基本信息
黄成钢  男  博导  中国科学院上海药物研究所
电子邮件: cghuang@simm.ac.cn
通信地址: 上海市浦东新区海科路501号2309室
邮政编码: 201203

招生信息

   
招生专业
100701-药物化学
招生方向
天然产物化学
中药及复方药效物质研究
中药体内药效物质发现方法学研究

教育背景

1995-07--1998-09   浙江大学   博士
1986-07--1989-09   黑龙江中医药大学   硕士
1978-07--1981-09   桂林医学院   理学学士

工作经历

   
工作简历
2000-09~现在, 中国科学院上海药物研究所, 研究员,研究组长,中心副主任,博士生导师。
1998-09~2000-09,中国科学院上海药物研究所, 博士后
1995-07~1998-09,浙江大学, 博士
1992-09~1995-07,浙江杭州康恩贝生物工程公司, 总工程师
1989-09~1992-07,浙江杭州药物研究所, 药化室主任
1986-07~1989-09,黑龙江中医药大学, 硕士
1981-09~1986-07,广西百色地区药品检验所, 化学室主任
1978-07~1981-09,桂林医学院, 理学学士
社会兼职
2010-09-01-今,同济大学兼职教授,
2010-09-01-今,上海市药学会中药专业委员会副主任,

专利与奖励

   
专利成果
( 1 ) 一种异黄酮类化合物的用途, 2011, 第 1 作者, 专利号: ZL 200510110641.3
( 2 ) 知母皂苷A作为制备治疗Ⅱ型糖尿病药物的应用, 2006, 第 1 作者, 专利号: ZL02160151.8
( 3 ) 一种皂苷类成分作为制备抗柯萨奇病毒药物的应用, 2007, 第 1 作者, 专利号: ZL03141639X
( 4 ) 毛蕊异黄酮-7-氧-B-D-吡喃葡萄糖苷或其盐在抗艾滋病中的应用, 2011, 第 1 作者, 专利号: ZL 200910053219.7
( 5 ) 一种治疗糖尿病的药物组合物及其制备方法, 2009, 第 1 作者, 专利号: ZL200510110763.2
( 6 ) 从中药王不留行中分离获得的三萜类化合物及它们的用途, 2011, 第 1 作者, 专利号: 200710042565.6
( 7 ) 呋甾烷型皂苷衍生物及其用途, 2015, 第 1 作者, 专利号: ZL201210567598.3
( 8 ) 皂苷衍生物及其用途, 2015, 第 1 作者, 专利号: ZL 201210576694.4
( 9 ) 知母皂苷A作为制备治疗Ⅱ型糖尿病药物的应用, 2006, 第 1 作者, 专利号: ZL02 160151.8
( 10 ) 预防和治疗糖尿病的药物组合物, 2013, 第 1 作者, 专利号: ZL201010022822.1
( 11 ) 含有苍术提取物的药物组合物, 2013, 第 1 作者, 专利号: ZL201010107882.3
( 12 ) 知母皂苷BIII的医药用途, 2012, 第 1 作者, 专利号: ZL201010238574.4
( 13 ) 知母宁复合物及其制备方法和应用, 2012, 第 1 作者, 专利号: ZL201010022823.6
( 14 ) 柴胡皂苷a作为唯一有效成份在制备抑制肝脏成纤维细胞增殖药物中的应用, 2011, 第 1 作者, 专利号: ZL200610026138.4
( 15 ) 知母皂苷BⅢ的制备方法及其用途, 2011, 第 1 作者, 专利号: ZL200710040730.4
( 16 ) 用于帕金森氏病的组合物及其制备方法, 2018, 第 1 作者, 专利号: 2017114828961
( 17 ) 一种菝葜皂苷元衍生物及其制备方法和应用, 2017, 第 1 作者, 专利号: 2017114828961
( 18 ) 一种抗抑郁化合物及其制备方法和应用, 2017, 第 1 作者, 专利号: CN2017/120134
( 19 ) 一种用于治疗高血脂症及动脉粥样硬化的药物组合物, 2017, 第 1 作者, 专利号: 2017103128956
( 20 ) 含有螺甾烷化合物的组合物及其用途, 2015, 第 1 作者, 专利号: 201510640941.6
( 21 ) 一种化学合成毛蕊异黄酮苷的方法, 2015, 第 1 作者, 专利号: 201510821795.7
( 22 ) 褐藻多糖及其制备方法和用途, 2016, 第 1 作者, 专利号: 201610123664.6
( 23 ) 含小檗碱和知母皂苷的组合物及其应用, 2016, 第 1 作者, 专利号: 201610143268.X
( 24 ) 一种用于治疗老年痴呆病的药物组合物, 2016, 第 2 作者, 专利号: 201611038340.9
( 25 ) 一种抗抑郁化合物及其制备方法和应用, 2016, 第 1 作者, 专利号: 201611260514.6
( 26 ) 一种用于治疗非酒精性脂肪性肝病的药物组合物, 2017, 第 1 作者, 专利号: 201710119133.4
( 27 ) 皂苷衍生物及其用途, 2012, 第 1 作者, 专利号: PCT/CN2012/087265
( 28 ) 呋甾烷型皂苷衍生物及其用途, 2012, 第 1 作者, 专利号: PCT/CN2012/087260
( 29 ) 一种用于治疗高血脂症及动脉粥样硬化的药物组合物, 2018, 第 1 作者, 专利号: PCT/CN2018/085524
( 30 ) 一种抗抑郁化合物及其制备方法和应用, 2017, 第 1 作者, 专利号: PCT/CN2017/120134

出版信息

   
发表论文
(1) Determining the protective effects of Yin-Chen-Hao Tang against acute liver injury induced by carbon tetrachloride using 16S rRNA gene sequencing and LC/MS-based metabolomics,, J. Pharm. Biomed. Anal., 2019, 第 11 作者
(2) Metabolic profiling analysis of corilagin in vivo and in vitro using high-performance liquid chromatography quadrupole time-of-flight mass spectrometry, J. Pharm. Biomed. Anal., 2019, 第 11 作者
(3) Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 1: Metabolic profiles from the liver-centric perspective, J. Ethnopharmacol., 2019, 第 11 作者
(4) Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption, Front Pharmacol, 2019, 第 11 作者
(5) Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro, J Ethnopharmacol, 2019, 第 11 作者
(6) Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of Calycosin-7-O-ß-D-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC-MS/MS, Journal of Pharmaceutical and Biomedical Analysis, 2018, 第 11 作者
(7) A sensitive HPLC-MS/MS method for the simultaneous determination of Anemoside B4, Anemoside A3 and 23-hydroxybetulinic acid: application to the pharmacokinetics and liver distribution of Pulsatilla chinensis saponins, Biomed. Chromatogr, 2018, 第 11 作者
(8) A validated LC-MS/MS method for simultaneous quantitative analysis of three saponins and five alkaloids in the Gouteng-Baitouweng herb pair in rat plasma, liver and brain by LC-MS/MS and its application to pharmacokinetics , liver first pass effect , liver and brain distribution., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2018, 第 11 作者
(9) Metabolism, pharmacokinetics and hepatic disposition of xanthones and saponins on Zhimu treatments for exploratively interpreting the discrepancy between the herbal safety and timosaponin- A3 induced hepatotoxicity, Acta Pharmacol Sin., 2018, 第 11 作者
(10) Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection, Biomed Chromatogr, 2018, 第 11 作者
(11) Asymmetric Synthesis of the C15(-)C32 Fragment of Alotamide and Determination of the Relative Stereochemistry, Mar Drugs, 2018, 第 11 作者
(12) Evaluation of the chemical consistency of Yin-Chen-Hao-Tang prepared by combined and separated decoction methods using high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis, J. Sep. Sci., 2018, 第 11 作者
(13) Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS, J. Agric. Food Chem., 2018, 第 11 作者
(14) Pharmacokinetics of mangiferin and its metabolite -norathyriol. Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo., Biofactors, 2016, 第 11 作者
(15) Structural elucidation and protective role of a polysaccharide from Sargassumfusiforme on ameliorating learning and memory deficiencies in mice., CarbohydrPolym, 2016, 第 11 作者
(16) Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example, Analytical and Bioanalytical Chemistry, 2016, 第 11 作者
(17) Pharmacokinetics of mangiferin and its metabolite- norathyriol. Part 2: influence of UGT, CYP450, P-gp, and enterobacteria and the potential interaction in RhizomaAnemarrhenae decoction with timosaponin B2 as the major contributor, Biofactors, 2016, 第 11 作者
(18) The rapid antidepressant and anxiolytic-like effects of YY-21 involve enhancement of excitatory synaptic transmission via activation of mTOR signaling in the mPFC, Eur Neuropsychopharmacol, 2016, 第 11 作者
(19) The pharmacokinetics and metabolism of neomangiferin, a major bioactive component in Anemarrhena asphodeloides, Med. Chem, 2016, 第 11 作者
(20) Comprehensive Evaluation of the Metabolism of Genipin-1-β-D-gentiobioside in Vitro and in Vivo by Using HPLC-Q-TOF, J. Agric. Food Chem., 2016, 第 11 作者
(21) Stereoisomerism metabolites found in rats after oral administration of timosaponin B-II using HPLC-Q-TOF-MS and NMR methods, Rsc Advances, 2015, 第 11 作者
(22) The Hepatobiliary Disposition of Timosaponin B2 is Highly Dependent on Influx/efflux Transporters but not Metabolism, Drug MetabDispos, 2015, 第 11 作者
(23) Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants, Eur J Neurosci, 2015, 第 11 作者
(24) Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine, Xenobiotica, 2015, 第 11 作者
(25) Cytotoxic activities of chemical constituents from rhizomes of Anemarrhenaasphodeloides and their analogues, Archives of Pharmacal Research, 2015, 第 11 作者
(26) Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS,, Analytical and Bioanalytical Chemistry, 2014, 第 11 作者
(27) Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters, Acta Pharmacologica Sinica, 2014, 第 11 作者
(28) Rapid characterization and determination of multiple components in Bu-Shen-Yi-Qi-Fang by high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry, Journal of Separation Science, 2014, 第 11 作者
(29) Identification of multiple constituents from seed of Vaccariasegetalis with an adsorbent-separation strategy based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 2014, 第 11 作者
(30) HIM-herbal ingredients in-vivo metabolism database, Journal of Cheminformatics, 2013, 第 11 作者
(31) Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2013, 第 11 作者
(32) Metabolism and tissue distribution study of Vaccaria seeds (Wang-Bu-Liu-Xing) in benign prostatic hyperplasia model rat: Toward an in-depth study for its bioactive components, Journal of Pharmaceutical and Biomedical Analysis, 2013, 第 11 作者
(33) Analysis of Multiple Constituents in Cong-Ming-Tang, a Chinese Herbal Formula for the Treatment of Amnesia, by High-performance Liquid Chromatography with Quadrupole Time-of-flight Mass Spectrometry, Phytochemical Analysis, 2013, 第 11 作者
(34) Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats, Drug Metab Dispos, 2012, 第 11 作者
(35) Structure elucidation of in vivo and in vitro metabolites of mangiferin, Journal of Pharmaceutical and Biomedical Analysis, 2011, 第 11 作者
(36)  Characterization of the Multiple Absorbed in Rats after Oral Administration of Chai-Huang Decoction by Liquid Chromatography Coupled with Electrosprary-Ionization Mass Spectometry, Chemistry Biodiversity, 2010, 第 11 作者
(37) Identification of major alkaloids in rat urine by HPLC-DAD-ESI-MS/MS method following oral administration of Cortex Phellodendri decoction, Helvetica Chimica Acta, 2009, 第 11 作者
(38)  In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-β-D-glucopyranoside against Coxsackie Virus B3, Biological Pharmaceutical Bulletin, 2009, 第 11 作者
(39) Identification of major alkaloids and steroidal saponins in rat serum by HPLC-DAD-MS/MS method following oral administration of Huangbai-Zhimu herb-pair Extract., Biomedical Chromatography, 2008, 第 11 作者
(40) Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction., Biomedical Chromatography, 2008, 第 11 作者
(41) Cytotoxic triterpenoid Saponins from Vaccaria segetalis, Journal of Asian Natural Products Research, 2008, 第 11 作者
(42) Determination of calycosin 7-O-β-D-glucoside in rat plasma and urine by HPLC, Biomedical Chromatography, 2007, 第 11 作者
(43) Identification and determination of four metabolites of mangiferin in rat urine, Journal of Pharmaceutical and Biomedical Analysis, 2007, 第 11 作者
(44) A high-performance liquid chromatographicmethod for saikosaponin a quantification in rat plasma, Biomedical Chromatography, 2007, 第 11 作者
(45) Structure elucidation and complete NMR spectral assignments of a novel sesquiterpene glycoside from Ixeris sonchifoli, Magnetic Resonance in Chemistry, 2007, 第 11 作者
(46) Two new secoiridoid Glycosides from Tripterospermum Chinense (Migo), Helvetica Chimica Acta, 2007, 第 11 作者
(47) A new hopane triterpene from Dipentodon sinicus (Celastraceae), Biochemical Systematics and Ecology, 2007, 第 11 作者
(48) Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats, Life Sciences, 2006, 第 11 作者
(49) Determination of geniposide in rat urine after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction by high-performance liquid chromatography, Journal of chromatographic science, 2006, 第 11 作者
(50) Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-γ, Journal of Cardiovascular Pharmacology, 2006, 第 11 作者
(51) Determination of human plasma protein binding of baicalin by ulterfiltration and high performance liquid chromatography, Biomedical Chromatography, 2006, 第 11 作者
(52) SPE-HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction, Biomedical Chromatography, 2006, 第 11 作者
(53) Large-scale isolation and purification of scoparone from Herba artemisiae scopariae by high-speed counter-current chromatography, Chromatographia, 2006, 第 11 作者
(54) High-performance liquid chromatographic method for the determination of mangiferin in rat plasma and urine, Biomedical Chromatography, 2006, 第 11 作者
发表著作
Clinical Chemistry Research, Chapter 4: Identification and Analysis of Effective Components in Animal Biofluids following Administration of Natural Medicines,, Nova Science Publishers Inc., 2009-03, 第 1 作者
Recent Advances in Theories and Practice of Chinese Medicine, Chapter 21: Study on Metabolism of Natural Medical Components in vivo: Metabolism Study in Rat After Oral Administration of Rhubarb Decoction and Characterization, Identification of the Rat Metabolite of Scutellariabaicalensis, InTech, Croatia, 2011-12, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于体内过程的两种知母药对配伍机制研究, 主持, 国家级, 2011-01--2014-12
( 2 ) 毛蕊异黄酮苷体内代谢转化与抗柯萨奇病毒作用关系研究, 主持, 国家级, 2014-01--2017-12
( 3 ) 治疗2型糖尿病中药复方 RG02组分配伍新药临床前研究, 主持, 国家级, 2009-01--2011-12
( 4 ) 治疗2型糖尿病1类化学复方新药ZH-063的临床前个性化特征研究, 主持, 部委级, 2015-10--2018-12
( 5 ) 治疗糖尿病和抑郁症中药复方药效物质基础及作用机理系统研究, 主持, 部委级, 2007-11--2010-12
( 6 ) 治疗老年性痴呆中药复方组分候选新药CM-02研究, 主持, 省级, 2013-09--2016-09
( 7 ) 中药复方药效组分快速锁定关键技术, 主持, 国家级, 2017-07--2020-12
( 8 ) 治疗抑郁症1.1类候选新药YY-23, 主持, 部委级, 2015-09--2016-07
( 9 ) 痰热清注射液药效物质及药理机制研究, 主持, 院级, 2016-01--2019-12
( 10 ) 抗抑郁1.1类创新药物临床前研究及 天然药物提取中试平台建设, 主持, 部委级, 2019-01--2020-12
( 11 ) 中药复方及组分配伍成药性评价, 主持, 院级, 2017-12--2019-12