基本信息
刘利  女  博导  中国科学院化学研究所
电子邮件: lliu@iccas.ac.cn
通信地址: 北京海淀中关村北一街2号
邮政编码: 100190

研究领域

        有机合成方法学

        不对称有机反应

        水相有机反应

教育背景

   
学历

博士

学位
1987北京师范大学 理学学士
1990北京师范大学 理学硕士
1995中国科学院化学研究所 理学博士

工作经历

   
工作简历
1990-1991 云南师范大学化学系 教师
1995-1999中国科学院研究生院 副教授
1999-2001 比利时根特大学有机化学系 博士后
2002 美国西雅图华盛顿大学 博士后
2003-今 中科院化学所 研究员,博士生导师

出版信息

   
发表论文
[1] He, Yinming, Liu, Li, Cheng, Liang. A Short Review of Research Progress on the Synthesis Approaches of Aza-Dibenzocyclooctyne Derivatives. MOLECULES[J]. 2023, 28(9): http://dx.doi.org/10.3390/molecules28093715.
[2] Yi-Zhan Wang, Shao-Dong Liu, Liang Cheng, Li Liu, Chao-Jun Li. Asymmetric addition of hydrazones as alkyl carbanion equivalents with aryl imines in water. Org. Chem. Front.[J]. 2023, 3021-3026, [3] Sun, Xin, Liu, Li, Cheng, Liang. Photo- and Tetrazine-Responsive Modulation of trans-Zeatin. JOURNAL OF ORGANIC CHEMISTRY. 2023, http://dx.doi.org/10.1021/acs.joc.2c02601.
[4] Wang, ZhaoLi, Liu, AnDi, Liu, Li, Cheng, Liang. Recent Advances in the Synthesis of 5-(Hetero)aryl Uracil Derivatives. SYNLETT. 2023, http://dx.doi.org/10.1055/a-2091-1071.
[5] Jin XiaoYang, Wu ChuanShuo, An-Di Liu, Liu Li, Cheng Liang. Synthesis of Rigid Rod, Trigonal, and Tetrahedral Nucleobase-Terminated Molecules. SYNTHESIS-STUTTGART[J]. 2022, 54(6): 1643-1651, http://dx.doi.org/10.1055/a-1695-0820.
[6] Xie, LiJun, Lin, CuiLian, Liu, Li, Cheng, Liang. A chemical labeling of N-6-formyl adenosine (f(6)A) RNA. CHINESE CHEMICAL LETTERS[J]. 2022, 33(3): 1563-1566, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000772416400078.
[7] Xiao-Yang Jin, Zu-Rui Huang, Li-Jun Xie, Li Liu, Da-Li Han, Liang Cheng. Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA. Angewandte Chemie International Edition[J]. 2022, 61: e202210652-, [8] Lan, Ling, Sun, YingJie, Jin, XiaoYang, Xie, LiJun, Liu, Li, Cheng, Liang. A Light-Controllable Chemical Modulation of m(6)A RNA Methylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(33): 18116-18121, http://dx.doi.org/10.1002/anie.202103854.
[9] SongChen Yu, Liang Cheng, Li Liu. Asymmetric Organocatalysis with Chiral Covalent Organic Frameworks. ORGANIC MATERIALS[J]. 2021, 3(2): 245-253, https://doaj.org/article/67563c4487ad4a2f8b55ae65b665b668.
[10] Gao, YuTing, Liu, ShaoDong, Cheng, Liang, Liu, Li. A fast and direct iodide-catalyzed oxidative 2-selenylation of tryptophan. CHEMICAL COMMUNICATIONS[J]. 2021, 57(28): 3504-3507, http://dx.doi.org/10.1039/d1cc00700a.
[11] Wang, YiZhan, Liu, Qi, Cheng, Liang, Yu, SongChen, Liu, Li, Li, ChaoJun. Addition reactions of organic carbanion equivalents via hydrazones in water. TETRAHEDRON[J]. 2021, 80: http://dx.doi.org/10.1016/j.tet.2020.131889.
[12] Xie, LiJun, Liu, Li, Cheng, Liang. Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases. BIOCHEMISTRY[J]. 2020, 59(3): 230-239, https://www.webofscience.com/wos/woscc/full-record/WOS:000510530400004.
[13] Xie, LiJun, Liu, Li, Cheng, Liang. Modifying Methionine on Proteins. CHEMBIOCHEM. 2020, 21(4): 461-463, http://dx.doi.org/10.1002/cbic.201900533.
[14] Wang, Ruili, Lan, Ling, Liu, Li, Cheng, Liang. Asymmetric polymerase chain reaction and loop-mediated isothermal amplification (AP-LAMP) for ultrasensitive detection of microRNAs. CHINESE CHEMICAL LETTERS[J]. 2020, 31(1): 159-162, http://lib.cqvip.com/Qikan/Article/Detail?id=7101029661.
[15] Sun, YingJie, Liu, Li, Cheng, Liang. Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides. CHEMICAL COMMUNICATIONS[J]. 2020, 56(48): 6484-6487, https://www.webofscience.com/wos/woscc/full-record/WOS:000544281500030.
[16] Jin, XiaoYang, Wang, RuiLi, Xie, LiJun, Kong, DeLong, Liu, Li, Cheng, Liang. A Chemical Photo-Oxidation of 5-Methyl Cytidines. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 361(20): 4685-4690, http://dx.doi.org/10.1002/adsc.201900811.
[17] Xie, LiJun, Yang, XiaoTi, Wang, RuiLi, Cheng, HouPing, Li, ZhiYan, Liu, Li, Mao, Lanqun, Wang, Ming, Cheng, Liang. Identification of Flavin Mononucleotide as a Cell-Active Artificial N-6-Methyladenosine RNA Demethylase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(15): 5028-5032, http://dx.doi.org/10.1002/anie.201900901.
[18] Liu, JieJie, Lan, Ling, Gao, YuTing, Liu, Qi, Cheng, Liang, Wang, Dong, Liu, Li. Visible-Light-Mediated Stereoselective 1,2-Iodoalkylation of Alkynes. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 361(6): 1283-1288, https://www.webofscience.com/wos/woscc/full-record/WOS:000462674700012.
[19] Li, XueDong, Gao, YuTing, Sun, YingJie, Jin, XiaoYang, Wang, Dong, Liu, Li, Cheng, Liang. A NaI/H2O2-Mediated Sulfenylation and Selenylation of Unprotected Uracil and Its Derivatives. ORGANIC LETTERS[J]. 2019, 21(17): 6643-6647, [20] Zhong, NengJun, Wang, YiZhan, Cheng, Liang, Wang, Dong, Liu, Li. Recent advances in the annulation of Morita-Baylis-Hillman adducts. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(29): 5214-5227, https://www.webofscience.com/wos/woscc/full-record/WOS:000439945800001.
[21] Liu Li. 5. Iodide/H2O2 Catalyzed Intramolecular Oxidative Amination for the Synthesis of 3,2 '-Pyrrolidinyl Spirooxindoles. MOLECULES. 2018, [22] Liu, JieJie, Huang, HongYan, Cheng, Liang, Liu, Qi, Wang, Dong, Liu, Li. A catalyst-free intermolecular trans-iodoalkylation of alkynes. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(6): 899-903, https://www.webofscience.com/wos/woscc/full-record/WOS:000424695100007.
[23] Liu, Qi, Liu, JieJie, Cheng, Liang, Wang, Dong, Liu, Li. TEMPO promoted direct multi-functionalization of terminal alkynes with 2-oxindoles/benzofuran-2(3H)-one. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(29): 5228-5231, [24] Liu Li. Ruthenium-Catalyzed Decarboxylative C-H Alkenylation in Aqueous Media: A Synthesis of Tetrahydropyridoindoles. JORGCHEM. 2018, [25] Liu, JieJie, Cheng, Liang, Huang, HongYan, Wei, Feng, Wang, Dong, Liu, Li. Unprecedented formation of 3-(tetrahydrofuran-2-yl)-4H-chromen-4-one in a reaction between 3,3a-dihydro-9H-furo3,4-b chromen-9-one and malononitrile. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2017, 15(23): 5078-5088, http://dx.doi.org/10.1039/c7ob00904f.
[26] Xie, LiJun, Wang, RuiLi, Wang, Dong, Liu, Li, Cheng, Liang. Visible-light-mediated oxidative demethylation of N-6-methyl adenines. CHEMICAL COMMUNICATIONS[J]. 2017, 53(77): 10734-10737, http://dx.doi.org/10.1039/c7cc05544g.
[27] 程靓. Unprecedented formation of 3-(tetrahydrofuran-2-yl)-4H-chromen-4-one in the reaction between 3,3a-dihydro-9H-furo[3,4-b]chromen-9-one with malononitrile. Org. Biomol. Chem.. 2017, [28] Gu, Chunling, Li, Yangxiong, Xiao, Lu, Fu, Hongbing, Wang, Dong, Cheng, Liang, Liu, Li. Tunable Heck-Mizoroki Reaction of Dibromonaphthalene Diimide with Aryl Ethylenes: Design, Synthesis, and Characterization of Coplanar NDI-Based Conjugated Molecules. JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 82(23): 12806-12812, http://dx.doi.org/10.1021/acs.joc.7b02140.
[29] Huang, HongYan, Cheng, Liang, Liu, JieJie, Wang, Dong, Liu, Li, Li, ChaoJun. Transition-Metal-Free Alkynylation of 2-Oxindoles through Radical-Radical Coupling. JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 82(5): 2656-2663, https://www.webofscience.com/wos/woscc/full-record/WOS:000395726000033.
[30] Kong, DeLong, Cheng, Liang, Yue, Tao, Wu, HongRu, Feng, WeiChun, Wang, Dong, Liu, Li. Cobalt-Catalyzed Peroxidation of 2-Oxindoles with Hydroperoxides. JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 81(13): 5337-5344, https://www.webofscience.com/wos/woscc/full-record/WOS:000379456500010.
[31] Liu Li. Organocatalytic Enantioselective Reaction of Cyclopent-2-enone-. Adv. Synth. Catal. 2016, [32] Kong, DeLong, Cheng, Liang, Wu, HongRu, Li, YangXiong, Wang, Dong, Liu, Li. A metal-free yne-addition/1,4-aryl migration/decarboxylation cascade reaction of alkynoates with C-sp3-H centers. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(7): 2210-2217, http://dx.doi.org/10.1039/c5ob02478a.
[33] 程靓. Intermolecular Dearomative Oxidative Coupling of Indoles with Ketones and Sulfonylhydrazines Catalyzed by I2 for the Synthesis of [2,3]-Fused Indoline Tetrahydropyridazines. Sci. China Chem.. 2016, [34] Wu, HongRu, Cheng, Liang, Kong, DeLong, Huang, HongYan, Gu, ChunLing, Liu, Li, Wang, Dong, Li, ChaoJun. FeCl3-Mediated Radical Tandem Reactions of 3-Benzyl-2-oxindoles with Styrene Derivatives for the Stereoselective Synthesis of Spirocyclohexene Oxindoles. ORGANIC LETTERS[J]. 2016, 18(6): 1382-1385, https://www.webofscience.com/wos/woscc/full-record/WOS:000372664600042.
[35] Wei, Feng, Cheng, Liang, Huang, Hongyan, Liu, Jiejie, Wang, Dong, Liu, Li. Intermolecular dearomative oxidative coupling of indoles with ketones and sulfonylhydrazines catalyzed by I-2: synthesis of 2,3-fused indoline tetrahydropyridazines. SCIENCE CHINA-CHEMISTRY[J]. 2016, 59(10): 1311-1316, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5814418&detailType=1.
[36] Wei, Feng, Ren, ChuanLi, Wang, Dong, Liu, Li. Highly Enantioselective 3+2 Cycloaddition of Vinylcyclopropane with Nitroalkenes Catalyzed by Palladium(0) with a Chiral Bis(tert-amine) Ligand. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2015, 21(6): 2335-2338, http://dx.doi.org/10.1002/chem.201405407.
[37] Li, Yangxiong, Liu, Li, Kong, Delong, Wang, Dong, Feng, Weichun, Yue, Tao, Li, Chaojun. Palladium-Catalyzed Alkynylation of Morita-Baylis-Hillman Carbonates with (Triisopropylsilyl)acetylene on Water. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 80(12): 6283-6290, http://dx.doi.org/10.1021/acs.joc.5b00728.
[38] Wu, HongRu, Huang, HongYan, Ren, ChuanLi, Liu, Li, Wang, Dong, Li, ChaoJun. Fe-III-Catalyzed Cross-Dehydrogenative Arylation (CDA) between Oxindoles and Arenes under an Air Atmosphere. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2015, 21(47): 16743-16748, http://dx.doi.org/10.1002/chem.201502519.
[39] Wei, Feng, Huang, HongYon, Zhong, NengJun, Gu, ChunLing, Wang, Dong, Liu, Li. Highly Enantioselective 3+2-Annulation of Isatin-Derived Morita-Baylis-Hillman Adducts with Cyclic Sulfonimines. ORGANIC LETTERS[J]. 2015, 17(7): 1688-1691, http://dx.doi.org/10.1021/acs.orglett.5b00456.
[40] Huang, HongYan, Wu, HongRu, Wei, Feng, Wang, Dong, Liu, Li. Iodine-Catalyzed Direct Olefination of 2-Oxindoles and Alkenes via Cross-Dehydrogenative Coupling (CDC) in Air. ORGANIC LETTERS[J]. 2015, 17(15): 3702-3705, http://dx.doi.org/10.1021/acs.orglett.5b01662.
[41] Liu Li. Highly enantioselective reaction of 2-oxindoles with (3-indonyl)methanols by cooperative Catalysis of a Lewis acid and organocatalyst. Org. Biomol. Chem.. 2014, [42] Zhang, JiaQiang, Liu, JieJie, Gu, ChunLing, Wang, Dong, Liu, Li. Tunable Base-Controlled Regioselective Cascade Reaction of 2-Mercaptobenzimidazole with Morita-Baylis-Hillman Acetates of Nitroalkenes. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 2014(27): 5885-5889, http://dx.doi.org/10.1002/ejoc.201402752.
[43] Liu Li. Asymmetric direct α-alkylation of 2-oxindoles with Michler's hydrol catalyzed by bis-cinchona alkaloid–Brønsted acid via an SN1-type pathway. Chem. Commun.. 2013, [44] Zhong, Nengjun, Liu, Li, Wang, Dong, Chen, YongJun. Enantioselective tandem reaction of chromone-derived Morita-Baylis-Hillman carbonates with benzylamines catalyzed by a trifunctional organocatalyst: the synthesis of chiral 3-aminomethylene-flavanones. CHEMICAL COMMUNICATIONS[J]. 2013, 49(35): 3697-3699, http://dx.doi.org/10.1039/c3cc41011k.
[45] Li, YangXiong, Xuan, QingQing, Liu, Li, Wang, Dong, Chen, YongJun, Li, ChaoJun. A Pd(0)-Catalyzed Direct Dehydrative Coupling of Terminal Alkynes with Allylic Alcohols To Access 1,4-Enynes. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 135(34): 12536-12539, http://dx.doi.org/10.1021/ja406025p.
[46] Wang, Yan, Liu, Li, Zhang, Tao, Zhong, NengJun, Wang, Dong, Chen, YongJun. Diastereo- and Enantioselective 3+2 Cycloaddition Reaction of Morita-Baylis-Hillman Carbonates of Isatins with N-Phenylmaleimide Catalyzed by Me-DuPhos. JOURNAL OF ORGANIC CHEMISTRY[J]. 2012, 77(8): 4143-4147, http://dx.doi.org/10.1021/jo3002535.
[47] Wang Xiaoming, Meng Fanye, Wang Yan, Han Zhaobin, Chen Yongjun, Liu Li, Wang Zheng, Ding Kuiling. Aromatic Spiroketal Bisphosphine Ligands: Palladium-Catalyzed Asymmetric Allylic Amination of Racemic Morita-Baylis-Hillman Adducts. ANGEWCHEMINTED[J]. 2012, 51(37): 9276-9282, http://www.irgrid.ac.cn/handle/1471x/682108.

指导学生

王炎  硕士研究生  070303-有机化学  80032-化学研究所

武陈  博士研究生  070303-有机化学  80032-化学研究所

张涛  硕士研究生  070303-有机化学  80032-化学研究所

乔桢  博士研究生  070303-有机化学  80032-化学研究所