基本信息
秦建华  女  博导  中国科学院大连化学物理研究所
电子邮件: jhqin@dicp.ac.cn
通信地址: 大连市中山路457号大连化学物理研究所1807组
邮政编码: 116023

研究领域

主要致力于微流控器官芯片、类器官及其与生命科学的前沿交叉研究。针对人体生命系统的复杂性,融合化学、工程学和生物

医学等多学科方法,研究探索实现人体重要组织器官体外重塑的新策略、新体系,体外建立功能性器官生理模拟微系统,以利

于在整体层面解析人体器官生理、病理过程及组织器官间互作,为组器官发育、器官制造、疾病研究和药物研发等提供新

思路、策略和方法。

主要研究方向:

微流控器官芯片

干细胞与类器官

生物材料设计及应用

疾病模型与药物评价

微分析检测技术


招生信息

热忱欢迎分析化学、生物医学工程、生物技术、材料学、医学、生物学和药学等专业学生报考


招生专业
070302-分析化学
083100-生物医学工程
071009-细胞生物学
招生方向
微流控系统及生物医学应用
器官芯片与类器官

教育背景

2001-09--2005-06   中国科学院大连化学物理研究所   分析化学专业博士学位
学位
博士
出国学习工作

香港大学理学院访问学者,加拿大多伦多大学博士后、访问学者。

工作经历

中科院大连化学物理研究所首席研究员,研究组组长,辽宁省微流控芯片重点实验室主任。国际刊物Lab on a Chip副主编,英国皇家化学会 Fellow. 入选RSC卓越研究-百名化学界女性,  2021年大连化学物理研究所优秀导师奖。中国科学院大学未来技术学院生物芯片教研室副主任,中科院战略性先导A器官重建与制造专项总体组专家,中科院脑科学与智能技术卓越创新中心骨干,香港科技大学客座教授。中国生物工程学会生物传感、生物芯片与纳米生物技术专业委员会主任委员。 已发表SCI论文150余篇,引用>5000次,出版著作2部,授权发明专利37项,主持科技部、基金委和中科院等科研项目19项,已培养博士研究生25名,指导博士后16名。

专利与奖励

授权技术发明专利37 项,转让2项。团队成果获辽宁省技术发明二等奖,辽宁省技术发明一等奖,大连市技术发明一等奖,国家科学技术进步二等奖等多项

专利成果
( 1 ) 一种基于纳米电纺丝的细胞一维生长方法, 发明, 2017, 第 1 作者, 专利号: CN201310654919.8
( 2 ) 一种集成化药物筛选与染色微流控芯片, 实用新型, 2017, 第 1 作者, 专利号: CN201621324529.X
( 3 ) 一种微流控芯片及利用微流控芯片的核酸提取纯化方法, 发明, 2018, 第 1 作者, 专利号: CN201410770871.1
( 4 ) 一种微流控芯片及其制备方法和应用, 发明, 2018, 第 1 作者, 专利号: CN201410735524.5
( 5 ) 一种基于微流控芯片的多功能区域细胞三维共培养方法, 发明, 2018, 第 1 作者, 专利号: CN201410736755.8
( 6 ) 用于超快核酸扩增的集成微阀微流控芯片及其制备方法, 发明, 2018, 第 1 作者, 专利号: CN201410749217.2
( 7 ) 一种基于微流控芯片的快速多通量提取血液样本DNA的方法, 发明, 2019, 第 1 作者, 专利号: ZL201410768138.6
( 8 ) 一种与三维培养相组合的transwell微流控芯片及其制备方法, 发明, 2019, 第 1 作者, 专利号: ZL201510873494.9
( 9 ) 一种小型多用途细胞培养及实验装置, 发明, 2019, 第 1 作者, 专利号: ZL201510350560.4
( 10 ) 一种基于微流控芯片的血清糖谱分型方法, 发明, 2019, 第 1 作者, 专利号: ZL201510852581.6
( 11 ) 一种基于微流控芯片的人心脏模型的建立方法, 发明, 2019, 第 1 作者, 专利号: ZL201510869868.X
( 12 ) 一种基于微流控技术建立骨质疏松模型的方法, 发明, 2019, 第 1 作者, 专利号: ZL201510651915.3
( 13 ) 一种利用表面微结构激活星形胶质细胞的方法, 发明, 2020, 第 1 作者, 专利号: CN201410734704.1
( 14 ) 基于微流控技术的复合空腔微纤维的制备方法, 发明, 2020, 第 1 作者, 专利号: CN201611104451.5
( 15 ) 一种基于微流控芯片的细胞双向侵袭监测方法, 发明, 2020, 第 1 作者, 专利号: CN201510652081.8
( 16 ) 一种基于微流控芯片的肾小球体系及其应用, 发明, 2021, 第 1 作者, 专利号: CN201610896833.X
( 17 ) 基于微流控芯片的模拟药物体内代谢过程的肝-肾体系, 发明, 2021, 第 1 作者, 专利号: CN201610893829.8
( 18 ) 基于微流控芯片的模拟药物体内代谢过程的肝-血脑屏障体系, 发明, 2021, 第 1 作者, 专利号: CN201610894829.X
( 19 ) 基于微流控芯片制备复杂形态微纤维的方法及专用芯片, 发明, 2021, 第 1 作者, 专利号: CN201611102522.8
( 20 ) 一种基于物理模版的电纺丝图案化制备方法, 发明, 2021, 第 1 作者, 专利号: CN201611112253.3

出版信息

至今发表SCI论文100余篇,出版著作2 部,国际出版社著作章节5章

发表论文
(1) Controllable Fabrication of Composite CoreShell Capsules at a Macroscale as Organoid Biocarriers, ACS Applied Bio Materials, 2021, 通讯作者
(2) One-Step Generation of Aqueous-Droplet-Filled Hydrogel Fibers as Organoid Carriers Using an All-in-Water Microfluidic System, ACS Applied Materials & Interfaces, 2021, 通讯作者
(3) A flexible microfluidic strategy to generate grooved microfibers for guiding cell alignment, Biomaterials Science, 2021, 通讯作者
(4) Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis, Lab Chip, 2021, 通讯作者
(5) Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoids Engineering, Advanced Science, 2020, 通讯作者
(6) Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-chip System, ACS Biomaterials Science & Engineering, 2020, 通讯作者
(7) Microengineered hiPSC-Derived 3D Amnion Tissue Model to Probe Amniotic Inflammatory Responses under Bacterial Exposure, ACS Biomaterials Science & Engineering, 2020, 通讯作者
(8) Biomimetic Human Disease Model of SARS-CoV-2 Induced Lung Injury and Immune Responses on Organ Chip System, Advanced Science, 2020, 通讯作者
(9) SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip, Science Bulletin, 2020, 通讯作者
(10) HiPSC-derived multi-organoids on chip system for safety assessment of antidepressant drug, Lab Chip., 2020, 通讯作者
(11) Amnion-on-a-chip: modeling human amniotic development in mid-gestation from pluripotent stem cells, Lab Chip, 2020, 通讯作者
(12) A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection, Cell Death and Disease, 2020, 通讯作者
(13) One-step synthesis of composite hydrogel capsules to support liver organoid generation, Biomaterials Science, 2020, 通讯作者
(14) Flexible Generation of Multi-Aqueous Core Hydrogel Capsules Using Microfluidic Aqueous Two-Phase System, Advanced Materials Technologies, 2020, 通讯作者
(15) Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model, Microsystems & Nanoengineering, 2020, 通讯作者
(16) Assessment of Air Pollutant PM2.5 Pulmonary Exposure Using a 3D Lung-on-Chip Model, ACS Biomaterials Science & Engineering, 2020, 通讯作者
(17) Engineering human islet organoids from iPSCs using an organ-on-chip platform, Lab Chip, 2019, 通讯作者
(18) One-Step Generation of Core-Shell Gelatin Methacrylate (GelMA) Microgels Using a Droplet Microfluidic System, Adv. Mater. Technol, 2019, 通讯作者
(19) Simple fabrication of inner chitosan-coated alginate hollow microfiber with higher stability, Journal of Biomedical Materials Research Part B, 2019, 通讯作者
(20) A microfluidic strategy to fabricate ultra-thin polyelectrolyte hollow microfibers as 3D cellular carriers, Materials Science and Engineering: C, 2019, 通讯作者
(21) Integrated microfluidic device for enrichment and identification of circulating tumor cells from the blood of patients with colorectal cancer, DISEASE MARKERS, 2019, 通讯作者
(22) Microfluidic strategies for label-free exosomes isolation and analysis, TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 通讯作者
(23) Microfluidic device for on-chip isolation and detection of circulating exosomes in blood of breast cancer patients, Biomicrofluidics, 2019, 通讯作者
(24) A biomimetic human gut-on-a chip for modeling drug metabolism in intestine, ARTIFICIAL ORGANS, 2019, 通讯作者
(25) A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier, TOXICOLOGY IN VITRO, 2019, 通讯作者
(26) Advances in hydrogels in organoids and organs-on-a-chip, ADVANCED MATERIALS, 2019, 通讯作者
(27) A Microfluidic Strategy for Controllable Generation of Water-in-Water Droplets as Biocompatible Microcarriers, Small, 2018, 通讯作者
(28) In situ differentiation and generation of functional liver organoids from human iPSCs in a 3D perfusable chip system, Lab Chip, 2018, 通讯作者
(29) Human brain organoid-on-a-chip to model prenatal nicotine exposure, Lab Chip, 2018, 通讯作者
(30) Engineering Brain Organoids to Probe Impaired Neurogenesis Induced by Cadmium, ACS Biomaterials Science & Engineering, 2018, 通讯作者
(31) Placental barrier-on-a-chip: modeling placental inflammatory responses to bacterial infection, ACS Biomaterials Science & Engineering, 2018, 通讯作者
(32) Probing the Bi-directional Interaction Between Microgliaand Gliomas in a Tumor Microenvironment on a Microdevice., Neurochem Res, 2017, 通讯作者
(33) Assessment of cadmium-induced nephrotoxicity using a kidney-on-a-chip device., Toxicology Research, 2017, 通讯作者
(34) A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice., Lab on a Chip, 2017, 通讯作者
(35) Drug absorption related nephrotoxicity assessment on an intestine-kidney chip., Biomicrofluidics, 2017, 通讯作者
(36) Bioinspired onion epithelium-like structure promotes the maturation of cardiomyocytes derived from human pluripotent stem cells., Biomaterials Science, 2017, 通讯作者
(37) In situ generation of human brain organoids on a micropillar array., Lab on a Chip, 2017, 通讯作者
(38) Hollow Fiber System for Simple Generation of Human Brain Organoids., Integrative Biology, 2017, 通讯作者
(39) Simple Spinning of Heterogeneous Hollow Microfiber on Chip., Advanced Materials, 2016, 通讯作者
(40) Patterning hypoxic multicellular spheroids in a 3D matrix –a promising method for anti-tumor drug screening, Biotechnology Journal, 2016, 通讯作者
(41) Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice, Integrative Biology, 2016, 通讯作者
(42) Regulating cell behaviors on micropillar topographies affected by interfacial energy, RSC Adv, 2015, 通讯作者
(43) A high efficiency microfluidic-based photocatalytic microreactor using electrospun nanofibrous TiO2 as photocatalyst., Nanoscale, 2015, 通讯作者
(44) Flexible fabrication of shape-controlled collagen building blocks for self-assembly of 3D microtissues, Small, 2015, 通讯作者
(45) Human induced pluripotent stem cell-derived beating cardiac tissues on paper, Lab on a Chip, 2015, 通讯作者
(46) Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy, Oncotarget, 2015, 通讯作者
(47) Microfluidic platform towards point-of-care diagnostics in infectious diseases, Journal of Chromatography A, 2015, 通讯作者
(48) Hypoxia combined with spheroid culture improves cartilage specific function in chondrocytes, Integrative Biology, 2015, 通讯作者
(49) A droplet microchip with substance exchange capability for the developmental study of C. elegans., Lab on a Chip, 2015, 通讯作者
(50) Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-a-induced VCAM-1, ICAM-1and EL expression via the NF-kB pathway, Biochimie, 2015, 通讯作者
(51) Flexible Fabrication of Biomimetic Bamboo-like Hybrid Microfibers, Advanced Materials, 2014, 通讯作者
(52) Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices, Biomaterials, 2014, 通讯作者
(53) Regulation of cell migration and osteogenic differentiation in mesenchymal stem cells under extremely low fluidic shear stress., Biomicrofluidics, 2014, 通讯作者
(54) Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip., Integrative Biology, 2014, 通讯作者
(55) Facile Synthesis of Biomimetic Honeycomb Material with Biological Functionality, Small, 2013, 通讯作者
(56) An integrated microfluidic device for characterizing chondrocyte metabolism in response to distinct levels of fluid flow stimulus., Microfluid Nanofluid, 2013, 通讯作者
(57) High throughput generation and trapping of individual agarose microgel using microfluidic approach, Microfluidics and Nanofluidics, 2013, 通讯作者
(58) Biomimetic tumor microenvironment on a microfluidic platform., Biomicrofluidics, 2013, 通讯作者
(59) A simple microfluidic strategy for cell migration assay in an in-vitro wound healing model., Wound Repair and Regeneration, 2013, 通讯作者
(60) Simple localization of nanofiber scaffolds via SU-8 photoresist and their use for parallel 3D cellular assays., Advanced Materials, 2012, 通讯作者
(61) Flexible Generation of Gradient Electrospinning Nanofibers Using a Microfluidic Assisted Approach., LANGMUIR, 2012, 通讯作者
(62) Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices, Integrative Biology, 2012, 通讯作者
(63) A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime, Lab on a chip, 2012, 通讯作者
(64) Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device., Biomed Microdevices, 2012, 通讯作者
(65) Fast detection of genetic information by an optimized PCR in an interchangeable chip, Biomedical Microdevices, 2012, 通讯作者
(66) Microalgal motility measurement microfluidic chip for toxicity assessment of heavy metals., Anal Bioanal Chem, 2012, 通讯作者
(67) hesis of shape-controlled particles based on synergistic effect of geometry confinement, double emulsion template, and polymerization quenching., Microfluid Nanofluid, 2012, 通讯作者
(68) Electrical control of individual droplet breaking and droplet content extraction, Analytical Chemistry, 2011, 通讯作者
(69) Controllable Synthesis of Anisotropic Elongated Particles Using Microvalve-actuated Microfluidic Approach, Journal of Material chemistry, 2011, 通讯作者
(70) Nanofiber-modified surface directed cell migration and orientation in microsystem., Biomicrofluidics, 2011, 通讯作者
(71) Patterned Paper as a Low-cost, Flexible Substrate for Rapid Prototyping PDMS Microdevices via “liquid molding”, Analytical Chemistry, 2011, 通讯作者
(72) Droplet Microfluidics for Characterizing the Neurotoxin-induced Responses in Individual Caenorhabditis elegans, Lab on a Chip, 2010, 通讯作者
(73) Microvalve and Micropump Controlled Shuttle Flow Microfluidic Device for Rapid DNA Hybridization, Lab on a Chip, 2010, 通讯作者
(74)  Wax-bonding 3D microfluidic chips, Lab on a Chip, 2010, 通讯作者
(75) A microfluidic device integrated with multichamber polymerase chain reaction and multichannel separation for genetic analysis, Analytica Chimica Acta, 2010, 通讯作者
(76) A simple photolithography method for microfluidic device fabrication using sunlight as UV source, Microfluidics and nanofluidics, 2010, 通讯作者
(77) 243. Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device, Lab on a Chip, 2010, 通讯作者
(78) The Effects of Insulin-Like Growth Factor-1 and Basic Fibroblast Growth Factor on the Proliferation of Chondrocytes Embedded in Collagen Gel Using an integrated microfluidic device, Tissue Engineering, 2010, 第 2 作者
(79) 240. Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells, Biomedical Microdevices, 2010, 通讯作者
(80) Fabrication and characterization of paper-based microfluidics prepared in nitrocellulose membrane by wax printing, Analytical Chemistry, 2010, 通讯作者
发表著作
(1) 微流控芯片实验室,  Microfluidc Chip, 科学出版社, 2006-09, 第 2 作者
(2) 《图解版微流控芯片实验室》, illustration of Microfluidc Chip, 科学出版社, 2008-09, 第 2 作者

合作情况

与香港大学, 香港科技大学, 加拿大多伦多大学,美国圣母大学等建立合作关系