General
胡有洪 男 汉族 博导 上海药物研究所
Youhong HU, Professor
Email: yhhu@mail.shcnc.ac.cn
Telephone: 50806600-3526
Address: No.555 Zuchongzhi Road
Postcode: 201203

Research Areas

Medicinal Chemistry; Chemical Biology; Combinatorial Chemistry; Multi-component Reaction and Diversity-oriented Synthesis; Process Chemistry 

By the MCR and cascade reactions, the novel structural diversified drug-like or natural-product-like compound libraries (~3400 compounds) were generated. Through cell-based or enzymebased assays, several novel anticancer and antiviral compounds have been found.

Education

1994-1997 Ph.D., Organic Synthesis Chemistry Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China 

1991-1994 M.S., Organometallic Chemistry, Lanzhou University, China 

1987-1991 B.S., Organic Chemistry, Lanzhou University, China

Experience

   
Work Experience
2005.5-Present  Professor, Shanghai Institute of Materia Medica 

2001.7-2005.4  Senior Scientist, VivoQuest Inc. 

2001.4-2001.7  Visiting Scientist, The Aaron Diamond AIDS Research Center Rockefeller University 

2000.8-2001.4  Postdoc. Researcher, Harvard Medical School, Institute of Chemistry & Cell Biology 

1998.9-2000.8  Postdoc. Researcher, Drug Discovery Program, Georgetown University Medical Center 

1997.9-1998.7  Visiting Scholar, Lab of Organic Chemistry, School of Agricultural Sciences, Nagoya University, Japan

Teaching Experience
Medicinal Chemistry, Shanghai Institute of Materia Medica

Publications

1. Bo Chao, Shijun Lin, Qingdong Ma, Dong Lu, and Youhong Hu*, Copper(I)-Mediated Cascade Reactions: An Efficient Approach to the Synthesis of Functionalized Benzofuro[3,2-d]pyrimidines, Org. Lett., 2012, DOI: 10.1021/ol3006437.  

2. Bo Chao, Xian-Kun Tong, Wei Tang, De-Wen Li, Pei-Lan He, Jean-Michel Garcia, Li-Min Zeng, An-Hui Gao, Li Yang, Jia Li, Fa-Jun Nan, Michael Jacobs, Ralf Altmeyer, Jian-Ping Zuo,* and You-Hong Hu*, Discovery and Optimization of 2,4-Diaminoquinazoline Derivatives as a New Class of Potent Dengue Virus Inhibitors, J. Med.Chem.,2012,55(7), 3135-3143. 

3. S.-L. Huang, R.-T. Yu, J. Gong, Y. Feng, Y.-L. Dai, F. Hu, Y.-H. Hu, Y.-D. Tao*, Y. Leng*, Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia, 2012, 55(5), 1469-1481. 

4. Jianwei Yan, Ning Huang, Shukun Li, Liu-Meng Yang, Weiqiang Xing, Yong-Tang Zheng*, Youhong Hu*, Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors, Bio. & Med. Chem. Lett., 2012, DOI:10.1016/j.bmcl. 2012.01.037.

5. Hongbing Zhao, Haitian Quan, Chengying Xie, Yongping Xu, Fuchun Xie, Youhong Hu, Liguang Lou*, YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance, Cancer Letters 2012, 314, 54–62. 

6. Jian Gong, Fuchun Xie, Wenming Ren, Hong Chen and Youhong Hu*, Domino reactions of 2-methyl chromones containing an electron withdrawing group with chromone-fused dienes Org. Biomol. Chem., 2012, 10(3), 486-489.

7. Hong Chen, Fuchun Xie, Jian Gong, and Youhong Hu*, Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds J. Org. Chem., 2011, 76 (20), 8495–8500.  

8. Fuchun Xie, Hongbing Zhao, Dewen Li, Hong Chen, Haitian Quan, Xiaojing Shi, Liguang Lou*, and Youhong Hu*, Synthesis and Biological Evaluation of 2,4,5-Substituted Pyrimidines as a New Class of Tubulin Polymerization Inhibitors J. Med.Chem. 2011, 54(9), 3200-3205.  

9. Yang Liu, Liping Huang, Fuchun Xie, Xuxing Chen and Youhong Hu*, Synthesis of novel functional polycyclic chromones through Michael addition and double cyclizations Org. Biomol. Chem., 2011, 9(8), 2680-2684. 

10. Dewen Li, Shudong Duan, and Youhong Hu*, Three-Component One-Pot Approach to Synthesize Benzopyrano[4,3-d]pyrimidines, J. Comb. Chem., 2010, 12(6), 895-899. 

11. Xiao-dong Zhang, Jian-wei Yan, Gui-rui Yan, Xiao-yun Sun, Jun Ji, Yi-ming Li, You-hong Hu*, He-yao Wang*, Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight gain, hyperlipidemia, and hepatic steatosis in db/db mice, Acta Pharmacologica Sinica, 2010, 31, 1470-1477.  

12. Yang Liu, Liping Huang, Fuchun Xie, and Youhong Hu*, Base-Promoted One-Pot Tandem Reaction of 3-(1-Alkynyl)chromones under Microwave Irradiation to Functionalized Amino-Substituted Xanthones, J. Org. Chem., 2010, 75 (18), 6304–6307. 

13. Jian Gong, Fuchun Xie, Hong Chen and Youhong Hu*, An Efficient Approach to Functionalized Benzo[a]xanthones through Reactions of 2-Methyl-3-(1-alkynyl)chromones with Electron-Deficient Chromone-Fused Dienes, Org. Lett., 2010, 12 (17), 3848–3851. 

14. Fuchun Xie, Hong Chen, Youhong Hu*, Efficient Construction of 3C-Xanthone-Linked 3C-Chromone Scaffold by Novel Double Michael Additions and Cyclizations, Org. Lett., 2010, 12(13), 3086-3089. 

15. Fuchun Xie, Xuan Pan, Shijun Lin and Youhong Hu*, A base-promoted desalicyloylative dimerization of 3-(1-alkynyl)chromones: An unusual approach to 2-alkynyl xanthones, Org. Biomol. Chem., 2010, 8(6), 1378-1381.

16. Jia Liu, Xiaoyan Chen, Youhong Hu, Gang Cheng and Dafang Zhong*, Quantification of the major metabolites of bromhexine in human plasma using RRLC–MS/MS and its application to pharmacokinetics, Journal of Pharmaceutical and Biomedical Analysis, 2010, 51(5), 1134–1141. 

17. Lizhi Zhao, Fuchun Xie, Gang Cheng, Youhong Hu*, A Base-Promoted Tandem Reaction of 3-(1-Alkynyl)chromones with 1,3-Dicarbonyl Compounds: An Efficient Approach to Functional Xanthones, Angew. Chem. Int. Ed., 2009, 48(35), 6520–6523.

18. Fuchun Xie, Hongbing Zhao, Lizhi Zhao, Liguang Lou, Youhong Hu*, Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity, Bioorganic & Medicinal Chemistry Letters, 2009, 19(1), 275-278. 

19. Xu Sun, Xiao-Dong Zhang, Gang Cheng, You-Hong Hu* and He-Yao Wang* Inhibition of hepatic stellate cell proliferation by heat shock protein 90 inhibitors in vitro, Molecular and Cellular Biochemistry, 2009, 330(1-2), 181–185. 

20. Jian Meng, Lizhi Zhao, Youhong Hu, Xiaoyan Chen, Dafang Zhong *, Synthesis of [3-3H]20(S)-protopanaxadiol, J. Label Compd. Radiopharm, 2009, 52(11-12), 482–484.

Research Interests

Medicinal Chemistry; Chemical Biology; Combinatorial Chemistry; Multi-component Reaction and Diversity-oriented Synthesis; Process Chemistry

Students

已指导学生

程刚  博士研究生  100701-药物化学  

赵立志  博士研究生  100701-药物化学  

谢福春  博士研究生  100701-药物化学  

林世军  博士研究生  100701-药物化学  

刘杨  博士研究生  100701-药物化学  

龚健  硕士研究生  077901-药物化学  

李德文  硕士研究生  077901-药物化学  

闫建伟  博士研究生  100701-药物化学  

晁博  博士研究生  100701-药物化学  

邢唯强  博士研究生  100701-药物化学  

盛佳  硕士研究生  077901-药物化学  

陈红  博士研究生  100701-药物化学  

黄丽平  博士研究生  100701-药物化学  

段书冬  博士研究生  100701-药物化学  

金世玉  硕士研究生  085235-制药工程  

任文明  博士研究生  100701-药物化学  

陆栋  博士研究生  100701-药物化学  

现指导学生

万鹏辉  硕士研究生  105500-药学  

张玉芳  博士研究生  100701-药物化学  

陈菁菁  硕士研究生  078001-药物化学  

彭润泽  博士研究生  100701-药物化学  

谢志铖  硕士研究生  078001-药物化学  

段文迪  硕士研究生  078001-药物化学  

赵琪良  硕士研究生  105500-药学