基本信息
王贺瑶  女  博导  中国科学院上海药物研究所
电子邮件: hywang@simm.ac.cn
通信地址: 上海浦东新区祖冲之路555号
邮政编码: 201203

招生信息

   
招生专业
100706-药理学
招生方向
代谢内分泌药理学

教育背景

1992-04--1997-03   日本神户大学医学研究科   博士

工作经历

   
工作简历
2005-04~现在, 中国科学院上海药物研究所, 课题组长/研究员
2002-04~2005-03,日本国立国际医疗中心, 研究员
1997-08~2002-03,日本千叶大学, 研究员
1992-04~1997-03,日本神户大学医学研究科, 博士
社会兼职
2010-11-24-今,上海市科技系统少数民族联合会, 副理事长

专利与奖励

   
奖励信息
(1) 桂皮中低聚原花青素类化学成分及其降血糖活性成分研究, 三等奖, 市地级, 2014
专利成果
( 1 ) 一种从黑桑中提取的化合物作为酪氨酸酶抑制剂的用途, 2012, 第 1 作者, 专利号: ZL200710171483.1
( 2 ) 苯并大环内酯类化合物(3R)-去-O-甲基毛狄泼老素、其衍生物及其制备方法和用途, 2012, 第 1 作者, 专利号: ZL200810200074.4
( 3 ) 异戊烯基黄酮化合物作为胰脂肪酶抑制剂的用途, 2011, 第 1 作者, 专利号: ZL200910047752.2
( 4 ) 一种白桂木提取物及其制备方法和用途, 2011, 第 1 作者, 专利号: ZL201010022635.3
( 5 ) 黄酮类化合物在制备抗代谢性疾病药物中的用途, 2013, 第 2 作者, 专利号: ZL201110001869.4
( 6 ) 一种从黑桑中提取的化合物在制备酪氨酸酶抑制剂中的应用, 2011, 第 1 作者, 专利号: ZL200710171484.6
( 7 ) 化合物(E)–5–[6–羟基–5–(3–甲基–1–丁烯基)–2–苯并呋喃基] 苯–1,3–二醇在制备胰脂肪酶抑制剂中的用途, 2012, 第 2 作者, 专利号: ZL200910047608.9
( 8 ) 一种呋喃香豆素类衍生物及其制备方法和用途, 2011, 第 2 作者, 专利号: 201110028966.2
( 9 ) 月桂烷型倍半萜类化合物或其衍生物、及其制备方法和用途, 2013, 第 2 作者, 专利号: ZL200810040588.8
( 10 ) 取代磺酰胺类化合物及其制备方法、药物组合物和应用, 2009, 第 1 作者, 专利号: 200910046727.2
( 11 ) 光叶桂木提取物及其用途, 2012, 第 2 作者, 专利号: 200910047607.4
( 12 ) 一种具有胰脂肪酶抑制活性的苯并大环内酯类化合物及其合成方法和用途, 2013, 第 2 作者, 专利号: ZL200910201463.3
( 13 ) 溴化烯炔类化合物及其制备方法和用途, 2014, 第 1 作者, 专利号: ZL201110180360.0
( 14 ) 取代的酰肼类化合物及其制备方法、药物组合和用途, 2015, 第 3 作者, 专利号: ZL201110124762.9
( 15 ) 异戊烯基黄酮化合物及其在制备胰脂肪酶抑制剂中的用途, 2014, 第 2 作者, 专利号: ZL201110137006.X
( 16 ) 一类2,4,6-三异丙基苯类化合物在制备治疗糖尿病的药物中的用途, 2014, 第 1 作者, 专利号: ZL201110310346.8
( 17 ) 联杂芳基羧酸类化合物、其制备方法,包含该化合物的药物组合物、及用途, 2015, 第 2 作者, 专利号: ZL201110108003.3
( 18 ) 蜂斗菜酚化合物在制备酪氨酸酶抑制剂中的应用, 2015, 第 5 作者, 专利号: ZL201210193531.8
( 19 ) 溴化烯炔化合物E,E-22-溴-9,11,19-三炔-17,21-二烯二十二酸酯合成方法, 2015, 第 2 作者, 专利号: ZL 2012 1 0345768.3
( 20 ) 溴化烯炔化合物E-18-溴-5,7,15-三炔-17-烯十八酸酯的制备方法, 2015, 第 2 作者, 专利号: ZL 2012 1 0347339.X
( 21 ) β-氨基羟基类化合物、其制备方法、药物组合物及其用途, 2013, 第 3 作者, 专利号: 201310090905.X
( 22 ) 连钱草提取物、制备方法及其用于降糖减肥降脂的用途, 2014, 第 2 作者, 专利号: 201410104913.9
( 23 ) 4-羟基水杨酰苯胺化合物在制备酪氨酸酶抑制剂中的应用, 2014, 第 1 作者, 专利号: 201410707460.8
( 24 ) 连钱草提取物、制备方法及其用于降糖减肥降脂的用途, 2014, 第 2 作者, 专利号: 201410104913.9
( 25 ) 苯丙酸类衍生物的合成和用途, 2015, 第 2 作者, 专利号: 201510500222.4
( 26 ) 一类4,5-二取代咪唑衍生物及其制备方法和用途, 2015, 第 3 作者, 专利号: 201510960383.1
( 27 ) 一种噻吩丙酸类化合物、其药物组合物、制备方法和用途, 2016, 第 3 作者, 专利号: 201610140007.2
( 28 ) 溴化烯炔类化合物及其制备方法和用途, 2016, 第 1 作者, 专利号: ZL 2014 1 0268413.8
( 29 ) 溴化烯炔类化合物及其制备方法和用途, 2016, 第 1 作者, 专利号: ZL 2014 1 0268413.8
( 30 ) 磺酰胺类化合物及其在制备治疗糖尿病的药物中的用途, 2016, 第 2 作者, 专利号: 201610989682.2
( 31 ) 一类溴代不饱和脂肪酸酯的合成新方法, 2018, 第 2 作者, 专利号: ZL 2014 1 0235574.7

出版信息

   
发表论文
(1) 5,4-dihydroxy-7,8-dimethoxyflavanone and Alizarin from Dodonaea viscosa are Activators of PPARγ, Planta Med, 2018, 通讯作者
(2) Isolation, identification and bioactivities of abietane diterpenoids from Premna szemaoensis, RSC Advances, 2018, 通讯作者
(3) Benzbromarone aggravates hepatic steatosis in obese individuals, BBA - Molecular Basis of Disease, 2018, 通讯作者
(4) From hit to lead: Structure-based discovery of naphthalene-1-sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4., European Journal of Medicinal Chemistry, 2018, 通讯作者
(5) Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors, Journal of Chemical Information and Modeling, 2017, 通讯作者
(6) Sanggenol F exerts anti-diabetic effects via promoting adipocyte differentiation and modifying adipokines expression., Endocrine, 2017, 通讯作者
(7) Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold, Journal of Medicinal Chemistry, 2017, 通讯作者
(8) Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-RafV600E inhibitors, Acta Pharmacologica Sinica., 2017, 通讯作者
(9) Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK., Int. J. Mol. Sci., 2017, 通讯作者
(10) Ginsenoside Rb2 enhances the anti-inflammatory effect of ω-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression., Acta Pharmacologica Sinica., 2017, 通讯作者
(11) Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety, Bioorganic & Medicinal Chemistry, 2017, 通讯作者
(12) Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay, Scientific Reports, 2016, 通讯作者
(13) Trimer procyanidin oligomers contribute to the protective effects of cinnamon extracts on pancreatic β-cells in vitro, Acta Pharmacologica Sinica, 2016, 通讯作者
(14) Chlorogenic Acid Derivatives from Gynura nepalensis Protect H9c2 Cardiomyoblasts Against H2O2-Induced Apoptosis, Acta Pharmacologica Sinica, 2016, 通讯作者
(15) Preparation of Methylated Products of A-type Procyanidin Trimersin Cinnam on Bark and Their Protective Effects on Pancreatic β-Cell, Journal of Food Science, 2016, 通讯作者
(16) Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination, European Journal of Medicinal Chemistry, 2015, 通讯作者
(17) (2S)-7,4'-dihydroxy-8-prenylflavan stimulates adipogenesis and glucose uptake through p38MAPK pathway in 3T3-L1 cells, Biochemical and Biophysical Research Communications, 2015, 通讯作者
(18) Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors, ACS Med. Chem. Lett., 2015, 通讯作者
(19) Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase-4 Inhibitors, Arch. Pharm. Chem. Life Sci., 2015, 通讯作者
(20) Inhibition of Calcium Influx Reduces Dysfunction and Apoptosis in Lipotoxic Pancreatic β-Cells via Regulation of Endoplasmic Reticulum Stress, PLoS One, 2015, 通讯作者
(21) Inhibitory Effects of (2′R)-2′,3′-dihydro-2′-(1-hydroxy-1-methylethyl)-2,6′-bibenzofuran-6,4′-diol on Mushroom Tyrosinase and Melanogenesis in B16-F10 Melanoma Cells, Phytotherapy Research, 2015, 通讯作者
(22) Discovery of N-substituted 3-arylisoquinolone derivatives as antitumor agents originating from O-substituted 3-arylisoquinolines via [2,3] or [3,3] rearrangement, European Journal of Medicinal Chemistry, 2014, 通讯作者
(23) Brominated polyunsaturated lipids from the Chinese sponge Xestospongia testudinaria as a new class of pancreatic lipase inhibitors, European Journal of Medicinal Chemistry, 2014, 通讯作者
(24) Cinnamtannin D‑1 Protects Pancreatic β‑Cells from Palmitic Acid-Induced Apoptosis by Attenuating Oxidative Stress, Journal of Agricultural and Food Chemistry, 2014, 通讯作者
(25) A Small-Molecule Antagonist of GPR40 that Protects against Pancreaticβ-Cells Dysfunction in db/db Mice, PLOS ONE., 2013, 通讯作者
(26) Dodoviscin A Inhibits Melanogenesis in Mouse B16-F10 Melanoma Cells, Planta Medica, 2013, 通讯作者
(27) Overman rearrangement and PomeranzeFritsch reaction for the synthesis of benzoazepinoisoquinolones to discover novel antitumor agents, European Journal of Medicinal Chemistry, 2013, 通讯作者
(28) Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice., Acta Pharmacologica Sinica, 2013, 通讯作者
(29) The essential role for aromatic cluster in the β3 adrenergic receptor, Acta Pharmacologica Sinica., 2012, 通讯作者
(30) Combining pharmacophore, docking and substructure search approaches to identify and optimize novel B-RafV600E inhibitors, Biooranic Medicinal Chemistry Letters, 2012, 通讯作者
(31) Diverse Mechanisms of Antidiabetic Effects of the Different Procyanidin Oligomer Types of Two Different Cinnamon Species on db/db Mice, Journal of Agricultural and Food Chemistry, 2012, 通讯作者
(32) Inhibition of GPR40 protects MIN6 β-cells from palmitate-induced ER stress and apoptosis, Journal of Cellular Biochemistry, 2012, 通讯作者
(33) PDE5 inhibitor promotes melanin synthesis through the PKG pathway in B16 melanoma cells, Journal of Cellular Biochemistry, 2012, 通讯作者
(34) Isoprenylated Flavonoid and Adipogenesis-Promoting Constituents from Dodonaea Viscosa, Journal of Natural Products, 2012, 第 4 作者
(35) Isoprenylated Flavonoids and Adipogenesis-Promoting Constituents from Morus nigra, Journal of Natural Products, 2011, 通讯作者
(36) 1H NMR-based metabonomic analysis of metabolic changes of serum and liver in Zucker obese rats, Analytical Letters, 2011, 通讯作者
(37) New isoprenylated flavonoids and adipogenesis-promoting constituents, BMCL, 2011, 通讯作者
(38) Classification of 5-HT(1A) receptor agonists and antagonists using GA-SVM method,  Acta Pharmacol Sin, 2011, 通讯作者
(39) Sildenafil promotes adipogenesis through a PKG pathway., Biochemical and Biophysical Research Communications, 2010, 通讯作者
(40) DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats, Biomedicine Pharmacotherapy., 2010, 通讯作者
(41) Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice, Acta Pharmacologica Sinica, 2010, 通讯作者
(42) A Metabonomic Comparison of Urinary Changes in Zucker and GK Rats, Journal of Biomedicine and Biotechnology, 2010, 通讯作者
(43)  Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening, Bioorg Med Chem Lett. , 2010, 通讯作者
(44)  Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice, Acta Pharmacologica Sinica, 2010, 通讯作者
(45) nhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro, Molecular and Cellular Biochemistry, 2009, 通讯作者
(46) Berberine induces G1 arrest by regulating nuclear translocation of FoxO1 in hepatic stellate cells and prevents experimental liver fibrosis, Biological Pharmaceutical Bulletin, 2009, 通讯作者
(47) Effects of Pro-Arg, a novel dipeptide derived from protamine hydrolysate on H2O2-induced oxidative stress in human diploid fibroblasts, Biological Pharmaceutical Bulletin, 2009, 通讯作者
(48)  Inhibitory Effect of 2, 4, 2?, 4?-tetrahydroxy-3- (3-methyl-2-butenyl)-chalcone on Tyrosinase Activity and Melanin Biosynthesis, Biological Pharmaceutical Bulletin, 2009, 通讯作者
(49) New Isoprenylated 2-Arylbenzofurans and Pancreatic Lipase Inhibitory Constituents from Artocarpus nitidus, Chemistry Biodiversity, 2009, 通讯作者
(50) A novel class of antagonists for the FFAs receptor GPR40, Biochemical and Biophysical Research Communications, 2009, 通讯作者
(51)  Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus., Nature genetics, 2008, 通讯作者
(52) Production and characterization of anti-oxidative peptides from protamine hydrolysate., Journal of Food Biochemistry, 2008, 通讯作者
(53) Identification and functional analysis of CBLB mutations in type 1 diabetes, Biochemical and Biophysical Research Communications, 2008, 第 3 作者
(54) Genetic Reconstitution of Autoimmune Type 1 Diabetes With Two Major Susceptibility Genes in the Rat, Diabetes, 2007, 第 4 作者
(55) Cblb is a major susceptibility gene for rat type 1 diabetes mellitus. , Nature genetics, 2002, 第 3 作者
(56) 

科研活动

   
科研项目
( 1 ) 新型抗糖尿病药物靶标FABP4及其小分子抑制剂药理机制研究, 主持, 国家级, 2015-01--2018-12
( 2 ) 抑制钙信号减少脂肪酸引起的胰岛β细胞损伤及机制研究, 主持, 省级, 2014-07--2017-06
( 3 ) 上海市中国西医结合临床重大项目(心力衰竭), 主持, 省级, 2015-09--2017-09
( 4 ) 海洋来源溴化烯炔类胰脂肪酶抑制剂成药性研究, 参与, 省级, 2015-07--2018-06
( 5 ) 海洋来源溴化烯炔类胰脂肪酶抑制剂成药性研究, 参与, 市地级, 2015-09--2016-08
( 6 ) 基于新结构噻吩丙酸类GPR40完全激动剂的成药性优化及抗II型糖尿病研究, 参与, 部委级, 2016-05--2017-12
( 7 ) TD04系列化合物促小鼠胰岛新生活性评价, 主持, 院级, 2015-12--2016-12
( 8 ) Ex4-Fc在动物水平降糖活性评价, 主持, 院级, 2016-12--2017-12
( 9 ) 新型DGAT1抑制剂降脂候选药物研究, 主持, 市地级, 2016-09--2017-08
( 10 ) 抑制FABP4改善组织慢性低度炎症和糖脂代谢紊乱作用机制研究, 主持, 市地级, 2016-09--2018-08
( 11 ) 人参皂苷Rb2调节肝细胞自噬改善非酒精性脂肪肝药理机制研究, 主持, 市地级, 2017-05--2018-04
( 12 ) 低聚原花青素CinnamtanninD1通过促进自噬保护胰岛β细胞的药理机制研究, 主持, 国家级, 2018-01--2021-12
( 13 ) 一类新型FABP4/ 5抑制剂的结构优化与活性研究, 参与, 市地级, 2018-04--2018-04