基本信息
黄成钢  男  博导  中国科学院上海药物研究所
电子邮件: cghuang@simm.ac.cn
通信地址: 上海市浦东新区海科路501号2309室
邮政编码: 201203

招生信息

   
招生专业
100701-药物化学
100800-中药学
招生方向
天然产物化学
中药分析学

教育背景

1995-07--1998-09   浙江大学   博士
1986-07--1989-09   黑龙江中医药大学   硕士
1978-07--1981-09   桂林医学院   理学学士

工作经历

   
工作简历
2000-09~现在, 中国科学院上海药物研究所, 研究员,研究组长,中心副主任,博士生导师。
1998-09~2000-09,中国科学院上海药物研究所, 博士后
1995-07~1998-09,浙江大学, 博士
1992-09~1995-07,浙江杭州康恩贝生物工程公司, 总工程师
1989-09~1992-07,浙江杭州药物研究所, 药化室主任
1986-07~1989-09,黑龙江中医药大学, 硕士
1981-09~1986-07,广西百色地区药品检验所, 化学室主任
1978-07~1981-09,桂林医学院, 理学学士
社会兼职
2010-09-01-今,同济大学兼职教授,
2010-09-01-今,上海市药学会中药专业委员会副主任,

专利与奖励

   
专利成果
( 1 ) 一种异黄酮类化合物的用途, 2011, 第 1 作者, 专利号: ZL 200510110641.3
( 2 ) 知母皂苷A作为制备治疗Ⅱ型糖尿病药物的应用, 2006, 第 1 作者, 专利号: ZL02160151.8
( 3 ) 一种皂苷类成分作为制备抗柯萨奇病毒药物的应用, 2007, 第 1 作者, 专利号: ZL03141639X
( 4 ) 毛蕊异黄酮-7-氧-B-D-吡喃葡萄糖苷或其盐在抗艾滋病中的应用, 2011, 第 1 作者, 专利号: ZL 200910053219.7
( 5 ) 一种治疗糖尿病的药物组合物及其制备方法, 2009, 第 1 作者, 专利号: ZL200510110763.2
( 6 ) 从中药王不留行中分离获得的三萜类化合物及它们的用途, 2011, 第 1 作者, 专利号: 200710042565.6
( 7 ) 呋甾烷型皂苷衍生物及其用途, 2015, 第 1 作者, 专利号: ZL201210567598.3
( 8 ) 皂苷衍生物及其用途, 2015, 第 1 作者, 专利号: ZL 201210576694.4
( 9 ) 知母皂苷A作为制备治疗Ⅱ型糖尿病药物的应用, 2006, 第 1 作者, 专利号: ZL02 160151.8
( 10 ) 预防和治疗糖尿病的药物组合物, 2013, 第 1 作者, 专利号: ZL201010022822.1
( 11 ) 含有苍术提取物的药物组合物, 2013, 第 1 作者, 专利号: ZL201010107882.3
( 12 ) 知母皂苷BIII的医药用途, 2012, 第 1 作者, 专利号: ZL201010238574.4
( 13 ) 知母宁复合物及其制备方法和应用, 2012, 第 1 作者, 专利号: ZL201010022823.6
( 14 ) 柴胡皂苷a作为唯一有效成份在制备抑制肝脏成纤维细胞增殖药物中的应用, 2011, 第 1 作者, 专利号: ZL200610026138.4
( 15 ) 知母皂苷BⅢ的制备方法及其用途, 2011, 第 1 作者, 专利号: ZL200710040730.4
( 16 ) 用于帕金森氏病的组合物及其制备方法, 2018, 第 1 作者, 专利号: 2017114828961
( 17 ) 一种菝葜皂苷元衍生物及其制备方法和应用, 2017, 第 1 作者, 专利号: 2017114828961
( 18 ) 一种抗抑郁化合物及其制备方法和应用, 2017, 第 1 作者, 专利号: CN2017/120134
( 19 ) 一种用于治疗高血脂症及动脉粥样硬化的药物组合物, 2017, 第 1 作者, 专利号: 2017103128956
( 20 ) 含有螺甾烷化合物的组合物及其用途, 2015, 第 1 作者, 专利号: 201510640941.6
( 21 ) 一种化学合成毛蕊异黄酮苷的方法, 2015, 第 1 作者, 专利号: 201510821795.7
( 22 ) 褐藻多糖及其制备方法和用途, 2016, 第 1 作者, 专利号: 201610123664.6
( 23 ) 含小檗碱和知母皂苷的组合物及其应用, 2016, 第 1 作者, 专利号: 201610143268.X
( 24 ) 一种用于治疗老年痴呆病的药物组合物, 2016, 第 2 作者, 专利号: 201611038340.9
( 25 ) 一种抗抑郁化合物及其制备方法和应用, 2016, 第 1 作者, 专利号: 201611260514.6
( 26 ) 一种用于治疗非酒精性脂肪性肝病的药物组合物, 2017, 第 1 作者, 专利号: 201710119133.4
( 27 ) 皂苷衍生物及其用途, 2012, 第 1 作者, 专利号: PCT/CN2012/087265
( 28 ) 呋甾烷型皂苷衍生物及其用途, 2012, 第 1 作者, 专利号: PCT/CN2012/087260
( 29 ) 一种用于治疗高血脂症及动脉粥样硬化的药物组合物, 2018, 第 1 作者, 专利号: PCT/CN2018/085524
( 30 ) 一种抗抑郁化合物及其制备方法和应用, 2017, 第 1 作者, 专利号: PCT/CN2017/120134

出版信息

   
发表论文
(1) Determining the protective effects of Yin-Chen-Hao Tang against acute liver injury induced by carbon tetrachloride using 16S rRNA gene sequencing and LC/MS-based metabolomics,, J. Pharm. Biomed. Anal., 2019, 通讯作者
(2) Metabolic profiling analysis of corilagin in vivo and in vitro using high-performance liquid chromatography quadrupole time-of-flight mass spectrometry, J. Pharm. Biomed. Anal., 2019, 通讯作者
(3) Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 1: Metabolic profiles from the liver-centric perspective, J. Ethnopharmacol., 2019, 通讯作者
(4) Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption, Front Pharmacol, 2019, 通讯作者
(5) Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro, J Ethnopharmacol, 2019, 通讯作者
(6) Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of Calycosin-7-O-ß-D-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC-MS/MS, Journal of Pharmaceutical and Biomedical Analysis, 2018, 通讯作者
(7) A sensitive HPLC-MS/MS method for the simultaneous determination of Anemoside B4, Anemoside A3 and 23-hydroxybetulinic acid: application to the pharmacokinetics and liver distribution of Pulsatilla chinensis saponins, Biomed. Chromatogr, 2018, 通讯作者
(8) A validated LC-MS/MS method for simultaneous quantitative analysis of three saponins and five alkaloids in the Gouteng-Baitouweng herb pair in rat plasma, liver and brain by LC-MS/MS and its application to pharmacokinetics , liver first pass effect , liver and brain distribution., J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2018, 通讯作者
(9) Metabolism, pharmacokinetics and hepatic disposition of xanthones and saponins on Zhimu treatments for exploratively interpreting the discrepancy between the herbal safety and timosaponin- A3 induced hepatotoxicity, Acta Pharmacol Sin., 2018, 通讯作者
(10) Material basis studies of anti-Influenza A active ingredients in Tanreqing Injection, Biomed Chromatogr, 2018, 通讯作者
(11) Asymmetric Synthesis of the C15(-)C32 Fragment of Alotamide and Determination of the Relative Stereochemistry, Mar Drugs, 2018, 通讯作者
(12) Evaluation of the chemical consistency of Yin-Chen-Hao-Tang prepared by combined and separated decoction methods using high-performance liquid chromatography and quadrupole time-of-flight mass spectrometry coupled with multivariate statistical analysis, J. Sep. Sci., 2018, 通讯作者
(13) Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS, J. Agric. Food Chem., 2018, 通讯作者
(14) Pharmacokinetics of mangiferin and its metabolite -norathyriol. Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo., Biofactors, 2016, 通讯作者
(15) Structural elucidation and protective role of a polysaccharide from Sargassumfusiforme on ameliorating learning and memory deficiencies in mice., CarbohydrPolym, 2016, 通讯作者
(16) Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example, Analytical and Bioanalytical Chemistry, 2016, 通讯作者
(17) Pharmacokinetics of mangiferin and its metabolite- norathyriol. Part 2: influence of UGT, CYP450, P-gp, and enterobacteria and the potential interaction in RhizomaAnemarrhenae decoction with timosaponin B2 as the major contributor, Biofactors, 2016, 通讯作者
(18) The rapid antidepressant and anxiolytic-like effects of YY-21 involve enhancement of excitatory synaptic transmission via activation of mTOR signaling in the mPFC, Eur Neuropsychopharmacol, 2016, 通讯作者
(19) The pharmacokinetics and metabolism of neomangiferin, a major bioactive component in Anemarrhena asphodeloides, Med. Chem, 2016, 通讯作者
(20) Comprehensive Evaluation of the Metabolism of Genipin-1-β-D-gentiobioside in Vitro and in Vivo by Using HPLC-Q-TOF, J. Agric. Food Chem., 2016, 通讯作者
(21) Stereoisomerism metabolites found in rats after oral administration of timosaponin B-II using HPLC-Q-TOF-MS and NMR methods, Rsc Advances, 2015, 通讯作者
(22) The Hepatobiliary Disposition of Timosaponin B2 is Highly Dependent on Influx/efflux Transporters but not Metabolism, Drug MetabDispos, 2015, 通讯作者
(23) Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants, Eur J Neurosci, 2015, 通讯作者
(24) Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine, Xenobiotica, 2015, 通讯作者
(25) Cytotoxic activities of chemical constituents from rhizomes of Anemarrhenaasphodeloides and their analogues, Archives of Pharmacal Research, 2015, 通讯作者
(26) Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS,, Analytical and Bioanalytical Chemistry, 2014, 通讯作者
(27) Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters, Acta Pharmacologica Sinica, 2014, 通讯作者
(28) Rapid characterization and determination of multiple components in Bu-Shen-Yi-Qi-Fang by high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry, Journal of Separation Science, 2014, 通讯作者
(29) Identification of multiple constituents from seed of Vaccariasegetalis with an adsorbent-separation strategy based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 2014, 通讯作者
(30) HIM-herbal ingredients in-vivo metabolism database, Journal of Cheminformatics, 2013, 通讯作者
(31) Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 2013, 通讯作者
(32) Metabolism and tissue distribution study of Vaccaria seeds (Wang-Bu-Liu-Xing) in benign prostatic hyperplasia model rat: Toward an in-depth study for its bioactive components, Journal of Pharmaceutical and Biomedical Analysis, 2013, 通讯作者
(33) Analysis of Multiple Constituents in Cong-Ming-Tang, a Chinese Herbal Formula for the Treatment of Amnesia, by High-performance Liquid Chromatography with Quadrupole Time-of-flight Mass Spectrometry, Phytochemical Analysis, 2013, 通讯作者
(34) Metabolism and pharmacokinetics of mangiferin in conventional rats, pseudo-germ-free rats, and streptozotocin-induced diabetic rats, Drug Metab Dispos, 2012, 通讯作者
(35) Structure elucidation of in vivo and in vitro metabolites of mangiferin, Journal of Pharmaceutical and Biomedical Analysis, 2011, 通讯作者
(36)  Characterization of the Multiple Absorbed in Rats after Oral Administration of Chai-Huang Decoction by Liquid Chromatography Coupled with Electrosprary-Ionization Mass Spectometry, Chemistry Biodiversity, 2010, 通讯作者
(37) Identification of major alkaloids in rat urine by HPLC-DAD-ESI-MS/MS method following oral administration of Cortex Phellodendri decoction, Helvetica Chimica Acta, 2009, 通讯作者
(38)  In Vivo and in Vitro Antiviral Activities of Calycosin-7-O-β-D-glucopyranoside against Coxsackie Virus B3, Biological Pharmaceutical Bulletin, 2009, 通讯作者
(39) Identification of major alkaloids and steroidal saponins in rat serum by HPLC-DAD-MS/MS method following oral administration of Huangbai-Zhimu herb-pair Extract., Biomedical Chromatography, 2008, 通讯作者
(40) Identification of major xanthones and steroidal saponins in rat urine by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry technology following oral administration of Rhizoma Anemarrhenae decoction., Biomedical Chromatography, 2008, 通讯作者
(41) Cytotoxic triterpenoid Saponins from Vaccaria segetalis, Journal of Asian Natural Products Research, 2008, 通讯作者
(42) Determination of calycosin 7-O-β-D-glucoside in rat plasma and urine by HPLC, Biomedical Chromatography, 2007, 通讯作者
(43) Identification and determination of four metabolites of mangiferin in rat urine, Journal of Pharmaceutical and Biomedical Analysis, 2007, 通讯作者
(44) A high-performance liquid chromatographicmethod for saikosaponin a quantification in rat plasma, Biomedical Chromatography, 2007, 通讯作者
(45) Structure elucidation and complete NMR spectral assignments of a novel sesquiterpene glycoside from Ixeris sonchifoli, Magnetic Resonance in Chemistry, 2007, 通讯作者
(46) Two new secoiridoid Glycosides from Tripterospermum Chinense (Migo), Helvetica Chimica Acta, 2007, 通讯作者
(47) A new hopane triterpene from Dipentodon sinicus (Celastraceae), Biochemical Systematics and Ecology, 2007, 通讯作者
(48) Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats, Life Sciences, 2006, 通讯作者
(49) Determination of geniposide in rat urine after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction by high-performance liquid chromatography, Journal of chromatographic science, 2006, 通讯作者
(50) Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-γ, Journal of Cardiovascular Pharmacology, 2006, 通讯作者
(51) Determination of human plasma protein binding of baicalin by ulterfiltration and high performance liquid chromatography, Biomedical Chromatography, 2006, 通讯作者
(52) SPE-HPLC method for the determination and pharmacokinetic studies on geniposide in rat serum after oral administration of traditional Chinese medicinal preparation Yin-Zhi-Ku decoction, Biomedical Chromatography, 2006, 通讯作者
(53) Large-scale isolation and purification of scoparone from Herba artemisiae scopariae by high-speed counter-current chromatography, Chromatographia, 2006, 通讯作者
(54) High-performance liquid chromatographic method for the determination of mangiferin in rat plasma and urine, Biomedical Chromatography, 2006, 通讯作者
发表著作
Clinical Chemistry Research, Chapter 4: Identification and Analysis of Effective Components in Animal Biofluids following Administration of Natural Medicines,, Nova Science Publishers Inc., 2009-03, 第 1 作者
Recent Advances in Theories and Practice of Chinese Medicine, Chapter 21: Study on Metabolism of Natural Medical Components in vivo: Metabolism Study in Rat After Oral Administration of Rhubarb Decoction and Characterization, Identification of the Rat Metabolite of Scutellariabaicalensis, InTech, Croatia, 2011-12, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于体内过程的两种知母药对配伍机制研究, 主持, 国家级, 2011-01--2014-12
( 2 ) 毛蕊异黄酮苷体内代谢转化与抗柯萨奇病毒作用关系研究, 主持, 国家级, 2014-01--2017-12
( 3 ) 治疗2型糖尿病中药复方 RG02组分配伍新药临床前研究, 主持, 国家级, 2009-01--2011-12
( 4 ) 治疗2型糖尿病1类化学复方新药ZH-063的临床前个性化特征研究, 主持, 部委级, 2015-10--2018-12
( 5 ) 治疗糖尿病和抑郁症中药复方药效物质基础及作用机理系统研究, 主持, 部委级, 2007-11--2010-12
( 6 ) 治疗老年性痴呆中药复方组分候选新药CM-02研究, 主持, 省级, 2013-09--2016-09
( 7 ) 中药复方药效组分快速锁定关键技术, 主持, 国家级, 2017-07--2020-12
( 8 ) 治疗抑郁症1.1类候选新药YY-23, 主持, 部委级, 2015-09--2016-07
( 9 ) 痰热清注射液药效物质及药理机制研究, 主持, 院级, 2016-01--2019-12
( 10 ) 抗抑郁1.1类创新药物临床前研究及 天然药物提取中试平台建设, 主持, 部委级, 2019-01--2020-12
( 11 ) 中药复方及组分配伍成药性评价, 主持, 院级, 2017-12--2019-12