基本信息

吴丽 女  化学与化工学院
电子邮件: wuli@ucas.ac.cn
通信地址: 北京市怀柔区怀北镇怀北庄380号,中国科学院大学东区392室
邮政编码: 101408

招生信息

博士后,专业硕士和学位硕士

教育背景

   
学历

2007年  天津大学  博士学位

学位

2007年  天津大学  博士学位

工作经历

2017-至今   中国科学院大学化学学院   副教授

2014-2016  中国科学院大学化学与化工学院   讲师

2011-2014  北京大学医学部   博士后

2007-2009  日本甲南大学先端生命工学研究(FIBER)   博士后


专利与奖励

2013年  北京大学医学部优秀博士后

出版信息

1.     Qingju Liu, Yongqi Ke, Yuhe Kan, Xinjing Tang, Xiangjun Li*, Yujian He* and Li Wu*, Compatibility and Fidelity of Mirror-image Thymidine in Transcription Events by T7 RNA Polymerase, Molecular Therapy - Nucleic Acids, 2020, 21, 604-613.

2.     Xu Yang, Kunhao Yang, Li Wu*, Jingkui Yang* and Yujian He*, Fe3O4 nanoparticles functionalized with poly(ethylene glycol) for the selective separation and enrichment of Au(III), New Journal of Chemistry, 2020, 44, 1313-1319.

3.     陈露,季禾茗,莫蒙武,雷华军,卜新雅,何裕建,封禄田*吴丽*,偶氮苯修饰的发夹DNARNA转录的光调控, 中国科学院大学学报2020, 37 (3): 416-423.

4.     Yuhe Kan, Lu Chen, Dao Lin, Xinya Bu, Mengwu Mo, Liang Yan, Zhenjun Yang, Yuanlongfei*, Li Wu* and Yujian He*, Replication of DNA containing mirror- image thymidine in E. coli cells, Chemical Research in Toxicology, 2020, 33(9), 2276-2285.

5.     Liang Yan, Yongqi Ke, Yuhe Kan, Dao Lin, Jingkui Yang*, Yujian He* and Li Wu*, New insight into enzymatic hydrolysis of peptides with site-specific amino acid D-isomerization, Bioorganic chemistry, 2020, 105doi.org/10.1016/j.bioorg.2020.104389

6.     Yuhe Kan, Li Wu* and Yujian He*, Mutation analysis of L-thymidine-induced replication products using restriction enzyme mediated assay, Current Protocol in Nucleic Acid Chemistry, 2020, 83(1) doi.org/10.1002/cpnc.121.

 

7.  吴亚,史俊,吴丽*,有机合成协同思政教育的课程体系构建探索,大学化学, 收稿日期:2020-07-26

8.  专利:严良,吴丽,杨镜奎,何裕建,聚乙二醇(PEG 200)化含D-氨基酸多肽的合成与酶解的促进,中国科学院大学,2020325日。申请号202010220029.6

9.      Mengwu Mo, Dejia Kong, Heming Ji, Dao Lin, Xinjing Tang, Zhenjun Yang, Yujian He*, and Li Wu*,  Reversible photocontrol of thrombin activity by replacing loops of thrombin binding aptamer using azobenzene derivatives. Bioconjugate Chemistry, 2019, 30(1), 231241.

10.      Huajun Lei, Mengwu Mo, Yujian He, Ya Wu*, Wufu Zhu* and Li Wu*, Bioactivatable reductive cleavage of azobenzene for controlling functional dumbbell oligodeoxynucleotides, Bioorganic Chemistry 2019, 91, doi: https://doi.org/10.1016/j.bioorg.2019.103106.

11.      Zhongqiu Li, Mengru Ti, Kunhao Yang, Xiangjun Li, Li Wu*, Yujian He*Colorimetric detection of iron (II) using 4-mercaptobenzoic acid and 3,3′,5,5′-tetramethylbenzidine modified silver nanoparticles, Microchemical Journal, 2019, 151,104254-104260.

12.      Yuhe Kan, Zhikun Zhang, Kunhao Yang , Mengru Ti, Yongqi Ke, Li Wu*, Jingkui Yang* and Yujian He*, Influence of D-amino Acids in Beer on Formation of Uric Acid, Food technology and biotechnology, 2019, 57(3), 418-425.

13.      Zhongqiu Li, Kunhao Yanga, Yueguang Lv, Qingnan Wang, Chang Li, Li Wu*, Yujian He*, A rapid pretreatment of PVC products for high-throughput and visual detection of trace heavy metals, Monatshefte für Chemie - Chemical Monthly, 2019, 10.1007/s00706-019-02506-3.

14.      季禾茗, 孔德佳, 莫蒙武, 雷华军, , 赵瑞琪, , 何裕建, 封禄田*, *, 偶氮苯修饰的DNA对引物延伸的光调控, 中国科学院大学学报, 2019, 36(1), 38-47.

15.  李昶,吴丽*,何裕建*,北京怀沙河污染现状及主要污染源分析, 中国科学院大学学报,2019, 已接受.

16.  卜新雅,陈露,阚玉贺,雷华军,何裕建,封禄田*吴丽*,手性氨基酸对DNA链式聚合反应的影响,中国科学院大学学报,2019,已接受.

17.  Kunhao Yang, Long Pan, Lingling Gong, Qingju Liu, Zhongqiu Li, Li Wu* and Yujian He*, Colorimetric and visual determination of Au(III) ions using PEGylated gold nanoparticles, Microchimica Acta, 2018, 185(2), 95-102.

18.  Kunhao Yang, Zhongqiu Li, Yueguang Lv, Chuyi Yu, Peilong Wang, Xiaoou Su, Li Wu* and Yujian He*, Graphene and AuNPs based electrochemical aptasensor for ultrasensitive detection of hydroxylated polychlorinated biphenyl, Analytica Chimica Acta, 2018, 1041, 94-101.

19.  孔德佳,莫蒙武,季禾茗,雷华军,陈露,李元昊,何裕建,汤新景,郑鹏武*吴丽*,偶氮苯作用的核酸开关在生物体内的可逆光调控,中国科学: 化学, 2018, 48(7), 698-711.

20.  雷华军,莫蒙武,孔德佳,季禾茗,何裕建,郑鹏武*吴丽*,生物体系中还原裂解氮氮双键的研究进展,中国科学: 化学, 2018, 49(2), 256-265.

21.  刘庆菊,何裕建,吴丽*,李向军*, D-氨基酸诱导的酿酒酵母细胞内活性氧的累积.中国科学院大学学报, 2018, 35(4), 473-480.

22.  Liangliang Zhang, Duanwei Liang, Yuan Wang, Dong Li, Jinhao Zhang, Li Wu, Mengke Feng, Fan Yi, Luzheng Xu, Liandi Lei, Quan Du and XinJing Tang*, Caged circular siRNAs for photomodulation of gene expression in cells and mice, Chemical Science, 2018, 9, 44-51.

23.  Lingling Gong, Bibai Du, Long Pan, Qingju Liu, Kunhao Yang, Wei Wang, Hong Zhao*, Li Wu* and Yujian He*, Colorimetric aggregation assay for arsenic(III) using gold nanoparticles, Microchimica Acta, 2017, 184(4), 1185–1190.

24.  Qingju Liu, Li Chen, Zhikun Zhang, Bibai Du, Yating Xiao, Kunhao Yang, Lingling Gong, Li Wu*, Xiangjun Li* and Yujian He*, pH-dependent enantioselectivity of D-amino acid oxidase in aqueous solution, Scientific Reports, 2017, 7(1), 10.1038/s41598-017-03177-y.

25.  Qingju Liu, Chuanfang Zhao, Jincheng Huang, Li Chen, Kunhao Yang, Lingling Gong, Yuguo Du, Chuyi Yu, Li Wu*, Xiangjun Li* and Yujian He*, Enantioselectivity of D-amino acid oxidase in presence of Ionic liquids, RSC Advance, 2017, 7(54), 34110 – 34117.

26.  Yating Xiao, Qingju Liu, XinJing Tang, Zhenjun Yang, Li Wu* and Yujian He*, Mirror-image thymidine discriminates against incorporation of dNTP into DNA and repairs itself by DNA polymerases, Bioconjugate Chemistry, 2017, 28 (8), 2125–2134.

27.  Ya Wu and Li Wu*, Acid generation by 1,4-bis(phenylsulfonyloxy)benzene and their photochemical mechanism, Monatshefte für Chemie - Chemical Monthly, 2017, 148(4), 675–682.

28.  Yuzhuo Ji, Jiali Yang, Li Wu, Lijia Yu, and Xinjing Tang*, Photochemical regulation of gene expression using caged siRNAs with single terminal vitamin E modification, Angew. Chem. Int. Ed., 2016, 55(6), 2152–2156.

29.  Long Pan, Mengying Xu, Zilu Liu, Bibai Du, Kunhao Yang, Li Wu, Peng He and Yujian He*, Facile method for the synthesis of Fe3O4@HCP core–shell porous magnetic microspheres for fast separation of organic dyes from aqueous solution, RSC Adv., 2016, 6, 47530–47535.

30.  Bibai Du, Peilong Wang, Can Xiao, Ying Zhou, Li Wu, Hong Zhao, Xiaoou Su, Jingkui Yang*, Yujian He*, Antibody-free colorimetric determination of total aflatoxins by mercury(II)-mediated aggregation of lysine-functionalized gold nanoparticles, Microchim. Acta, 2016, 183, 4, 1493-1500.

31.  Li Wu, Yujian He* and Xinjing Tang*, Photoregulating RNA digestion using azobenzene linked dumbbell antisense oligodeoxynucleotides, Bioconjugate Chem., 2015, 26, 10701079.

32.  Li Wu, Ya Wu, Hongwei Jin, Liangren Zhang, Yujian He* and Xinjing Tang*.  Photoswitching properties of hairpin ODNs with azobenzene derivatives at the loop position, Med. Chem. Commun., 2015, 6, 461–468.

33.  Li Wu, Jie Wang and Xinjing Tang*, Synthesis of site-specifically phosphate-caged siRNAs, Current Protocols in Nucleic Acid Chemistry, 2015, 61:6.12.1-6.12.15. doi: 10.1002/0471142700.nc0612s61.

34.  Li Wu, Fen Pei, Jinhao Zhang, Junzhou Wu, Mengke Feng, Yuan Wang, Hongwei Jin, Liangren Zhang, Xinjing Tang*, Synthesis of site-specifically phosphate-caged siRNAs and evaluation of their RNAi activity and stability, Chem. Eur. J., 2014, 20(38), 12114-12122.

35.  Li Wu, Wang Y., Wu J., Lv C., Wang J. and Xinjing Tang*, Caged circular antisense oligonucleotides for photomodulation of RNA digestion and gene expression in cells. Nucleic Acids Res., 2013, 41(1), 677-686.

36.  Yuan Wang, Li Wu, Peng Wang, Cong Lv, Zhenjun Yang and Xinjing Tang*. Manipulation of gene expression in zebrafish using caged circular morpholino oligomers. Nucleic Acids Res., 2012, 40, 11155-11162.

37.  Li Wu, Kazuya Koumoto and Naoki Sugimoto*, Reversible stability switching of a hairpin DNA via a molecularly designed photo-responsive linker unit, Chem. Commun., 2009, 45, 1915-1917. 


科研活动

国家自然科学基金面上项目

2018/01-2021/12

主持

北京市自然科学基金面上项目

2019/01-2021/12

主持

国家自然科学基金青年项目

2014/01-2016/12

主持

国家重点研究发展计划重点专项

2016/07-2020/12

参加

大中型企业委托项目

2016/02-2017/04

主持

北京市与中央高校共建一流学科研究项目

2019/06-2019/12

主持

分子科学科教融合创新项目

2017/09-2019/12

主持

北京大学天然药物及仿生药物国家重点实验室开放基金

2014/09-2020/08

主持

青年教师科研启动基金

2015/06-2017/06

主持

中国博士后基金项目

2012/01-2013/12

主持

指导学生

   
研究生

硕士:肖亚婷、季禾茗、孔德佳、陈露、雷华军、莫蒙武、吴翔宇、卜新雅、柯咏琪、罗航、王昱、金朝阳

博士:刘庆菊、阚玉贺、林岛、严良