基本信息
胡振华  女  博导  中国科学院自动化研究所
电子邮件: zhenhua.hu@ia.ac.cn
通信地址: 北京市海淀区中关村东路 95 号中 国科学院自动化研究所智能化大厦9#905
邮政编码: 100190

研究领域

以计算机技术为主要手段,以生物医学成像为主题,主要研究内容包含三个方面:新型生物医学成像模型与方法,新型生物医学成像系统,生物医学应用与临床转化。

招生信息

博导招生专业

模式识别与智能系统,研究方向:医学影像处理与分析

计算机应用技术,研究方向:生物特征识别与系统

生物医学工程


硕导招生专业

模式识别与智能系统,研究方向:医学影像处理与分析

工作经历

工作简历

  • 中国科学院自动化研究所,中国科学院分子影像重点实验室, 研究员,2016.10 – 至今

  • 中国科学院自动化研究所,中国科学院分子影像重点实验室, 副研究员,2014.11 – 2016.09

  • 中国科学院自动化研究所,中国科学院分子影像重点实验室, 助理研究员,2012.09 – 2014.10


部分学术任职

  • Frontiers in Biomedical Physics期刊编委(Frontiers Editorial Office),以及多个国际SCI期刊审稿人,包括IEEE Transactions on Medical Imaging、Applied Physics Letters、Molecular Imaging and Biology、Nanomedicine: Nanotechnology, Biology, and Medicine、Bioorganic & Medicinal Chemistry、EJNMMI Research、Frontiers in Physics等。

  • 中国医师协会整合医学医师分会整合肿瘤学专业委员会(学组)第一届委员会,常务委员,2017.04 – 2020.04

  • 中国研究型医院学会消化内镜分子影像学专业委员会,常务委员,2014.12 – 2019.12

  • 泛亚消化内镜技术创新战略联盟,常务理事,2015.05 – 2018.05

  • 中国抗癌协会整合肿瘤学分会第一届委员会,委员,2017.04-至今

  • 中华医学会核医学分会PET/MR脑功能成像专业委员会,委员,2017.09 – 2018.09

  • Society of Nuclear Medicine and Molecular Imaging(美国核医学与分子影像学会),会员,2013.07 – 至今


获奖和专利

部分学术获奖

  • 北京自然科学基金会杰出青年学者奖, , 省级, 2019
  • 北京市科技新星奖, , 省级, 2018
  • 中美核医学青年研究学者奖, , 其他, 2017
  • 国家自然科学基金优秀青年学者奖, , 国家级, 2016
  • 中美核医学青年研究学者奖, 其他, 2016
  • 第八届国际发明展览会金奖, 其他, 2014
  • 世界分子影像大会旅行资助奖, 其他, 2014
  • 中美核医学青年研究学者奖, 其他, 2013


部分发明专利

  • 基于契伦科夫效应的内窥平面成像系统和方法, 发明, 2015, 第 1 作者, 专利号: ZL2014103022055

  • 近红外荧光手术成像系统及其使用方法, 发明, 2019, 第 2 作者, 专利号: CN109480776A

  • 契伦科夫光学术中成像系统及其使用方法, 发明, 2018, 第 2 作者, 专利号: CN109480874A

  • 近红外二区荧光断层成像系统, 发明, 2018, 第 3 作者, 专利号: CN109044277A

  •  近红外二区单通道分时复用成像系统及其使用方法, 发明, 2020, 第 2 作者, 专利号: CN110833399A

  •  近红外二区/一区双模态荧光断层成像系统及方法, 发明, 2019, 第 2 作者, 专利号: CN110327020A

  • 术中组织契伦科夫荧光成像系统及其图像处理方法, 发明, 2019, 第 2 作者, 专利号: CN110327019A

  •  Intraoperative near-infrared-I and near-infrared-II multispectral fluorescent navigation system and method of using the same, 发明, 2019, 第 2 作者, 专利号: US-2020-0132599-A1

  • Second near-infrared window / first near-infrared window dual-mode fluorescence tomography system and method, 发明, 2020, 第 2 作者, 专利号: US16/845,267

发表论文

近年发表部分SCI期刊论文情况:

  1. Hu Z, Fang C, Li B, Zhang Z, Cao C, Cai M, Su S, Sun X, Shi X, Li C, Zhou T, Zhang Y, Chi C, He P, Xia X, Chen Y, Gambhir SS*, Cheng Z*, Tian J*. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows. Nature Biomedical Engineering. 2020; 4(3): 259-271.

  2. Hu Z, Chen W, Tian J*, Cheng Z*. NIRF nanoprobes for cancer molecular imaging: approaching clinic. Trends in Molecular Medicine. 2020; 26(5): 469-482. (Highlighted as Featured Article)

  3. Cai M, Zhang Z, Shi X, Yang J, Hu Z*, Tian J*. Non-negative iterative convex refinement approach for accurate and robust reconstruction in Cerenkov luminescence tomography. IEEE Transactions on Medical Imaging. 2020; doi:10.1109/TMI.2020.2987640.

  4. Cai M, Zhang Z, Shi X, Hu Z*, Tian J*. NIR-II/NIR-I fluorescence molecular tomography of heterogeneous mice based on gaussian weighted neighborhood fused lasso method. IEEE Transactions on Medical Imaging. 2020; doi:10.1109/TMI.2020.2964853.

  5. Zheng S, Zhang Z, Qu Y, Zhang X, Guo H, Shi X, Cai M, Cao C, Hu Z*, Liu H*, Tian J*. Radiopharmaceuticals and Fluorescein Sodium Mediated TripleModality Molecular Imaging Allows Precise ImageGuided Tumor Surgery. Advanced Science. 2019:1900159. (Highlighted as Back Cover Article)

  6. Zhang Z, Cai M, Bao C, Hu Z*, Tian J*. Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models. Nanomedicine: Nanotechnology, Biology and Medicine. 2019; 17:62-70. (Highlighted as Featured Article and Cover Article)

  7. Zhang Z, Qu Y, Cao Y, Shi X, Guo H, Zhang X, Zheng S, Liu H*, Hu Z*, Tian J*. A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer. Journal of Biophotonics. 2020; 13(3): e201960152. (Highlighted as Featured Article and Back Cover Article)

  8. Zhang Z, Cai M, Gao Y, Shi X, Zhang X, Hu Z*, Tian J*. A novel Cerenkov luminescence tomography approach using multilayer fully connected neural network. Physics in Medicine and Biology. 2019; 64(24): 245010.

  9. Liu M, Zheng S, Zhang X, Guo H, Shi X, Kang X, Qu Y, Hu Z*, Tian J*. Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer. Nanomedicine: Nanotechnology, Biology, and Medicine. 2018; 14(1):205-213. (Highlighted as Featured Article and Cover Article)

  10. Hu Z, Zhao M, Qu Y, Zhang X, Zhang M, Liu M, Guo H, Zhang Z, Wang J*, Yang W*, Tian J*. In vivo three-dimensional radiopharmaceutical excited fluorescence tomography. Journal of Nuclear Medicine. 2017; 58(1):169-174.

  11. Hu Z, Chi C, Liu M, Guo H, Zhang Z, Zeng C, Ye J, Wang J, Tian J*, Yang W*, Xu W*. Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery. Nanomedicine: Nanotechnology, Biology and Medicine. 2017; 13(4):1323-1331.

  12. Guo H, He X*, Liu M, Zhang Z, Hu Z*, Tian J*. Weight multispectral reconstruction strategy for enhanced reconstruction accuracy and stability with Cerenkov luminescence tomography. IEEE Transactions on Medical Imaging. 2017; 36(6):1337-1346.

  13. Liu M, Guo H, Liu H, Zhang Z, Chi C, Hui H, Dong D, Hu Z*, Tian J*. In vivo pentamodal tomographic imaging for small animals. Biomedical Optics Express. 2017; 8(3):1356-1371.

  14. Guo H, Hu Z*, He X*, Zhang X, Liu M, Zhang Z, Shi X, Zheng S, Tian J*. Non-convex sparse regularization approach framework for high multiple-source resolution in Cerenkov luminescence tomography. Optics Express, 2017, 25(23):28068-28085.

  15. Hu Z, Qu Y, Wang K, Zhang X, Zha J, Song T, Bao C, Liu H, Wang Z, Wang J, Liu Z, Liu H*, Tian J*. In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging. Nature Communications. 2015; 6:7560.

  16. Wang K, Chi C, Hu Z, Liu M, Hui H, Shang W, Peng D, Zhang S, Ye J, Liu H, Tian J*.Optical molecular imaging frontiers in oncology: the pursuit of accuracy and sensitivity. Engineering. 2015;1(3): 309-323.

  17. Liu H, Yang X, Song T, Bao C, Shi L, Hu Z*, Wang K*, Tian J*. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method. Journal of Biomedical Optics. 2015; 20(8):086007.

  18. Song T, Liu X*, Qu Y, Liu H, Bao C, Leng C, Hu Z*, Wang K*, Tian J*. A novel endoscopic Cerenkov luminescence imaging system for intraoperative surgical navigation. Molecular Imaging. 2015; 14:443-449.

  19. Hu Z, Yang W, Liu H, Wang K, Bao C, Song T, Wang J*, Tian J*. From PET/CT to PET/MRI: advances in instrumentation and clinical applications. Molecular Pharmaceutics. 2014; 11(11):3798-3809.

  20. Ding X, Wang K, Jie B, Luo Y, Hu Z*, Tian J. Probability method for Cerenkov luminescence tomography based on conformance error minimization. Biomedical Optics Express. 2014; 5(7):2091-2112.

  21. Hu Z, Yang W, Ma X, Ma W, Qu X, Liang J*, Wang J*, Tian J*. Cerenkov luminescence tomography of aminopeptidase N (APN/CD13) expression in mice bearing HT1080 tumors. Molecular Imaging. 2013; 12(3):173-181.

  22. Hu Z, Ma X, Qu X, Yang W, Liang J, Wang J*, Tian J*. Three-dimensional noninvasive monitoring iodine-131 uptake in the thyroid using a modified Cerenkov luminescence tomography approach. PLoS ONE. 2012; 7(5): e37623.

  23. Hu Z, Chen X, Liang J*, Qu X, Chen D, Yang W, Wang J, Cao F, Tian J*. Single photon emission computed tomography-guided Cerenkov luminescence tomography. Journal of Applied Physics. 2012; 112(2):024703.

  24. Yang W, Qin W, Hu Z, Suo Y, Zhao R, Ma X, Ma W, Wang T, Liang J, Tian J, Wang J*. Comparison of Cerenkov luminescence imaging (CLI) and gamma camera imaging for visualization of let-7 expression in lung adenocarcinoma A549 cells. Nuclear Medicine and Biology. 2012; 39(7):948-953.

  25. Qin C, Zhong J, Hu Z, Yang X, Tian J*. Recent advances in Cerenkov luminescence and tomography imaging. IEEE Journal of Selected Topics in Quantum Electronics. 2012; 18(3):1084-1093.

  26. Ren N, Zhao H, Zhu S, Qu X, Liu H, Hu ZLiang J*, Tian J*. Voxel classification methodology for rapid Monte Carlo simulation of light propagation in complex media. Chinese Optics Letters. 2011; 9(4):041701-1-4.

  27. Zhang Q, Zhao H, Chen D, Qu X, Chen X, He X, Li W, Hu Z, Liu J, Liang J*, Tian J*. Source sparsity based primal-dual interior-point method for three-dimensional bioluminescence tomography. Optical Communication. 2011; 284(24):5871-5876.

  28. Hu Z, Liang J, Yang W, Fan W, Li C, Ma X, Chen X, Ma X, Li X, Qu X, Wang J*, Cao F*, Tian J*. Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation. Optics Express. 2010; 18(24):24441-24450. 

  29. Liu J, Wang Y, Qu X, Li X, Ma X, Han R, Hu Z, Chen X, Sun D, Zhang R, Chen D, Chen D, Chen X, Liang J*, Cao F*, Tian J*. In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models. Optical Express. 2010; 18(12):13102-13113. 


部分国际会议论文发表情况:                                                                

  1. Shi X, Zhang Z, Hu Z*, Tian J*. A doped nanoparticle mediate 18F-FDG excited fluorescence molecular imaging. The 2019 SPIE Photonics West, San Francisco, USA, February. 2-7 (oral presentation)

  2. Hu Z, Zhang Z, Guo H, Tian J. Intraoperative Cerenkov luminescence imaging for image-guided resection of low rectal cancer on swine models. The 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Philadelphia, USA, Jun. 23-26 (oral presentation)

  3. Hu Z, Zhang Z, Guo H, Liu M, Shi X, Tian J. Construction of a novel intraoperative Cerenkov luminescence imaging system for image-guided resection of colorectal cancer on patients. The 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Denver, USA, Jun. 10-14 (oral presentation) (2017 Young Investigator Award from the Chinese American Society of Nuclear Medicine).

  4. Hu Z, Liu M, Guo H, Zhang Z, Tian J. Image-guided cancer surgery using a novel nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging. The 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, San Diego, USA, Jun. 11-15 (oral presentation) (2016 Young Investigator Award from the Chinese American Society of Nuclear Medicine).

  5. Hu Z, Ding X, Jia X, Tian J. Comparison of Cerenkov luminescence imaging and positron emission tomography for the detection of subcutaneous breast tumor in animal models. The 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Baltimore, USA, Jun. 6-10.

  6. Hu Z, Tan T, Qu Y, Zhang X, Liu H, Tian J. High resolution micro-endoscopy for the diagnosis of gastric carcinoma and precancerous lesions. The 2015 World Molecular Imaging Congress, Honolulu, USA, Sept. 2-5.

  7. Hu Z, Qu Y, Wang K, Song T, Zhang X, Liu H, Tian J. A preliminary study: radiopharmaceuticals induced fluorescence imaging in vivo. The 2014 World Molecular Imaging Congress, Seoul, Korea, Sept. 17-20 (KSMI Travel Stipend Award for the World Molecular Imaging Congress).

  8.  Hu Z, Wang K, Song T, Tian J. A new optical imaging strategy: 18F-FDG induced rare earth luminescence imaging. The 2014 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, St. Louis, USA, Jun. 7-11.

  9. Hu Z, Qu Y, Wang K, Zhang X, Liu H, Tian J. In vivo radiopharmaceutical excitation fluorescence imaging. The 2014 IEEE nuclear science symposium and medical imaging conference, Seattle, USA, Nov. 8-15.

  10. Hu Z, Wang K, Liu H, Mu W, Zhang Q, Du Y, Tian J. Endoscopic Cerenkov luminescence tomography of rats with gastric tumors. The 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Vancouver, Canada, Jul. 8-12 (oral presentation) (2013 Young Investigator Award for the Chinese American Society of Nuclear Medicine).

  11. Hu Z, Liu H, Wang K, Mu W, Ding X, Tian J. Bronchoscopic Cerenkov luminescence imaging of the radioactive source with 18F-FDG. The 2013 World Molecular Imaging Congress, Georgia, USA, Sept. 18-21.

  12.  Hu Z, Yang W, Ma X, Ma W, Chen Z, Qu X, Wang J, Liang J, Tian J. Cerenkov-based optical tomography of APN/CD13 expression in the nude mice bearing HT1080 fibrosarcoma tumours. The 2012 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Miami, USA, Jul. 9-13.

  13. Hu Z, Zhou Y, Lin X, Yang W, Qu X, Liang J, Wang J, Tian J. Penetration depth limits of Cerenkov luminescence generation from electron-emitting radiotracer. The 2011 World Molecular Imaging Congress, San Diego, USA, Sept. 7-10.

  14. Song T, Hu Z, Lu J, Wang K, Liu X, Tian J. In vitro and in vivo endoscopic Cerenkov luminescence imaging. The 2014 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, St. Louis, USA, Jun. 7-11 (oral presentation).

  15. Song T, Bao C, Hu Z, Wang K, Liu X, Tian J. Endoscopic Cerenkov luminescence imaging: in vivo small animal tumor model validation. The 2015 Society of Photo-Optical Instrumentation Engineers Medical Imaging, Orlando, USA, Feb. 21-26.

  16. Liu H, Hu Z, Wang K, Tian J. Cerenkov luminescence tomography based on preconditioning orthogonal matching pursuit. The 2015 Society of Photo-Optical Instrumentation Engineers Medical Imaging, Orlando, USA, Feb. 21-26.

  17.  Liu H, Hu Z, Wang K, Song T, Bao C, Tian J. Cerenkov luminescence tomography based on the high-order simplified spherical harmonics approximation. The 2014 World Molecular Imaging Congress, Seoul, Korea, Sept. 17-20.

  18. Song T, Hu Z, Wang K, Liu X, Tian J. A research of small animal Cerenkov surgical navigation system. The 2014 World Molecular Imaging Congress, Seoul, Korea, Sept. 17-20.

  19.  Liu H, Hu Z, Wang K, Mu W, Tian J. An improved multispectral Cerenkov luminescence tomography for the mouse with the implanted radioactive source. The 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Vancouver, Canada, Jul. 8-12.

  20. Wang K, Hu Z, Liu H, Mu W, Tian J. In vivo hybrid spectral Cerenkov luminescence tomography using positron-emitting radiopharmaceutical 18F-FDG. The 2013 World Molecular Imaging Congress, Georgia, USA, Sept. 18-21.

  21. Mu W, Liu H, Shen W, Hu Z, Wang K, Tian J. Automatic extraction of Region of Interest from the emerging Cerenkov Luminescence Endoscopy Images. The 2013 World Molecular Imaging Congress, Georgia, USA, Sept. 18-21.

  22. Mu W, Liu H, Ding X, Song T, Hu Z, Wang K, Tian J. Uncoupled Endoscopic Cerenkov luminescence Imaging of Small Animals. The 13th Annual Conference of Chinese Biophysics Society, Nanchang, Jiangxi, 2013, Oct. 28-Nov. 1. 

等国际会议邀请报告和论文及国内报告二十余次。

科研活动

作为项目负责人的部分科研项目情况:

  1. 国家自然科学基金优秀青年科学基金项目,“分子影像”,主持

  2. 科技部国家重点研发计划数字诊疗装备研发重点专项(青年科学家项目),“基于核素放射激发荧光断层成像的肿瘤检测新技术”,主持;

  3. 北京市自然科学基金杰出青年科学基金,“新型活体光学分子影像技术研发与应用”主持;

  4. 北京市科技新星计划,“基于放射激发荧光分子成像的肿瘤早期检测新技术”,主持;

  5. 国家自然科学基金面上项目,“放射激发荧光断层成像用于微小肿瘤诊疗一体化的研究”,主持;

  6. 中国科学院科研装备研制项目,“小动物活体多靶点多谱段光学断层分子成像系统”,主持;

  7. 国家自然科学基金青年项目,“基于混合谱的契伦科夫光学断层成像重建方法研究”,主持。

合作情况


项目协作单位

中国人民解放军总医院(301医院)

中国人民解放军总医院第三医学中心

首都医科大学附属北京天坛医院

北京协和医院

北京大学肿瘤医院

北京大学

指导学生

现指导学生

曹财广  博士研究生  081104-模式识别与智能系统  

李聪  硕士研究生  081104-模式识别与智能系统  

沈碧螺  硕士研究生  085211-计算机技术  

史小静  博士研究生  081104-模式识别与智能系统  

博士后/讲师

丁新涛         安徽师范大学  博士

博士研究生

蔡美山         中国科学院自动化研究所,中国科学院分子影像重点实验室

史小静         中国科学院自动化研究所,中国科学院分子影像重点实验室

曹财广         中国科学院自动化研究所,中国科学院分子影像重点实验室

    玮         中国科学院自动化研究所,中国科学院分子影像重点实验室(已毕业)   

刘海哮         中国科学院自动化研究所,中国科学院分子影像重点实验室(已毕业)

张泽宇         西安电子科技大学(访问学生)

屈巧俊         山西医科大学(访问学生)

张玮琪         南方医科大学珠江医院(访问学生)

杨俊莹         南方医科大学珠江医院(访问学生)

郭红波         西北大学(访问学生,已毕业)

刘沐寒         西安电子科技大学(访问学生,已毕业)


硕士研究生

李   聪         中国科学院自动化研究所,中国科学院分子影像重点实验室

沈碧螺         中国科学院自动化研究所,中国科学院分子影像重点实验室

郭李爽         北京航空航天大学(访问学生)

张笑宁         北京航空航天大学(访问学生)

亢福胜         西华大学(访问学生,已毕业)

宋天明         哈尔滨理工大学(访问学生,已毕业)

包成鹏         哈尔滨理工大学(访问学生,已毕业)