071009-细胞生物学
071011-生物物理学

生物大分子药物输送系统及免疫应答机制
溶酶体在维持蛋白质平衡中的作用

1997-09--2000-09   上海医药工业研究院   博士
1994-09--1997-06   沈阳药科大学   药剂学硕士

   

2003-10~现在, 中科院生物物理研究所, 副研究员，研究员
2001-12~2003-10,Harvard University and Northeastern University, Research Associate
2000-11~2001-12,University of Minnesota, Postdoctoral fellow

2015-03-16-2019-03-16,中国药学会纳米药物专业委员会, 委员
2013-11-30-2017-10-31,中国生物物理学会第十届理事会, 理事
2011-06-01-今,生物物理学会分子影像学专业委员会, 副主任委员
2009-07-01-2013-06-30,生物物理学学会第九届理事会, 理事

生物技术药物
SAXS在生物学中的应用

   

（1） 国家科学技术奖, 二等奖, 国家级, 2012
（2） 中国专利优秀奖, , 部委级, 2010
（3） 2009年中国科学院“优秀研究生指导教师”, , 院级, 2009
（4） 中国药学会科学技术奖，药物的新型纳米输送系统研究, 二等奖, 其他, 2008

（ 1 ）  一种PEG衍生化磷脂包载的前列腺素E1的胶束制剂, 发明, 2010, 第 1 作者, 专利号: ZL200810105113.2
（ 2 ） 聚乙二醇衍生化磷脂包载的蒽环类抗肿瘤抗生素纳米胶束制剂, 发明, 2010, 第 1 作者, 专利号: ZL200510059621.8
（ 3 ） 柚皮素和柚皮苷作为转化生长因子-β1信号通路抑制剂的应用, 发明, 2014, 第 1 作者, 专利号: 特许第5484320号
（ 4 ） Use of Naringenin and Naringin as Inhibitors for Transforming Growth Factor-β1 Signaling Pathway, 发明, 2014, 第 1 作者, 专利号: European Paten No 2163247

   

[1] Yin, Xiaozhe, Zeng, Wenfeng, Wu, Bowen, Wang, Luoyang, Wang, Zihao, Tian, Hongjian, Wang, Luyao, Jiang, Yunhan, Clay, Ryan, Wei, Xiuli, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Jin, Lingtao, Liang, Wei. PPAR alpha Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction. CELL REPORTS[J]. 2020, 33(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000582719300008.
[2] Wang, Luyao, Wang, Zihao, Qin, Yan, Liang, Wei. Delivered antigen peptides to resident CD8 alpha(+) DCs in lymph node by micelle-based vaccine augment antigen-specific CD8(+) effector T cell response. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS[J]. 2020, 147: 76-86, https://www.webofscience.com/wos/woscc/full-record/WOS:000510313900008.
[3] Wang, Luoyang, Zeng, Wenfeng, Wang, Luyao, Wang, Zihao, Yin, Xiaozhe, Qin, Yan, Zhang, Fayun, Zhang, Chunling, Liang, Wei. Naringenin Enhances the Antitumor Effect of Therapeutic Vaccines by Promoting Antigen Cross-Presentation. JOURNAL OF IMMUNOLOGY[J]. 2020, 204(3): 622-631, https://www.webofscience.com/wos/woscc/full-record/WOS:000508649800014.
[4] Zhang, Chao, Zeng, Wenfeng, Yao, Yi, Xu, Bin, Wei, Xiuli, Wang, Luoyang, Yin, Xiaozhe, Barman, Apurba Kumar, Zhang, Fayun, Zhang, Chunling, Song, Qibin, Liang, Wei. Naringenin Ameliorates Radiation-Induced Lung Injury by Lowering IL-1 beta Level. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS[J]. 2018, 366(2): 341-348, https://www.webofscience.com/wos/woscc/full-record/WOS:000442126300012.
[5] Guan, Xiaoyang, Chaffey, Patrick K, Wei, Xiuli, Gulbranson, Daniel R, Ruan, Yuan, Wang, Xinfeng, Li, Yaohao, Ouyang, Yan, Chen, Liqun, Zeng, Chen, Koelsch, Theo N, Tran, Amy H, Liang, Wei, Shen, Jingshi, Tan, Zhongping. Chemically Precise Glycoengineering Improves Human Insulin. ACS CHEMICAL BIOLOGY[J]. 2018, 13(1): 73-81, https://www.webofscience.com/wos/woscc/full-record/WOS:000423252600008.
[6] Han, Qiusen, Wang, Xinhuan, Jia, Xinghang, Cai, Shuangfei, Liang, Wei, Qin, Yan, Yang, Rong, Wang, Chen. CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy. NANOSCALE[J]. 2017, 9(18): 5927-5934, http://dx.doi.org/10.1039/c7nr01460k.
[7] Liu, Zhida, Zhou, Chang, Qin, Yan, Wang, Zihao, Wang, Luyao, Wei, Xiuli, Zhou, Yinjian, Li, Qicheng, Zhou, Hang, Wang, Wenjun, Fu, YangXin, Zhu, Mingzhao, Liang, Wei. Coordinating antigen cytosolic delivery and danger signaling to program potent cross-priming by micelle-based nanovaccine. CELL DISCOVERY[J]. 2017, 3: 17007-, http://dx.doi.org/10.1038/celldisc.2017.7.
[8] Wei Liang. Naringenin Ameliorates Acute Inflammation by Regulating Intracellular Cytokine Degradatio. the Journal of Immunology. 2017, [9] Fang, Xiaocui, Yang, Tao, Wang, Luoyang, Yu, Jibing, Wei, Xiuli, Zhou, Yinjian, Wang, Chen, Liang, Wei. Nano-cage-mediated refolding of insulin by PEG-PE micelle. BIOMATERIALS[J]. 2016, 77: 139-148, http://www.corc.org.cn/handle/1471x/2176433.
[10] Fayun Zhang, Wenjuan Dong, Wenfeng Zeng, Lei Zhang, Chao Zhang, Yuqi Qiu, Luoyang Wang, Xiaozhe Yin, Chunling Zhang, Wei Liang. Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation. BREAST CANCER RESEARCH : BCR. 2016, 18: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818388/.
[11] Dong, Wenjuan, Wei, Xiuli, Zhang, Fayun, Hao, Junfeng, Huang, Feng, Zhang, Chunling, Liang, Wei. A dual character of flavonoids in influenza A virus replication and spread through modulating cell-autonomous immunity by MAPK signaling pathways. SCIENTIFIC REPORTS[J]. 2014, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000346254800002.
[12] Wei Liang. Poly(ethylene glycol)-mediated conformational alteration of α-chymotrypsin prevents inactivation of insulin by stabilizing active intermediates. Mol Pharm. Mol Pharm. 2014, [13] Qin, Lei, Zhang, Fayun, Lu, Xiaoyan, Wei, Xiuli, Wang, Jing, Fang, Xiaocui, Si, Duanyun, Wang, Yiguang, Zhang, Chunling, Yang, Rong, Liu, Changxiao, Liang, Wei. Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors. JOURNAL OF CONTROLLED RELEASE[J]. 2013, 171(2): 133-142, http://dx.doi.org/10.1016/j.jconrel.2013.07.005.
[14] Wang, Jing, Wang, Yiguang, Liang, Wei. Delivery of drugs to cell membranes by encapsulation in PEG-PE micelles. JOURNAL OF CONTROLLED RELEASE[J]. 2012, 160(3): 637-651, http://dx.doi.org/10.1016/j.jconrel.2012.02.021.
[15] Wang, Jing, Fang, Xiaocui, Liang, Wei. Pegylated Phospholipid Micelles Induce Endoplasmic Reticulum-Dependent Apoptosis of Cancer Cells but not Normal Cells. ACS NANO[J]. 2012, 6(6): 5018-5030, http://www.irgrid.ac.cn/handle/1471x/756882.
[16] Du, Gangjun, Jin, Lingtao, Han, Xiaofen, Song, Zihui, Zhang, Hongyan, Liang, Wei. Naringenin: A Potential Immunomodulator for Inhibiting Lung Fibrosis and Metastasis. CANCER RESEARCH[J]. 2009, 69(7): 3205-3212, http://www.irgrid.ac.cn/handle/1471x/757780.
[17] Tang, Ning, Du, Gangjun, Wang, Nan, Liu, Chunchun, Hang, Haiying, Liang, Wei. Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE[J]. 2007, 99(13): 1004-1015, https://www.webofscience.com/wos/woscc/full-record/WOS:000248118900008.

（ 1 ） 药用生物纳米材料, Biological and Pharmaceutical Nanomaterials, 科学出版社, 2009-09, 第 1 作者

   

（ 1 ） 纳米材料的自组装及其在生物体内转运机制的研究, 主持, 国家级, 2008-12--2011-12
（ 2 ） 纳米药物的临床安全性和有效性评价, 主持, 部委级, 2014-07--2018-06
（ 3 ） YPS345治疗放化疗引起的肺损伤的合作开发, 主持, 院级, 2016-05--2019-12

（1）PEG-PE micelle based vaccine for treatment of HPV positive cervical carcinoma   2016-04-20
（2）PEG-PE micelle mediated refolding of insulin   2015年中国药物制剂大会   2015-09-26
（3）基于聚合物胶束的生物大分子药物纳米输送系统   2013年中国药物制剂大会   2013-10-26
（4）Fast crossing cell membrane of doxorubicin by encapsulated into PEG-PE micelles   的第十一次全国暨第二次国际膜生物学研讨会   Jiang Wang, Wei Liang   2010-11-09

已指导学生

张玲  02  19184  

曲卉  02  19183  

唐宁  01  19183  

陆晓燕  01  19184  

金凌涛  01  19184  

秦蕾  01  19184  

曾文峰  01  19184  

王静  01  19184  

方小翠  01  19182  

于继兵  01  19182  

周畅  01  19182  

现指导学生

张超  01  19182  

尹晓哲  02  19183  

路路  02  63228  

王洛洋  01  19182  

杨韬  01  19182  

李浩  02  19182  

郑楠  02  19182  

王路瑶  01  19182  

王子昊  01  19182  

郑子峰  02  19182  

何奕霏   02  19182