基本信息
卫涛涛  男  博导  中国科学院生物物理研究所
电子邮件: weitt@ibp.ac.cn
通信地址: 中科院生物物理所3505房间
邮政编码: 100101

招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
生物膜动态变化、稳态维持的分子机制与重大疾病

教育背景

1996-09--1999-06   中国科学院生物物理研究所   博士
1993-09--1996-07   湖北省化学研究所   硕士
1989-09--1993-06   华中理工大学(现华中科技大学)   学士

工作经历

   
工作简历
2008-03~现在, 中国科学院生物物理研究所, 研究员
2001-02~2008-03,中国科学院生物物理研究所, 副研究员
1999-07~2001-02,中国科学院生物物理研究所, 助理研究员
1996-09~1999-06,中国科学院生物物理研究所, 博士
1993-09~1996-07,湖北省化学研究所, 硕士
1989-09~1993-06,华中理工大学(现华中科技大学), 学士
社会兼职
2017-12-31-今,生物化学与生物物理进展, 常务编委
2017-11-01-今,中国生物物理学会, 理事
2015-12-31-今,中国生物物理学会膜生物学分会, 理事、秘书长
2015-01-01-今,中国抗癌协会纳米肿瘤学专业委员会, 委员
2012-10-30-今,中国生物物理学会自由基生物学分会, 理事
2004-12-01-今,中华预防医学会自由基预防医学专业委员会, 常务委员

教授课程

科研论文写作
细胞生物学

专利与奖励

   
奖励信息
(1) 国家级一流本科课程, , 国家级, 2020
(2) 中国科学院大学生命科学学院精品课程, 研究所(学校), 2019

出版信息

   
发表论文
(1) PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition., European Journal of Pharmacology, 2021, 通讯作者
(2) KAP1-associated transcriptional inhibitory complex regulates C2C12 myoblasts differentiation and mitochondrial biogenesis via miR-133a repression., Cell Death and Disease, 2020, 通讯作者
(3) Airway relaxation mechanisms and structural basis of osthole to improve lung function in asthma., Science Signaling, 2020, 通讯作者
(4) Genetically Encoded FapR-NLuc as a Biosensor to Determine Malonyl-CoA in Situ at Subcellular Scales, Bioconjugate Chemistry, 2019, 通讯作者
(5) 14-3-3 proteins recognize phosphorylated TFEB by a non-canonical mode for controlling TFEB cytoplasmic localization, Autophagy, 2019, 通讯作者
(6) Transforming growth factor (TGF)-β1-induced miR-133a inhibits myofibroblast differentiation and pulmonary fibrosis., Cell Death & Disease, 2019, 通讯作者
(7) Detection of tBid oligomerization and membrane permeabilization by graphene-based single-molecule surface-induced fluorescence attenuation, Nano Letters, 2019, 通讯作者
(8) Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms., Biochemical and Biophysical Research Communications, 2018, 通讯作者
(9) Human Elongation Factor 4 regulates cancer bioenergetics by acting as a mitochondrial translation switch., Cancer Research, 2018, 通讯作者
(10) SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice, EBioMedicine, 2018, 通讯作者
(11) Prediction of protein lysine acylation by integrating primary sequence information with multiple functional features., Journal of Proteome Research, 2016, 通讯作者
(12) Interactions of graphene with mammalian cells: Molecular mechanisms and biomedical insights., Advanced Drug Delivery Reviews, 2016, 通讯作者
(13) ESeroS-GS protects neuronal cells from oxidative stress by stabilizing lysosomes., Molecules, 2016, 通讯作者
(14) Phorbol myristate acetate suppresses breast cancer cell growth via down-regulation of P-Rex1 expression., Protein & Cell, 2016, 通讯作者
(15) Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I., Free Radical Biology & Medicine, 2015, 通讯作者
(16) Lysine malonylation is elevated in type 2 diabetic mouse models and enriched in metabolic associated proteins., Molecular & Cellular Proteomics, 2015, 通讯作者
(17) Inhibition of cancer cell migration by gold nanorods: molecular mechanisms and implications for cancer therapy., Advanced Functional Materials, 2014, 通讯作者
(18) The α-tocopherol derivative ESeroS-GS induces cell death and inhibits cell motility of breast cancer cells through the regulation of energy metabolism., European Journal of Pharmacology, 2014, 通讯作者
(19) Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets., Biomaterials, 2014, 通讯作者
(20) Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin., Protein & Cell, 2014, 通讯作者
(21) Inputs and outputs of insulin receptor., Protein & Cell, 2014, 通讯作者
(22) The inhibition of migration and invasion of cancer cells by graphene via the impairment of mitochondrial respiration., Biomaterials, 2014, 通讯作者
(23) Hydrogen peroxide impairs autophagic flux in a cell model of nonalcoholic fatty liver disease., Biochemical and Biophysical Research Communications, 2013, 通讯作者
(24) Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase., Protein Cell, 2013, 通讯作者
(25) Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis., Journal of Lipid Research, 2012, 通讯作者
(26) The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways., Biomaterials, 2012, 通讯作者
(27) TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death., Biochimica et Biophysica Acta Molecular Cell Research, 2012, 第 4 作者
(28) The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways., Biomaterials, 2012, 第 4 作者
(29) 质膜钙离子ATP酶, Plasma membrane calcium ATPase., 生物物理学报, 2012, 通讯作者
(30) 神经型一氧化氮合酶的活性调控, The regulation of neuronal nitric oxide synthase activity., 生物物理学报, 2012, 通讯作者
(31) 溶酶体与细胞凋亡, Lysosomes and apoptosis., 生命科学, 2011, 通讯作者
(32) The inhibition of death receptor mediated apoptosis through lysosome stabilization following internalization of carboxyfullerene nanoparticles., Biomaterials , 2011, 通讯作者
(33) ESeroS-GS modulates lipopolysaccharide-induced macrophage activation by impairing the assembly of TLR-4 complexes in lipid rafts., Biochimica et Biophysica Acta Molecular Cell Research , 2011, 通讯作者
(34) Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid., Cellular and Molecular Life Sciences , 2010, 通讯作者
(35) Induction of inducible nitric oxide synthase increases the production of reactive oxygen species in RAW264.7 macrophages., Bioscience Reports, 2010, 通讯作者
(36) Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4., Cancer Research, 2009, 第 3 作者
(37) Chymotrypsin B Cached in Rat Liver Lysosomes and Involved in Apoptotic Regulation through a Mitochondrial Pathway.,  The Journal of Biological Chemistry, 2008, 第 3 作者
(38) Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-b1–42., Journal of Pineal Research, 2008, 通讯作者
(39) The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis., Nanotechnology , 2008, 通讯作者
发表著作
( 1 ) 纳米酶学, Nanozymology, Springer Nature, 2020-01, 第 3 作者

科研活动

   
科研项目
( 1 ) 功能纳米材料与肿瘤间质细胞的相互作用, 主持, 国家级, 2012-01--2016-12
( 2 ) 生物膜转运及其调控机制的研究, 参与, 国家级, 2010-01--2014-12
( 3 ) 溶酶体胰凝乳蛋白酶的新功能探索, 主持, 国家级, 2011-01--2013-12
( 4 ) 线粒体丙酮酸转运复合物作为抗糖尿病药物新靶标的发现与确证, 主持, 部委级, 2018-01--2019-12
( 5 ) 铁基纳米材料类酶效应与急性髓系白血病诊疗技术, 参与, 国家级, 2017-07--2022-06
( 6 ) 蛋白质丙二酰化修饰调控肿瘤细胞糖酵解的机制研究, 主持, 国家级, 2017-01--2020-12
( 7 ) 膜脂-蛋白质相互作用介导溶酶体膜通透的机制研究, 主持, 国家级, 2015-01--2018-12
( 8 ) 溶酶体参与能量与物质代谢稳态调控的蛋白质机器, 主持, 国家级, 2019-11--2024-10
( 9 ) 线粒体互作网络调控线粒体稳态并参与乳腺癌发生发展的机制研究, 主持, 国家级, 2021-01--2023-12