General

Professor Quan Chen,

Institute of Zoology, Chinese Academy of Sciences
Email: chenq@ioz.ac.cn
Telephone: 01064807321
Address: 1 Beichen West Road,  Chaoyang District, Beijing, China
Postcode: 100101

Research Areas

  1. Molecular regulation of mitochondrial apoptosis
  2. Molecular regulation of mitochondrial autophagy  and dynamics
  3. Circulating cancer stem cells in cancer metastasis and therapy

Education

1981-1985  B.S. in Biology,  Department of Biology, Hubei University, China 

1987-1990    MSc. in Cell Biology , Institute of Kunming Zoology,Chinese Academy of Sciences.

1990-1993    Ph.D. in Cell Biology, Institute of Zoology, Chinese Academy of Sciences.


Experience

   
Work Experience

2000- Present  Professor of the State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences.

2007- Present  Adjunct Professor of College of Life Sciences, Nankai University, Tianjin, China.

2007-2011       Deputy Dean of College of Life Sciences, Nankai University, Tianjin, China.

2003-2011       Director of the State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences.

1997-2000      Research Fellow, Department of Cancer Biology, Lerner Research Institute and Department of Radiation Oncology,

                        The Cleveland Clinic Foundation, Cleveland, Ohio.

1994-1997       Research Associate, Department of Molecular and Cellular Pharmacology, School of Biological Sciences,

                                     University of Manchester, England, UK.

               1993-1994       Research Assistant, State Key Laboratory of Membrane Biology, Institute of Zoology Chinese Academy of Sciences.


Publications

   
Papers

Selected papers

  1. Ma B, Cheng H, Chen L, Mu C, Gao R, Wu S, Chen Q, Zhu Y*. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signaling pathways. Nature Communication, 7:11123, 2016.
  2. Chen M, Chen ZH, Wang YY, Tan Z, Zhu CZ, Li YJ, Han Z, Chen LB, Gao RZ, Liu L*, Chen Q*. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy, 12(4):1-14, 2016.
  3. Ma B, Chen Y, Chen L, Cheng HC, Mu C, Li J, Gao R, Zhou C, Cao L, Liu J , Zhu Y*, Chen Q*, Wu S* Hypoxia regulates Hippo signaling through the SIAH2 ubiquitin E3 ligase. Nature Cell Biology, 171:95–103, 2015.
  4.  Chen G, Han Z., Feng D, Chen YF, Chen LB, Wu H, Huang L, Zhou CQ, Cai XY, Fu CY, Duan LW, Wang XH, Liu L, Liu XQ, Shen YQ, Zhu YS*, Chen, Q*. A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Molecular Cell, 54: 362-377, 2014.
  5. Yue W, Chen ZH, Liu HY, Yan C, Chen M, Feng D, Yan C, Wu H, Du L, Wang YY, Liu JH, Huang XH, Xia LX, Liu L., Wang XH., Jin HJ, Wang J, Song ZY, Hao XJ*, Chen Q*. A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Research, 24(4):482-96, 2014.
  6. Du L, Rao G, Wang H, Li B, Tian W, Cui JT, He L, Laffin B, Tian X, Hao C, Liu H, Sun X, Zhu Y, Tang DG, Mehrpour M, Lu Y*, Chen Q*.CD44-positive cancer stem cells expressing cellular prion protein contribute to metastatic capacity in colorectal cancer, Cancer Research, 73(8): 2682-2694 (cover) , 2013.
  7.  Lei Liu, Du Feng, Guo Chen, Ming Chen, Qiaoxia Zheng, Pingping Song, Qi Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi, Lei Huang, Peng Xue, Baowei Li, Xiaohui Wang, Haijing Jin, Jun Wang, Fuquan Yang, Pingsheng Liu, Yushan Zhu, Senfang Sui & Quan Chen*. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cellsNature Cell Biology, 14 (2):177-185, 2012.
  8. Wang HX, Song PP, Du L, Tian WL, Yue W, Liu M, Li DW, Wang B, Zhu YS, Zhou J*, Chen Q* . Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson’s disease. Journal of Biological Chemistry286(13):11649-58, 2011
  9. Zhang J., Liu WH, Liu JC, Xiao WM, Liu L, Jiang CS, Sun X, Liu PS, Zhu YS, Zhang CM, and Chen Q* . G protein β2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nature Communications, 1, 101-110, 2010.
  10. Du L, Wang H, He L, Zhang J, Ni B, Wang X, Jin H, Cahuzac N, Mehrpour M, Lu Y*, Chen Q*. CD44 is of functional importance for colorectal cancer stem cell. Clinical Cancer research, 14, 6751-6760, 2008.