真菌被广泛应用于医药、食品、能源和轻工等诸多领域。里氏木霉具有强大的蛋白合成与分泌能力，酿酒酵母与米曲霉为天然产物生物合成的优良底盘细胞。周志华课题组近期的研究目标为：解析植物与真菌天然化合物的合成途径及挖掘与功能鉴定相关生物元件，研究并改造真菌底盘细胞中蛋白质和次生代谢产物合成的调控网络，实现植物与真菌天然化合物和高附加值的蛋白质产品于真菌底盘细胞中的高效合成。主要研究方向包括：（1）解析植物与真菌天然化合物的合成途径；（2）催化元件的规模化挖掘、功能鉴定、改造及催化机制研究；（3）里氏木霉中蛋白质合成与分泌调控机制的研究及其改造及其于高附加值的蛋白质产品的应用；（４）重要植物或真菌天然化合物的真菌细胞工厂的设计、构建与适配性优化。

（1）招收微生物学、分子生物学、生物工程、酶工程、代谢工程及合成生物学领域的硕博连读生、博士生和专业硕士生；

（2）招收国际博士研究生，要求具有微生物分子生物学及遗传学的理论知识及研究基础，对酶工程、代谢工程及合成生物学方向有浓厚的兴趣；

071005-微生物学

2004年12月-2020年4月受聘于中国科学院上海生命科学院植物生理生态研究所

2020年5月至今：中国科学院分子植物科学卓越创新中心

2005年入选中科院****，同年入选上海市浦江人才计划。2007年获中科院****择优支持。2011年-2016年973项目的合成生物专项的课题组长，2018年-2023年国家重点研发计划’合成生物专项’的首席科学家。多年来在真菌分子遗传与合成生物学领域开展研究，在稀有人参皂苷和淫羊藿苷的生物合成方面率先形成了从生物合成路线探索、合成元件挖掘表征、细胞工厂One-Port合成到元件途径优化和产物产量提高的合成生物学创新链；近年来负责组织院内多家单位合作构建了中科院合成生物学元件与数据库，为天然化合物的合成生物学研究与应用提供技术支撑；在国际上率先构建了丝状真菌的基因组编辑系统，设计与改造了多种丝状真菌底盘细胞，应用于天然化合物或蛋白质的合成，并解析丝状真菌里氏木霉的蛋白合成与分泌调控机制。在Cell Research, Molecular plant, Science Bulletin, Metabolic Engineering, Cell Discovery, Molecular Microbiology等重要国际期刊上发表80多篇论文。在生物元件的创制方面已获得专利授权10多项，其中获得1项美国、2项日本、1项韩国和1项印度的授权专利，多项研究成果已经转让国内的医药企业。

合成生物学与系统生物学

1.    Li C#, Yan X#, Xu Z#, Wang Y, Shen X, Zhang L, Zhou Z*, Wang P*. Pathway elucidation of   bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae. Communications biology 2022, 5: 775.

2.  Jiang, Y. G.;  Ma, J. F.;  Wei, Y. J.;  Liu, Y. N.;  Zhou, Z. H.;  Huang, Y. P.;  Wang, P. P.; Yan, X., De novo biosynthesis of sex pheromone components of Helicoverpa armigera through an artificial pathway in yeast. Green Chem 2022, 24 (2), 767-778.

3.   Xiaodong Li, Yinmei Wang, Zhenjun Fan, Yan Wang, Pingping Wang*, Xing Yan*, Zhihua Zhou*. High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae. Metabolic Engineering 2021, 66: 87-97;

4.  Pingping Wang#, Chaojing Li#, Xiaodong Li#, Wenjun Huang#, Yan Wang, Jiali Wang, Yanjun Zhang, Xiaoman Yang, Xing Yan*, Ying Wang* and Zhihua Zhou*. Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli. Science Bulletin (2021) doi: 10.1016/j.scib.2021.03.002

 5. Pingping Wang, Jiali Wang, Guoping Zhao, Xing Yan*, Zhihua Zhou*. Systematic optimization of the yeast cell factory for sustainable and high efficiency production of bioactive ginsenoside Compound K. Synthetic and Systems Biotechnology 2021, 6: 69-76;

6.  Shunxing Chai, Zhihua Zhu, Ernuo Tian, Meili Xiao, Yan Wang, Gen Zou*&Zhi-hua Zhou1*. Building a Versatile Protein Production Platform Using Engineered Trichoderma reesei. ACS Synthetic Biology 2022, 11(1) : 486-496

7.   Yu, L., Xiao, M., Zhu, Z., Wang, Y., Zhou, Z., Wang, P., & Zou, G.. Efficient genome editing in Claviceps purpurea using a CRISPR/Cas9 ribonucleoprotein method. Synthetic and Systems Biotechnology 2022, 7(2), 664-670.

8.  Zhenjun Fan#, Yan Wang#, Chengshuai Yang, Zhihua Zhou, Pingping Wang*, Xing Yan*. Identification of a novel multifunctional oxidosqualene cyclase from Zea mays sheds light on the biosynthetic pathway of three pentacyclic triterpenoids. Synthetic and Systems Biotechnology 2022, 7(4):1167–1172.

9  Hongguan Xing, Pingping Wang, Xing Yan, Yi Yang, Xinliang Li, Rui Liu, Zhihua Zhou*, Thermostability enhancement of Escherichia coli phytase by error-prone polymerase chain reaction (epPCR) and site-directed mutagenesis, Front bioeng biotechnology 2023, 11:1167530. doi: 10.3389/fbioe.2023.1167530.

10.   Hongguan Xing#, Liyan Zhu#, Pingping Wang , Guoping Zhao , Zhihua Zhou , Yi Yang , Hong Zou ,Xing Yan. Display of receptor-binding domain of SARS-CoV-2 Spike protein variants on the Saccharomyces cerevisiae cell surface. Front Immunol 2022, 13, 935573.

11. Hongguan Xing, Gen Zou, Chunyan Liu, Shunxing Chai, Xing Yan, Xinliang Li, Rui Liu, Yi Yang, Zhihua Zhou*. Improving the thermostability of a GH11 xylanase by directed evolution and rational design guided by B-factor analysis. Enzyme and Microbial Technology 2021（143）：109720.

12. Gen Zou#,  Meili Xiao#,  Shunxing Chai,  Zhihua Zhu,  Ying Wang and Zhihua Zhou*. Efficient genome editing in filamentous fungi via an improved CRISPR-Cas9 ribonucleoprotein method facilitated by chemical reagents. Microb Biotechnol (2020) doi: 10.1111/1751-7915.13652.  

13. Gen Zou#, Dapeng Bao#, Ying Wang#, Sichi Zhou , Meili Xiao, Zhanshan Yang, Yinmei Wang, Zhihua Zhou*. Alleviating product inhibition of Trichoderma reesei cellulase complex with a product-activated mushroom endoglucanase. Bioresour Technol (2020) 319:124119. doi: 10.1016/j.biortech.2020.124119.

14.     Gen Zou and Zhihua Zhou*. CRISPR/Cas9-Mediated Genome Editing of Trichoderma reesei. Methods in Molecular Biology (2020) 2234: 87-99.

15.     ChengshuaiYang，Chaojing Li, Wei Wei1 , Yongjun Wei, Qunfang Liu, Guoping Zhao, JianminYue, XingYan*, Pingping Wang* and Zhihua Zhou*. The unprecedented diversity of UGT94 family UDP glycosyltransferases in Panax plants and their contribution to ginsenoside biosynthesis. Scientific Reports（2020）10：1-11.

16.     Yongjun Wei, Yuqian Wu, Lei Zhang, Zhihua Zhou , Haokui Zhou * and Xing Yan*，Genome recovery and metatranscriptomic confirmation of functional acetate-oxidizing bacteria from enriched anaerobic biogas digesters，Environmental Pollution，265，1-10.

17.     Yu Ping^#, Xiaodong Li^#, Baofu Xu, Wei Wei, Wenping Wei, Guoyin Kai, ZhiHua Zhou*, and Youli Xiao*, Building Microbial Hosts for Heterologous Production of N-methylpyrrolinium, ACS Synthetic Biology，2019，DOI: 10.1021/acssynbio.8b00483 

18.     Yu Ping#, Xiaodong Li#, Wenjing You#, Guoqiang Li#, Mengquan Yang, Wenping Wei, ZhiHua Zhou*, and Youli Xiao*, De Novo Production of the Plant-Derived Tropine and Pseudotropine in Yeast, ACS Synthetic Biology 2019, doi: 10.1021/acssynbio.9b00152.

19.     Pingping Wang, Wei Wei, Wei Ye, Xiaodong Li, Wenfang Zhao, Chengshuai Yang, Chaojing Li, Xing Yan*, Zhihua Zhou*. Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency, Cell Discovery 2019, 5 (5): 1-14

20.     Gen Zou, Yanping Jiang, Rui Liu, Zhihua Zhu, Zhihua Zhou*, The putative β-glucosidase BGL3I regulates cellulase induction in Trichoderma reesei. Biotechnology for Biofuels (2018) 11:314;

21.     Chengshuai Yang, Weichao Li, Chen Li, Zhihua Zhoua∗, Youli Xiaoa∗, Xing Yana∗. Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast. Phytochemistry 2018 155:83-92

22.     王平平、杨成帅、李晓东、蒋雨果、严兴、周志华*， 植物天然化合物的人工合成之路. 有机化学 (Chinese Journal of Organic Chemistry) （SCI）. 2018. 38：2199-2214

23.     Yongjun Wei, Lei Zhang, Zhihua Zhou and Xing Yan, Diversity of Gene Clusters for Polyketide and Nonribosomal Peptide Biosynthesis Revealed by Metagenomic Analysis of the Yellow Sea Sediment, Frontiers in Microbiology, 2018. (9) 295：1-12.

24.     Rui Liu, Ling Chen, Yanping Jiang, Gen Zou and Zhihua Zhou. A novel transcription factor specifically regulates glycoside hydrolase 11 xylanase genes in Trichoderma reesei. Biotechnology for Biofuels (2017) 10:194

25.     Wei Wei‡, Tong Liu‡, Xinfeng Li, Ruofan Wang, Wei Zhao, Guoping Zhao, Shimin Zhao*, Zhihua Zhou*. Lysine acetylation regulates the function of the global anaerobic transcription factor FnrL in Rhodobacter sphaeroides: Acetylation of FnrL in Rhodobacter sphaeroides. Molecular Microbiology (2017)104：278-293

26.     Ma L, Chen L, Zhang L, Zou G, Liu R, Jiang Y, Zhou Z. RNA Sequencing Reveals Xyr1 as a Transcription Factor Regulating Gene Expression beyond Carbohydrate Metabolism. Biomed Res Int. 2016:4841756. doi: 10.1155/2016/4841756

27.     Ling Chen, Gen Zou, Jingzhi Wang, Jin Wang, Rui Liu, Yanping Jiang, Guoping Zhao, Zhihua Zhou. Characterization of the Ca2+-responsive signaling pathway in regulating the expression and secretion of cellulases in Trichoderma reesei Rut-C30. Molecular Microbiology (2016) 100: 560-575.

28.     Wei Y, Zhou H, Zhang J, Zhang L, Geng A, Liu F, Zhao G, Wang S, Zhou Z, Yan X. (2015). "Insight into Dominant Cellulolytic Bacteria from Two Biogas Digesters and Their Glycoside Hydrolase Genes." PLoS One 10(6).

29.     Wei W, Wang P, Wei Y, Liu Q, Yang C, G Zhao, Yue J *, Yan X *, Zhou Z * Characterizations of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts. Molecular Plant (2015) 8(9): 1412-1424  15

30.     Rui Liu, Ling Chen, Yanping Jiang, Zhihua Zhou*, Gen Zou*. Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system. Cell Discovery (2015) 1, 15007; doi:10.1038/celldisc.2015.7

31.     Wang P., Y Wei, Y Fan, Q Liu, W Wei, C Yang, L Zhang, G Zhao, J Yue*, X Yan*, Z Zhou*. Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts. Metab Eng (2015) 29: 97-105. 27

32.     Qian C, Liu N, Yan X, Wang Q, Zhou Z*, Wang Q*. Engineering a high-performance, metagenomic-derived novel xylanase with improved soluble protein yield and thermostability. Enzyme and Microbial Technology (2015) 70: 35–41

33.     Yan X, Y Fan, W Wei, P Wang, Q Liu, L Zhang, G Zhao^*, J Yue^*, Z Zhou^*. Production of bioactive ginsenoside compound K in metabolically engineered yeast. Cell Research(2014) 24:770–773 

34.     Meiling Zhang, Ning Liu, Changli Qian,Qianfu Wang, Qian Wang, Yanhua Long,Yongping Huang, Zhihua Zhou, Xing Yan. Phylogenetic and Functional Analysis of Gut Microbiota of a Fungus-Growing Higher Termite: Bacteroidetes from Higher Termites Are a Rich Source of β-Glucosidase Genes. Microbial Ecology, 2014，68:416–425

35.     Tong Liu, Li Zhu, Wei Wei, Zhihua Zhou*. Function of glucose catabolic pathways in hydrogen production from glucose in　Rhodobacter sphaeroides 6016, International Journal of Hydrogen Energy (2014) 39( 9) 4215–4221 (http://dx.doi.org/10.1016/j.ijhydene.2013.12.188)

36.     Ling Chen, Gen Zou, Lei Zhang, Ronald P. de Vries, Xing Yan, Jun Zhang, Rui Liu, Chengshu Wang, Yinbo Qu, Zhihua Zhou* (2014) The distinctive regulatory roles of PrtT in the cell metabolism of Penicillium oxalicum. Fungal Genet Biol 63:42-54. ( http://dx.doi.org/10.1016/j.fgb.2013.12.001).

37.     Wei Wei , Ling Chen, Gen Zou, Qianfu Wang, Xing Yan, Jun Zhang, Chengshu Wang^*, Zhihua Zhou^* (2013) N-Glycosylation Affects the Proper Folding, Enzymatic Characteristics and Production of a Fungal β-Glucosidase. Biotechnol Bioeng110 (12): 3075-3084

38.     Han Q, Liu N , H Robinson, L Cao, C Qian, Q Wang, L Xie, H Ding, Q Wang, Y Huang, Jianyong Li^*, Zhihua Zhou^* (2013) Biochemical Characterization and Crystal Structure of a GH10 Xylanase from Termite Gut Bacteria Reveal a Novel Structural Feature and Significance of Its Bacterial Ig-like Domain. Biotechnol Bioeng110 (12): 3093-3103

39.     Liu Ning, Lei Zhang, Haokui Zhou, Meiling Zhang, Xing Yan, Qian Wang, Yanhua Long, Lei Xie, Shengyue Wang, Yongping Huang, and Zhihua Zhou* (2013) Metagenomic insights into metabolic capacities of the gut microbiota in a fungus-cultivating termite. PLoS ONE, 2013, 8(7): e69184. doi:10.1371/journal.pone.0069184

40.     Xing Yan, Alei Geng, Jun Zhang, Yongjun Wei, Lei Zhang, Changli Qian, Qianfu Wang, Shengyue Wang & Zhihua Zhou (2013). Discovery of (hemi-)cellulase genes in a metagenomic library from a biogas digester using 454 pyro-sequencing. Applied Microbiology and Biotechnology (2013) 97:8173–8182

41.     Liu G, Zhang L, Qin Y, Zou G, Li Z, Yan X, Wei X, Chen M, Chen L, Zheng K, Zhang J, Ma L, Li J, Liu R, Xu H, Bao X, Fang X, Wang L, Zhong Y, Liu W, Zheng H, Wang S, Wang C, Xun L, Zhao GP*, Wang T*, Zhou Z*, Qu Y* (2013) Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Sci. Rep. 3, 1569; DOI:10.1038/srep01569 　

42.     Liu GD, Zhang L, et al. Zhou ZH* and Qu YB* (2013).Genomic and Secretomic Analyses Reveal Unique Features of the Lignocellulolytic Enzyme System of Penicillium decumbens. PLoS ONE 01/2013 8(2):e55185 　　　

43.     Ruisong Yu, Ruofan Wang, Ting Bi, Weining Sun, Zhihua Zhou* (2013) Blocking the butyrate-formation pathway impairs hydrogen production in Clostridium perfringens. Acta Biochim Biophys Sin. 45:408-415.

44.     Qianfu Wang, Changli Qian, Xiao-Zhou Zhang, Nin Liu, Xing Yan, Zhihua Zhou* (2012) Characterization of a novel thermostable -glucosidase from a metagenomic library of termite gut. Enzyme and Microbial Technology 51: 319– 324.　　6

45.     Gen Zou, Shaohua Shi, Yanping Jiang, Joost van den Brink, Ronald P de Vries, Ling Chen, Jun Zhang, Liang Ma, Chengshu Wang and Zhihua Zhou*(2012) Construction of a cellulase hyper-expression system in Trichoderma reesei by promoter and enzyme engineering. Microbial Cell Factories 2012, 11:21.

46.     Alei Geng, Gen Zou, Xing Yan, Qianfu Wang, Jun Zhang, Fanghua Liu, Baoli Zhu, Zhihua Zhou*(2012) Expression and characterization of a novel metagenome-derived cellulase Exo2b and its application to improve cellulase activity in Trichoderma reesei. Applied Microbiology and Biotechnology 96(4):951-62 

47.     Yongzhen Tao, Deng Liu, Xing Yan, Zhihua Zhou, Jeong K. Lee, and Chen Yang. Network identification and flux quantification of glucose metabolism in Rhodobacter sphaeroides under photoheterotrophic H2-producing conditions. Journal of Bacteriology (2012) 194:274-83

48.     Liang Ma, Jun Zhang，Gen Zou，Chengshu Wang，Zhihua Zhou* (2011). Improvement of cellulase activity in Trichoderma reesei by heterologous expression of a beta-glucosidase gene from Penicillium decumbens. Enzyme and Microbial Technology 49: 366– 371.

49.     Ruofan Wang, Wenming Zong, Changli Qian, Yongjun Wei，Ruisong Yu, Zhihua Zhou* (2011) Isolation of Clostridium perfringens strain W11 and optimization of its biohydrogen production by genetic modification. International Journal of Hydrogen Energy 36: 12159-12167;

50.     Jun Zhang, Yongjun Wei, Wei Xiao, Zhihua Zhou, Xing Yan* (2011) Performance and spatial community succession of an anaerobic baffled reactor treating acetone–butanol–ethanol fermentation wastewater. Bioresource Technology102: 7407–7414.

51.     Ning Liu, Xing Yan, Meiling Zhang, Lei Xie, Qian Wang,Yongping Huang, Xuguo Zhou, Shengyue Wang, Zhihua Zhou* (2011) Microbiome of fungus-growing termites: a new reservoir for mining lignocellulase genes, Applied and Environmental Microbiology (2011)77：48-56.   

52.     于瑞嵩,宗文明,周志华.异源表达【FeFe】氢酶的基因工程大肠杆菌的构建. 微生物学报(2011)51(11):1468-1475;

53.     王钱福，严兴，魏维，张磊，钱昌丽，周志华. 生物元件的挖掘、改造与标准化.生命科学 (2011) 23：860-868

54.     Tong Liu, Xinfeng Li, Zhihua Zhou* (2010) Improvement of Hydrogen Yield By Hupr Gene Knock-Out And Nifa Gene Overexpression In Rhodobacter Sphaeroides 6016. International Journal of Hydrogen Energy35: 9603-9610; 

55.     Yue Huang, Wenming Zong, Xing Yang, Ruofan Wang, Christopher L. Hemme, Jizhong Zhou, Zhihua Zhou*(2010) Succession of the Bacterial Community and Dynamics of Hydrogen Producers in a Hydrogen-Producing Bioreactor. Applied and Environmental Microbiology 76: 3387-3390.

56.     Xinfeng Li, Tong Liu, Yongqiang Wu, Guoping Zhao, Zhihua Zhou* (2010)  Derepressive Effect of NH₄⁺ on Hydrogen Production by Deleting the glnA1 Gene in Rhodobacter sphaeroides. Biotechnology and Bioengineering 106 (4):564-572 IF3.7      

57.    Qin Sun, Wei Xiao, Dan Xin, Jiping Shi, Xing Yan, Zhihua Zhou* (2010) Statistical optimization of process parameters on biohydrogen production from sucrose by co-culture of Clostridium acidisoli sp. Nov and Rhodobacter sphaeroides. International Journal of Hydrogen Energy 35: 4076-4084;

58.     Alei Geng, Yanling He, Changli Qian, Xing Yan and Zhihua Zhou* (2010) Effect of Key Factors on Hydrogen Production from Cellulose in a Co-Culture of Clostridium thermocellum and C. thermopalmarium. Bioresource Technology 101: 4029-4033.

59.     Wenming Zong, Ruisong Yu, Peng Zhang, Meizhen Fan, Zhihua Zhou* (2009) Efficient hydrogen gas production from cassava and food waste by a two-step process of dark fermentation and photo-fermentation. Biomass and Bioenergy 33: 1458-1463       

60.     Fanghua Liu, Sibao Wang, Jianshe Zhang, Jun Zhang, Xing Yan, Haokui Zhou, Guoping Zhao and Zhihua Zhou* (2009) The structure of the bacterial and archaeal community in a biogas digester as revealed by denaturing gradient gel electrophoresis and 16S rDNA sequencing analysis. Journal of Applied Microbiology 106: 952–966.   

61.     Fanghua Liu, Guofang Lin, Guang Gao, Boqiang Qin, Jianshe Zhang, Guoping Zhao, Zhihua Zhou* and Jianhua Shen* (2009)Bacterial and archaeal assemblages in sediments of a large shallow freshwater lake, Lake Taihu, as revealed by denaturing gradient gel electrophoresis (DGGE). Journal of Applied Microbiology 106:1022–1032.      

62.  Yongzhen Tao, Yanling He, Yongqiang Wu, Fanghua Liu, Xinfeng Li, Wenming Zong and Zhihua Zhou* (2008) Characteristics of a new photosynthetic bacterial strain for hydrogen production and its application in wastewater treatment. International Journal of Hydrogen Energy 33: 963-973;  

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（ 4 ） Group of Glycosyltransferases and Use Thereof, 发明专利, 2021, 第 1 作者, 专利号: 2930237

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（ 6 ） 一组糖基转移酶及其应用, 专利授权, 2021, 第 1 作者, 专利号: CN107058446B

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（ 9 ） 调控里氏木霉蛋白表达效率的因子、调控方法及应用, 发明专利, 2021, 第 1 作者, 专利号: CN113106114A

（ 10 ） 糖基转移酶以及催化糖链延伸的方法, 发明专利, 2021, 第 1 作者, 专利号: CN112831481A

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（ 15 ） 新型黄酮异戊烯基转移酶及其应用, 发明专利, 2019, 第 1 作者, 专利号: CN109207448A

（ 16 ） 细胞色素P450、烟酰胺腺嘌呤二核苷酸-细胞色素P450还原酶及其应用, 发明专利, 2018, 第 1 作者, 专利号: CN108866142A

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（ 2 ） 乙酰化修饰在里氏木霉纤维素酶合成调控中的功能研究, 负责人, 国家任务, 2015-01--2018-12
（ 3 ） 稀有人参皂苷生物合成中重要生物元件及人工合成体系的设计、组装与适配, 负责人, 地方任务, 2014-07--2017-06
（ 4 ） 微生物发酵生产人参皂苷CK技术, 负责人, 企业委托, 2015-04--2018-04
（ 5 ） 木质纤维素酶研究和产业化, 负责人, 企业委托, 2015-12--2018-12
（ 6 ） 高品质稀有人参皂苷CK的制备及合成生物学关键技术研究, 负责人, 国家任务, 2017-01--2020-12
（ 7 ） 高效合成人参皂苷CK的酵母细胞工厂的研究, 负责人, 国家任务, 2017-01--2018-12
（ 8 ） 人参皂苷的细胞工厂合成关键技术研发及范, 负责人, 中国科学院计划, 2016-01--2017-12
（ 9 ） 面向天然产物生物合成的人工细胞, 参与, 中国科学院计划, 2018-01--2022-12
（ 10 ） 合成非天然基因组生产植物天然产物, 负责人, 中国科学院计划, 2018-01--2019-12
（ 11 ） 微生物发酵生产人参皂苷CK, 负责人, 其他任务, 2015-01--2020-12
（ 12 ） 木质纤维素酶研究和产业化, 负责人, 其他任务, 2016-01--2019-06
（ 13 ） 生物元器件标准化设计组装与应用研究, 负责人, 国家任务, 2019-07--2024-06
（ 14 ） 合成微生物与新功能研究, 参与, 国家任务, 2020-01--2024-12
（ 15 ） 三七特征性天然产物的合成途径解析及定向合成, 参与, 中国科学院计划, 2018-06--2023-05
（ 16 ） 生物资源衍生库建设, 负责人, 中国科学院计划, 2021-10--2024-09

已指导学生

刘芳华  博士研究生  071005-微生物学  

李欣峰  博士研究生  071005-微生物学  

于瑞嵩  博士研究生  071005-微生物学  

张珺  博士研究生  071005-微生物学  

刘通  博士研究生  071005-微生物学  

汪若凡  博士研究生  071005-微生物学  

马良  博士研究生  071005-微生物学  

魏勇军  博士研究生  071005-微生物学  

钱昌丽  博士研究生  071005-微生物学  

陈玲  博士研究生  071005-微生物学  

江艳萍  博士研究生  071005-微生物学  

魏维  博士研究生  071005-微生物学  

刘睿  博士研究生  071005-微生物学  

王平平  博士研究生  071005-微生物学  

杨成帅  博士研究生  071005-微生物学  

柴顺星  博士研究生  071005-微生物学  

邢宏观  博士研究生  071005-微生物学  

李晓东  博士研究生  071005-微生物学  

朱志华  博士研究生  071005-微生物学  

李超静  博士研究生  071005-微生物学  

熊伦艺  硕士研究生  085238-生物工程  

现指导学生

田尔诺  博士研究生  071005-微生物学  

樊震鋆  博士研究生  071005-微生物学  

魏文苹  博士研究生  071005-微生物学  

肖美丽  博士研究生  071005-微生物学  

马迩东  硕士研究生  071005-微生物学  

王引梅  博士研究生  071005-微生物学  

张通  博士研究生  071005-微生物学  

苏振  硕士研究生  086000-生物与医药  

张娜  博士研究生  071005-微生物学  

刘占圣  硕士研究生  086000-生物与医药