like virus isolated from bat guano, Arch Virol, 2012, 通讯作者
(43) Genetic diversity of novel circular ssDNA viruses in bats in China, J Gen Virol, 2011, 通讯作者
(44) Mutations in the G-H loop region of ephrin-B2 can enhance Nipah virus binding and infection, J Gen Virol, 2011, 通讯作者
(45) A novel hantavirus detected in Yunnan red-backed vole (Eothenomys miletus) in China, J Gen Virol , 2011, 通讯作者
(46) Hantavirus Outbreak Associated with Laboratory Rats in Yunnan, China, Infection, Genetics and Evolution, 2010, 通讯作者
(47) Assessment of UV-B damage in cyanophage PP, Aquat Microb Ecol, 2010, 通讯作者
(48) Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry, Arch Virol, 2010, 通讯作者
(49) Host Range, Prevalence and Genetic Diversity of Adenoviruses in Bats, J. Virol, 2010, 通讯作者
(50) Prevalence and Genetic Diversity of Adeno-Associated Viruses in Bats, China, J Gen Virol, 2010, 通讯作者
(51) Intra-species Diversity of SARS-Like Coronaviruses (CoVs) in Rhinolophus sinicus and Its Implications on the Origin of SARS-CoVs in human, J Gen Virol, 2010, 通讯作者
(52) Molecular detection of three shrimp viruses and genetic variation of white spot syndrome virus in Hainan Province, China, in 2007, J Fish Dis, 2009, 通讯作者
(53) Immunogenicity difference between the SARS coronavirus and the bat SARS-like coronavirus spike (S) proteins, Biochemical and Biophysical Research Communications, 2009, 通讯作者
(54) Difference in receptor usage between SARS coronavirus and SARS-like coronavirus of bat origin, J. Virol, 2008, 通讯作者
(55) A review of studies on animal reservoirs of the SARS coronavirus, Virus Research, 2008, 第 1 作者
(56) Construction of a non-infectious SARS coronavirus replicon for application in drug screening and analysis of viral protein function, Biochemical and Biophysical Research Communications, 2008, 通讯作者
(57) Antibodies to Nipah or Nipah-like Viruses in Bats, China, Emerging Infectious Diseases, 2008, 通讯作者
(58) Evidence of the Recombinant Origin of a Bat Severe Acute Respiratory Syndrome (SARS)-Like Coronavirus and Its Implications on the Direct Ancestor of SARS Coronavirus, J. Virol, 2008, 第 3 作者
发表著作
(1) 水生动物疾病学, 中国农业大学出版社, 2005-06, 第 2 作者
(2) 亚洲新发传染病, In Emerging Infections in Asia, Springer Science+Business Media, 2008-05, 第 2 作者
(3) SARS冠状病毒进化与现代分子流行病学, Evolution of SARS coronavirus and the relevance of modern molecular epidemiology, Elsevier, 2010-12, 第 1 作者
(4) 埃博拉病毒病, EBOLA VIRUS DISEASE, 浙江大学出版社, 2015-08, 第 2 作者
(5) 蝙蝠与病毒:新发传染病前沿, In Bats and Viruses: A New Frontier of Emerging Infectious Diseases, John Wiley & Sons, 2015-09, 第 2 作者

科研活动

   
科研项目
( 1 ) 蝙蝠携带人类病原体的发现与分离鉴定、分布特点、遗传进化规律及其对人, 主持, 国家级, 2013-01--2017-12
( 2 ) 广东和云南等地区啮齿类和小型哺乳动物携带冠状病毒情况调查, 主持, 国家级, 2014-01--2016-12
( 3 ) 病毒与宿主相互作用, 参与, 国家级, 2017-01--2019-12
( 4 ) 云南地区主要自然宿主及媒介昆虫病毒病原调查, 主持, 国家级, 2013-06--2018-05
( 5 ) 重要烈性病毒防控关键技术及产品研发, 参与, 部委级, 2016-01--2018-12
( 6 ) 蝙蝠SARS样冠状病毒适应宿主受体分子的进化机制及其跨种感染的风险的研究, 主持, 国家级, 2018-01--2021-12
( 7 ) 面向动物迁飞机理分析的高分辨多维协同雷达测量仪, 主持, 国家级, 2018-01--2022-12
( 8 ) 新病原的溯源、进化及传播机制, 主持, 部委级, 2018-07--2023-06
( 9 ) 猪新型冠状病毒病原生物学研究, 主持, 国家级, 2019-01--2023-12
( 10 ) 尼帕病毒研究, 主持, 部委级, 2019-01--2019-12
( 11 ) 2019新型冠状病毒应急科技攻关研究, 主持, 省级, 2020-01--2020-12
参与会议
(1)Sino-French collaboration on emerging infectious diseases   第三届“中法跨领域论坛”   2019-09-24
(2)Bat origin of emerging coronaviruses   世界病毒学学会第一次会议   2019-08-26
(3)Bat-borne emerging viral diseases   中国-巴西第二届传染病交流会   2019-06-26
(4)Risk assessment of bat coronavirus spillover and prevention strategy, 2018   第二届中德“全球化传染病挑战与应对”研讨会   2018-09-02
(5)From SARS to SADS: predict of emerging infectious diseases   中美传染病生态学与演进双边研讨会   2018-06-27
(6)Coronaviruses associated with human and animal diseases in China-From SARS to SADS   中美专家防治传染病和改善全球卫生研讨会   2018-01-16
(7)Evolution and pathogenicity of bat SARS-like coronavirus   2017《细胞》研讨会:新发和再发病毒会议   2017-10-01
(8)SARS coronavirus may have originated from frequent recombination events between SL-CoVs in a single horseshoe bat habitat   第二十七届德国病毒学会会议   2017-03-22
(9)Prevalence, animal origins and diagnosis of MERS-CoV    巴基斯坦新发病毒性出血热防控策略规划会议   2016-11-14
(10)Bat coronaviruses associated with human diseases   中华医学预防学会年会医学病毒学分会   2015-10-21
(11)Emerging viral zoonosis in China   中德医学会年会   2015-10-02
(12)Bat coronaviruses associated with human diseases   中国科学院-美国科学院新发传染病、实验室安全与全球卫生安全研讨会   2015-09-29
(13)The animal origin of SARS coronavirus; from genome to receptor usage   湖北省微生物学会年会   2015-08-22
(14)New evidence in support of bat origin of SARS coronavirus   2015美国病毒学会年会   2015-07-05
(15)The animal origin of SARS coronavirus; from genome to receptor usage   第三届“生物防护与新发传染病-病毒与宿主相互作用”年会   2015-02-12
(16)Isolation and identification of bat mammalian orthoreovirus from Chinese bats   第六届新生病毒性疾病控制学术研讨会   2014-10-29
(17)New evidence further supports bats as natural reservoirs of SARS coronavirus   第五届武汉现代病毒学国际研讨会   2013-10-30
(18) SARS病毒追踪溯源10年   海峡两岸热带医学研讨会   2013-10-18
(19)Bat viruses detected in China   德国病毒学学术年会(2012)   石正丽   2012-03-13