基本信息
沈建华  男  博导  中国科学院上海药物研究所
电子邮件: jhshen@simm.ac.cn
通信地址: 张江高科技园区海科路501
邮政编码: 201203

招生信息

   
招生专业
100701-药物化学
招生方向
糖尿病及其并发症新药研究
慢性炎症性肠炎新药研究
非酒精脂肪肝炎新药研究

工作经历

   
工作简历
2000-08~2018-06,中科院上海药物研究所, 研究员

专利与奖励

   
奖励信息
(1) 靶标动力学与药物设计, 二等奖, 国家级, 2007

出版信息

   
发表论文
(1) Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker., Eur J Med Chem, 2018, 第 11 作者
(2) Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3., Front Pharmacol, 2018, 第 11 作者
(3) Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2., J Med Chem, 2017, 第 11 作者
(4) Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects., Curr Med Chem, 2017, 第 11 作者
(5) Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect., Sci Rep, 2016, 第 11 作者
(6) OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition., Acta Pharmacol Sin, 2016, 第 11 作者
(7) Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema., J Med Chem, 2016, 第 11 作者
(8) Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes., J Med Chem, 2015, 第 11 作者
(9) Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors., J Med Chem, 2015, 第 11 作者
(10) 4-Benzofuranyloxynicotinamide derivatives are novel potent and orally available TGR5 agonists., Eur J Med Chem, 2014, 第 11 作者
(11) Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold., Eur J Med Chem., 2013, 第 11 作者
(12) Design, synthesis, and structure-activity relationships of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles as TGR5 agonists., ChemMedChem., 2013, 第 11 作者
(13) Triazole derivatives: a series of Darapladib analogues as orally active Lp-PLA2 inhibitors., Bioorg Med Chem Lett., 2013, 第 11 作者
(14) Design and synthesis of imidazole and triazole derivatives as Lp-PLA₂ inhibitors and the unexpected discovery of highly potent quaternary ammonium salts., Bioorg Med Chem Lett., 2013, 第 11 作者
(15) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists., J Med Chem, 2012, 第 11 作者

科研活动

   
科研项目
( 1 ) 抗糖尿病新药研究, 主持, 研究所(学校), 2011-07--2014-01
( 2 ) 抗动脉粥样硬化新药研究, 主持, 国家级, 2010-01--2014-12
( 3 ) 候选药物RP4个性化研究, 主持, 部委级, 2016-01--2017-12
( 4 ) 治疗糖尿病黄斑水肿候选药物VO1的临床前研究, 主持, 省级, 2018-04--2021-06
( 5 ) 基于非体循环药物策略的TGR5激动剂研究, 主持, 国家级, 2015-01--2018-12
( 6 ) 针对糖尿病肾病的Lp-PLA2酶及其抑制剂研究, 主持, 国家级, 2017-01--2020-12