Molecular toxicology of emerging environmental contaminants

Nano-bio-sensors for environmental monitoring and toxicant screening

1980-1985, B.Sc., Department of Applied Chemistry, University of Science and Technology of China

1985-1987, M.Sc. candidate, Department of Chemistry, Wuhan University, China

1987-1990, D. Phil. Inorganic Chemistry Laboartory/Queen's College, Oxford University, UK

1991-1995, postdoctoral fellow, Department of Chemistry, University of Rochester, USA

1995-2001, Research Scientist, IGEN International Inc., USA

2002-2004, Director, Department of Chemistry and Materials, National Engineering and Research Center for Biochips

2004-present, Professor, Group Leader, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences

2004-present, M.Sc course: Advanced Environmental Biology

2010           “Excellent Graduate Student Mentor Award”, Chinese Academy of Sciences

2013           “Outstanding Science & Technology Achievement Award”, Chinese Academy of Sciences

2013           “National Award for Experts with Outstanding Contributions”, Ministry of Personnel and Human Services, China

(97) Zhong-Min Li, Liang-Hong Guo*, Xiao-Min Ren

“Biotransformation of 8:2 fluorotelomer alcohol by recombinant human cytochrome P450s, human liver microsomes and human liver cytosol”

Environ. Sci.: Processes Impacts, 2016, 18, 538–546.

(96) Jie Hou, Bin Wan*, Yu Yang, Xiao-Min Ren, Liang-Hong Guo*, Jing-Fu Liu.

“Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation”

Int. J. Mol. Sci. 2016, 17, 409.

(95) Xiao-Min Ren, Lin-Ying Cao, Jing Zhang, Wei-Ping Qin, Yu Yang, Bin Wan, Liang-Hong Guo*.

“Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry”

Biochem. 2016, 55, 1989−1996.

(94) Hui Zhang , Liang-Hong Guo,* Lixia Zhao, Bin Wan, and Yu Yang

“Switching Oxygen Reduction Pathway by Exfoliating Graphitic Carbon Nitride for Enhanced Photocatalytic Phenol Degradation”

J. Phys. Chem. Lett. 2015, 6, 958−963.

(93) Yiping Wu, XiqiangYang, BintianZhang, Liang-HongGuo*

“An Electrochemiluminescence Biosensor for 8-oxo-7,8-Dihydro-2-deoxyguanosine Quantification and DNA Repair Enzyme Activity Analysis Using a Novel Bifunctional Probe”

Biosensors and Bioelectronics, 2015, 69. 235–240.

(92) Hui Zhang, Liang-Hong Guo,* Dabin Wang, Lixia Zhao, and Bin Wan

“Light-Induced Efficient Molecular Oxygen Activation on a Cu(II)-Grafted TiO₂/Graphene Photocatalyst for Phenol Degradation”

ACS Appl. Mater. Interfaces, 2015, 7, 1816−1823.

(91) Qiyan Lv, Bin Wan,* Liang-Hong Guo,* Lixia Zhao,Yu Yang

“In vitro immune toxicity of polybrominated diphenyl ethers on murine peritoneal macrophages: Apoptosis and immune cell dysfunction”

Chemosphere. 2015, 120, 621-630.

(90) Xiao-Min Ren, Yin-Feng Zhang, Liang-Hong Guo,* Zhan-Fen Qin,* Qi-Yan Lv, Lian-Ying Zhang

“Structure–activity relations in binding of perfluoroalkyl compounds to human thyroid hormone T3 receptor”

Arch. Toxicol. 2015, 89, 233–242.

(89) Jing Sun, Liang-Hong Guo,* Hui Zhang,* Lixia Zhao

“UV Irradiation Induced Transformation of TiO2 Nanoparticles in Water: Aggregation and Photoreactivity”

Environ. Sci. Technol. 2014, 48, 11962−11968.

(88) Dabin Wang, Lixia Zhao,* Liang-Hong Guo,* Hui Zhang

“Online Detection of Reactive Oxygen Species in Ultraviolet (UV)-Irradiated Nano-TiO₂ Suspensions by Continuous Flow Chemiluminescence”

Anal. Chem. 2014, 86, 10535−10539.

(87) Dapeng Zhanga, Lei Yin, Zihui Meng, Anchi Yu, Liang-hong Guo, Hailin Wang*

“A sensitive fluorescence anisotropy method for detection of lead (II)ion by a G-quadruplex-inducible DNA aptamer”

Analytica Chimica Acta, 2014, 812, 161– 167.

(86) Sufang Wang, Bin Wan, Lianying Zhang, Yu Yang,* Liang-Hong Guo*

“In vitro inhibition of lysine decarboxylase activity by organophosphate esters”

Biochemical Pharmacology. 2014, 92, 506-516.

(85) Sufang Wang, Qiyan Lv, Yu Yang,* Liang-Hong Guo,* Bin Wan, Lixia Zhao

“Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase”

Science of the Total Environment. 2014, 496, 381-388.

(84) Lianying Zhang, Xiao-Min Ren, Bin Wan, Liang-Hong Guo*

“Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ”

Toxicology and Applied Pharmacology. 2014, 279, 275-283.

(83) Lixia Zhao,* Fanglan Gen, Fan Di, Liang-Hong Guo,* Bin Wan, Yu Yang, Hui Zhang

“Polyamine-functionalized carbon nanodots: a novel chemiluminescence probe for selective detection of iron(III) ions”

RSC Adv. 2014, 4:, 45768-45771.

(82) 吴一萍, 郭良宏*

“DNA损伤的光电化学传感器检测”

《化学进展》，2014, 26, 1-9.

(81) Qiang Ma*, Hua Bai, Chao Wang, Guang-Cheng Xi, Qing Zhang, Xian-Shuang Meng, Yun-Xia Chen, Jing-Rui Li, Hui-Juan Ma, Liang-Hong Guo*

“Investigation of noncovalent interactions between hydroxylatedpolybrominated diphenyl ethers and bovine serum albumin usingelectrospray ionization-ion mobility-mass spectrometry”

International Journal of Mass Spectrometry, 2014, 357, 34-44.

(80) Jing Sun, Hui Zhang,* Liang-Hong Guo,* and Lixia Zhao

“Two-Dimensional Interface Engineering of a Titania−Graphene Nanosheet Composite for Improved Photocatalytic Activity”

ACS Appl. Mater. Interfaces, 2013, 5, 13035-13041.

(79) 刘世利, 陈守臻, 赵倩, 徐政虎，李玉贾，继辉, 郭良宏*

“光电化学竞争法检测生物素”

《分析化学》，2013, 10, 1477 -1481

(78) Lianying Zhang, Xiao-Min Ren, Liang-Hong Guo*

“Structure-Based Investigation on the Interaction of Perfluorinated Compounds with Human Liver Fatty Acid Binding Protein”

Environ. Sci. Technol. 2013, 47, 11293−11301.

(77) 李敏杰, 吴一萍, 张斌田, 郭良宏*

“DNA 脱碱基位点的检测与应用”

《分析化学》，2013, 7, 965-972.

(76) Yiping Wu, Bintian Zhang, Liang-Hong Guo*

“Label-Free and Selective Photoelectrochemical Detection of Chemical DNA Methylation Damage Using DNA Repair Enzymes”

Analytical Chemistry, 2013, 85, 6908−6914.

(75) P.-X. Dong, B. Wan*, Z.-X. Wang, L.-H. Guo*, Y. Yang, L. Zhao

“Exposure of single-walled carbon nanotubes impairs the functions of primarily cultured murine peritoneal macrophages”

Nanotoxicology, 2013, 7, 1028-1042.

(74) Wan, B*.; Wang Z. X.; Lv, Q. Y.; Dong, P. X.; Zhao, LX; Yang, Y; Guo, L. H*.

“Single-walled carbon nanotubes and graphene oxides induce autophagosome accumulation and lysosome impairment in primarilycultured murine peritoneal macrophages”

Toxicology Letters, 2013, 221, 118-127.

(73) Li, X. X.; Gao, Y.; Guo, L. H.*; Jiang, G. B.

“Structure-dependent activities of hydroxylated polybrominated diphenyl ethers on human estrogen receptor”

Toxicology, 2013, 309, 15-22.

(72) Zhao, LX.*; Di, F.; Wang, DB.; Guo, L. H.*; Yang, Y.; Wan, B.; Zhang, H.

“Chemiluminescence of carbon dots under strong alkaline solutions: a novel insight into carbon dot optical properties”

Nanoscale, 2013, 5, 2655-2658.

(71) Ren, X. M.; Guo, L. H.*

“Molecular toxicology of polybrominated diphenyl ethers: nuclear hormone receptor mediated pathways”

Environmental Science: Processes & Impacts, 2013, 15, 702-708.

(70) Ren, X.M.; Guo, L. H.*; Gao, Y.; Zhang, B. T.; Wan, B.

“Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination”

Toxicology and Applied Pharmacology, 2013, 268, 256-263.

(69) C. Liang, M. Zou*, L.-H. Guo, W. Gui, G. Zhu

“Development of a bead-based immunoassay for detection of triazophos

and application validation”

Food and Agricultural Immunology, 2013, 24, 9-20

(68) Y. Gao, X. Li, L.-H. Guo*

“Assessment of Estrogenic Effects of Perfluoroalkyl Acids by Monitoring Ligand-induced Conformation State of Human Estrogen Receptor”

Environmental Science & Technology, 2013, 47, 634-641.

(67) Y. Gao, L.-H. Guo*

“Development of a Label-free Competitive Ligand Binding Assay with Human Serum Albumin on Molecularly Engineered Surface Plasmon Resonance Sensor Chip”

Analytical Methods, 2012, 4, 3718-3723.

(66) M.-Y. Wei, L.-H. Guo*, P. Famouri

“Electrocatalytic oxidation of tyrosines shows signal enhancement in label-free protein biosensors”

TRAC-Trends in Analytical Chemistry, 2012, 39, 130-148.

(65) Z. Fan, Y. S. Keum, Q. X. Li, W. L. Shelver, L.-H. Guo*

“Development of indirect competitive fluorescence immunoassay for 2,2’,4,4’-tetrabromodiphenyl ether using DNA/dye conjugate as antibody multiple labels”

Journal of Environmental Science, 2012, 24, 1334-1340.

(64) B. Zhang, L.-H. Guo*, M. Greenburg*

“Quantification of 8-OxodGuo Lesions in Double-Stranded DNA Using

a Photoelectrochemical DNA Sensor”

Analytical Chemistry, 2012, 84, 6048−6053

(63) B. Zhang, L.-H. Guo*

“Highly sensitive and selective photoelectrochemical DNA sensor for the detection of Hg²⁺ in aqueous solutions”

Biosensor & Bioelectronics, 2012, 37, 112–115.

(62) X. M. Ren, L.-H. Guo*

“Assessment of the Binding of Hydroxylated Polybrominated Diphenyl Ethers to Thyroid Hormone Transport Proteins Using a Site-Specific Fluorescence Probe”

Environmental Science & Technology, 2012, 46, 4633−4640

(61) P. X. Dong, B. Wan*, L.-H. Guo

“In vitro toxicity of acid-functionalized single-walled carbon nanotubes: effects on murine macrophages and gene expression profiling”

Nanotoxicology, 2012, 6, 288-303.

(60) Z. Fan, Y. S. Keum, Q. X. Li, W. L. Shelver, L.-H. Guo*

“Sensitive immunoassay detection of multiple environmental chemicals on protein microarrays using DNA/dye conjugate as a fluorescent label”

Journal of Environmental Monitoring, 2012, 14, 1345–1352.

(59) Q. Ma∗, G.-C. Xi, C. Wang, H. Bai, Q. Zhang, H.-W. Xi, L.-H. Guo^∗

“Comprehensive two-dimensional separation for the analysis of alkylphenol ethoxylates employing hydrophilic interaction chromatography coupled with ion mobility-mass spectrometry”

International Journal of Mass Spectrometry, 2012, 315, 31– 39.

(58) Y. Liu, S. Jia, L.-H. Guo∗

“Development of microplate-based photoelectrochemical DNA biosensor array

for high throughput detection of DNA damage”

Sensors and Actuators B, 2012, 161, 334– 340.

(57) M.-Y. Wei, R. Huang, L.-H. Guo*

“High catalytic activity of indium tin oxide nanoparticle modified electrode towards electro-oxidation of ascorbic acid”

Journal of Electroanalytical Chemistry, 2012, 664, 156–160.

(56) Chizhou Liang, Mingqiang Zou,* Liang-hong Guo, Guoyang Huang, Jianfei Lu, Yong Xu, Linfei Shou

“Comparison of Different Elisa Formats for the Detection of Cephalexin and Application Validation”

Analytical Letters, 2012, 45, 1617–1631.

(55) J. Cao, L.-H. Guo*, B. Wan, Y. Wei

“In vitro fluorescence displacement investigation of thyroxine transport disruption by bisphenol A”

Journal of Environmental Sciences, 2011, 23, 315–321.

(54) Y. Yang, L.-H. Guo∗, N. Qu, M.-Y. Wei, L.-X. Zhao, B. Wan

“Label-free electrochemical measurement of protein tyrosine kinase activity and

inhibition based on electro-catalyzed tyrosine signaling”

Biosensors and Bioelectronics, 2011, 28, 284– 290.

(53) Q. Ma, C. Wang, H. Bai, H.-W. Xi, G.-C. Xi, X.-M. Ren, Y. Yang, L.-H. Guo*

“Comprehensive Two-Dimensional Separation of Hydroxylated Polybrominated Diphenyl Ethers by Ultra-Performance Liquid Chromatography Coupled with Ion Mobility-Mass Spectrometry”

J. Am. Soc. Mass Spectrom. 2011,

(52) B. Zhang, X. Du, S. Jia, J. He, L.-H. Guo*

“Rapid assessment of DNA damage induced by polystyrene nanosphere suspension using a photoelectrochemical DNA sensor”

Science China: Chemistry, 2011, 54, 1260–1265.

(51) R. Huang, M.-Y. Wei, L.-H. Guo∗

“Enhanced electrogenerated chemiluminescence of Ru(bpy)₃²⁺ /tripropylamine

system on indium tin oxide nanoparticle modified transparent electrode”

Journal of Electroanalytical Chemistry, 2011, 656, 136–139.

(50) M.-Y. Wei∗, L.-H. Guo∗, P. Famouri

“DNA biosensors based on metallo-intercalator probes and electrocatalytic amplification”

Microchim Acta, 2011, 172, 247–260

(49) N. Qu, L.-H. Guo∗, B.-Z. Zhu∗

“An electrochemical biosensor for the detection of tyrosine oxidation induced by

Fenton reaction”

Biosensors and Bioelectronics, 2011, 26, 2292–2296.

(48) 万斌∗，郭良宏

“多溴联苯醚的环境毒理研究进展”

《环境化学》，2011, 30，

(47) Yin Wei∗, Yuan Lin, Ai-Qian Zhang∗, Liang-Hong Guo, Jie Cao

“Evaluation of the noncovalent binding interactions between polycyclic aromatic

hydrocarbon metabolites and human p53 cDNA”

Science of the Total Environment, 2010, 408, 6285–6290.

(46) J. Cao, Y. Lin, L.-H. Guo∗, A.-Q. Zhang∗, Y. Wei, Y. Yang

“Structure-based investigation on the binding interaction of hydroxylated

polybrominated diphenyl ethers with thyroxine transport proteins”

Toxicology, 2010, 277, 20–28.

(45) R. Huang, L.-R. Wang, L.-H. Guo∗

“Highly sensitive electrochemiluminescence displacement method for the study of DNA/small molecule binding interactions”

Anal. Chim. Acta. 2010, 676, 41–45.

(44) R. Huang, L.-H. Guo*

“Lack of nano size effect on electrochemistry of dopamine at a gold nanoparticle modified indium tin oxide electrode”

Sci. China Chem., 2010, 53, 1778–1783.

(43) S. Jia, B.-Z. Zhu, L.-H. Guo*

“Detection and mechanistic investigation of halogenated benzoquinone induced DNA damage by photoelectrochemical DNA sensor”

Anal. Bioanal. Chem. 2010, 397, 2395–2400

(42) 杨郁, 郭良宏*

“超分子主体化合物环糊精应用于环境污染物分离分析的研究进展”

《科学通报》，2009, 54, 128 – 137.

(41) L-R. Wang, Y. Wang, J.-W. Chen∗, L.-H. Guo∗

“A structure-based investigation on the binding interaction of hydroxylated

polycyclic aromatic hydrocarbons with DNA”

Toxicology, 2009, 262, 250–257.

(40) Q. Zhang, R. Huang, L.-H. Guo∗

“One-step and high-density protein immobilization on epoxysilane-modified silica nanoparticles”

Chinese Sci Bull, 2009, 54, 2620-2626.

(39) M.-Y. Wei, S.-D. Wen, X.-Q. Yang, L.-H. Guo*

“Development of redox-labeled electrochemical immunoassay for polycyclic aromatic hydrocarbons with controlled surface modification and catalytic voltammetric detection”

Biosensors and Bioelectronics, 2009, 24, 2909–2914.

(38) Y. Wei, L.-H. Guo*

“Binding interaction between polycyclic aromatic compounds and DNA by fluorescence displacement method”

Environmental Toxicology and Chemistry, 2009, 28, 940–945.

(37) 韦明元，郭良宏*

“环境污染物的免疫传感检测方法进展’’

《化学进展》，2009, 21, 492-502.

(36) X.-Q. Yang, L.-H. Guo*

“Enhanced Electrochemical Activity of Redox-labels in Multi-layered Protein Films on Indium Tin Oxide Nanoparticle-based Electrode”

Analytica Chimica Acta, 2009, 21, 373.

(35) Y. Chen, L.-H. Guo*

“Combined fluorescence and electrochemical investigation on the binding interaction between organic acid and human serum albumin”

Journal of Environmental Sciences. 2009, 632, 15.

(34) M. Liang, L.-H. Guo*

“Application of nanomaterials in environmental analysis and monitoring”

Journal of Nanoscience and Nanotechnology. 2009, 9, 2283.

(33) Y. Chen, L.-H. Guo*

“Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin”

Archives of Toxicology. 2009, 83, 255.

(32) N. Qu, B. Wan, L.-H. Guo*

“Label-free electrochemical differentiation of phosphorylation and non-phosphorylated peptides by electro-catalyzed tyrosine oxidation”

The Analyst. 2008, 133, 1246.

(30) L. Wang, N. Qu, L.-H. Guo*

“Electrochemical displacement method for the investigation of the binding interaction of polycyclic organic compounds with DNA”

Analytical Chemistry. 2008, 80, 3910.

(29) S. Jia, M. Liang, L.-H. Guo*

“Photoelectrochemical detection of oxidative DNA damage induced by Fenton reaction with low concentration and DNA-associated Fe²⁺”

Journal of Physical Chemistry B. 2008, 112, 4461.

(28) S. Zhu, Q. Zhang, L.-H. Guo*

“Part-per-trillion level detection of estradiol by competitive fluorescence immunoassay using DNA/dye conjugate as antibody multiple labels”

Analytica Chimica Acta. 2008, 624, 141.

(27) M. Liang, S. Jia, S. Zhu, L.-H. Guo*

“Photoelectrochemical Sensor for the Rapid Detection of in Situ DNA Damage Induced by Enzyme-Catalyzed Fenton Reaction”

Environmental Science & Technology, 2008, 42, 635.

(26) Q. Zhang, L.-H. Guo*

“Multiple Labeling of Antibodies with Dye/DNA Conjugate for Sensitivity Improvement in Fluorescence Immunoassay”

Bioconjugate Chemistry, 2007, 18, 1668.

(25) M. Liang, L.-H. Guo*

“Photoelectrochemical DNA Sensor for the Rapid Detection of DNA Damage Induced by Styrene Oxide and Fenton Reaction”

Environmental Science & Technology, 2007, 41, 658.

(24) L.-H. Guo*, N. Qu.

“Chemical-Induced Unfolding of Cofactor-Free Protein Monitored by Electrochemistry”.

Analytical Chemistry, 2006, 78, 6275.

(23) M. Liang, S. Liu, M. Wei, L.-H. Guo*

“Photoelectrochemical Oxidation of DNA by Ruthenium Tris(bipyridine) on a Tin Oxide Nanoparticle Electrode”.

Analytical Chemistry. 2006, 78, 621

(22) L.-H. Guo*, M. Wei, H. Chen*

“Multiple DNA Binding Modes of a Metallointercalator Revealed by DNA Film Voltammetry”.

Journal of Physical Chemistry B, 2006, 110, 20568.

(21) M. Wei, L.-H. Guo*, H. Chen*

“Determination of Surface-Immobilized Double-Stranded DNA Using a Metallointercalator and Catalytic Voltammetry”.

Microchimica Acta, 2006, 155, 409.

(20) C. Li, S. Liu, L.-H. Guo*

“A New Chemically Amplified Electrochemical System for DNA Detection in Solution”

Electrochemistry Communications. 2005, 7, 23

(19) L.-H. Guo*, X.-Q. Yang

“A New Chemically Amplified Electrochemical System for the Detection of Biological Affinity Reactions: Direct and Competitive Biotin Assay”

The Analyst. 2005, 130, 1027

(18) D. Dong, D. Zheng, F. Wang, X. Yang, N. Wang, Y. Li, L.-H. Guo*, J. Cheng

“Quantitative Photoelectrochemical Detection of Biological Affinity Reaction: The Biotin-Avidin Interaction”.

Analytical Chemistry. 2004, 76, 499.

(17) G. Yi*, H. Lu, S. Zhao, Y. Ge, W. Yang, D. Chen*, L.-H. Guo*

“Synthesis, characterization, and biological application of size-controlled nanocrystalline NaYF₄:Yb,Er infrared-to-visible up-conversion phosphors”.

Nano Letters. 2004, 4, 2191.

(16) H. Lu, G. Yi, S. Zhao, D. Chen^*, L.-H. Guo*, J. Cheng

“Synthesis and Characterization of Multi-functional Nanoparticles Possessing Magnetic, Up-conversion Fluorescence and Bio-affinity Properties”

Journal of Materials Chemistry. 2004, 14, 1336.

(15) D. Zheng, N. Wang, F. Wang, D. Dong, Y. Li, X. Yang, L.-H. Guo*, and J. Cheng

“Sensitive Chemically Amplified Electrochemical Detection of Ruthenium Tris-(2,2’-bipyridine) on Tin-doped Indium Oxide Electrode”

Analytica Chimica Acta. 2004, 508, 225.

(14) L. Su, X. Qiu*, L.-H. Guo, F. Zhang, and C. Tung

“Amperometric Glucose Sensor Based on Enzyme-modified Boron-doped Diamond Electrode by Cross-linking Method ”

Sensors and Actuators B. 2004, 99, 499.

(13) L.-H. Guo; G. McLendon*; H. Razafitrimo; Y. Gao.

“Photo-active and electro-active protein films prepared by reconstitution with metalloporphyrins self-assembled on gold”.

Journal of Materials Chemistry. 1996, 6, 369.

(11) H. Razafitrim; E. Ettedgui; Y. Gao*; L.-H. Guo; G. L. McLendon.

“X-ray photoemission study of the interface formation between calcium and self-assembled alkanethiol monolayers”.

Applied Physics Letters. 1995, 67, 2621.

(10) L.-H. Guo; S. Mukamel; G. McLendon*.

"Photophysical probes of a protein/semiconductor electrode interface".

Journal of the American Chemical Society. 1995, 117, 546.

(9) L.-H. Guo*; J.S. Facci; G. McLendon*

"Distance dependence of electron transfer rates in bilayers of a ferrocene Langmuir-Blodgett monolayer and a self-assembled monolayer on gold".

Journal of Physical Chemistry. 1995, 99, 8458.

(8) L-H. Guo; J.S. Facci*; G. McLendon*.

"Effect of structure on the electrochemistry of Langmuir-Blodgett monolayers of 16-ferrocenylhexadecanoic acid on a self-assembled alkanethiol monolayer".

Journal of Physical Chemistry. 1995, 99, 4106.

(7) L.-H. Guo; J. S. Facci*; G. McLendon*; R. Mosher.

"Effect of gold topography and surface pretreatment on the self-assembly of alkanethiol monolayers".

Langmuir. 1994, 10, 4588.

(6) A. L. Burrows; L.-H. Guo; H. A. O. Hill*; G. L. McLendon; F. Sherman.

"Direct electrochemistry of proteins: investigation of yeast cytochrome c mutants and their complexes with cytochrome b5".

European Journal of Biochemistry. 1991, 202, 543.

(4) L.-H. Guo, H. O. A, Hill*, D. J. Hopper, G. A. Lawrance, G. S. Sanghera

"Direct voltammetry of the Chromatium vinosum enzyme, sulfide:cytochrome c  oxidoreductase (flavocytochrome c₅₅₂)".

Journal of Biological Chemistry. 1990, 265, 1958.

(3) S. Bagby; P. D. Barker; L.-H. Guo; H. A. O. Hill*.

"Direct electrochemistry of protein-protein complexes involving cytochrome c, cytochrome b5 and plastocyanin"

Biochemistry. 1990, 29, 3213.

(2) L.-H. Guo; H. A. O. Hill*; D. J. Hopper; G. A. Lawrance; G. S. Sanghera.

"Direct unmediated electrochemistry of the enzyme p-cresolmethylhydroxylase"

Journal of Electroanalytical Chemistry. 1989, 266, 379.

(1) P. D. Barker; L.-H. Guo; H. A. O. Hill*; G. S. Sanghera.

"The direct, unmediated electrochemistry of protein-protein complexes"

Biochemical Society Transaction. 1988, 16, 957.

(26) "Molecular toxicological studies of perfluoroalkyl acids". At The 12th International Symposium on Persistent Toxic Substances. (November 16-20, 2015), Riverside, California, USA.

(25) "Toxicology and Health Effects of Persistent Organic Pollutants". At Japan Analytical and Scientific Instruments Show. (September 3-5, 2014), Makuhari-Messe, Chiba, Japan.

(24) "Identification of Cellular Target of Perfluoroalkyl Acids by Protein Tyrosine Phosphatase Electrochemical Sensor". At The 14th International Society of Electrochemistry Topical Meeting. (March 29-April 1, 2014), Nanjing, China.

(23) "Structure-dependent Activities of Hydroxylated Polybrominated Diphenyl Ethers on Human Estrogen Receptor". at The 10th International Symposium on Persistent Toxic Substances. (August 13-17, 2013), Edmonton, Alberta, Canada.

(22) "Dynamic monitoring of ROS generation in TiO₂ photocatalytic reactions by flow injection chemiluminescence". At IWA Symposium on Environmental Nanotechnology. (April 24-27, 2013), Nanjing, China.

(21) "Structural Insight into Thyroid Hormone Activity of Hydroxylated Polybrominated Diphenyl Ethers". at The 9th International Symposium on Persistent Toxic Substances. (Oct 23-27, 2012), Miami, USA.

(20) "Photoelectrochemical Sensor for the Quantification of 8-oxodGuo Lesions in Double-stranded DNA Films". at The 244^th American Chemical Society National Meetings & Exposition. (Aug 19-23, 2012), Philadelphia, USA.

(19) "Tyrosine as Intrinsic Signal Reporter in Label-free Electrochemical Biosensors and Biosensing". at The 57^th International Conference on Analytical Sciences & Spectroscopy. (Aug 28-31, 2011), Toronto, Canada.

(18) "Molecular Indicators for the Toxicological Effects of Persistent Organic Pollutants". at The 18th International Conference on Environmental Indicators. (Sept 13-16, 2010), Hefei, China.

(17) "Electrochemical Investigation on the Binding Interaction of Polycyclic Aromatic Hydrocarbons with DNAs". at The 12th International Beijing Conference and Exhibition on Instrumental Analysis. (Nov 25-28, 2009), Beijing, China.

(16) "Environmental Biosensor and Biosensing". at The 6th Sino-French Workshop on Surface Electrochemistry of Molecules of Biological Interest & Biosensor Applications. (Nov 29-Dec 1, 2009), Lyon, France.

(15) "Electrochemical Investigation on the Binding Interaction of Polycyclic Aromatic Hydrocarbons with DNAs". at The 12th International Beijing Conference and Exhibition on Instrumental Analysis. (Nov 25-28, 2009), Beijing, China.

(14) "Photoelectrochemical Sensor for Rapid Screening of DNA Damaging Chemicals". at Wuhan International Conference on the Environment. (Oct 15-18, 2009), Wuhan, China.

(13) "Nano-electrocatalytic Property or Lack of It on Indium Tin Oxide and Gold Nanoparticle Modified Electrodes". at The Twelfth International Symposium on Electroanalytical Chemistry. (Aug 12-15, 2009), Changchun, China.

(12) "Electrochemical Investigation on the Binding Interaction of Organic Molecules with DNAs and Proteins". at The 12th International Beijing Conference and Exhibition on Instrumental Analysis. (Oct 18-21, 2007), Beijing, China.

(11) "Fluorescent Probes for Signal Enhancement in Immunoassays and for the Investigation of PAH/DNA Interactions". at Colloqium Spectroscopicum International XXXV. (Sept 23-27, 2007), Xiamen, China.

(10) "Photoelectrochemical Sensor for Rapid Detection of in-situ Enzymatically Driven DNA Damage". at The Eleventh International Symposium on Electroanalytical Chemistry. (Aug 16-19, 2007), Changchun, China.

(9) "Nano-Bio-Sensors for Environmental Monitoring". at The CAS-AIST-DEDO Workshop on Energy- and Environment-Related Nanotechnology. (Dec 11-13, 2006), Beijing, China.

(8) "Photoelectrochemical DNA Sensor for Rapid Screening of DNA-Damaging Agents". at The Third International Symposium on Persistent Toxic Substances. (Oct 22-25, 2006), Beijing, China.

(7) "Rapid Photoelectrochemical Methods for Screening DNA-damaging Agents". at The International Workshop on Water Contaminants & Health Effects. (Jul 5-8, 2006), Alberta, Canada.

(6) "Selective photoelectrochemical detection of native and damaged DNA". at. The 10th International Symposium on Electroanalytical Chemistry (Oct 16-19, 2005), Changchun, China.

(5) "Study of DNA/small molecule interaction by DNA film electrochemistry". at The 11th International Beijing Conference and Exhibition on Instrumental Analysis. (Oct 20-23, 2005), Beijing, China.

(4) "Electrochemical Study of Binding Interaction between Transition-metal Complex and DNA". At The 40th IUPAC Congress. (Aug 14-19, 2005), Beijing, China.

(3) "Electrochemical and photoelectrochemical study of DNA/small molecule interaction and detection of double-stranded and damaged DNA ". at The 2nd International Symposium on Persistent Toxic Substances. (May 15-18, 2005), Beijing, China.

(2) "Chemically amplified electrochemical detection of bio-affinity reactions ". at The 5th Asian Conference on Electrochemistry. (May 9-12, 2005), Shanghai, China.

(1) "Chemically Amplified Electrochemical Detection of Biological Affinity Reactions". At The First International Symposium on Persistent Toxic Substances. (Nov 7-11, 2004), Beijing, China.

已指导学生

梁敏敏  博士研究生  083001-环境科学  

曲娜  博士研究生  083001-环境科学  

陈艳敏  硕士研究生  083001-环境科学  

朱胜超  硕士研究生  083001-环境科学  

张勤  博士研究生  083001-环境科学  

韦明元  博士研究生  083001-环境科学  

王丽荣  博士研究生  083001-环境科学  

高铭徽  硕士研究生  083001-环境科学  

黄荣富  博士研究生  083001-环境科学  

曹洁  博士研究生  083001-环境科学  

贾素萍  博士研究生  083001-环境科学  

刘阳  硕士研究生  070302-分析化学  

高宇  博士研究生  083001-环境科学  

董平轩  博士研究生  083001-环境科学  

范子彦  博士研究生  083001-环境科学  

任肖敏  博士研究生  083001-环境科学  

马强  博士研究生  083001-环境科学  

张斌田  博士研究生  083001-环境科学  

李欣欣  硕士研究生  083001-环境科学  

张连营  博士研究生  083001-环境科学  

孙静  博士研究生  083001-环境科学  

汪素芳  博士研究生  083001-环境科学  

吕琪妍  博士研究生  083001-环境科学  

吴一萍  博士研究生  070302-分析化学  

王大彬  博士研究生  083001-环境科学  

李忠民  硕士研究生  077601-环境科学  

现指导学生

马海艳  博士研究生  070302-分析化学  

冯锐  博士研究生  083001-环境科学  

曹林英  博士研究生  070302-分析化学  

赵可达  博士研究生  083001-环境科学  

崔雪晶  博士研究生  083001-环境科学  

辛岩  博士研究生  083001-环境科学  

李栋   博士研究生  083001-环境科学