071005-微生物学
086000-生物与医药

KSHV潜伏机制研究
高通量病原体检测技术研究
HBV及肝癌研究

1998-09--2001-06   中南大学湘雅医学院   博士
1995-09--1998-06   重庆医科大学   硕士
1989-09--1994-06   重庆医科大学临床医学系   学士

   

2006-08~现在, 中国科学院上海巴斯德研究所, 研究员，课题组长，副所长，诊断中心主任
2002-05~2006-08,美国宾夕法尼亚大学, 博士后
1998-09~2001-06,中南大学湘雅医学院, 博士
1995-09~1998-06,重庆医科大学, 硕士
1994-07~1995-08,四川省屏山县人民医院, 住院医师
1989-09~1994-06,重庆医科大学临床医学系, 学士

2015-01-01-今,JMV副主编,
2014-12-19-今,IHW科学顾问,
2014-11-03-今,病理生理学常委,
2014-09-06-今,JV编委,

高级免疫学与病毒学系列讲座

   

（1） 万人计划领军人才, 国家级, 2016
（2） 科技部中青年科技创新领军人才（国家创新人才推进计划）, 国家级, 2015
（3） 上海市领军人才, 省级, 2015
（4） 上海市先进工作者, 省级, 2015
（5） 国家杰出青年科学基金, , 部委级, 2014
（6） 药明康德生命化学研究奖（学者奖）, , 其他, 2012
（7） 国务院政府特殊津贴, , 国家级, 2011
（8） 明治乳业生命科学奖, , 专项, 2010
（9） 赛诺菲安万特-上海青年人才奖, , 其他, 2009
（10） “新世纪百千万人才工程”, , 国家级, 2009
（11） 上海市浦江人才计划, , 市地级, 2008
（12） 中国科学院****, , 院级, 2006

   

（1） Genome-wide mapping of the binding sites and structural analysis of KSHV vIRF2 reveal it is a DNA-binding transcription factor., J Virol, 2015, 通讯作者
（2） Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7., J Virol., 2015, 通讯作者
（3） Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88., J Virol., 2015, 通讯作者
（4） Oncogenic Herpesvirus KSHV Hijacks BMP-Smad1-Id Signaling to Promote Tumorigenesis., PLoS Pathog., 2014, 通讯作者
（5） Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice, J Virol., 2014, 通讯作者
（6） Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency., J Virol., 2014, 通讯作者
（7） Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus., J Virol., 2014, 通讯作者
（8） Latency-Associated Nuclear Antigen of Kaposi Sarcoma-Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1, Cancer Res, 2014, 通讯作者
（9） Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection, J Virol, 2014, 通讯作者
（10） Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses., Emerging Microbes and Infections., 2013, 通讯作者
（11） The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor β (TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia. , J Biol Chem, 2013, 通讯作者
（12） Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma., Protein Cell., 2013, 通讯作者
（13） Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-Jκ and Are Responsible for LANA-Mediated RTA Repression. , J Virol, 2012, 通讯作者
（14） Kaposi sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5., J Virol, 2012, 通讯作者
（15） MicroRNAs and unusual small RNAs discovered in Kaposi s sarcoma-associated herpesvirus virions., J Virol. , 2012, 通讯作者
（16） Looking at Kaposi Sarcoma-Associated Herpesvirus Host Interactions from a microRNA Viewpoint, Front Microbiol., 2011, 通讯作者
（17） Kaposi sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65, J Virol, 2011, 通讯作者
（18） A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKε, Cell Res., 2011, 通讯作者
（19） miR-K12-7-5p encoded by Kaposi sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA., Plos one, 2011, 通讯作者
（20） Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposis sarcoma-associated herpesvirus., J Virol, 2010, 通讯作者
（21） Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor., Cancer Biol Ther, 2009, 第 1 作者
（22） Kaposi sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element. , viology, 2008, 通讯作者
（23） Detection of Epstein-Barr virus in T-cell prolymphocytic leukemia cells in vitro, J Clin Virol, 2008, 第 1 作者
（24） Kaposi sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein., Proc Natl Acad Sci U S A., 2007, 第 1 作者
（25） Epstein-Barr Virus (EBV): infection, propagation, quantitation, and storage. , Curr Protoc Microbiol, 2007, 第 1 作者
（26） Activated Notch1 Is Critical for Proliferation of KSHV Associated B Lymphoma Cell Lines in vitro, J Virol, 2006, 第 1 作者
（27） Intracellular- activated Notch1 can reactivate Kaposi sarcoma-associated herpesvirus from latency. , Virology, 2006, 第 1 作者
（28） Induction of KSHV Latency Associated Nuclear Antigen by the Lytic Transactivator RTA: A Novel Mechanism for Establishment of Latency., J Virol , 2005, 第 1 作者
（29） KSHV Reactivation is Regulated by Interaction of LANA with RBP-Jk, the Major Downstream Effector of the Notch Signaling Pathway.,  J Virol, 2005, 第 1 作者
（30） Kaposi’s Sarcoma- Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency.,  J Virol., 2004, 第 1 作者

   

（ 1 ） TLE2与卡波氏肉瘤病毒蛋白RTA相互作用功能意义, 负责人, 国家任务, 2010-01--2012-12
（ 2 ） KSHV潜伏感染的分子机制研究, 负责人, 国家任务, 2011-01--2015-12
（ 3 ） 呼吸系统与中枢神经系统病毒病, 负责人, 国家任务, 2009-01--2011-08
（ 4 ） HIV对KSHV生命周期调控机制的研究, 负责人, 地方任务, 2007-09--2011-08
（ 5 ） 肿瘤病毒致瘤机制研究, 负责人, 其他国际合作项目, 2008-06--2011-07
（ 6 ） 卡波氏肉瘤相关疱疹病毒潜伏感染, 负责人, 国家任务, 2013-01--2017-12
（ 7 ） 疱疹病毒感染与致病过程中蛋白质机器的功能机制, 负责人, 国家任务, 2016-06--2021-05
（ 8 ） KSHV潜伏感染与致瘤机制, 负责人, 国家任务, 2015-01--2019-12
（ 9 ） Versatile functions of LANA in KSHV pathogenesis, 负责人, 其他国际合作项目, 2015-03--2019-02
（ 10 ） 卡波氏肉瘤相关疱疹病毒（KSHV）基因组在卡波氏肉瘤组织中的表观遗传修饰研究, 负责人, 国家任务, 2014-01--2016-12

（1）KSHV RTA Hijacks WNT pathway to up-regulate JAG1 and laterally inhibits viral reactivation in neighboring cells   2015-10-13
（2）Towards, better undestanding of KSHV latency and oncogenesis.   2014-09-09
（3）Oncogenic Herpesvirus KSHV Hijacks Bmp-Smad1-ID Signaling To Promote Tumorigenesis   2014-07-25
（4）Latency Associated Nuclear Antigen of Kaposi's Sarcoma Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1.   2013-06-29
（5）Small Regulatory RNAs discovered in kaposi's sarcomaassociated herpesvirus virions.    2012-09-13
（6）A KSHVencoded microRNA attenuates TGFbeta signaling through suppression of SMAD5    2011-08-10
（7）A KSHV encoded miRNA attenuates interferon signalling and contributes to viral latency maintenance by targeting    2010-08-29
（8）The cellular corepressor TLE2 inhibits Replication and Transcription activator mediated transactivation and lytic reactivation of Kaposi's sarcoma associated herpesvirus    2009-09-13